JP2018516962A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2018516962A5 JP2018516962A5 JP2017564108A JP2017564108A JP2018516962A5 JP 2018516962 A5 JP2018516962 A5 JP 2018516962A5 JP 2017564108 A JP2017564108 A JP 2017564108A JP 2017564108 A JP2017564108 A JP 2017564108A JP 2018516962 A5 JP2018516962 A5 JP 2018516962A5
- Authority
- JP
- Japan
- Prior art keywords
- polysaccharide
- protein
- conjugate
- composition
- carrier
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 229920001282 polysaccharide Polymers 0.000 claims 45
- 239000005017 polysaccharide Substances 0.000 claims 45
- 150000004676 glycans Chemical class 0.000 claims 42
- 239000000203 mixture Substances 0.000 claims 29
- 102000004169 proteins and genes Human genes 0.000 claims 24
- 108090000623 proteins and genes Proteins 0.000 claims 24
- 102000014914 Carrier Proteins Human genes 0.000 claims 17
- 108010078791 Carrier Proteins Proteins 0.000 claims 17
- 238000000034 method Methods 0.000 claims 15
- 101710087657 Manganese ABC transporter substrate-binding lipoprotein Proteins 0.000 claims 12
- 108010071134 CRM197 (non-toxic variant of diphtheria toxin) Proteins 0.000 claims 10
- 229960000814 tetanus toxoid Drugs 0.000 claims 9
- 229960003983 diphtheria toxoid Drugs 0.000 claims 8
- 238000001179 sorption measurement Methods 0.000 claims 6
- 239000002671 adjuvant Substances 0.000 claims 5
- 238000009472 formulation Methods 0.000 claims 5
- 229940031999 pneumococcal conjugate vaccine Drugs 0.000 claims 5
- 241000193998 Streptococcus pneumoniae Species 0.000 claims 4
- AZDRQVAHHNSJOQ-UHFFFAOYSA-N alumane Chemical class [AlH3] AZDRQVAHHNSJOQ-UHFFFAOYSA-N 0.000 claims 4
- 239000003795 chemical substances by application Substances 0.000 claims 4
- XLJMAIOERFSOGZ-UHFFFAOYSA-M cyanate Chemical compound [O-]C#N XLJMAIOERFSOGZ-UHFFFAOYSA-M 0.000 claims 4
- 229940031000 streptococcus pneumoniae Drugs 0.000 claims 4
- 229960005486 vaccine Drugs 0.000 claims 4
- WVDDGKGOMKODPV-UHFFFAOYSA-N Benzyl alcohol Chemical compound OCC1=CC=CC=C1 WVDDGKGOMKODPV-UHFFFAOYSA-N 0.000 claims 3
- 241000588724 Escherichia coli Species 0.000 claims 3
- HEMHJVSKTPXQMS-UHFFFAOYSA-M Sodium hydroxide Chemical compound [OH-].[Na+] HEMHJVSKTPXQMS-UHFFFAOYSA-M 0.000 claims 3
- 238000004220 aggregation Methods 0.000 claims 3
- 230000002776 aggregation Effects 0.000 claims 3
- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 3
- 239000008362 succinate buffer Substances 0.000 claims 3
- 241000193738 Bacillus anthracis Species 0.000 claims 2
- 108091003079 Bovine Serum Albumin Proteins 0.000 claims 2
- 101710194807 Protective antigen Proteins 0.000 claims 2
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 2
- 229940065181 bacillus anthracis Drugs 0.000 claims 2
- 229940098773 bovine serum albumin Drugs 0.000 claims 2
- 239000000872 buffer Substances 0.000 claims 2
- 108010045069 keyhole-limpet hemocyanin Proteins 0.000 claims 2
- LXCFILQKKLGQFO-UHFFFAOYSA-N methylparaben Chemical compound COC(=O)C1=CC=C(O)C=C1 LXCFILQKKLGQFO-UHFFFAOYSA-N 0.000 claims 2
- 108010040473 pneumococcal surface protein A Proteins 0.000 claims 2
- 239000003755 preservative agent Substances 0.000 claims 2
