MX2007011848A - Antagonistas del receptor de procineticina i. - Google Patents
Antagonistas del receptor de procineticina i.Info
- Publication number
- MX2007011848A MX2007011848A MX2007011848A MX2007011848A MX2007011848A MX 2007011848 A MX2007011848 A MX 2007011848A MX 2007011848 A MX2007011848 A MX 2007011848A MX 2007011848 A MX2007011848 A MX 2007011848A MX 2007011848 A MX2007011848 A MX 2007011848A
- Authority
- MX
- Mexico
- Prior art keywords
- prokineticin
- receptor antagonists
- compounds
- prokinetin
- intermediates
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D239/00—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings
- C07D239/02—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings
- C07D239/24—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members
- C07D239/28—Heterocyclic compounds containing 1,3-diazine or hydrogenated 1,3-diazine rings not condensed with other rings having three or more double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
- C07D239/46—Two or more oxygen, sulphur or nitrogen atoms
- C07D239/52—Two oxygen atoms
- C07D239/54—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals
- C07D239/545—Two oxygen atoms as doubly bound oxygen atoms or as unsubstituted hydroxy radicals with other hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, directly attached to ring carbon atoms
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/505—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim
- A61K31/513—Pyrimidines; Hydrogenated pyrimidines, e.g. trimethoprim having oxo groups directly attached to the heterocyclic ring, e.g. cytosine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/53—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with three nitrogens as the only ring hetero atoms, e.g. chlorazanil, melamine
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/04—Drugs for disorders of the alimentary tract or the digestive system for ulcers, gastritis or reflux esophagitis, e.g. antacids, inhibitors of acid secretion, mucosal protectants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/06—Anti-spasmodics, e.g. drugs for colics, esophagic dyskinesia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
- A61P1/12—Antidiarrhoeals
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P15/00—Drugs for genital or sexual disorders; Contraceptives
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P29/00—Non-central analgesic, antipyretic or antiinflammatory agents, e.g. antirheumatic agents; Non-steroidal antiinflammatory drugs [NSAID]
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P35/00—Antineoplastic agents
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/14—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom
- C07D251/16—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom
- C07D251/20—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hydrogen or carbon atoms directly attached to at least one ring carbon atom to only one ring carbon atom with no nitrogen atoms directly attached to a ring carbon atom
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/30—Only oxygen atoms
- C07D251/34—Cyanuric or isocyanuric esters
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/38—Sulfur atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D251/00—Heterocyclic compounds containing 1,3,5-triazine rings
- C07D251/02—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings
- C07D251/12—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
- C07D251/26—Heterocyclic compounds containing 1,3,5-triazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with only hetero atoms directly attached to ring carbon atoms
- C07D251/40—Nitrogen atoms
- C07D251/42—One nitrogen atom
- C07D251/46—One nitrogen atom with oxygen or sulfur atoms attached to the two other ring carbon atoms
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07D—HETEROCYCLIC COMPOUNDS
- C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
- C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
- C07D403/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings linked by a chain containing hetero atoms as chain links
Abstract
Esta invencion se refiere a ciertos compuestos novedosos de la formula (I) (ver formula (I)) y metodos para preparar estos compuestos, composiciones, intermediarios y derivados del mismo y para el tratamiento de trastornos mediados por el receptor de procineticina 1 o procinetina 1.
