JP2013155195A5 - - Google Patents

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Publication number
JP2013155195A5
JP2013155195A5 JP2013099331A JP2013099331A JP2013155195A5 JP 2013155195 A5 JP2013155195 A5 JP 2013155195A5 JP 2013099331 A JP2013099331 A JP 2013099331A JP 2013099331 A JP2013099331 A JP 2013099331A JP 2013155195 A5 JP2013155195 A5 JP 2013155195A5
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Japan
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amino acid
cysteine
peptide
compound
group
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JP2013099331A
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English (en)
Japanese (ja)
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JP2013155195A (ja
JP5764613B2 (ja
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Publication of JP2013155195A5 publication Critical patent/JP2013155195A5/ja
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JP2013099331A 2009-07-29 2013-05-09 副甲状腺ホルモンを低減する治療剤 Active JP5764613B2 (ja)

Applications Claiming Priority (6)

Application Number Priority Date Filing Date Title
US22969509P 2009-07-29 2009-07-29
US61/229,695 2009-07-29
US25581609P 2009-10-28 2009-10-28
US61/255,816 2009-10-28
US31363510P 2010-03-12 2010-03-12
US61/313,635 2010-03-12

Related Parent Applications (1)

Application Number Title Priority Date Filing Date
JP2012523061A Division JP5270799B2 (ja) 2009-07-29 2010-07-29 副甲状腺ホルモンを低減する治療剤

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2014023488A Division JP2014094967A (ja) 2009-07-29 2014-02-10 副甲状腺ホルモンを低減する治療剤

Publications (3)

Publication Number Publication Date
JP2013155195A JP2013155195A (ja) 2013-08-15
JP2013155195A5 true JP2013155195A5 (enExample) 2014-03-27
JP5764613B2 JP5764613B2 (ja) 2015-08-19

Family

ID=43527590

Family Applications (3)

Application Number Title Priority Date Filing Date
JP2012523061A Active JP5270799B2 (ja) 2009-07-29 2010-07-29 副甲状腺ホルモンを低減する治療剤
JP2013099331A Active JP5764613B2 (ja) 2009-07-29 2013-05-09 副甲状腺ホルモンを低減する治療剤
JP2014023488A Pending JP2014094967A (ja) 2009-07-29 2014-02-10 副甲状腺ホルモンを低減する治療剤

Family Applications Before (1)

Application Number Title Priority Date Filing Date
JP2012523061A Active JP5270799B2 (ja) 2009-07-29 2010-07-29 副甲状腺ホルモンを低減する治療剤

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2014023488A Pending JP2014094967A (ja) 2009-07-29 2014-02-10 副甲状腺ホルモンを低減する治療剤

Country Status (29)

Country Link
US (11) US8999932B2 (enExample)
EP (5) EP3539555B1 (enExample)
JP (3) JP5270799B2 (enExample)
KR (1) KR101781841B1 (enExample)
CN (2) CN107674114B (enExample)
AU (1) AU2010278897B2 (enExample)
BR (1) BR112012002143B8 (enExample)
CA (1) CA2769525C (enExample)
CY (3) CY1118388T1 (enExample)
DK (2) DK3192520T3 (enExample)
ES (2) ES2729051T3 (enExample)
FR (1) FR17C1009I2 (enExample)
HR (2) HRP20161614T1 (enExample)
HU (3) HUE030960T2 (enExample)
IL (1) IL217749A (enExample)
LT (3) LT3192520T (enExample)
LU (1) LUC00008I2 (enExample)
MX (1) MX2012001213A (enExample)
NO (1) NO2017021I1 (enExample)
NZ (1) NZ597922A (enExample)
PL (2) PL2459208T3 (enExample)
PT (2) PT2459208T (enExample)
RU (1) RU2557654C3 (enExample)
SG (2) SG10201406921SA (enExample)
SI (2) SI2459208T1 (enExample)
SM (3) SMT201700014T1 (enExample)
TW (1) TWI520744B (enExample)
WO (1) WO2011014707A2 (enExample)
ZA (1) ZA201200726B (enExample)

