BR112016004108A2 - métodos para expressar uma molécula antigênica ou uma parte da mesma e para geração de uma resposta imune, composição farmacêutica, célula ou população de células, usos de uma população de células e de uma molécula antigênica, moléculas antigênica, agentes de fotossensibilização e ligante tlr e agente, produto, e, kit - Google Patents
métodos para expressar uma molécula antigênica ou uma parte da mesma e para geração de uma resposta imune, composição farmacêutica, célula ou população de células, usos de uma população de células e de uma molécula antigênica, moléculas antigênica, agentes de fotossensibilização e ligante tlr e agente, produto, e, kitInfo
- Publication number
- BR112016004108A2 BR112016004108A2 BR112016004108A BR112016004108A BR112016004108A2 BR 112016004108 A2 BR112016004108 A2 BR 112016004108A2 BR 112016004108 A BR112016004108 A BR 112016004108A BR 112016004108 A BR112016004108 A BR 112016004108A BR 112016004108 A2 BR112016004108 A2 BR 112016004108A2
- Authority
- BR
- Brazil
- Prior art keywords
- antigenic
- cell population
- antigenic molecule
- cell
- immune response
- Prior art date
Links
- 230000000890 antigenic effect Effects 0.000 title abstract 7
- 238000000034 method Methods 0.000 title abstract 7
- 239000003795 chemical substances by application Substances 0.000 title abstract 3
- 230000028993 immune response Effects 0.000 title abstract 3
- 239000003504 photosensitizing agent Substances 0.000 title abstract 3
- 239000003446 ligand Substances 0.000 title 1
- 239000008194 pharmaceutical composition Substances 0.000 title 1
- 238000002255 vaccination Methods 0.000 abstract 4
- 210000004027 cell Anatomy 0.000 abstract 3
- 239000000203 mixture Substances 0.000 abstract 2
- 229960005486 vaccine Drugs 0.000 abstract 2
- 102000002689 Toll-like receptor Human genes 0.000 abstract 1
- 108020000411 Toll-like receptor Proteins 0.000 abstract 1
- 239000000427 antigen Substances 0.000 abstract 1
- 230000030741 antigen processing and presentation Effects 0.000 abstract 1
- 210000000612 antigen-presenting cell Anatomy 0.000 abstract 1
- 102000036639 antigens Human genes 0.000 abstract 1
- 108091007433 antigens Proteins 0.000 abstract 1
- 239000011230 binding agent Substances 0.000 abstract 1
- 230000000694 effects Effects 0.000 abstract 1
- 238000002649 immunization Methods 0.000 abstract 1
- 230000003053 immunization Effects 0.000 abstract 1
- 238000000338 in vitro Methods 0.000 abstract 1
- 238000001727 in vivo Methods 0.000 abstract 1
- 230000001404 mediated effect Effects 0.000 abstract 1
- 229940124856 vaccine component Drugs 0.000 abstract 1
Classifications
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- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K39/12—Viral antigens
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- A—HUMAN NECESSITIES
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- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/40—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil
- A61K31/409—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having five-membered rings with one nitrogen as the only ring hetero atom, e.g. sulpiride, succinimide, tolmetin, buflomedil having four such rings, e.g. porphine derivatives, bilirubin, biliverdine
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- A—HUMAN NECESSITIES
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- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
