JP7258463B2 - 多糖－タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 - Google Patents

多糖－タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 Download PDF

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JP7258463B2
JP7258463B2 JP2017564108A JP2017564108A JP7258463B2 JP 7258463 B2 JP7258463 B2 JP 7258463B2 JP 2017564108 A JP2017564108 A JP 2017564108A JP 2017564108 A JP2017564108 A JP 2017564108A JP 7258463 B2 JP7258463 B2 JP 7258463B2
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polysaccharide
protein
conjugate
pneumococcal
crm197
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JP2018516962A5 (enExample
JP2018516962A (ja
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デレ、ラジーブ・ムハラサカント
マルビヤ、ヒテシュ・クマー
ジャナ、スワパン・クマー
ピサル、サンバージー・シャンカル
マリヤ、アサ・ディネシュ
マホー、スニル
ゴータム、マニッシュ・マヘシュクマー
ジョシ、チェタン・ビラス
マレパティ、ベンカタ・バムシ・クリシュナ
ジャダフ、プラシャント・シバジ
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Serum Institute Of Indiaprivate Ltd
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
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    • A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
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    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/02—Inorganic compounds
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
    • A61K47/12—Carboxylic acids; Salts or anhydrides thereof
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    • A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
    • A61K47/22—Heterocyclic compounds, e.g. ascorbic acid, tocopherol or pyrrolidones
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    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/6415—Toxins or lectins, e.g. clostridial toxins or Pseudomonas exotoxins
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    • A61P31/04—Antibacterial agents
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    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K39/00—Medicinal preparations containing antigens or antibodies
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    • A61K2039/55505—Inorganic adjuvants
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    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55511—Organic adjuvants
    • A61K2039/55516—Proteins; Peptides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/70—Multivalent vaccine

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  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Oncology (AREA)
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  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Oil, Petroleum & Natural Gas (AREA)
  • Toxicology (AREA)
  • Inorganic Chemistry (AREA)
  • Virology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Medicinal Preparation (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
JP2017564108A 2015-06-08 2016-06-03 多糖－タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法 Active JP7258463B2 (ja)

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JP2021129726A JP2021185152A (ja) 2015-06-08 2021-08-06 多糖−タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法

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IN2185MU2015 2015-06-08
IN2185/MUM/2015 2015-06-08
PCT/IB2016/053265 WO2016199003A1 (en) 2015-06-08 2016-06-03 Methods for improving the adsorption of polysaccharide-protein conjugates and multivalent vaccine formulation obtained thereof

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JP2021129726A Pending JP2021185152A (ja) 2015-06-08 2021-08-06 多糖−タンパク質結合体の吸着およびそれから得られた多価のワクチン製剤を改善するための方法

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EP3302542A1 (en) 2018-04-11
KR20180030498A (ko) 2018-03-23
CA2988366A1 (en) 2016-12-15
KR102876828B1 (ko) 2025-10-27
CO2017012628A2 (es) 2018-03-28
MX2017015985A (es) 2018-08-15
IL256118A (en) 2018-02-28
CN107847571A (zh) 2018-03-27
EP3302542A4 (en) 2019-04-10
EA201792470A1 (ru) 2018-10-31
CA2988366C (en) 2021-12-07
US10729780B2 (en) 2020-08-04
JP2021185152A (ja) 2021-12-09
SA517390495B1 (ar) 2023-03-23
ZA201708325B (en) 2019-05-29
NZ738090A (en) 2023-09-29
AU2016276269B2 (en) 2021-01-28
KR102690378B1 (ko) 2024-08-01
PE20180460A1 (es) 2018-03-06
IL256118B (en) 2021-12-01
AU2024202450A1 (en) 2024-10-31
KR20240007690A (ko) 2024-01-16
AU2016276269A1 (en) 2018-01-18
BR112017026343A2 (pt) 2019-11-19
US20180161445A1 (en) 2018-06-14
JP2018516962A (ja) 2018-06-28
PH12017502244A1 (en) 2018-06-11
MY187461A (en) 2021-09-23
WO2016199003A1 (en) 2016-12-15

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