BRPI0519232A2 - vacinas de conjugados de sacarÍdeos - Google Patents
vacinas de conjugados de sacarÍdeosInfo
- Publication number
- BRPI0519232A2 BRPI0519232A2 BRPI0519232-3A BRPI0519232A BRPI0519232A2 BR PI0519232 A2 BRPI0519232 A2 BR PI0519232A2 BR PI0519232 A BRPI0519232 A BR PI0519232A BR PI0519232 A2 BRPI0519232 A2 BR PI0519232A2
- Authority
- BR
- Brazil
- Prior art keywords
- compositions
- carrier protein
- conjugates
- conjugate vaccines
- pathogens
- Prior art date
Links
- 150000001720 carbohydrates Chemical class 0.000 title abstract 3
- 108010060123 Conjugate Vaccines Proteins 0.000 title 1
- 229940031670 conjugate vaccine Drugs 0.000 title 1
- 239000000203 mixture Substances 0.000 abstract 4
- 102000014914 Carrier Proteins Human genes 0.000 abstract 3
- 108010078791 Carrier Proteins Proteins 0.000 abstract 3
- 210000001744 T-lymphocyte Anatomy 0.000 abstract 2
- 239000000427 antigen Substances 0.000 abstract 2
- 102000036639 antigens Human genes 0.000 abstract 2
- 108091007433 antigens Proteins 0.000 abstract 2
- 244000052769 pathogen Species 0.000 abstract 2
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/385—Haptens or antigens, bound to carriers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0266—Klebsiella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/025—Enterobacteriales, e.g. Enterobacter
- A61K39/0275—Salmonella
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/085—Staphylococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/09—Lactobacillales, e.g. aerococcus, enterococcus, lactobacillus, lactococcus, streptococcus
- A61K39/092—Streptococcus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/095—Neisseria
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/102—Pasteurellales, e.g. Actinobacillus, Pasteurella; Haemophilus
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/104—Pseudomonadales, e.g. Pseudomonas
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/02—Bacterial antigens
- A61K39/107—Vibrio
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/06—Antibacterial agents for tuberculosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/04—Antibacterial agents
- A61P31/08—Antibacterial agents for leprosy
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/14—Antivirals for RNA viruses
- A61P31/16—Antivirals for RNA viruses for influenza or rhinoviruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
- A61P31/12—Antivirals
- A61P31/20—Antivirals for DNA viruses
- A61P31/22—Antivirals for DNA viruses for herpes viruses
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
- A61P37/04—Immunostimulants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
- A61K2039/55505—Inorganic adjuvants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6068—Other bacterial proteins, e.g. OMP
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
- A61K2039/6031—Proteins
- A61K2039/6075—Viral proteins
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/70—Multivalent vaccine
-
- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
- Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
- Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Landscapes
- Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Veterinary Medicine (AREA)
- Chemical & Material Sciences (AREA)
- Immunology (AREA)
- Microbiology (AREA)
- Mycology (AREA)
- Epidemiology (AREA)
- Virology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Oncology (AREA)
- Communicable Diseases (AREA)
- Molecular Biology (AREA)
- Engineering & Computer Science (AREA)
- Biotechnology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Pulmonology (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Peptides Or Proteins (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB0428394.1A GB0428394D0 (en) | 2004-12-24 | 2004-12-24 | Saccharide conjugate vaccines |
| PCT/IB2005/004050 WO2006067632A2 (en) | 2004-12-24 | 2005-12-23 | Saccharide conjugate vaccines |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| BRPI0519232A2 true BRPI0519232A2 (pt) | 2009-01-06 |
Family
ID=34130952
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| BRPI0519232-3A BRPI0519232A2 (pt) | 2004-12-24 | 2005-12-23 | vacinas de conjugados de sacarÍdeos |
Country Status (14)
| Country | Link |
|---|---|
| US (2) | US20080260773A1 (enExample) |
| EP (1) | EP1838345B1 (enExample) |
| JP (3) | JP5737824B2 (enExample) |
| CN (1) | CN101111261B (enExample) |
| AT (1) | ATE492290T1 (enExample) |
| AU (1) | AU2005317683B2 (enExample) |
| BR (1) | BRPI0519232A2 (enExample) |
| CA (1) | CA2594524C (enExample) |
| DE (1) | DE602005025531D1 (enExample) |
| ES (1) | ES2356670T3 (enExample) |
| GB (1) | GB0428394D0 (enExample) |
| NZ (2) | NZ556486A (enExample) |
| RU (1) | RU2454244C2 (enExample) |
| WO (1) | WO2006067632A2 (enExample) |
Families Citing this family (67)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JPH0788795B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788794B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788796B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788798B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| JPH0788797B2 (ja) | 1985-09-10 | 1995-09-27 | マツダ株式会社 | エンジンの空燃比制御装置 |
| EP2277541A1 (en) * | 2000-06-29 | 2011-01-26 | SmithKline Beecham Biologicals S.A. | Multivalent vaccine composition |
| WO2002020059A2 (en) | 2000-09-01 | 2002-03-14 | The Government Of The United States Of America As Represented By The Secretary, Department Of Health And Human Services | Vibrio cholerae o139 conjugate vaccines |
| ES2330083T3 (es) * | 2000-10-27 | 2009-12-04 | Novartis Vaccines And Diagnostics S.R.L. | Acidos nucleicos y proteinas de estreptococos de los grupos a y b. |
| MX339524B (es) | 2001-10-11 | 2016-05-30 | Wyeth Corp | Composiciones inmunogenicas novedosas para la prevencion y tratamiento de enfermedad meningococica. |
| WO2007000341A2 (en) | 2005-06-27 | 2007-01-04 | Glaxosmithkline Biologicals S.A. | Immunogenic composition |
| KR20150038626A (ko) | 2006-03-17 | 2015-04-08 | 더 거버먼트 오브 더 유나이티드 스테이츠 오브 아메리카 에즈 레프리젠티드 바이 더 세크러테리 오브 더 디파트먼트 오브 헬스 앤드 휴먼 서비시즈 | 복합 다가 면역원성 콘쥬게이트의 제조 방법 |
| EP2601969B1 (en) * | 2006-09-29 | 2016-03-30 | Takeda Vaccines, Inc. | Norovirus vaccine formulations |
| GB0622282D0 (en) * | 2006-11-08 | 2006-12-20 | Novartis Ag | Quality control methods |
