ATE477251T1 - Pyrrolverbindungen als glykogen synthase kinase 3 inhibitoren - Google Patents
Pyrrolverbindungen als glykogen synthase kinase 3 inhibitorenInfo
- Publication number
- ATE477251T1 ATE477251T1 AT03749133T AT03749133T ATE477251T1 AT E477251 T1 ATE477251 T1 AT E477251T1 AT 03749133 T AT03749133 T AT 03749133T AT 03749133 T AT03749133 T AT 03749133T AT E477251 T1 ATE477251 T1 AT E477251T1
- Authority
- AT
- Austria
- Prior art keywords
- gsk3
- glycogen synthase
- synthase kinase
- disorders
- inhibitors
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D231/00—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings
- C07D231/02—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings
- C07D231/10—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members
- C07D231/12—Heterocyclic compounds containing 1,2-diazole or hydrogenated 1,2-diazole rings not condensed with other rings having two or three double bonds between ring members or between ring members and non-ring members with only hydrogen atoms, hydrocarbon or substituted hydrocarbon radicals, directly attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
- C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
- A61P15/08—Drugs for genital or sexual disorders; Contraceptives for gonadal disorders or for enhancing fertility, e.g. inducers of ovulation or of spermatogenesis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P17/00—Drugs for dermatological disorders
- A61P17/02—Drugs for dermatological disorders for treating wounds, ulcers, burns, scars, keloids, or the like
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/28—Drugs for disorders of the nervous system for treating neurodegenerative disorders of the central nervous system, e.g. nootropic agents, cognition enhancers, drugs for treating Alzheimer's disease or other forms of dementia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/04—Anorexiants; Antiobesity agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P3/00—Drugs for disorders of the metabolism
- A61P3/08—Drugs for disorders of the metabolism for glucose homeostasis
- A61P3/10—Drugs for disorders of the metabolism for glucose homeostasis for hyperglycaemia, e.g. antidiabetics
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P37/00—Drugs for immunological or allergic disorders
- A61P37/02—Immunomodulators
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/10—Drugs for disorders of the cardiovascular system for treating ischaemic or atherosclerotic diseases, e.g. antianginal drugs, coronary vasodilators, drugs for myocardial infarction, retinopathy, cerebrovascula insufficiency, renal arteriosclerosis
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P9/00—Drugs for disorders of the cardiovascular system
- A61P9/12—Antihypertensives
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D233/00—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings
- C07D233/54—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members
- C07D233/56—Heterocyclic compounds containing 1,3-diazole or hydrogenated 1,3-diazole rings, not condensed with other rings having two double bonds between ring members or between ring members and non-ring members with only hydrogen atoms or radicals containing only hydrogen and carbon atoms, attached to ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D249/00—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms
- C07D249/02—Heterocyclic compounds containing five-membered rings having three nitrogen atoms as the only ring hetero atoms not condensed with other rings