- A61K31/4353—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems
- A61K31/437—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom ortho- or peri-condensed with heterocyclic ring systems the heterocyclic ring system containing a five-membered ring having nitrogen as a ring hetero atom, e.g. indolizine, beta-carboline
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- A61K31/7088—Compounds having three or more nucleosides or nucleotides
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- A61K2039/5154—Antigen presenting cells [APCs], e.g. dendritic cells or macrophages
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- C12N2710/00—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA dsDNA viruses
- C12N2710/00011—Details
- C12N2710/20011—Papillomaviridae
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- Y—GENERAL TAGGING OF NEW TECHNOLOGICAL DEVELOPMENTS; GENERAL TAGGING OF CROSS-SECTIONAL TECHNOLOGIES SPANNING OVER SEVERAL SECTIONS OF THE IPC; TECHNICAL SUBJECTS COVERED BY FORMER USPC CROSS-REFERENCE ART COLLECTIONS [XRACs] AND DIGESTS
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- Y02A—TECHNOLOGIES FOR ADAPTATION TO CLIMATE CHANGE
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- Y02A50/30—Against vector-borne diseases, e.g. mosquito-borne, fly-borne, tick-borne or waterborne diseases whose impact is exacerbated by climate change
Abstract
a presente invenção se refere a um método de vacinação ou imunização envolvendo o uso de um agente de fotossensibilização, uma molécula antigênica, por exemplo, um componente de vacina e um agente que aumenta o efeito da vacinação mediada por internalização fotoquímica (pci) em que o agente é um ligante para um receptor do tipo toll (tlr) como aqui definido, e irradiação com luz de um comprimento de onda efetivo para ativar o agente de fotossensibilização. a invenção também se refere a antigênico, por exemplo, composições de vacina, útil em tal método. a invenção também provê um método para geração de antígeno apresentando células que podem ser usadas para gerar uma resposta imune, por exemplo, por vacinação, que envolve usar os mesmos componentes como acima para introduzir moléculas antigênicas, por exemplo, componentes de vacina, em célular para alcançar apresentação de antígeno, e para composições antigênicas úteis em tal método. a invenção também provê uso de células geradas in vitro por tais métodos para administração a um paciente in vivo para elicitar uma resposta imune, por exemplo, para alcançar vacinação. também é provido um método para internalização de uma molécula antigênica em uma célula.
Applications Claiming Priority (3)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
GBGB1315292.1A GB201315292D0 (en) | 2013-08-28 | 2013-08-28 | Compound and method |
GB201406597A GB201406597D0 (en) | 2014-04-11 | 2014-04-11 | Compound and method |
PCT/EP2014/068313 WO2015028574A1 (en) | 2013-08-28 | 2014-08-28 | Compound and method for vaccination and immunisation |
Publications (1)
Publication Number | Publication Date |
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BR112016004108A2 true BR112016004108A2 (pt) | 2017-10-17 |
Family
ID=51655692
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
