|
GB323103A
(en)
|
1928-12-07 |
1929-12-24 |
Fred Cunningham Firth |
Improvements relating to shaper mechanism for winding yarn on weft bobbins in spinning mules
|
|
US4057685A
(en)
|
1972-02-02 |
1977-11-08 |
Abbott Laboratories |
Chemically modified endotoxin immunizing agent
|
|
US4356170A
(en)
|
1981-05-27 |
1982-10-26 |
Canadian Patents & Development Ltd. |
Immunogenic polysaccharide-protein conjugates
|
|
US4673574A
(en)
|
1981-08-31 |
1987-06-16 |
Anderson Porter W |
Immunogenic conjugates
|
|
SE8205892D0
(sv)
|
1982-10-18 |
1982-10-18 |
Bror Morein |
Immunogent membranproteinkomplex, sett for framstellning och anvendning derav som immunstimulerande medel och sasom vaccin
|
|
US4459286A
(en)
|
1983-01-31 |
1984-07-10 |
Merck & Co., Inc. |
Coupled H. influenzae type B vaccine
|
|
US4663160A
(en)
|
1983-03-14 |
1987-05-05 |
Miles Laboratories, Inc. |
Vaccines for gram-negative bacteria
|
|
US4761283A
(en)
|
1983-07-05 |
1988-08-02 |
The University Of Rochester |
Immunogenic conjugates
|
|
US6090406A
(en)
|
1984-04-12 |
2000-07-18 |
The Liposome Company, Inc. |
Potentiation of immune responses with liposomal adjuvants
|
|
US5916588A
(en)
|
1984-04-12 |
1999-06-29 |
The Liposome Company, Inc. |
Peptide-containing liposomes, immunogenic liposomes and methods of preparation and use
|
|
US4695624A
(en)
|
1984-05-10 |
1987-09-22 |
Merck & Co., Inc. |
Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency
|
|
US4882317A
(en)
|
1984-05-10 |
1989-11-21 |
Merck & Co., Inc. |
Covalently-modified bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers and methods of preparing such polysaccharides and conjugataes and of confirming covalency
|
|
US4808700A
(en)
|
1984-07-09 |
1989-02-28 |
Praxis Biologics, Inc. |
Immunogenic conjugates of non-toxic E. coli LT-B enterotoxin subunit and capsular polymers
|
|
US4709017A
(en)
|
1985-06-07 |
1987-11-24 |
President And Fellows Of Harvard College |
Modified toxic vaccines
|
|
IT1187753B
(it)
|
1985-07-05 |
1987-12-23 |
Sclavo Spa |
Coniugati glicoproteici ad attivita' immunogenica trivalente
|
|
US5057540A
(en)
|
1987-05-29 |
1991-10-15 |
Cambridge Biotech Corporation |
Saponin adjuvant
|
|
NL8802046A
(nl)
|
1988-08-18 |
1990-03-16 |
Gen Electric |
Polymeermengsel met polyester en alkaansulfonaat, daaruit gevormde voorwerpen.
|
|
NZ241926A
(en)
|
1988-08-25 |
1993-08-26 |
Liposome Co Inc |
Immunisation dosage form comprising a salt of an organic acid derivative of a sterol and an antigen
|
|
DE3841091A1
(de)
|
1988-12-07 |
1990-06-13 |
Behringwerke Ag |
Synthetische antigene, verfahren zu ihrer herstellung und ihre verwendung
|
|
US7118757B1
(en)
*
|
1988-12-19 |
2006-10-10 |
Wyeth Holdings Corporation |
Meningococcal class 1 outer-membrane protein vaccine
|
|
CA2006700A1
(en)
|
1989-01-17 |
1990-07-17 |
Antonello Pessi |
Synthetic peptides and their use as universal carriers for the preparation of immunogenic conjugates suitable for the development of synthetic vaccines
|
|
HU212924B
(en)
|
1989-05-25 |
1996-12-30 |
Chiron Corp |
Adjuvant formulation comprising a submicron oil droplet emulsion
|
|
AU651949B2
(en)
|
1989-07-14 |
1994-08-11 |
American Cyanamid Company |
Cytokine and hormone carriers for conjugate vaccines
|
|
IT1237764B
(it)
|
1989-11-10 |
1993-06-17 |
Eniricerche Spa |
Peptidi sintetici utili come carriers universali per la preparazione di coniugati immunogenici e loro impiego per lo sviluppo di vaccini sintetici.