Applications Claiming Priority (2)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
US66500205P | 2005-03-24 | 2005-03-24 | |
PCT/US2006/009613 WO2006104715A1 (en) | 2005-03-24 | 2006-03-14 | Prokineticin 1 receptor antagonists |
Publications (1)
Publication Number | Publication Date |
---|---|
MX2007011848A true MX2007011848A (es) | 2008-04-22 |
Family
ID=36609632
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
MX2007011848A MX2007011848A (es) | 2005-03-24 | 2006-03-14 | Antagonistas del receptor de procineticina i. |
Country Status (13)
Country | Link |
---|---|
US (2) | US7968710B2 (es) |
EP (1) | EP1866290B1 (es) |
JP (1) | JP2008534500A (es) |
KR (1) | KR20080006564A (es) |
CN (2) | CN101326168A (es) |
AR (1) | AR053451A1 (es) |
AU (1) | AU2006229793A1 (es) |
BR (1) | BRPI0609315A2 (es) |
CA (1) | CA2602576A1 (es) |
MX (1) | MX2007011848A (es) |
MY (1) | MY153719A (es) |
TW (1) | TW200720260A (es) |
WO (1) | WO2006104715A1 (es) |
Families Citing this family (19)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
US7968710B2 (en) * | 2005-03-24 | 2011-06-28 | Janssen Pharmaceutica Nv | Prokineticin 1 receptor antagonists |
JP2009518409A (ja) * | 2005-12-06 | 2009-05-07 | メルク エンド カムパニー インコーポレーテッド | モルホリンカルボキサミドプロキネチシン受容体アンタゴニスト |
JP5452934B2 (ja) * | 2005-12-29 | 2014-03-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | プロキネチシン1受容体アンタゴニスト |
CN101405002A (zh) * | 2005-12-29 | 2009-04-08 | 詹森药业有限公司 | 激肽原2受体拮抗剂 |
JP2011502154A (ja) * | 2007-10-30 | 2011-01-20 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | アミノヘテロアリールを含むプロキネチシン1受容体拮抗物質連邦政府支援研究又は開発に関する陳述下に記述される本発明の研究及び開発は、連邦政府の支援によるものではない。 |
US8722896B2 (en) | 2008-12-17 | 2014-05-13 | The Regents Of The University Of California | Prokineticin receptor antagonists and uses thereof |
PT2399910E (pt) * | 2009-02-13 | 2014-05-02 | Shionogi & Co | Novo derivado de triazina e composição farmacéutica que contém o mesmo |
CA2803545A1 (en) * | 2010-06-28 | 2012-01-12 | Janssen Pharmaceutica Nv | Prokineticin 1 receptor antagonists for the treatment of pain |
WO2012006003A1 (en) * | 2010-06-28 | 2012-01-12 | Janssen Pharmaceutica Nv | Prokineticin 1 receptor antagonists for the treatment of pain |
CN103140221A (zh) | 2010-08-10 | 2013-06-05 | 盐野义制药株式会社 | 新型杂环衍生物和含有其的药物组合物 |
US9718790B2 (en) | 2010-08-10 | 2017-08-01 | Shionogi & Co., Ltd. | Triazine derivative and pharmaceutical composition having an analgesic activity comprising the same |
JP6124351B2 (ja) | 2012-02-09 | 2017-05-10 | 塩野義製薬株式会社 | 複素環および炭素環誘導体 |
SG11201406013PA (en) * | 2012-03-30 | 2014-11-27 | Nissan Chemical Ind Ltd | Triazinone compound and t-type calcium channel inhibitor |
WO2014078306A1 (en) | 2012-11-13 | 2014-05-22 | Regeneron Pharmaceuticals, Inc. | Anti-prokineticin receptor (prokr) antibodies and uses thereof |
TWI637949B (zh) | 2013-06-14 | 2018-10-11 | 塩野義製藥股份有限公司 | 胺基三衍生物及含有其等之醫藥組合物 |
US9988373B2 (en) | 2013-12-26 | 2018-06-05 | Shionogi & Co., Ltd. | Nitrogen-containing six-membered cyclic derivatives and pharmaceutical composition comprising the same |
AU2016252686B2 (en) | 2015-04-24 | 2019-03-14 | Shionogi & Co., Ltd. | 6-membered heterocyclic derivative and pharmaceutical composition comprising same |
MX2019004107A (es) | 2016-10-17 | 2019-08-05 | Shionogi & Co | Derivado heterociclico nitrogenado biciclico y composicion farmaceutica que lo contiene. |
CN115073431B (zh) * | 2021-04-14 | 2023-09-05 | 盐野义制药株式会社 | 具有病毒增殖抑制作用的三嗪衍生物及含有其的药物组合物 |
Family Cites Families (13)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
