BR112015007126A2 - composição, método para induzir uma resposta imune, e, uso de uma composição - Google Patents

composição, método para induzir uma resposta imune, e, uso de uma composição

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Publication number
BR112015007126A2
BR112015007126A2 BR112015007126A BR112015007126A BR112015007126A2 BR 112015007126 A2 BR112015007126 A2 BR 112015007126A2 BR 112015007126 A BR112015007126 A BR 112015007126A BR 112015007126 A BR112015007126 A BR 112015007126A BR 112015007126 A2 BR112015007126 A2 BR 112015007126A2
Authority
BR
Brazil
Prior art keywords
conjugates
composition
immune response
saccharide
linear
Prior art date
Application number
BR112015007126A
Other languages
English (en)
Inventor
Berti Francesco
Brogioni Giulia
Del Giudice Giuseppe
Romano Maria
Costantino Paolo
Original Assignee
Glaxosmithkline Biologicals Sa
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Glaxosmithkline Biologicals Sa filed Critical Glaxosmithkline Biologicals Sa
Publication of BR112015007126A2 publication Critical patent/BR112015007126A2/pt

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/385—Haptens or antigens, bound to carriers
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/02—Bacterial antigens
    • A61K39/095—Neisseria
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
    • A61K47/50—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates
    • A61K47/51—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent
    • A61K47/62—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient the non-active ingredient being chemically bound to the active ingredient, e.g. polymer-drug conjugates the non-active ingredient being a modifying agent the modifying agent being a protein, peptide or polyamino acid
    • A61K47/64—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent
    • A61K47/646—Drug-peptide, drug-protein or drug-polyamino acid conjugates, i.e. the modifying agent being a peptide, protein or polyamino acid which is covalently bonded or complexed to a therapeutically active agent the entire peptide or protein drug conjugate elicits an immune response, e.g. conjugate vaccines
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/04—Antibacterial agents
    • A61P31/06—Antibacterial agents for tuberculosis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/10—Antimycotics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P33/00—Antiparasitic agents
    • A61P33/02—Antiprotozoals, e.g. for leishmaniasis, trichomoniasis, toxoplasmosis
    • A61P33/04—Amoebicides
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A61P37/02—Immunomodulators
    • A61P37/04—Immunostimulants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/555—Medicinal preparations containing antigens or antibodies characterised by a specific combination antigen/adjuvant
    • A61K2039/55505—Inorganic adjuvants
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/60—Medicinal preparations containing antigens or antibodies characteristics by the carrier linked to the antigen
    • A61K2039/6031—Proteins
    • A61K2039/6037—Bacterial toxins, e.g. diphteria toxoid [DT], tetanus toxoid [TT]
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/62—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier
    • A61K2039/627—Medicinal preparations containing antigens or antibodies characterised by the link between antigen and carrier characterised by the linker
    • Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
    • Y02—TECHNOLOGIES OR APPLICATIONS FOR MITIGATION OR ADAPTATION AGAINST CLIMATE CHANGE
    • Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
    • Y02A50/00—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE in human health protection, e.g. against extreme weather
    • Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Veterinary Medicine (AREA)
  • Animal Behavior & Ethology (AREA)
  • General Health & Medical Sciences (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Medicinal Chemistry (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Epidemiology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Communicable Diseases (AREA)
  • Oncology (AREA)
  • Virology (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pulmonology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Medicinal Preparation (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)