Families Citing this family (34)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101668421B (zh) 2006-11-16 2014-05-21 凯制药公司 用于治疗甲状旁腺功能亢进和高钙血症的聚阳离子钙调节肽
ES2729051T3 (es) * 2009-07-29 2019-10-30 Kai Pharmaceuticals Inc Agentes terapéuticos para reducir los niveles de hormona paratiroidea
EP2546231B1 (en) 2010-03-04 2018-11-07 EA Pharma Co., Ltd. Alkylamine derivative
EP2543660A4 (en) 2010-03-04 2014-04-30 Ajinomoto Kk PROPHYLACTIC OR THERAPEUTIC ACTIVE AGAINST DIABETES OR ADIPOSITAS
WO2011118843A1 (ja) 2010-03-24 2011-09-29 味の素株式会社 グルタミン酸エステル誘導体又はその塩
JPWO2011126099A1 (ja) 2010-04-02 2013-07-11 味の素株式会社 糖尿病又は肥満症の予防又は治療剤
WO2012170955A1 (en) * 2011-06-08 2012-12-13 Kai Pharmaceuticals, Inc. Therapeutic agents for regulating serum phosphorus
AU2012335009B2 (en) * 2011-11-10 2017-08-31 Kai Pharmaceuticals, Inc. Calcimimetics and methods for their use
WO2013158739A1 (en) 2012-04-17 2013-10-24 Brown University Neuroprotective composition and method of use
US20200354428A9 (en) 2013-06-23 2020-11-12 Wisconsin Alumni Research Foundation Analogues of parathyroid hormone (1-34) that function as agonists of the parathyroid hormone receptor-1 and display modified activity profiles
CA2916222C (en) * 2013-06-28 2021-05-18 Amgen Inc. Stable liquid formulation of amg 416 (etelcalcetide)
PL3126373T3 (pl) * 2014-04-03 2020-07-27 Amgen Inc. Sposób wytwarzania amg 416
CN105504012A (zh) * 2014-09-30 2016-04-20 深圳翰宇药业股份有限公司 一种多肽的制备方法
WO2016065052A1 (en) 2014-10-22 2016-04-28 Extend Biosciences, Inc. Insulin vitamin d conjugates
US9585934B2 (en) 2014-10-22 2017-03-07 Extend Biosciences, Inc. Therapeutic vitamin D conjugates
US10858389B2 (en) 2015-03-26 2020-12-08 Amgen Inc. Solution phase method for preparing etelcalcetide
US9336841B1 (en) * 2015-04-16 2016-05-10 Taiwan Semiconductor Manufacturing Co., Ltd. Pipeline register with data alignment therein
CN106928321B (zh) * 2015-12-31 2019-07-26 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
CN106928320B (zh) * 2015-12-31 2021-01-15 深圳翰宇药业股份有限公司 一种合成Etelcalcetide的方法
US10105375B2 (en) 2016-08-30 2018-10-23 Wisconsin Alumni Research Foundation Combination of low dose 2-methylene-19-nor-(20S)1α, 25-dihydroxyvitamin D3 and calcimimetics to treat secondary hyperparathyroidism
MA50582A (fr) * 2017-11-07 2020-09-16 Alphacore Pharma Llc Méthodes de traitement et de protection contre une maladie cardiaque, une maladie cardiovasculaire et des états et des symptômes associés
RU2020123405A (ru) 2017-12-20 2022-01-20 ЕА Фарма Ко., Лтд. Лекарственная композиция для профилактики или лечения вторичного гиперпаратиреоза при поддерживающем диализе
KR101933685B1 (ko) * 2018-06-29 2018-12-28 주식회사 에스알바이오텍 약물이 코팅된 마이크로 니들 및 이의 제조방법
KR20210124958A (ko) * 2018-11-02 2021-10-15 앰퍼샌드 바이오파마슈티컬스, 인코포레이티드 국소적으로 적용되는 완충제(buffers)를 사용하는 양이온 과부하 및 전해질 불균형의 위험 가능성 관리를 위한 제형 및 방법
JP7166309B2 (ja) 2019-04-03 2022-11-07 Eaファーマ株式会社 安定性の良好な医薬組成物
WO2021038431A1 (en) 2019-08-26 2021-03-04 Auro Peptides Ltd An improved process for the preparation of etelcalcetide hydrochloride
AU2020399030A1 (en) * 2019-12-09 2022-06-23 Beijing Tuo Jie Biopharmaceutical Co. Ltd. Calcium-sensing receptor agonist compound and application thereof
US20230223125A1 (en) * 2020-05-04 2023-07-13 University Of Louisville Research Foundation, Inc. Artificial intelligence-based systems and methods for dosing of pharmacologic agents
AU2021338639B2 (en) * 2020-09-10 2024-05-23 Shaanxi Micot Pharmaceutical Technology Co., Ltd. Bispecific fusion polypeptide compound
US11359134B2 (en) 2020-10-19 2022-06-14 Saudi Arabian Oil Company Treatment fluids and methods for recovering hydrocarbons from a subterranean formation
TW202313655A (zh) * 2021-06-08 2023-04-01 大陸商北京拓界生物醫藥科技有限公司 鈣敏感受體激動劑化合物的鹽酸鹽及醫藥組成物和其應用
TW202247854A (zh) * 2021-06-08 2022-12-16 大陸商北京拓界生物醫藥科技有限公司 一種鈣敏感受體激動劑的組成物及其應用
US12233115B2 (en) 2022-09-30 2025-02-25 Extend Biosciences, Inc. Long-acting parathyroid hormone
WO2025054169A1 (en) * 2023-09-05 2025-03-13 Wake Forest University Health Sciences Compositions and methods for topical treatment