- C07D249/08—1,2,4-Triazoles; Hydrogenated 1,2,4-triazoles
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D401/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom
- C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
- C07D405/14—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D413/00—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms
- C07D413/14—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and oxygen atoms as the only ring hetero atoms containing three or more hetero rings
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D453/00—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids
- C07D453/02—Heterocyclic compounds containing quinuclidine or iso-quinuclidine ring systems, e.g. quinine alkaloids containing not further condensed quinuclidine ring systems
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D487/00—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00
- C07D487/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, not provided for by groups C07D451/00 - C07D477/00 in which the condensed system contains two hetero rings
- C07D487/08—Bridged systems
Landscapes
- Organic Chemistry (AREA)
- Chemical & Material Sciences (AREA)
- Health & Medical Sciences (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Animal Behavior & Ethology (AREA)
- Veterinary Medicine (AREA)
- Chemical Kinetics & Catalysis (AREA)
- General Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Health & Medical Sciences (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Diabetes (AREA)
- Cardiology (AREA)
- Neurology (AREA)
- Endocrinology (AREA)
- Obesity (AREA)
- Reproductive Health (AREA)
- Neurosurgery (AREA)
- Hematology (AREA)
- Heart & Thoracic Surgery (AREA)
- Immunology (AREA)
- Biomedical Technology (AREA)
- Hospice & Palliative Care (AREA)
- Emergency Medicine (AREA)
- Vascular Medicine (AREA)
- Psychiatry (AREA)
- Child & Adolescent Psychology (AREA)
- Dermatology (AREA)
- Gynecology & Obstetrics (AREA)
- Pregnancy & Childbirth (AREA)
- Urology & Nephrology (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Plural Heterocyclic Compounds (AREA)
- Nitrogen Condensed Heterocyclic Rings (AREA)
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US40584602P | 2002-08-23 | 2002-08-23 | |
PCT/US2003/026625 WO2004018455A1 (en) | 2002-08-23 | 2003-08-21 | Pyrrole based inhibitors of glycogen synthase kinase 3 |
Publications (1)
Publication Number | Publication Date |
---|---|
ATE477251T1 true ATE477251T1 (de) | 2010-08-15 |
Family
ID=31946938
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
AT03749133T ATE477251T1 (de) | 2002-08-23 | 2003-08-21 | Pyrrolverbindungen als glykogen synthase kinase 3 inhibitoren |
Country Status (11)
Country | Link |
---|---|
US (2) | US7250443B2 (de) |
EP (1) | EP1537099B1 (de) |
JP (1) | JP2006501243A (de) |
KR (1) | KR20050038631A (de) |
CN (1) | CN1688573A (de) |
AT (1) | ATE477251T1 (de) |
AU (1) | AU2003268184A1 (de) |
CA (1) | CA2496246A1 (de) |
DE (1) | DE60333762D1 (de) |
TW (1) | TW200413352A (de) |
WO (1) | WO2004018455A1 (de) |
Families Citing this family (65)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
KR0174535B1 (ko) * | 1989-09-04 | 1999-02-01 | 알렌 제이 스피글 | 베타-락탐 함유 화합물 및 그의 제조방법 |
EP1568698A1 (de) * | 2004-02-27 | 2005-08-31 | Aventis Pharma Deutschland GmbH | Pyrrolderivate als faktor-xa-inhibitoren |
US8771754B2 (en) * | 2004-09-17 | 2014-07-08 | Vanderbilt University | Use of GSK3 inhibitors in combination with radiation therapies |