| AR064642A1 (es) | 2006-12-22 | 2009-04-15 | Wyeth Corp | Polinucleotido vector que lo comprende celula recombinante que comprende el vector polipeptido , anticuerpo , composicion que comprende el polinucleotido , vector , celula recombinante polipeptido o anticuerpo , uso de la composicion y metodo para preparar la composicion misma y preparar una composi |
| GB0700136D0 (en) * | 2007-01-04 | 2007-02-14 | Glaxosmithkline Biolog Sa | Process for manufacturing vaccines |
| GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
| CA2698397C (en) | 2007-09-18 | 2018-03-27 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| US20100266636A1 (en) | 2007-09-18 | 2010-10-21 | Ligocyte Pharmaceuticals, Inc. | Method of conferring a protective immune response to norovirus |
| US20110189223A1 (en) * | 2008-04-16 | 2011-08-04 | Glaxosmithkline Biologicals S.A. | Vaccine |
| EP2303286A4 (en) * | 2008-06-16 | 2011-12-28 | Academia Sinica | COMPOSITIONS FOR GENERATING IMMUNE REACTIONS SPECIFIC TO GLOBO H AND SSEA3 AND THEIR USES IN CANCER TREATMENT |
| NO2324113T3 (enExample) | 2008-08-08 | 2018-07-28 | ||
| CN105535955B (zh) * | 2009-06-16 | 2019-04-23 | 中央研究院 | Globo h及含新颖糖脂质佐剂的相关抗癌疫苗 |
| US8974799B2 (en) | 2009-09-30 | 2015-03-10 | Novartis Ag | Conjugation of Staphylococcus aureus type 5 and type 8 capsular polysaccharides |
| WO2011041691A1 (en) * | 2009-10-02 | 2011-04-07 | University Of Iowa Research Foundation | Methods of improving vaccine immunogenicity |
| GB201003922D0 (en) | 2010-03-09 | 2010-04-21 | Glaxosmithkline Biolog Sa | Conjugation process |
| WO2011123042A1 (en) * | 2010-04-01 | 2011-10-06 | Independent Pharmaceutica Ab | Vaccination procedure and products for use therein |
| SI2608805T2 (sl) | 2010-08-23 | 2025-09-30 | Wyeth Llc | Stabilne formulacije antigenov rLP2086 neisserie meningitidis |
| BR112013005329A2 (pt) | 2010-09-10 | 2017-05-02 | Wyeth Llc | variantes não lipidadas de antígenos orf2086 de neisseria meningitidis |
| US20120135025A1 (en) * | 2010-10-20 | 2012-05-31 | Genocea Biosciences, Inc. | Chlamydia antigens and uses thereof |
| MX356426B (es) | 2011-04-04 | 2018-05-29 | Univ Iowa Res Found | Metodos para mejorar inmunogenicidad de vacuna. |
| CA2835630A1 (en) | 2011-05-11 | 2012-11-15 | Richard Malley | Modified biotin-binding protein, fusion proteins thereof and applications |
| CN102807621B (zh) | 2011-06-01 | 2016-04-13 | 厦门大学 | 包含白喉毒素无毒突变体crm197或其片段的融合蛋白 |
| EA035442B1 (ru) | 2011-07-11 | 2020-06-17 | Такеда Вэксинс, Инк. | Композиции, содержащие буфер, вакцины, которые содержат композиции, содержащие буфер, и пути их применения |
| SA115360586B1 (ar) | 2012-03-09 | 2017-04-12 | فايزر انك | تركيبات لعلاج الالتهاب السحائي البكتيري وطرق لتحضيرها |
| MX2018011291A (es) | 2012-03-09 | 2023-01-31 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| US10722569B2 (en) | 2012-07-05 | 2020-07-28 | Children's Medical Center Corporation | Bacterial biofilm matrix as a platform for protein delivery |
| US9777076B2 (en) | 2012-07-16 | 2017-10-03 | Pfizer Inc. | Saccharides and uses thereof |
| BR112015007126A2 (pt) * | 2012-10-02 | 2017-08-08 | Glaxosmithkline Biologicals Sa | composição, método para induzir uma resposta imune, e, uso de uma composição |
