EA201001625A1 - Человеческие сывороточные альбуминовые линкеры и их конъюгаты - Google Patents

Человеческие сывороточные альбуминовые линкеры и их конъюгаты

Info

Publication number
EA201001625A1
EA201001625A1 EA201001625A EA201001625A EA201001625A1 EA 201001625 A1 EA201001625 A1 EA 201001625A1 EA 201001625 A EA201001625 A EA 201001625A EA 201001625 A EA201001625 A EA 201001625A EA 201001625 A1 EA201001625 A1 EA 201001625A1
Authority
EA
Eurasian Patent Office
Prior art keywords
serum albumin
human serum
conjugates
links
diagnostic
Prior art date
Application number
EA201001625A
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English (en)
Other versions
EA022201B1 (ru
Inventor
Шарлотт Макдонах
Майкл Фельдхаус
Александра Хухалов
Original Assignee
Мерримак Фармасьютикалз, Инк.
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
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Application filed by Мерримак Фармасьютикалз, Инк. filed Critical Мерримак Фармасьютикалз, Инк.
Publication of EA201001625A1 publication Critical patent/EA201001625A1/ru
Publication of EA022201B1 publication Critical patent/EA022201B1/ru

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/32—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against translation products of oncogenes
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K14/00—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • C07K14/435—Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof from animals; from humans
    • C07K14/76—Albumins
    • C07K14/765—Serum albumin, e.g. HSA
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/30—Immunoglobulins specific features characterized by aspects of specificity or valency
    • C07K2317/31—Immunoglobulins specific features characterized by aspects of specificity or valency multispecific
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/60—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments
    • C07K2317/62—Immunoglobulins specific features characterized by non-natural combinations of immunoglobulin fragments comprising only variable region components
    • C07K2317/622—Single chain antibody (scFv)
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2319/00—Fusion polypeptide
    • C07K2319/31—Fusion polypeptide fusions, other than Fc, for prolonged plasma life, e.g. albumin

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Biochemistry (AREA)
  • General Chemical & Material Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Public Health (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • Biophysics (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Zoology (AREA)
  • Toxicology (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • Immunology (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicinal Preparation (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)

Abstract

Настоящее изобретение относится к человеческому сывороточному альбуминовому (HSA) линкеру и конъюгированным с ним связывающим, диагностическим и терапевтическим агентам. Также раскрываются способы и наборы для диагностического и терапевтического применения конъюгата HSA линкера.
EA201001625A 2008-04-11 2009-04-10 Агент, способный связываться с опухолевой клеткой, содержащий линкер на основе hsa, и его применение EA022201B1 (ru)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US12394208P 2008-04-11 2008-04-11
US11579708P 2008-11-18 2008-11-18
PCT/US2009/040259 WO2009126920A2 (en) 2008-04-11 2009-04-10 Human serum albumin linkers and conjugates thereof

Publications (2)

Publication Number Publication Date
EA201001625A1 true EA201001625A1 (ru) 2011-06-30
EA022201B1 EA022201B1 (ru) 2015-11-30

Family

ID=41162659

Family Applications (1)

Application Number Title Priority Date Filing Date
EA201001625A EA022201B1 (ru) 2008-04-11 2009-04-10 Агент, способный связываться с опухолевой клеткой, содержащий линкер на основе hsa, и его применение

Country Status (15)

Country Link
EP (2) EP2288715B1 (ru)
JP (2) JP5639039B2 (ru)
KR (1) KR20110008086A (ru)
CN (1) CN102057054B (ru)
AU (1) AU2009234253C1 (ru)
BR (1) BRPI0911652A2 (ru)
CA (1) CA2721093A1 (ru)
EA (1) EA022201B1 (ru)
ES (1) ES2525065T3 (ru)
IL (1) IL208598A (ru)
MX (1) MX2010011145A (ru)
NZ (1) NZ589086A (ru)
PL (1) PL2288715T3 (ru)
WO (1) WO2009126920A2 (ru)
ZA (1) ZA201008048B (ru)

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