US20060204980A1 (en) * | 2004-12-28 | 2006-09-14 | Altieri Dario C | Colorectal cancer therapies |
PL2351772T3 (pl) | 2005-02-18 | 2017-01-31 | Glaxosmithkline Biologicals Sa | Białka i kwasy nukleinowe z bakterii Escherichia coli związanej z zapaleniem opon mózgowo-rdzeniowych/posocznicą |
NZ560929A (en) | 2005-02-18 | 2009-12-24 | Novartis Vaccines & Diagnostic | Immunogens from uropathogenic escherichia coli |
US20100017895A1 (en) | 2005-07-18 | 2010-01-21 | Amy Weiner | Small animal model for hcv replication |
AU2006310339B2 (en) | 2005-11-04 | 2013-01-10 | Novartis Ag | Influenza vaccines including combinations of particulate adjuvants and immunopotentiators |
CA2628206A1 (en) | 2005-11-04 | 2007-05-10 | Novartis Vaccines And Diagnostics S.R.L. | Influenza vaccine with reduced amount of oil-in-water emulsion as adjuvant |
US20110180430A1 (en) | 2005-11-04 | 2011-07-28 | Novartis Vaccines And Diagnostics Srl | Adjuvanted influenza vaccines including cytokine-inducing agents |
EP3714900A1 (de) | 2005-11-04 | 2020-09-30 | Seqirus UK Limited | Adjuvierte impfstoffe mit nichtvirenähnlichen antigenen aus influenza-viren, die in einer zellkultur gezüchtet wurden |
BR122019013216B8 (pt) | 2006-01-27 | 2021-07-27 | Seqirus Uk Ltd | ensaio imunológico para análise de uma vacina contra influenza |
ES2388556T3 (es) | 2006-03-23 | 2012-10-16 | Novartis Ag | Compuestos inmunopotenciadores |
EP2357184B1 (de) | 2006-03-23 | 2015-02-25 | Novartis AG | Imidazochinoxalinverbindungen als Immunmodulatoren |
CA2646349A1 (en) | 2006-03-24 | 2007-10-04 | Novartis Vaccines And Diagnostics Gmbh & Co Kg | Storage of influenza vaccines without refrigeration |
US20100285062A1 (en) | 2006-03-31 | 2010-11-11 | Novartis Ag | Combined mucosal and parenteral immunization against hiv |
US20110206692A1 (en) | 2006-06-09 | 2011-08-25 | Novartis Ag | Conformers of bacterial adhesins |
DE102006027229A1 (de) * | 2006-06-09 | 2007-12-20 | Grünenthal GmbH | 1,3-Disubstituierte 4-Methyl-1H-pyrrol-2-carbonsäureamide und ihre Verwendung zur Herstellung von Arzneimitteln |
GB0614460D0 (en) | 2006-07-20 | 2006-08-30 | Novartis Ag | Vaccines |
EP2586790A3 (de) | 2006-08-16 | 2013-08-14 | Novartis AG | Immunogene von uropathogenen Escherichia coli |
EP3456348A1 (de) | 2006-09-11 | 2019-03-20 | Seqirus UK Limited | Herstellung von influenza-virus-impfstoffen ohne verwendung von eiern |
CN101553252A (zh) | 2006-12-06 | 2009-10-07 | 诺华有限公司 | 包含来自于四株流感病毒的抗原的疫苗 |
GB0700562D0 (en) | 2007-01-11 | 2007-02-21 | Novartis Vaccines & Diagnostic | Modified Saccharides |
UY30892A1 (es) | 2007-02-07 | 2008-09-02 | Smithkline Beckman Corp | Inhibidores de la actividad akt |
AU2008269439B2 (en) | 2007-06-27 | 2013-12-19 | Novartis Ag | Low-additive influenza vaccines |
GB0713880D0 (en) | 2007-07-17 | 2007-08-29 | Novartis Ag | Conjugate purification |
GB0714963D0 (en) | 2007-08-01 | 2007-09-12 | Novartis Ag | Compositions comprising antigens |
GB0810305D0 (en) | 2008-06-05 | 2008-07-09 | Novartis Ag | Influenza vaccination |
GB0818453D0 (en) | 2008-10-08 | 2008-11-12 | Novartis Ag | Fermentation processes for cultivating streptococci and purification processes for obtaining cps therefrom |
AU2009227674C1 (en) | 2008-03-18 | 2015-01-29 | Seqirus UK Limited | Improvements in preparation of influenza virus vaccine antigens |
EP2400964A4 (de) * | 2009-01-30 | 2012-08-01 | Glaxosmithkline Llc | Kristallines n-{(1-s)-2-amino-1-[(3-fluorphenyl)methyl]ethyl}-5-chlor-4-(4-chlor-1-methyl-1h-pyrazol-5-yl)-2-thiophencarboxamid hydrochlorid |