BR112016004108A BR112016004108A2 (pt) | 2013-08-28 | 2014-08-28 | métodos para expressar uma molécula antigênica ou uma parte da mesma e para geração de uma resposta imune, composição farmacêutica, célula ou população de células, usos de uma população de células e de uma molécula antigênica, moléculas antigênica, agentes de fotossensibilização e ligante tlr e agente, produto, e, kit |
Country Status (10)
Country | Link |
---|---|
US (1) | US10610582B2 (pt) |
EP (1) | EP3038619B1 (pt) |
JP (2) | JP6684215B2 (pt) |
KR (1) | KR102374556B1 (pt) |
CN (1) | CN105873585A (pt) |
AU (1) | AU2014314149B2 (pt) |
BR (1) | BR112016004108A2 (pt) |
CA (1) | CA2922320C (pt) |
ES (1) | ES2959398T3 (pt) |
WO (1) | WO2015028574A1 (pt) |
Families Citing this family (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
AU2014314149B2 (en) * | 2013-08-28 | 2019-12-19 | Pci Biotech As | Compound and method for vaccination and immunisation |
EP3185901B1 (en) * | 2014-08-28 | 2023-10-04 | PCI Biotech AS | Compound and method |
GB201503776D0 (en) | 2015-03-05 | 2015-04-22 | Pci Biotech As | Compound and method |
AU2018227583B2 (en) * | 2017-03-03 | 2023-06-01 | Obsidian Therapeutics, Inc. | CD19 compositions and methods for immunotherapy |
CN107029236B (zh) * | 2017-04-18 | 2020-04-10 | 中国医学科学院生物医学工程研究所 | 一种吲哚菁绿自组装纳米疫苗及制备方法 |
EP3621629A4 (en) * | 2017-05-11 | 2021-03-17 | Theralase Biotech Inc. | VACCINE CONTAINING CANCER CELLS INACTIVATED BY PHOTODYNAMIC TREATMENT WITH METAL-BASED COORDINATION COMPLEXES, AND IMMUNOTHERAPY METHOD USING THE LATTER |
GB201718631D0 (en) | 2017-11-10 | 2017-12-27 | Pci Biotech As | Method |
US20210002372A1 (en) * | 2018-03-02 | 2021-01-07 | United States Government As Represented By The Department Of Veterans Affairs | Methods and compositions for treating natalizumab-associated progressive multifocal encephalopathy |
CN108486120B (zh) * | 2018-04-28 | 2019-12-06 | 新乡医学院 | 一种新型CpG ODN序列及其在抗黑色素瘤上的应用 |
CN112778372A (zh) * | 2019-11-11 | 2021-05-11 | 苏州泽璟生物制药股份有限公司 | 咪唑并喹啉取代磷酸酯类激动剂及其制备方法和应用 |
CN112957475B (zh) * | 2021-02-04 | 2022-07-22 | 李文峰 | 一种预防和或治疗肿瘤的组合物及应用 |
CN115252772A (zh) * | 2021-04-30 | 2022-11-01 | 华普生物技术(江苏)股份有限公司 | 人工合成的含CpG单链脱氧寡核苷酸在疫苗中的应用 |
BR112023024392A2 (pt) * | 2021-05-24 | 2024-02-15 | Cha Vaccine Res Institute Co Ltd | Uso de uma formulação de combinação farmacêutica, uso de lipopeptídeos e poli(i:c), e pelo menos um ingrediente ativo adicional |
Family Cites Families (25)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
NO180167C (no) | 1994-09-08 | 1997-02-26 | Photocure As | Fotokjemisk fremgangsmåte til å innföre molekyler i cellers cytosol |
GB9905911D0 (en) | 1999-03-15 | 1999-05-05 | Photocure As | Method |
US20020022032A1 (en) | 1999-04-23 | 2002-02-21 | Curry Patrick Mark | Immuno-adjuvant PDT treatment of metastatic tumors |
AU2210402A (en) | 2000-11-29 | 2002-06-11 | Norwegian Radium Hospital Res | Photochemical internalization for virus-mediated molecule delivery into the cyosol |
KR100980153B1 (ko) * | 2000-11-29 | 2010-09-03 | 피씨아이 바이오테크 에이에스 | 사이토졸 내로의 분자 전달을 위한 광화학적 내부이행 |
GB0121023D0 (en) | 2001-08-30 | 2001-10-24 | Norwegian Radium Hospital Res | Compound |
US20050013812A1 (en) * | 2003-07-14 | 2005-01-20 | Dow Steven W. | Vaccines using pattern recognition receptor-ligand:lipid complexes |
GB2420784A (en) * | 2004-11-25 | 2006-06-07 | Pci Biotech As | Phototherapeutic amphiphilic phthalocyanine-based compounds where 1 peripheral ring system is more hydrophilic & has more hydrophilic groups than the other 3 |