|
|
SE466259B
(sv)
|
1990-05-31 |
1992-01-20 |
Arne Forsgren |
Protein d - ett igd-bindande protein fraan haemophilus influenzae, samt anvaendning av detta foer analys, vacciner och uppreningsaendamaal
|
|
DE69113564T2
(de)
|
1990-08-13 |
1996-05-30 |
American Cyanamid Co |
Faser-Hemagglutinin von Bordetella pertussis als Träger für konjugierten Impfstoff.
|
|
US5153312A
(en)
|
1990-09-28 |
1992-10-06 |
American Cyanamid Company |
Oligosaccharide conjugate vaccines
|
|
IT1262896B
(it)
|
1992-03-06 |
1996-07-22 |
|
Composti coniugati formati da proteine heat shock (hsp) e oligo-poli- saccaridi, loro uso per la produzione di vaccini.
|
|
FI945483A7
(fi)
|
1992-05-23 |
1995-01-20 |
Smithkline Beecham Biologicals S A |
Hepatiitti B - pinta-antigeenejä ja muita antigeenejä sisältäviä yhdistelmärokotteita
|
|
ES2142346T3
(es)
|
1992-06-18 |
2000-04-16 |
Harvard College |
Adn, polipeptido, celula, composicion y vacunas contra la toxina de la difteria.
|
|
CA2138997C
(en)
|
1992-06-25 |
2003-06-03 |
Jean-Paul Prieels |
Vaccine composition containing adjuvants
|
|
IL102687A
(en)
|
1992-07-30 |
1997-06-10 |
Yeda Res & Dev |
Conjugates of poorly immunogenic antigens and synthetic pepide carriers and vaccines comprising them
|
|
DE69331495T2
(de)
|
1992-08-31 |
2002-10-31 |
Baxter Healthcare S.A., Wallisellen |
Impfstoffe gegen neisseria meningitidis gruppe c
|
|
US5425946A
(en)
|
1992-08-31 |
1995-06-20 |
North American Vaccine, Inc. |
Vaccines against group C Neisseria meningitidis
|
|
RU2068270C1
(ru)
*
|
1993-01-13 |
1996-10-27 |
Научно-исследовательский институт вакцин и сывороток им.И.И.Мечникова |
Антиген менингококков группы в
|
|
AU685443B2
(en)
|
1993-03-23 |
1998-01-22 |
Smithkline Beecham Biologicals (Sa) |
Vaccine compositions containing 3-O deacylated monophosphoryl lipid A
|
|
ES2210262T3
(es)
|
1993-09-22 |
2004-07-01 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Procedimiento que permite activar un glucido soluble con la ayuda de nuevos reactivos cianilantes para producir estructuras inmunogenas.
|
|
GB9326174D0
(en)
|
1993-12-22 |
1994-02-23 |
Biocine Sclavo |
Mucosal adjuvant
|
|
GB9326253D0
(en)
|
1993-12-23 |
1994-02-23 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6455673B1
(en)
|
1994-06-08 |
2002-09-24 |
President And Fellows Of Harvard College |
Multi-mutant diphtheria toxin vaccines
|
|
US5917017A
(en)
|
1994-06-08 |
1999-06-29 |
President And Fellows Of Harvard College |
Diphtheria toxin vaccines bearing a mutated R domain
|
|
US6239116B1
(en)
|
1994-07-15 |
2001-05-29 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
US6429199B1
(en)
|
1994-07-15 |
2002-08-06 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules for activating dendritic cells
|
|
US6207646B1
(en)
|
1994-07-15 |
2001-03-27 |
University Of Iowa Research Foundation |
Immunostimulatory nucleic acid molecules
|
|
AUPM873294A0
(en)
|
1994-10-12 |
1994-11-03 |
Csl Limited |
Saponin preparations and use thereof in iscoms
|
|
UA56132C2
(uk)
|
1995-04-25 |
2003-05-15 |
Смітклайн Бічем Байолоджікалс С.А. |
Композиція вакцини (варіанти), спосіб стабілізації qs21 відносно гідролізу (варіанти), спосіб приготування композиції вакцини
|
|
FR2734484B1
(fr)
|
1995-05-24 |
1997-06-27 |
Pasteur Merieux Serums Vacc |
Composition vaccinale liquide et procede de fabrication
|
|
BR9608612A
(pt)
*
|
1995-06-07 |
1999-05-04 |
Smithkline Beecham Biolog |
Vacina compreendendo um conjugado de antígeno de polissacarídeo - proteína portadora e proteína portadora livre
|
|
EP1082965B1
(en)
|
1995-06-23 |
2009-06-10 |