GB1504304A (en) * | 1974-02-15 | 1978-03-15 | Ici Ltd | Process of combating fungal and bacterial infections of plants with triazine dione derivatives |
US6485938B1 (en) | 1999-11-16 | 2002-11-26 | Zymogenetics, Inc. | Nucleic acid molecules that encodes human Zven1 |
MXPA03003902A (es) | 2000-11-03 | 2004-04-02 | Univ California | Polipeptidos de proquineticina, composiciones relacionadas y metodos. |
WO2003084936A2 (en) | 2002-04-10 | 2003-10-16 | Orchid Chemicals & Pharmaceuticals Limited | Amino substituted pyrimidinone derivatives useful in the treatment of inflammation and immunological |
CA2500772A1 (en) | 2002-10-07 | 2004-04-22 | Zymogenetics, Inc. | Uses of human zven antagonists |
WO2004087054A2 (en) | 2003-03-25 | 2004-10-14 | The Regents Of The University Of California | Methods for modulating gastric secretion using prokineticin receptor antagonists. |
US20050170455A1 (en) | 2003-06-20 | 2005-08-04 | Qun-Yong Zhou | Novel prokineticin receptor isoforms and methods of use |
JP4658044B2 (ja) | 2003-07-07 | 2011-03-23 | ニューロクライン バイオサイエンシーズ,インコーポレイテッド | 性腺刺激ホルモン放出ホルモンレセプターアンタゴニストとしてのピリミジン−2,4−ジオン誘導体 |
WO2005091925A2 (en) | 2004-03-05 | 2005-10-06 | The Regents Of The University Of California | Primate prokineticin and prokineticin receptor polypeptides, related compositions and methods |
WO2006102112A2 (en) * | 2005-03-24 | 2006-09-28 | Janssen Pharmaceutica N.V. | Prokineticin 1 receptor |
BRPI0609317A2 (pt) | 2005-03-24 | 2010-03-16 | Janssen Pharmaceutica Nv | derivados de pirimidindiona como antagonistas de receptores de procineticina 2 |
US7968710B2 (en) * | 2005-03-24 | 2011-06-28 | Janssen Pharmaceutica Nv | Prokineticin 1 receptor antagonists |
JP5452934B2 (ja) * | 2005-12-29 | 2014-03-26 | ジヤンセン・フアーマシユーチカ・ナームローゼ・フエンノートシヤツプ | プロキネチシン1受容体アンタゴニスト |
-
2006
- 2006-03-14 US US11/375,407 patent/US7968710B2/en not_active Expired - Fee Related
- 2006-03-14 MX MX2007011848A patent/MX2007011848A/es unknown
- 2006-03-14 CN CNA2006800178008A patent/CN101326168A/zh active Pending
- 2006-03-14 KR KR1020077024515A patent/KR20080006564A/ko not_active Application Discontinuation
- 2006-03-14 JP JP2008503045A patent/JP2008534500A/ja not_active Withdrawn
- 2006-03-14 EP EP06738649.0A patent/EP1866290B1/en active Active
- 2006-03-14 BR BRPI0609315-9A patent/BRPI0609315A2/pt not_active Application Discontinuation
- 2006-03-14 WO PCT/US2006/009613 patent/WO2006104715A1/en active Application Filing
- 2006-03-14 AU AU2006229793A patent/AU2006229793A1/en not_active Abandoned
- 2006-03-14 CA CA002602576A patent/CA2602576A1/en not_active Abandoned
- 2006-03-15 CN CNA200680017645XA patent/CN101252934A/zh active Pending
- 2006-03-23 TW TW095109979A patent/TW200720260A/zh unknown
- 2006-03-23 AR ARP060101155A patent/AR053451A1/es unknown
- 2006-03-23 MY MYPI20061293A patent/MY153719A/en unknown
-
2011
- 2011-05-23 US US13/113,751 patent/US8362247B2/en active Active
Also Published As
Publication number | Publication date |
---|---|
EP1866290B1 (en) | 2013-05-01 |
KR20080006564A (ko) | 2008-01-16 |
CN101326168A (zh) | 2008-12-17 |
JP2008534500A (ja) | 2008-08-28 |
AU2006229793A1 (en) | 2006-10-05 |
CN101252934A (zh) | 2008-08-27 |
MY153719A (en) | 2015-03-13 |
BRPI0609315A2 (pt) | 2010-03-09 |
US8362247B2 (en) | 2013-01-29 |
US7968710B2 (en) | 2011-06-28 |
WO2006104715A1 (en) | 2006-10-05 |
EP1866290A1 (en) | 2007-12-19 |
AR053451A1 (es) | 2007-05-09 |
TW200720260A (en) | 2007-06-01 |
US20060235018A1 (en) | 2006-10-19 |
US20120129862A1 (en) | 2012-05-24 |
CA2602576A1 (en) | 2006-10-05 |
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