US20090209508A1 (en) | 2005-05-16 | 2009-08-20 | Universite De Geneve | Compounds for Photochemotherapy |
WO2007133728A1 (en) * | 2006-05-12 | 2007-11-22 | The Trustees Of The University Of Pennsylvania | Photodynamic therapy-generated mesothelioma vaccine |
GB0613753D0 (en) * | 2006-07-11 | 2006-08-23 | Norwegian Radium Hospital Res | Method |
KR101035269B1 (ko) | 2007-04-23 | 2011-05-26 | 한국과학기술연구원 | 고분자 유도체-광감작제 복합체를 이용한 새로운 광역학치료제 |
US8180444B2 (en) * | 2007-06-22 | 2012-05-15 | Biolitec Pharma Marketing Ltd | Enhanced PhotoDynamic Therapy with immune system assist |
WO2009077908A1 (en) | 2007-12-14 | 2009-06-25 | University Of Lausanne | Colloidal particle comprising multivalent cyclic anions |
SI2276486T1 (sl) | 2008-03-24 | 2014-01-31 | 4Sc Discovery Gmbh | Novi substituirani imidazokinolini |
US20100129432A1 (en) | 2008-11-25 | 2010-05-27 | Taipei Medical University | Microorganism-killing combination |
ES2627420T3 (es) | 2009-06-12 | 2017-07-28 | Erasmus University Medical Center Rotterdam | Nanofotomedicamentos destinados al tratamiento fotodinámico del cáncer |
GB0914286D0 (en) * | 2009-08-14 | 2009-09-30 | Pci Biotech As | Method |
GB0914287D0 (en) * | 2009-08-14 | 2009-09-30 | Pci Biotech As | Compositions |
KR101228106B1 (ko) | 2010-01-21 | 2013-02-01 | 광주과학기술원 | 피부투과도, 세포유입 및 종양전달성이 증가된 나노운반체 |
US8728486B2 (en) | 2011-05-18 | 2014-05-20 | University Of Kansas | Toll-like receptor-7 and -8 modulatory 1H imidazoquinoline derived compounds |
CN109125718A (zh) | 2012-01-13 | 2019-01-04 | 哈佛学院董事会 | 在结构聚合装置中tlr激动剂的控制传递 |
WO2014139597A1 (en) * | 2013-03-15 | 2014-09-18 | Pci Biotech As | Method |
AU2014314149B2 (en) * | 2013-08-28 | 2019-12-19 | Pci Biotech As | Compound and method for vaccination and immunisation |
EP3129045B1 (en) | 2014-04-11 | 2022-03-02 | PCI Biotech AS | Method of treating melanoma |
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2014
- 2014-08-28 AU AU2014314149A patent/AU2014314149B2/en active Active
- 2014-08-28 EP EP14777533.2A patent/EP3038619B1/en active Active
- 2014-08-28 CA CA2922320A patent/CA2922320C/en active Active
- 2014-08-28 JP JP2016537301A patent/JP6684215B2/ja active Active
- 2014-08-28 KR KR1020167008093A patent/KR102374556B1/ko active IP Right Grant
- 2014-08-28 CN CN201480057929.6A patent/CN105873585A/zh active Pending
- 2014-08-28 ES ES14777533T patent/ES2959398T3/es active Active
- 2014-08-28 BR BR112016004108A patent/BR112016004108A2/pt active Search and Examination
- 2014-08-28 US US14/914,758 patent/US10610582B2/en active Active
- 2014-08-28 WO PCT/EP2014/068313 patent/WO2015028574A1/en active Application Filing
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2020
- 2020-03-27 JP JP2020058851A patent/JP7304307B2/ja active Active
Also Published As
Publication number | Publication date |
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JP7304307B2 (ja) | 2023-07-06 |
KR20160068751A (ko) | 2016-06-15 |
ES2959398T3 (es) | 2024-02-26 |
AU2014314149A1 (en) | 2016-03-10 |
US20160206725A1 (en) | 2016-07-21 |
JP2016529271A (ja) | 2016-09-23 |
CA2922320C (en) | 2022-11-22 |
US10610582B2 (en) | 2020-04-07 |
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AU2014314149B2 (en) | 2019-12-19 |
CA2922320A1 (en) | 2015-03-05 |
WO2015028574A1 (en) | 2015-03-05 |
KR102374556B1 (ko) | 2022-03-14 |
JP6684215B2 (ja) | 2020-04-22 |
CN105873585A (zh) | 2016-08-17 |
JP2020117516A (ja) | 2020-08-06 |
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