GlaxoSmithKline Biologicals S.A. |
A vaccine composition comprising a polysaccharide conjugate antigen adsorbed onto aluminium phosphate
|
|
GB9513261D0
(en)
|
1995-06-29 |
1995-09-06 |
Smithkline Beecham Biolog |
Vaccines
|
|
US6248334B1
(en)
*
|
1997-01-08 |
2001-06-19 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Process for preparing conjugate vaccines including free protein and the conjugate vaccines, immunogens, and immunogenic reagents produced by this process
|
|
ATE441432T1
(de)
|
1997-03-10 |
2009-09-15 |
Ottawa Hospital Res Inst |
Verwendung von nicht-methyliertem cpg dinukleotid in kombination mit aluminium als adjuvantien
|
|
US6818222B1
(en)
|
1997-03-21 |
2004-11-16 |
Chiron Corporation |
Detoxified mutants of bacterial ADP-ribosylating toxins as parenteral adjuvants
|
|
US6299881B1
(en)
|
1997-03-24 |
2001-10-09 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Uronium salts for activating hydroxyls, carboxyls, and polysaccharides, and conjugate vaccines, immunogens, and other useful immunological reagents produced using uronium salts
|
|
FR2763244B1
(fr)
|
1997-05-14 |
2003-08-01 |
Pasteur Merieux Serums Vacc |
Composition vaccinale multivalente a porteur mixte
|
|
GB9712347D0
(en)
|
1997-06-14 |
1997-08-13 |
Smithkline Beecham Biolog |
Vaccine
|
|
GB9713156D0
(en)
|
1997-06-20 |
1997-08-27 |
Microbiological Res Authority |
Vaccines
|
|
EP1279401B1
(en)
|
1997-09-05 |
2008-01-09 |
GlaxoSmithKline Biologicals S.A. |
Oil in water emulsions containing saponins
|
|
GB9725084D0
(en)
|
1997-11-28 |
1998-01-28 |
Medeva Europ Ltd |
Vaccine compositions
|
|
US6284250B1
(en)
*
|
1998-02-05 |
2001-09-04 |
The Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Simplified method for removing free protein during preparation of protein-polysaccharide conjugates and vaccines using restricted-access media
|
|
CA2320223A1
(en)
|
1998-02-12 |
1999-08-19 |
American Cyanamid Company |
Pneumococcal and meningococcal vaccines formulated with interleukin-12
|
|
US7018637B2
(en)
|
1998-02-23 |
2006-03-28 |
Aventis Pasteur, Inc |
Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines
|
|
US6303114B1
(en)
|
1998-03-05 |
2001-10-16 |
The Medical College Of Ohio |
IL-12 enhancement of immune responses to T-independent antigens
|
|
KR20010042573A
(ko)
|
1998-04-09 |
2001-05-25 |
장 스테판느 |
애쥬번트 조성물
|
|
US6562798B1
(en)
|
1998-06-05 |
2003-05-13 |
Dynavax Technologies Corp. |
Immunostimulatory oligonucleotides with modified bases and methods of use thereof
|
|
GB9817052D0
(en)
|
1998-08-05 |
1998-09-30 |
Smithkline Beecham Biolog |
Vaccine
|
|
CN1263510C
(zh)
|
1998-08-19 |
2006-07-12 |
巴克斯特健康护理股份有限公司 |
多糖-蛋白质缀合物或寡糖-蛋白质缀合物、其制备方法及其应用
|
|
CN101926993B
(zh)
|
1998-10-16 |
2013-12-04 |
史密丝克莱恩比彻姆生物有限公司 |
佐剂系统及疫苗
|
|
US6585973B1
(en)
|
1998-10-29 |
2003-07-01 |
Henry M. Jackson Foundation For The Advancement Of Military Medicine |
Method for preparing solid phase conjugated vaccine
|
|
WO2000056359A2
(en)
|
1999-03-19 |
2000-09-28 |
Smithkline Beecham Biologicals S.A. |
Vaccine against streptococcus pneumoniae
|
|
CA2365914A1
(en)
|
1999-04-09 |
2000-10-19 |
Techlab, Inc. |
Recombinant clostridium toxin a protein carrier for polysaccharide conjugate vaccines
|
|
WO2001021207A2
(en)
|
1999-09-24 |
2001-03-29 |
Smithkline Beecham Biologicals S.A. |
Use of combination of polyoxyethylene sorbitan ester and octoxynol as adjuvant and its use in vaccines
|
|
TR200200777T2
(tr)
|
1999-09-24 |
2002-09-23 |
Smithkline Beecham Biologicals S.A. |
Polioksietilen alkil eteri veya esteriyle en az bir iyonik olmayan yüzey aktif maddeli adjuvant.