| EP2953638B1 (en) | 2013-02-07 | 2023-07-05 | Children's Medical Center Corporation | Protein antigens that provide protection against pneumococcal colonization and/or disease |
| WO2014136064A2 (en) | 2013-03-08 | 2014-09-12 | Pfizer Inc. | Immunogenic fusion polypeptides |
| BR112016004463A2 (pt) | 2013-09-08 | 2017-10-17 | Pfizer | composições de neisseria meningitidis e métodos das mesmas |
| CN104069504B (zh) * | 2014-05-11 | 2019-09-24 | 江苏康泰生物医学技术有限公司 | 一种增强多糖蛋白结合物免疫原性的方法 |
| CN104004085B (zh) * | 2014-05-28 | 2017-01-11 | 山东大学 | 一种结核杆菌lam寡糖缀合物及其制备方法与应用 |
| US9107906B1 (en) | 2014-10-28 | 2015-08-18 | Adma Biologics, Inc. | Compositions and methods for the treatment of immunodeficiency |
| WO2016132294A1 (en) | 2015-02-19 | 2016-08-25 | Pfizer Inc. | Neisseria meningitidis compositions and methods thereof |
| CN108367063A (zh) * | 2015-07-21 | 2018-08-03 | 辉瑞公司 | 包含缀合的荚膜糖抗原的免疫原性组合物及其试剂盒和用途 |
| JP7099956B2 (ja) | 2015-12-04 | 2022-07-12 | デイナ ファーバー キャンサー インスティチュート,インコーポレイテッド | がんの治療のためのmica/bアルファ3ドメインによるワクチン接種 |
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| US11071779B2 (en) | 2016-06-17 | 2021-07-27 | Children's Medical Center Corporation | Biofilm matrix-boosted vaccine |
| CN110290804B (zh) * | 2016-10-03 | 2024-08-27 | 王锦堂 | 克雷伯氏肺炎杆菌的荚膜多糖疫苗 |
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| CN110730670A (zh) | 2017-03-28 | 2020-01-24 | 儿童医疗中心有限公司 | 基于多抗原提呈系统(maps)的金黄色葡萄球菌疫苗、免疫原性组合物以及它们的用途 |
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| BR112019026192B1 (pt) * | 2017-06-10 | 2022-05-10 | Inventprise, Llc | Vacinas de conjugado multivalente com polissacarídeos de conjugado bivalente ou multivalente que fornecem imunogenicidade e avidez melhoradas |
| TWI850197B (zh) | 2017-06-23 | 2024-08-01 | 美國馬里蘭大學巴爾的摩分校 | 免疫原性組成物 |
| CN109870581B (zh) * | 2017-12-04 | 2021-05-04 | 厦门万泰凯瑞生物技术有限公司 | 一种定量检测HBsAg的试剂盒及方法 |
| SG11202102007UA (en) | 2018-09-12 | 2021-03-30 | Affinivax Inc | Multivalent pneumococcal vaccines |
| KR20210088535A (ko) | 2018-09-12 | 2021-07-14 | 더 칠드런스 메디칼 센터 코포레이션 | 폐렴구균 융합 단백질 백신 |
| MX2022003682A (es) | 2019-09-27 | 2022-04-25 | Pfizer | Composiciones de neisseria meningitidis y metodos de las mismas. |
| WO2021158440A1 (en) * | 2020-02-06 | 2021-08-12 | Longhorn Vaccines And Diagnostics, Llc | Immunogenic compositions to treat and prevent microbial infections |
| US12053515B2 (en) | 2020-08-10 | 2024-08-06 | Inventprise, Inc. | Multivalent pneumococcal glycoconjugate vaccines containing emerging serotype 24F |
| CN113150084B (zh) * | 2021-03-23 | 2023-03-21 | 江苏坤力生物制药有限责任公司 | 一种纳米化的冠状病毒抗原及其应用 |
| CN113274489B (zh) * | 2021-04-30 | 2023-08-29 | 山东省药学科学院 | 一种预防真菌感染的几丁质寡糖疫苗及其制备方法 |
| WO2023039223A1 (en) | 2021-09-09 | 2023-03-16 | Affinivax, Inc. | Multivalent pneumococcal vaccines |
| CN114767846B (zh) * | 2022-04-21 | 2025-10-14 | 中国医学科学院医学生物学研究所 | 一种轮状非结构蛋白4在提高重组轮状病毒亚单位疫苗免疫功能中的应用 |
| CN115721711B (zh) * | 2022-10-28 | 2024-01-23 | 普大生物科技(泰州)有限公司 | 一种肺炎球菌荚膜多糖-带状疱疹病毒重组蛋白结合疫苗及其制备方法 |