- QELSKZZBTMNZEB-UHFFFAOYSA-N propylparaben Chemical compound CCCOC(=O)C1=CC=C(O)C=C1 QELSKZZBTMNZEB-UHFFFAOYSA-N 0.000 claims 2
- 239000001384 succinic acid Substances 0.000 claims 2
- 230000007704 transition Effects 0.000 claims 2
- -1 19A polysaccharide Chemical class 0.000 claims 1
- QCDWFXQBSFUVSP-UHFFFAOYSA-N 2-phenoxyethanol Chemical compound OCCOC1=CC=CC=C1 QCDWFXQBSFUVSP-UHFFFAOYSA-N 0.000 claims 1
- 108010060123 Conjugate Vaccines Proteins 0.000 claims 1
- 102100037840 Dehydrogenase/reductase SDR family member 2, mitochondrial Human genes 0.000 claims 1
- 101710082714 Exotoxin A Proteins 0.000 claims 1
- 101000812705 Gallus gallus Endoplasmin Proteins 0.000 claims 1
- 241000606768 Haemophilus influenzae Species 0.000 claims 1
- 108091006905 Human Serum Albumin Proteins 0.000 claims 1
- 102000008100 Human Serum Albumin Human genes 0.000 claims 1
- 108010052285 Membrane Proteins Proteins 0.000 claims 1
- 102000018697 Membrane Proteins Human genes 0.000 claims 1
- 206010030113 Oedema Diseases 0.000 claims 1
- 108010058846 Ovalbumin Proteins 0.000 claims 1
- 201000005702 Pertussis Diseases 0.000 claims 1
- 101710183389 Pneumolysin Proteins 0.000 claims 1
- 229920001213 Polysorbate 20 Polymers 0.000 claims 1
- 108010013381 Porins Proteins 0.000 claims 1
- 101710188053 Protein D Proteins 0.000 claims 1
- 241000589517 Pseudomonas aeruginosa Species 0.000 claims 1
- 101710132893 Resolvase Proteins 0.000 claims 1
- 102000010912 Transferrin-Binding Proteins Human genes 0.000 claims 1
- 230000002378 acidificating effect Effects 0.000 claims 1
- ILRRQNADMUWWFW-UHFFFAOYSA-K aluminium phosphate Chemical compound O1[Al]2OP1(=O)O2 ILRRQNADMUWWFW-UHFFFAOYSA-K 0.000 claims 1
- 235000019445 benzyl alcohol Nutrition 0.000 claims 1
- 229960004217 benzyl alcohol Drugs 0.000 claims 1
- 239000006227 byproduct Substances 0.000 claims 1
- 229940031670 conjugate vaccine Drugs 0.000 claims 1
- 230000021615 conjugation Effects 0.000 claims 1
- 239000012634 fragment Substances 0.000 claims 1
- 230000005847 immunogenicity Effects 0.000 claims 1
- 231100000518 lethal Toxicity 0.000 claims 1
- 230000001665 lethal effect Effects 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- QSHDDOUJBYECFT-UHFFFAOYSA-N mercury Chemical compound [Hg] QSHDDOUJBYECFT-UHFFFAOYSA-N 0.000 claims 1
- 229910052753 mercury Inorganic materials 0.000 claims 1
- 239000004292 methyl p-hydroxybenzoate Substances 0.000 claims 1
- 235000010270 methyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 229960002216 methylparaben Drugs 0.000 claims 1
- 230000007935 neutral effect Effects 0.000 claims 1
- 229940092253 ovalbumin Drugs 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 229960005323 phenoxyethanol Drugs 0.000 claims 1
- 239000000256 polyoxyethylene sorbitan monolaurate Substances 0.000 claims 1
- 235000010486 polyoxyethylene sorbitan monolaurate Nutrition 0.000 claims 1
- 229940068977 polysorbate 20 Drugs 0.000 claims 1
- 102000007739 porin activity proteins Human genes 0.000 claims 1
- 230000002335 preservative effect Effects 0.000 claims 1
- 239000004405 propyl p-hydroxybenzoate Substances 0.000 claims 1
- 235000010232 propyl p-hydroxybenzoate Nutrition 0.000 claims 1
- 229960003415 propylparaben Drugs 0.000 claims 1
- 238000003118 sandwich ELISA Methods 0.000 claims 1