WO2010100632A2 (en) | 2009-03-06 | 2010-09-10 | Novartis Ag | Chlamydia antigens |
SG175092A1 (en) | 2009-04-14 | 2011-11-28 | Novartis Ag | Compositions for immunising against staphylococcus aerus |
EP2424565A1 (de) | 2009-04-27 | 2012-03-07 | Novartis AG | Adjuvantierte impfstoffe zum schutz vor grippe |
US8513289B2 (en) | 2009-05-05 | 2013-08-20 | Merck Sharp & Dohme Corp. | P38 kinase inhibiting agents |
SG177533A1 (en) | 2009-07-07 | 2012-02-28 | Novartis Ag | Conserved escherichia coli immunogens |
RU2585227C2 (ru) | 2009-07-15 | 2016-05-27 | Новартис Аг | Композиции белка f rsv и способы их получения |
ES2526996T3 (es) | 2009-07-16 | 2015-01-19 | Novartis Ag | Inmunógenos desintoxicados de Escherichia coli |
GB0918392D0 (en) | 2009-10-20 | 2009-12-02 | Novartis Ag | Diagnostic and therapeutic methods |
GB0919690D0 (en) | 2009-11-10 | 2009-12-23 | Guy S And St Thomas S Nhs Foun | compositions for immunising against staphylococcus aureus |
KR101785257B1 (ko) * | 2009-12-01 | 2017-10-16 | 애브비 인코포레이티드 | 신규한 트리사이클릭 화합물 |
US9173954B2 (en) | 2009-12-30 | 2015-11-03 | Glaxosmithkline Biologicals Sa | Polysaccharide immunogens conjugated to E. coli carrier proteins |
KR20130121699A (ko) | 2010-05-28 | 2013-11-06 | 테트리스 온라인, 인코포레이티드 | 상호작용 혼성 비동기 컴퓨터 게임 기반구조 |
GB201009861D0 (en) | 2010-06-11 | 2010-07-21 | Novartis Ag | OMV vaccines |
US9192661B2 (en) | 2010-07-06 | 2015-11-24 | Novartis Ag | Delivery of self-replicating RNA using biodegradable polymer particles |
EP2667892B1 (de) | 2011-01-26 | 2019-03-27 | GlaxoSmithKline Biologicals SA | Rsv-immunisierungstherapie |
SG194755A1 (en) | 2011-05-13 | 2013-12-30 | Novartis Ag | Pre-fusion rsv f antigens |
WO2013009564A1 (en) | 2011-07-08 | 2013-01-17 | Novartis Ag | Tyrosine ligation process |
EP2554662A1 (de) | 2011-08-05 | 2013-02-06 | M Maria Pia Cosma | Verfahren zur Behandlung von Netzhautdegenerationserkrankungen |
US9493517B2 (en) | 2011-11-07 | 2016-11-15 | Glaxosmithkline Biologicals Sa | Conjugates comprising an antigen and a carrier molecule |
JP6007262B2 (ja) | 2012-01-06 | 2016-10-12 | ノーバス・インターナショナル・インコーポレイテッドNovus International,Inc. | スルホキシドベース界面活性剤 |
WO2013108272A2 (en) | 2012-01-20 | 2013-07-25 | International Centre For Genetic Engineering And Biotechnology | Blood stage malaria vaccine |
AU2013326584B2 (en) | 2012-10-02 | 2016-12-01 | Glaxosmithkline Biologicals Sa | Nonlinear saccharide conjugates |
US9987344B2 (en) | 2012-11-30 | 2018-06-05 | Glaxosmithkline Biologicals Sa | Pseudomonas antigens and antigen combinations |
EP2870974A1 (de) | 2013-11-08 | 2015-05-13 | Novartis AG | Salmonella-Konjugatimpfstoffe |
US20170165230A1 (en) | 2014-04-09 | 2017-06-15 | Christopher Rudd | Use of gsk-3 inhibitors or activators which modulate pd-1 or t-bet expression to modulate t cell immunity |
US10031153B2 (en) | 2014-06-27 | 2018-07-24 | Schlumberger Technology Corporation | Magnetic ranging to an AC source while rotating |
US10094850B2 (en) | 2014-06-27 | 2018-10-09 | Schlumberger Technology Corporation | Magnetic ranging while rotating |
US10227286B2 (en) | 2014-12-08 | 2019-03-12 | Fmc Corporation | 3-oxo-3-(arylamino)propanoates, a process for their preparation, and their use in preparing pyrrolidinones |
GB201519573D0 (en) | 2015-11-05 | 2015-12-23 | King S College London | Combination |
SG11201803979PA (en) | 2015-11-12 | 2018-06-28 | Novus Int Inc | Sulfur-containing compounds as solvents |
EP3231434A1 (de) | 2016-04-14 | 2017-10-18 | Fundacio Centre de Regulacio Genomica | Verfahren zur behandlung von parkinsonismus |