Family Cites Families (54)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US5602116A (en) 1988-08-02 1997-02-11 Bone Care International, Inc. Method for treating and preventing secondary hyperparathyroidism
US5869473A (en) 1988-08-02 1999-02-09 Bone Care International, Inc. Method for treating and preventing hyperparathyroidism
CA1333616C (en) 1989-03-09 1994-12-20 Hector F. Deluca 19-nor-vitamin d compounds
US5246925A (en) 1989-03-09 1993-09-21 Wisconsin Alumni Research Foundation 19-nor-vitamin D compounds for use in treating hyperparathyroidism
US5304121A (en) 1990-12-28 1994-04-19 Boston Scientific Corporation Drug delivery system making use of a hydrogel polymer coating
AU9131091A (en) 1990-11-07 1992-06-11 Scripps Research Institute, The Peptides that inhibit platelet binding of adhesion molecules
US6031003A (en) * 1991-08-23 2000-02-29 Nps Pharmaceuticals, Inc. Calcium receptor-active molecules
US5814603A (en) * 1992-06-12 1998-09-29 Affymax Technologies N.V. Compounds with PTH activity
US5886026A (en) 1993-07-19 1999-03-23 Angiotech Pharmaceuticals Inc. Anti-angiogenic compositions and methods of use
CA2145214A1 (en) 1995-02-28 1996-08-29 Rick E. Preddie Agents for pre-symptomatic diagnosis, prevention and cure huntington's disease (hd) in humans
US6099562A (en) 1996-06-13 2000-08-08 Schneider (Usa) Inc. Drug coating with topcoat
US5688489A (en) * 1995-09-15 1997-11-18 Resolution Pharmaceuticals, Inc. Non-receptor mediated imaging agents
EP0917537B1 (en) 1996-07-31 2005-09-07 The General Hospital Corporation Novel parathyroid hormone-related peptide analogs
US5895368A (en) * 1996-09-23 1999-04-20 Medisystems Technology Corporation Blood set priming method and apparatus
US6165977A (en) * 1996-10-18 2000-12-26 Board Of Trustees Of The Leland Stanford Junior University Isozyme-specific activators of protein kinase C methods and compositions
WO1998033812A1 (en) 1997-02-05 1998-08-06 Brigham And Women's Hospital, Inc. Mast cell protease peptide inhibitors
CN1261281A (zh) 1997-05-14 2000-07-26 罗纳·布朗克罗尔药制品有限公司 肽甲状旁腺激素类似物
IL132941A0 (en) * 1997-05-21 2001-03-19 Univ Leland Stanford Junior Composition and method for enhancing transport across biological membranes
US6258774B1 (en) 1998-03-19 2001-07-10 University Of Medicine And Dentistry Of New Jersey Carrier for in vivo delivery of a therapeutic agent
US7399489B2 (en) 1999-01-14 2008-07-15 Amylin Pharmaceuticals, Inc. Exendin analog formulations
JP2000336099A (ja) * 1999-05-27 2000-12-05 Sekisui Chem Co Ltd ペプチド及びc型肝炎抗体検出用試薬
US6051567A (en) 1999-08-02 2000-04-18 Abbott Laboratories Low oxygen content compositions of 1α, 25-dihydroxycholecalciferol
US6274169B1 (en) 1999-08-02 2001-08-14 Abbott Laboratories Low oxygen content compostions of 1α, 25-dihydroxycholecalciferol
US20020068342A1 (en) * 2000-02-09 2002-06-06 Rami Khosravi Novel nucleic acid and amino acid sequences and novel variants of alternative splicing
WO2002006218A2 (en) 2000-07-18 2002-01-24 Bone Care International, Inc. STABILIZED 1α-HYDROXY VITAMIN D
DE10041126A1 (de) * 2000-08-22 2002-04-04 Aventis Res & Tech Gmbh & Co DNA-bindende Peptiddomänen und ein Verfahren zur Bereitstellung solcher Domänen
US20080249016A1 (en) * 2000-09-18 2008-10-09 Sanos Bioscience A/S Use of GLP-2 in a combination treatment for bone-related disorders