- 238000004513 sizing Methods 0.000 claims 1
- 239000011780 sodium chloride Substances 0.000 claims 1
- 239000004094 surface-active agent Substances 0.000 claims 1
- RTKIYNMVFMVABJ-UHFFFAOYSA-L thimerosal Chemical compound [Na+].CC[Hg]SC1=CC=CC=C1C([O-])=O RTKIYNMVFMVABJ-UHFFFAOYSA-L 0.000 claims 1
- 229960004906 thiomersal Drugs 0.000 claims 1
- 229960001005 tuberculin Drugs 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2021129726A JP2021185152A (ja) | 2015-06-08 | 2021-08-06 | 多糖−タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 |
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| IN2185/MUM/2015 | 2015-06-08 | ||
| IN2185MU2015 | 2015-06-08 | ||
| PCT/IB2016/053265 WO2016199003A1 (en) | 2015-06-08 | 2016-06-03 | Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021129726A Division JP2021185152A (ja) | 2015-06-08 | 2021-08-06 | 多糖−タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018516962A JP2018516962A (ja) | 2018-06-28 |
| JP2018516962A5 true JP2018516962A5 (enExample) | 2019-07-11 |
| JP7258463B2 JP7258463B2 (ja) | 2023-04-17 |
Family
ID=57503115
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017564108A Active JP7258463B2 (ja) | 2015-06-08 | 2016-06-03 | 多糖－タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 |
| JP2021129726A Pending JP2021185152A (ja) | 2015-06-08 | 2021-08-06 | 多糖−タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021129726A Pending JP2021185152A (ja) | 2015-06-08 | 2021-08-06 | 多糖−タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 |
Country Status (17)
| Country | Link |
|---|---|
| US (1) | US10729780B2 (enExample) |
| EP (1) | EP3302542A4 (enExample) |
| JP (2) | JP7258463B2 (enExample) |
| KR (2) | KR102876828B1 (enExample) |
| CN (1) | CN107847571A (enExample) |
| AU (2) | AU2016276269B2 (enExample) |
| CA (1) | CA2988366C (enExample) |
| CO (1) | CO2017012628A2 (enExample) |
| EA (1) | EA201792470A1 (enExample) |
| IL (1) | IL256118B (enExample) |
| MX (1) | MX2017015985A (enExample) |
| MY (1) | MY187461A (enExample) |
| PE (1) | PE20180460A1 (enExample) |
| PH (1) | PH12017502244A1 (enExample) |
| SA (1) | SA517390495B1 (enExample) |
| WO (1) | WO2016199003A1 (enExample) |
| ZA (1) | ZA201708325B (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| IL255106B2 (en) | 2015-05-04 | 2023-04-01 | Pfizer | Protein-polysaccharide conjugates of group b streptococcus, methods for preparing conjugates, immunogenic preparations containing conjugates and their uses |
| MX2017015985A (es) * | 2015-06-08 | 2018-08-15 | Serum Inst Of India Private Ltd | Metodos para mejorar la adsorcion de conjugados de polisacarido-proteina y formulacion de vacuna multivalente obtenida con los mismos. |
| CN106822884B (zh) * | 2016-12-28 | 2021-04-30 | 北京民海生物科技有限公司 | 一种多价肺炎球菌荚膜多糖结合疫苗的制备方法 |
| US11951165B2 (en) | 2016-12-30 | 2024-04-09 | Vaxcyte, Inc. | Conjugated vaccine carrier proteins |
| KR20190103256A (ko) | 2016-12-30 | 2019-09-04 | 수트로박스, 인코포레이티드 | 비자연 아미노산을 갖는 폴리펩타이드-항원 접합체 |
| AU2018225083B2 (en) * | 2017-02-24 | 2023-06-01 | Merck Sharp & Dohme Llc | Pneumococcal conjugate vaccine formulations |
| US10729763B2 (en) | 2017-06-10 | 2020-08-04 | Inventprise, Llc | Mixtures of polysaccharide-protein pegylated compounds |