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| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4695624A (en) * | 1984-05-10 | 1987-09-22 | Merck & Co., Inc. | Covalently-modified polyanionic bacterial polysaccharides, stable covalent conjugates of such polysaccharides and immunogenic proteins with bigeneric spacers, and methods of preparing such polysaccharides and conjugates and of confirming covalency |
| ATE121947T1 (de) * | 1989-12-14 | 1995-05-15 | Ca Nat Research Council | Verbessertes meningokokkale polysaccharidkonjugatvakzin. |
| DE69615362T3 (de) * | 1995-06-07 | 2006-07-20 | Smithkline Beecham Biologicals S.A. | Impfstoff mit einem polysaccharidantigen-trägerprotein-konjugat und einem trägerprotein |
| CN1215337A (zh) * | 1995-06-23 | 1999-04-28 | 史密斯克莱·比奇曼生物公司 | 包含一种多糖抗原-载体蛋白共轭物和游离载体蛋白的疫苗 |
| PT969873E (pt) * | 1997-03-27 | 2006-09-29 | Pasteur Institut | Hidrato de carbono glicopeptido antigene multiplo, vacina abrangendo o mesmo e seu uso |
| US7018637B2 (en) * | 1998-02-23 | 2006-03-28 | Aventis Pasteur, Inc | Multi-oligosaccharide glycoconjugate bacterial meningitis vaccines |
| GB9808932D0 (en) * | 1998-04-27 | 1998-06-24 | Chiron Spa | Polyepitope carrier protein |
| EP1355673B1 (en) * | 2001-01-23 | 2012-05-30 | Sanofi Pasteur Inc. | Multivalent meningococcal polysaccharide-protein conjugate vaccine |
| GB0107658D0 (en) * | 2001-03-27 | 2001-05-16 | Chiron Spa | Streptococcus pneumoniae |
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2004
- 2004-12-24 GB GBGB0428394.1A patent/GB0428394D0/en not_active Ceased
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2005
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- 2005-12-23 JP JP2007547709A patent/JP5737824B2/ja not_active Expired - Fee Related
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- 2005-12-23 BR BRPI0519232-3A patent/BRPI0519232A2/pt not_active IP Right Cessation
- 2005-12-23 US US11/793,996 patent/US20080260773A1/en not_active Abandoned
- 2005-12-23 ES ES05850768T patent/ES2356670T3/es active Active
- 2005-12-23 AT AT05850768T patent/ATE492290T1/de not_active IP Right Cessation
- 2005-12-23 RU RU2007127993/10A patent/RU2454244C2/ru not_active IP Right Cessation
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2012
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2014
- 2014-08-05 US US14/451,907 patent/US20150165019A1/en not_active Abandoned
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|---|---|
| NZ593954A (en) | 2013-07-26 |
| JP2015155464A (ja) | 2015-08-27 |
| CN101111261B (zh) | 2013-03-27 |
| NZ556486A (en) | 2011-07-29 |
| CA2594524A1 (en) | 2006-06-29 |
| ATE492290T1 (de) | 2011-01-15 |
| DE602005025531D1 (de) | 2011-02-03 |
| CA2594524C (en) | 2015-05-19 |
| AU2005317683A1 (en) | 2006-06-29 |
| JP5737824B2 (ja) | 2015-06-17 |
| ES2356670T3 (es) | 2011-04-12 |
| JP2013049717A (ja) | 2013-03-14 |
| JP2008525423A (ja) | 2008-07-17 |
| US20150165019A1 (en) | 2015-06-18 |
| RU2007127993A (ru) | 2009-01-27 |
| WO2006067632A2 (en) | 2006-06-29 |
| AU2005317683B2 (en) | 2012-04-26 |
| EP1838345B1 (en) | 2010-12-22 |
| CN101111261A (zh) | 2008-01-23 |
| EP1838345A2 (en) | 2007-10-03 |
| US20080260773A1 (en) | 2008-10-23 |
| WO2006067632A3 (en) | 2007-03-29 |
| RU2454244C2 (ru) | 2012-06-27 |
| GB0428394D0 (en) | 2005-02-02 |
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