|
|
GB9928196D0
(en)
*
|
1999-11-29 |
2000-01-26 |
Chiron Spa |
Combinations of B, C and other antigens
|
|
DK1233784T3
(da)
|
1999-12-02 |
2008-09-01 |
Novartis Vaccines & Diagnostic |
Præparater og fremgangsmåder til stabilisering af biologiske molekyler efter lyofilisering
|
|
EP1311288A1
(en)
|
2000-01-20 |
2003-05-21 |
Ottawa Health Research Institute |
Immunostimulatory nucleic acids for inducing a th2 immune response
|
|
GB0007432D0
(en)
|
2000-03-27 |
2000-05-17 |
Microbiological Res Authority |
Proteins for use as carriers in conjugate vaccines
|
|
SI1296715T2
(sl)
|
2000-06-29 |
2016-03-31 |
Smithkline Beecham Biologicals S.A. |
Multivalentni sestavek cepiva
|
|
GB0108364D0
(en)
|
2001-04-03 |
2001-05-23 |
Glaxosmithkline Biolog Sa |
Vaccine composition
|
|
CA2423487C
(en)
|
2000-09-26 |
2015-12-15 |
Hybridon, Inc. |
Modulation of immunostimulatory activity of immunostimulatory oligonucleotide analogs by positional chemical changes
|
|
EP2957300B1
(en)
|
2001-01-23 |
2021-07-14 |
Sanofi Pasteur Inc. |
Multivalent meningococcal polysaccharide-protein conjugate vaccine
|
|
WO2002091998A2
(en)
|
2001-05-11 |
2002-11-21 |
Aventis Pasteur, Inc. |
Novel meningitis conjugate vaccine
|
|
GB0115176D0
(en)
|
2001-06-20 |
2001-08-15 |
Chiron Spa |
Capular polysaccharide solubilisation and combination vaccines
|
|
EP1409013B1
(en)
|
2001-07-26 |
2009-11-18 |
Novartis Vaccines and Diagnostics S.r.l. |
Vaccines comprising aluminium adjuvants and histidine
|
|
CA2492826C
(en)
|
2001-09-14 |
2016-12-13 |
Cytos Biotechnology Ag |
Encapsulation of unmethylated cpg-containing oligonucleotides into virus-like particles: method of preparation and use
|
|
JP4360906B2
(ja)
|
2001-09-14 |
2009-11-11 |
サイトス バイオテクノロジー アーゲー |
ウィルス様粒子によって誘導される免疫応答を高めるための、抗原提示細胞のインビボでの活性化
|
|
WO2003035836A2
(en)
|
2001-10-24 |
2003-05-01 |
Hybridon Inc. |
Modulation of immunostimulatory properties of oligonucleotide-based compounds by optimal presentation of 5' ends
|
|
BR0308768A
(pt)
|
2002-03-26 |
2005-02-15 |
Chiron Srl |
Sacarìdeos modificados possuindo estabilidade melhorada em água
|
|
SI2353608T1
(sl)
|
2002-10-11 |
2020-12-31 |
Glaxosmithkline Biologicals Sa |
Polipeptidna cepiva za široko zaščito proti hipervirulentnim meningokoknim linijam
|
|
PT2172213E
(pt)
|
2003-01-30 |
2013-06-03 |
Novartis Ag |
Vacinas injetáveis contra múltiplos serogrupos meningocócicos
|
|
GB0323103D0
(en)
|
2003-10-02 |
2003-11-05 |
Chiron Srl |
De-acetylated saccharides
|