WO2018217766A1 (en) | 2017-05-22 | 2018-11-29 | Whitehead Institute For Biomedical Research | Kcc2 expression enhancing compounds and uses thereof |
US10584306B2 (en) | 2017-08-11 | 2020-03-10 | Board Of Regents Of The University Of Oklahoma | Surfactant microemulsions |
EP3920885A1 (de) | 2019-02-08 | 2021-12-15 | Frequency Therapeutics, Inc. | Valproinsäureverbindungen und wnt-agonisten zur behandlung von ohrerkrankungen |
Family Cites Families (14)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US2488336A (en) | 1947-07-09 | 1949-11-15 | Du Pont | Production of nu-alkyl pyrroles |
DE1445762A1 (de) | 1964-04-29 | 1969-01-16 | Bayer Ag | Verfahren zur Herstellung von Chinonderivaten |
US3534061A (en) | 1967-12-04 | 1970-10-13 | Parke Davis & Co | N-(alpha-(p-methoxyphenyl)-beta-nitrostyryl)-phenoxyalkyl pyrroles |
JPH0681752B2 (ja) * | 1986-04-02 | 1994-10-19 | 大塚製薬株式会社 | カルボスチリル誘導体 |
US4985560A (en) | 1990-01-12 | 1991-01-15 | American Home Products Corporation | Pyridazino(4,5-b)indolizines |
US5376668A (en) * | 1990-08-21 | 1994-12-27 | Novo Nordisk A/S | Heterocyclic compounds |
AU7692696A (en) * | 1995-12-01 | 1997-06-27 | Novartis Ag | Heteroaryl derivatives |
JP4533534B2 (ja) * | 1998-06-19 | 2010-09-01 | ノバルティス バクシンズ アンド ダイアグノスティックス,インコーポレーテッド | グリコーゲンシンターゼキナーゼ3のインヒビター |
GB9915437D0 (en) | 1999-07-01 | 1999-09-01 | Cerebrus Ltd | Chemical compounds III |
JP2003516974A (ja) | 1999-12-17 | 2003-05-20 | カイロン コーポレイション | グリコーゲンシンターゼキナーゼ3のピラジンベースインヒビター |
ATE303383T1 (de) * | 1999-12-17 | 2005-09-15 | Chiron Corp | Bizyklische inhibitoren von glycogen synthase kinase 3 |
CA2397828C (en) * | 2000-01-19 | 2007-09-04 | Cadila Healthcare Ltd. | Compounds having hypolipidemic and hypocholesteremic activities, process for their preparation and pharmaceutical compositions containing them |
JP4292742B2 (ja) * | 2000-03-09 | 2009-07-08 | 小野薬品工業株式会社 | インドール誘導体、その製造方法および用途 |
WO2001090067A1 (fr) * | 2000-05-22 | 2001-11-29 | Takeda Chemical Industries, Ltd. | Inhibiteurs de tyrosine phosphatase |
-
2003
- 2003-08-21 AU AU2003268184A patent/AU2003268184A1/en not_active Abandoned
- 2003-08-21 CN CNA038243350A patent/CN1688573A/zh active Pending
- 2003-08-21 AT AT03749133T patent/ATE477251T1/de not_active IP Right Cessation
- 2003-08-21 CA CA002496246A patent/CA2496246A1/en not_active Abandoned
- 2003-08-21 EP EP03749133A patent/EP1537099B1/de not_active Expired - Lifetime
- 2003-08-21 DE DE60333762T patent/DE60333762D1/de not_active Expired - Lifetime
- 2003-08-21 WO PCT/US2003/026625 patent/WO2004018455A1/en active Application Filing
- 2003-08-21 KR KR1020057003094A patent/KR20050038631A/ko not_active Application Discontinuation
- 2003-08-21 US US10/646,625 patent/US7250443B2/en not_active Expired - Fee Related
- 2003-08-21 JP JP2004531200A patent/JP2006501243A/ja not_active Ceased
- 2003-08-22 TW TW092123152A patent/TW200413352A/zh unknown
-
2007
- 2007-06-12 US US11/761,937 patent/US7671049B2/en not_active Expired - Fee Related
Also Published As
Publication number | Publication date |
---|---|
CA2496246A1 (en) | 2004-03-04 |
KR20050038631A (ko) | 2005-04-27 |
US7250443B2 (en) | 2007-07-31 |
US20070244109A1 (en) | 2007-10-18 |
WO2004018455A1 (en) | 2004-03-04 |
EP1537099A1 (de) | 2005-06-08 |
EP1537099B1 (de) | 2010-08-11 |
US20040077707A1 (en) | 2004-04-22 |
DE60333762D1 (de) | 2010-09-23 |
JP2006501243A (ja) | 2006-01-12 |
US7671049B2 (en) | 2010-03-02 |
TW200413352A (en) | 2004-08-01 |
AU2003268184A1 (en) | 2004-03-11 |
CN1688573A (zh) | 2005-10-26 |
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