US20020168354A1 (en) * 2000-11-10 2002-11-14 Daria Mochly-Rosen psiepsilonRack peptide composition and method for protection against tissue damage due to ischemia
CA2434643C (en) * 2001-01-18 2013-10-29 The Board Of Trustees Of The Leland Stanford Junior University Peptides for activation and inhibition of.delta.pkc
AU2002240312A1 (en) 2001-02-08 2002-08-19 Pankaj Paranjp Enhanced oral and transcompartmental delivery of therapeutic or diagnostic agents using polymer conjugates
US20030036627A1 (en) * 2001-02-16 2003-02-20 Montelaro Ronald C. Virus derived antimicrobial peptides
ES2527339T3 (es) 2001-02-23 2015-01-23 Polyphor Ltd. Peptidomiméticos fijados a patrón con actividad antimicrobiana
WO2003014078A2 (en) * 2001-08-08 2003-02-20 The Research Foundation Of The State University Of New York Muc7d1 peptides as antifungal and antibacterial agents
WO2003013543A1 (en) 2001-08-08 2003-02-20 Genomed, Llc Treatment or prevention of acute renal failure
US7060023B2 (en) 2001-09-25 2006-06-13 The Foundry Inc. Pericardium reinforcing devices and methods of using them
US7037897B2 (en) * 2001-10-31 2006-05-02 Abbott Laboratories TRI-, TETRA-, and penta-peptides having antiangiogenic activity
JP2005287302A (ja) 2002-04-03 2005-10-20 Haruhiko Fujiwara ポリペプチドの架橋方法
US20040018976A1 (en) * 2002-05-14 2004-01-29 Feder John N. Polynucleotide encoding novel human G-protein coupled receptors, and splice variants thereof
ATE377023T1 (de) 2003-11-05 2007-11-15 Pevion Biotech Ltd Zusammensetzungen, die von melittin abgeleitet sind und peptide enthalten, und verfahren zur potenzierung von immunreaktionen gegen target- antigene
CA2549052A1 (en) * 2003-12-11 2005-06-30 The Board Of Trustees Of The Leland Stanford Junior University Isozyme-specific antagonists of protein kinase c
US7939634B2 (en) 2004-01-27 2011-05-10 Compugen Ltd. Polynucleotides encoding polypeptides and methods using same
JP2008508294A (ja) * 2004-07-27 2008-03-21 ジェンザイム・コーポレイション 骨の再生のためのチロトロピンの使用法
US7265092B2 (en) * 2004-09-30 2007-09-04 Kai Pharmaceuticals, Inc. Pharmaceutical formulation
DE102005013846A1 (de) 2005-03-24 2006-10-05 Ganymed Pharmaceuticals Ag Identifizierung von Oberflächen-assoziierten Antigenen für die Tumordiagnose und -therapie
KR100687932B1 (ko) * 2005-08-09 2007-02-27 삼성전자주식회사 영상표시장치 및 영상표시방법
AU2006285127A1 (en) * 2005-08-30 2007-03-08 Acologix, Inc. Regulation of mineral and skeletal metabolism
CN101668421B (zh) * 2006-11-16 2014-05-21 凯制药公司 用于治疗甲状旁腺功能亢进和高钙血症的聚阳离子钙调节肽
WO2008089491A2 (en) 2007-01-19 2008-07-24 Kai Pharmaceuticals, Inc. Modifications of peptide compositions to increase stability and delivery efficiency
WO2009046220A2 (en) * 2007-10-02 2009-04-09 Mdrna, Inc. Lipopeptides for delivery of nucleic acids
EP2229473A4 (en) 2007-12-07 2011-02-02 Steven A Goldstein IDENTIFICATION OF TOXIN LIGANDS
US20090318351A1 (en) * 2008-03-12 2009-12-24 Kevin Grimes Method of treating acute st-elevation myocardial infarction with a delta pkc antagonist
ES2729051T3 (es) 2009-07-29 2019-10-30 Kai Pharmaceuticals Inc Agentes terapéuticos para reducir los niveles de hormona paratiroidea
WO2012170955A1 (en) * 2011-06-08 2012-12-13 Kai Pharmaceuticals, Inc. Therapeutic agents for regulating serum phosphorus
AU2012335009B2 (en) 2011-11-10 2017-08-31 Kai Pharmaceuticals, Inc. Calcimimetics and methods for their use

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