Abstract

1 / 1 resumo “composiã‡ãƒo, mã‰todo para induzir uma resposta imune, e, uso de uma composiã‡ãƒo” este relatã³rio descritivo ã© direcionado aos conjugados de sacarã­deo nã£o lineares que compreendem polissacarã­deos que sã£o ligados a pelo menos dois peptã­deos que compreendem epã­topos de cã©lula t e nã£o tãªm nenhum dos epã­topos de cã©lula b conformacionais onde um dos peptã­deos ã© ligado a um sacarã­deo interno de modo que os conjugados tenham uma estrutura ramificada (isto ã©, nã£o linear). o relatã³rio descritivo tambã©m fornece mã©todos de fabricaã§ã£o destes conjugados, mã©todos de formulaã§ã£o destes conjugados em composiã§ãµes para o uso como vacinas e mã©todos para usar as composiã§ãµes para induzir uma resposta imune ao sacarã­deo capsular. o relatã³rio descritivo tambã©m fornece um novo peptã­deo carreador de poliepã­topo compreendendo o epã­topo pv1 do vã­rus da poliomielite. o novo peptã­deo carreador de poliepã­topo pode ser usado tanto em conjugados de sacarã­deo lineares assim como nos conjugados de sacarã­deo nã£o lineares.
BR112015007126A 2012-10-02 2013-10-02 composição, método para induzir uma resposta imune, e, uso de uma composição BR112015007126A2 (pt)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US201261709093P 2012-10-02 2012-10-02
PCT/EP2013/070496 WO2014053521A2 (en) 2012-10-02 2013-10-02 Nonlinear saccharide conjugates

Publications (1)

Publication Number Publication Date
BR112015007126A2 true BR112015007126A2 (pt) 2017-08-08

Family

ID=49293654

Family Applications (1)

Application Number Title Priority Date Filing Date
BR112015007126A BR112015007126A2 (pt) 2012-10-02 2013-10-02 composição, método para induzir uma resposta imune, e, uso de uma composição

Country Status (15)

Country Link
US (1) US20160101187A1 (pt)
EP (1) EP2903650B1 (pt)
JP (1) JP2015532276A (pt)
KR (1) KR20150060986A (pt)
CN (1) CN105307684A (pt)
AU (1) AU2013326584B2 (pt)
BR (1) BR112015007126A2 (pt)
CA (1) CA2885625A1 (pt)
EA (1) EA201590427A1 (pt)
ES (1) ES2672996T3 (pt)
IL (1) IL237826A0 (pt)
MX (1) MX2015004171A (pt)
SG (1) SG11201502197XA (pt)
TR (1) TR201808684T4 (pt)
WO (1) WO2014053521A2 (pt)

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CN104072765B (zh) * 2014-07-09 2017-07-28 中国科学院长春应用化学研究所 改性聚乙烯亚胺及其制备方法、药物‑基因载体系统及其制备方法
IL255106B2 (en) 2015-05-04 2023-04-01 Pfizer Protein-polysaccharide conjugates of group b streptococcus, methods for preparing conjugates, immunogenic preparations containing conjugates and their uses
SG11201901394XA (en) 2016-09-02 2019-03-28 Sanofi Pasteur Inc Neisseria meningitidis vaccine
US11951165B2 (en) 2016-12-30 2024-04-09 Vaxcyte, Inc. Conjugated vaccine carrier proteins
MD20190088A2 (ro) * 2017-05-05 2020-04-30 Serum Institute Of India Private Limited Metodă de eliminare a impurităţilor din preparatele pe bază de polizaharide capsulare bacteriene
WO2020010016A1 (en) 2018-07-04 2020-01-09 Sutrovax, Inc. Self-adjuvanted immunogenic conjugates
WO2020010000A1 (en) 2018-07-04 2020-01-09 Sutrovax, Inc. Improved methods for the preparation of immunogenic conjugates
BR112020026899A2 (pt) 2018-07-04 2021-03-30 Vaxcyte, Inc. Melhorias em conjugados imunogênicos
JP7257021B2 (ja) * 2018-09-03 2023-04-13 公立大学法人大阪 免疫賦活性乳化剤
CN113812409B (zh) * 2021-11-24 2022-03-01 山东科大创业生物有限公司 防治植物白粉病组合物及其制备方法、应用

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EA201590427A1 (ru) 2015-09-30
IL237826A0 (en) 2015-05-31
WO2014053521A3 (en) 2014-07-17
TR201808684T4 (tr) 2018-07-23
EP2903650B1 (en) 2018-04-04
CN105307684A (zh) 2016-02-03
AU2013326584B2 (en) 2016-12-01
JP2015532276A (ja) 2015-11-09
SG11201502197XA (en) 2015-04-29
KR20150060986A (ko) 2015-06-03
EP2903650A2 (en) 2015-08-12
WO2014053521A2 (en) 2014-04-10
ES2672996T3 (es) 2018-06-19
AU2013326584A1 (en) 2015-05-07

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