| BR112020004396A8 (pt) * | 2017-09-07 | 2023-01-31 | Merck Sharp & Dohme | Polissacarídeos pneumocócicos e uso dos mesmos em conjugados imunogênicos polissacarídeo-proteína carreadora |
| MX2020005779A (es) | 2017-12-06 | 2020-10-28 | Merck Sharp & Dohme | Composiciones que comprenden conjugados de polisacarido de streptococcus pneumoniae con proteina y metodos de uso de estos. |
| CN108524926B (zh) * | 2018-06-29 | 2021-06-29 | 康希诺生物股份公司 | 一种多价肺炎球菌结合疫苗的制剂组合及其应用 |
| GB201818517D0 (en) * | 2018-11-13 | 2018-12-26 | Univ Liverpool John Moores | Nanoparticles and uses thereof |
| KR20240169145A (ko) | 2018-12-19 | 2024-12-02 | 머크 샤프 앤드 돔 엘엘씨 | 스트렙토코쿠스 뉴모니아에 폴리사카라이드-단백질 접합체를 포함하는 조성물 및 그의 사용 방법 |
| BR112021024393A8 (pt) * | 2019-06-05 | 2023-01-31 | Merck Sharp & Dohme | Um conjugado de polissacarídeo-proteína pneumocócico de sorotipo 35b imunogênico e processo de conjugação para fabricar o mesmo |
| US12473379B2 (en) | 2019-09-06 | 2025-11-18 | Serum Institute Of India Private Limited | Method for obtaining purified bacterial polysaccharides |
| CN113607939B (zh) * | 2021-08-05 | 2024-10-22 | 艾美探索者生命科学研发有限公司 | 肺炎球菌多糖结合疫苗各型结合原液吸附率测定方法 |
| CN115006522B (zh) * | 2022-06-16 | 2025-08-22 | 北京智飞绿竹生物制药有限公司 | 一种双价痢疾结合物组合疫苗的制备方法 |
| MX2024004116A (es) * | 2023-04-17 | 2024-11-08 | Serum Institute Of India Pvt Ltd | Metodos para mejorar la adsorcion de conjugados de polisacarido-proteina y formulacion de vacuna multivalente obtenida de los mismos |
Family Cites Families (15)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2059692C (en) | 1991-01-28 | 2004-11-16 | Peter J. Kniskern | Pneumoccoccal polysaccharide conjugate vaccine |
| PT2172213E (pt) * | 2003-01-30 | 2013-06-03 | Novartis Ag | Vacinas injetáveis contra múltiplos serogrupos meningocócicos |
| BRPI0413309B8 (pt) * | 2003-08-06 | 2021-05-25 | The Government Of The Us Secretary Department Of Health And Human Services | método para a preparação de uma vacina conjugada de polissacarídeo-proteína |
| CA2605179A1 (en) * | 2005-04-18 | 2006-10-26 | Novartis Vaccines And Diagnostics, Inc. | Expressing hepatitis b virus surface antigen for vaccine preparation |
| PL3017827T3 (pl) * | 2005-12-22 | 2019-04-30 | Glaxosmithkline Biologicals Sa | Szczepionka z koniugatem polisacharydu pneumokokowego |
| AU2006327023A1 (en) * | 2005-12-23 | 2007-06-28 | Glaxosmithkline Biologicals Sa | Conjugate vaccines |
| TW200806315A (en) * | 2006-04-26 | 2008-02-01 | Wyeth Corp | Novel formulations which stabilize and inhibit precipitation of immunogenic compositions |
| US9610339B2 (en) * | 2007-06-26 | 2017-04-04 | Glaxosmithkline Biologicals, S.A. | Vaccine comprising Streptococcus pneumoniae capsular polysaccharide conjugates |
| TW201136603A (en) | 2010-02-09 | 2011-11-01 | Merck Sharp & Amp Dohme Corp | 15-valent pneumococcal polysaccharide-protein conjugate vaccine composition |
| US20130273098A1 (en) * | 2010-12-10 | 2013-10-17 | Jeffrey T. Blue | Novel formulations which mitigate agitation-induced aggregation of immunogenic compositions |
| CA2863178C (en) * | 2012-01-30 | 2021-04-06 | Serum Institute Of India Ltd. | Immunogenic composition |
| KR102057217B1 (ko) * | 2012-06-20 | 2020-01-22 | 에스케이바이오사이언스 주식회사 | 다가 폐렴구균 다당류-단백질 접합체 조성물 |
