HK1053577A2 - Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation - Google Patents

Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation Download PDF

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Publication number
HK1053577A2
HK1053577A2 HK02106593A HK02106593A HK1053577A2 HK 1053577 A2 HK1053577 A2 HK 1053577A2 HK 02106593 A HK02106593 A HK 02106593A HK 02106593 A HK02106593 A HK 02106593A HK 1053577 A2 HK1053577 A2 HK 1053577A2
Authority
HK
Hong Kong
Prior art keywords
pharmaceutical composition
treatment
malignanices
human
arginine deprivation
Prior art date
Application number
HK02106593A
Other languages
English (en)
Chinese (zh)
Inventor
郑宁民
梁润松
劳伟雄
Original Assignee
Bio-Cancer Treatment International Limited
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=30000613&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=HK1053577(A2) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Application filed by Bio-Cancer Treatment International Limited filed Critical Bio-Cancer Treatment International Limited
Publication of HK1053577A2 publication Critical patent/HK1053577A2/xx

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Classifications

    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/78—Hydrolases (3) acting on carbon to nitrogen bonds other than peptide bonds (3.5)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P15/00—Drugs for genital or sexual disorders; Contraceptives
    • A61P15/14—Drugs for genital or sexual disorders; Contraceptives for lactation disorders, e.g. galactorrhoea
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00—Medicinal preparations containing peptides

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Genetics & Genomics (AREA)
  • Veterinary Medicine (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Pharmacology & Pharmacy (AREA)
  • General Chemical & Material Sciences (AREA)
  • Public Health (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biomedical Technology (AREA)
  • Microbiology (AREA)
  • General Engineering & Computer Science (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • Biotechnology (AREA)
  • Oncology (AREA)
  • Gynecology & Obstetrics (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Endocrinology (AREA)
  • Pregnancy & Childbirth (AREA)
  • Reproductive Health (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Enzymes And Modification Thereof (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
  • Peptides Or Proteins (AREA)
  • Organic Low-Molecular-Weight Compounds And Preparation Thereof (AREA)
HK02106593A 2002-06-20 2002-09-06 Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation HK1053577A2 (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US39075702P 2002-06-20 2002-06-20
US60/390,757 2002-06-20

Publications (1)

Publication Number Publication Date
HK1053577A2 true HK1053577A2 (en) 2003-10-10

Family

ID=30000613

Family Applications (1)

Application Number Title Priority Date Filing Date
HK02106593A HK1053577A2 (en) 2002-06-20 2002-09-06 Pharmaceutical composition and method of treatment of human malignanices with arginine deprivation

Country Status (12)

Country Link
US (4) US7951366B2 (enExample)
EP (1) EP1517699B1 (enExample)
JP (2) JP5307042B2 (enExample)
CN (2) CN101433714A (enExample)
AT (2) ATE385807T1 (enExample)
AU (1) AU2002325782A1 (enExample)
DE (2) DE60319083T2 (enExample)
HK (1) HK1053577A2 (enExample)
IL (1) IL165858A (enExample)
MX (1) MXPA04012970A (enExample)
NZ (1) NZ537774A (enExample)
WO (1) WO2004001048A1 (enExample)

Families Citing this family (21)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN1745847A (zh) * 2004-09-08 2006-03-15 康达医药科技有限公司 用精氨酸酶治疗肝炎的药物组合物和方法
CN101002945B (zh) * 2006-01-20 2012-09-05 清华大学 一种用于肿瘤治疗的新型复合物
EP1996225A1 (en) * 2006-03-17 2008-12-03 Bio-Cancer Treatment International Limited Method and composition for protection against radiation
US20080138858A1 (en) * 2006-12-12 2008-06-12 Bio-Cancer Treatment International Ltd. Expression System for Recombinant Human Arginase I
US8815232B2 (en) * 2008-08-26 2014-08-26 Kyon Biotech Ag Compositions and methods for treating cancer
PT3778885T (pt) 2008-10-31 2023-05-31 Aerase Inc Composições de arginases humanas modificadas e métodos para o tratamento do cancro
EP2411040B1 (en) 2009-03-26 2015-09-23 The Hong Kong Polytechnic University Site-directed pegylation of arginases and the use thereof as anti-cancer and anti-viral agents
JP2012531893A (ja) * 2009-06-29 2012-12-13 ボード・オブ・リージエンツ，ザ・ユニバーシテイ・オブ・テキサス・システム アルギナーゼ製剤および方法
CN103184208B (zh) * 2011-12-27 2015-09-16 拜奥生物科技（上海）有限公司 人精氨酸酶和定点聚乙二醇化人精氨酸酶及其应用
WO2015165374A1 (en) 2014-04-29 2015-11-05 Bio-Cancer Treatment International Limited Methods and compositions for modulating the immune system with arginase i
JP2016117702A (ja) * 2014-12-22 2016-06-30 武輝 山田 ガン細胞の死滅法
CN105062941B (zh) * 2015-08-25 2019-03-05 江南大学 一种利用重组枯草芽孢杆菌全细胞转化生产l-鸟氨酸的方法
WO2017050240A1 (en) * 2015-09-21 2017-03-30 Bio-Cancer Treatment International Ltd. Method to treat cancer using arginine delpetor and ornithine decarboxylase (odc) inhibitor
CN105112391B (zh) * 2015-09-22 2018-07-06 浙江道尔生物科技有限公司 一种人源精氨酸酶突变体及其制备方法和用途
PT3496743T (pt) 2016-08-08 2022-03-30 Aerase Inc Composições e métodos para o tratamento do cancro com depleção de arginina e agentes imuno-oncológicos
TWI878212B (zh) 2017-12-05 2025-04-01 瑞典商伊梅爾迪卡製藥公司 用於治療精胺酸酶1缺乏症之方法及組合物
ES3049232T3 (en) 2018-05-31 2025-12-15 Univ Hong Kong Chinese Composition and application of arginine-depleting agents for cancer, obesity, metabolic disorders, and related complications and comorbidities
MX2021004463A (es) 2018-10-19 2021-08-24 Aerase Inc Terapia de disminución de arginina para el tratamiento de la deficiencia de gamt.
MX2022002437A (es) 2019-08-30 2022-06-02 Aeglea Biotherapeutics Inc Metodos para la produccion de arginasa humana recombinante 1 y sus usos.
EP4069280A4 (en) * 2019-12-02 2024-01-03 The Hong Kong Polytechnic University METHODS FOR INDUCING INTERMITTENT FASTING AND MODULATING AUTOPHAGY
CN115804845B (zh) * 2022-12-02 2025-09-30 华东理工大学 精氨酸剥夺在延缓衰老与联合化疗药物治疗肿瘤中的应用