| IN2015DN00694A (enExample) * | 2012-08-16 | 2015-06-26 | Pfizer | |
| CN103893751B (zh) * | 2014-03-26 | 2016-04-20 | 天津康希诺生物技术有限公司 | 一种肺炎球菌多糖蛋白缀合疫苗及其制备方法 |
| MX2017015985A (es) * | 2015-06-08 | 2018-08-15 | Serum Inst Of India Private Ltd | Metodos para mejorar la adsorcion de conjugados de polisacarido-proteina y formulacion de vacuna multivalente obtenida con los mismos. |
-
2016
- 2016-06-03 MX MX2017015985A patent/MX2017015985A/es unknown
- 2016-06-03 EA EA201792470A patent/EA201792470A1/ru unknown
- 2016-06-03 EP EP16806975.5A patent/EP3302542A4/en active Pending
- 2016-06-03 AU AU2016276269A patent/AU2016276269B2/en active Active
- 2016-06-03 WO PCT/IB2016/053265 patent/WO2016199003A1/en not_active Ceased
- 2016-06-03 JP JP2017564108A patent/JP7258463B2/ja active Active
- 2016-06-03 CN CN201680040596.5A patent/CN107847571A/zh active Pending
- 2016-06-03 KR KR1020237045298A patent/KR102876828B1/ko active Active
- 2016-06-03 KR KR1020187000352A patent/KR102690378B1/ko active Active
- 2016-06-03 US US15/580,653 patent/US10729780B2/en active Active
- 2016-06-03 MY MYPI2017704714A patent/MY187461A/en unknown
- 2016-06-03 CA CA2988366A patent/CA2988366C/en active Active
- 2016-06-03 PE PE2017002539A patent/PE20180460A1/es unknown
-
2017
- 2017-12-05 IL IL256118A patent/IL256118B/en unknown
- 2017-12-07 CO CONC2017/0012628A patent/CO2017012628A2/es unknown
- 2017-12-07 PH PH12017502244A patent/PH12017502244A1/en unknown
- 2017-12-07 ZA ZA2017/08325A patent/ZA201708325B/en unknown
- 2017-12-10 SA SA517390495A patent/SA517390495B1/ar unknown
-
2021
- 2021-08-06 JP JP2021129726A patent/JP2021185152A/ja active Pending
-
2024
- 2024-04-15 AU AU2024202450A patent/AU2024202450A1/en active Pending
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2018516962A5 (enExample) | ||
| JP7258463B2 (ja) | 多糖－タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 | |
| CA3066911C (en) | Multivalent conjugate vaccines with bivalent or multivalent conjugate polysaccharides that provide improved immunogenicity and avidity | |
| US8753649B2 (en) | Polysaccharide-protein conjugate vaccines | |
| CN103623405B (zh) | 多糖-蛋白轭合物疫苗 | |
| JP2020533439A5 (enExample) | ||
| CA2863178C (en) | Immunogenic composition | |
| JP2020533438A5 (enExample) | ||
| JP2020533442A5 (enExample) | ||
| JP2019513821A5 (enExample) | ||
| MX2012010388A (es) | Proceso de conjugacion de polisacaridos bacterianos con proteinas portadoras. | |
| US20230115072A1 (en) | Immunogenic Compositions of Polysaccharide-Protein Pegylated Compounds | |
| KR20190044663A (ko) | 네이세리아 메닌기티디스 백신 | |
| US20240000958A1 (en) | Novel carriers and conjugation methods | |
| KR102388325B1 (ko) | 저분자화 PRP를 사용한 Hib 컨쥬게이트 백신의 제조방법 | |
| JPWO2020058963A5 (enExample) | ||
| NZ738090B2 (en) | Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof | |
| RU2023120100A (ru) | Пневмококковые полисахариды и их применение в иммуногенных конъюгатах полисахарид-белок-носитель | |
| RU2020112314A (ru) | Пневмококковые полисахариды и их применение в иммуногенных конъюгатах полисахарид-белок-носитель | |
| RU2020112308A (ru) | Пневмококковые полисахариды и их применение в иммуногенных конъюгатах полисахарид-белок-носитель |