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5780286A (en) * 1996-03-14 1998-07-14 Smithkline Beecham Corporation Arginase II
US5851985A (en) * 1996-08-16 1998-12-22 Tepic; Slobodan Treatment of tumors by arginine deprivation
AU5192498A (en) 1996-12-03 1998-06-29 Kyowa Hakko Kogyo Co. Ltd. Tissue fibrosis inhibitor
WO1999043345A1 (en) 1998-02-26 1999-09-02 Eisai Co., Ltd. Amino acid degrading enzymes modulate cell death
US6413757B1 (en) * 2000-02-28 2002-07-02 Millennium Pharmaceuticals, Inc. 25312, a novel human agmatinase-like homolog
CN1324945A (zh) * 2000-05-19 2001-12-05 上海博德基因开发有限公司 一种新的多肽——精氨酸酶12和编码这种多肽的多核苷酸
CN1324942A (zh) * 2000-05-19 2001-12-05 上海博德基因开发有限公司 一种新的多肽——人精氨酸酶9和编码这种多肽的多核苷酸
KR100396983B1 (ko) 2000-07-29 2003-09-02 이강춘 고반응성의 가지 달린 고분자 유도체 및 고분자와 단백질또는 펩타이드의 접합체
DE10047204A1 (de) 2000-09-23 2002-04-25 Henkel Kgaa Topische Hautbehandlungsmittel mit Arginase
CN1345966A (zh) * 2000-09-26 2002-04-24 上海博德基因开发有限公司 一种新的多肽——人精氨酸酶35.42和编码这种多肽的多核苷酸
CN1345970A (zh) * 2000-09-29 2002-04-24 上海博德基因开发有限公司 一种新的多肽——含精氨酸酶结构域的蛋白质9.35和编码这种多肽的多核苷酸
KR20040004449A (ko) 2000-11-28 2004-01-13 휘닉스 파머컬러직스, 인크. 변형된 아르기닌 데이미나제
EP1499342A2 (en) 2002-01-25 2005-01-26 Cancer Treatments International Therapeutic composition for treatment of cancer by arginine depletion

Also Published As

Publication number Publication date
US7951366B2 (en) 2011-05-31
CN101433714A (zh) 2009-05-20
HK1109876A1 (en) 2008-06-27
DE60331871D1 (de) 2010-05-06
US20080248018A1 (en) 2008-10-09
ATE461707T1 (de) 2010-04-15
DE60319083T2 (de) 2009-02-05
HK1071687A1 (en) 2005-07-29
US8679810B2 (en) 2014-03-25
MXPA04012970A (es) 2005-08-18
ATE385807T1 (de) 2008-03-15
US20090123450A1 (en) 2009-05-14
IL165858A0 (en) 2006-01-15
IL165858A (en) 2010-12-30
JP2010148509A (ja) 2010-07-08
NZ537774A (en) 2007-01-26
JP2013172743A (ja) 2013-09-05
EP1517699B1 (en) 2008-02-13
AU2002325782A1 (en) 2004-01-06
CN1918298B (zh) 2011-06-29
DE60319083D1 (de) 2008-03-27
WO2004001048A1 (en) 2003-12-31
US20080226617A1 (en) 2008-09-18
EP1517699A1 (en) 2005-03-30
US20050244398A1 (en) 2005-11-03
CN1918298A (zh) 2007-02-21
JP5307042B2 (ja) 2013-10-02

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Effective date: 20100905