CN106232616A - 两亲性合成抗菌肽、其药物组合物及其用途 - Google Patents

两亲性合成抗菌肽、其药物组合物及其用途 Download PDF

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CN106232616A
CN106232616A CN201580020639.9A CN201580020639A CN106232616A CN 106232616 A CN106232616 A CN 106232616A CN 201580020639 A CN201580020639 A CN 201580020639A CN 106232616 A CN106232616 A CN 106232616A
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derivative
pharmaceutically acceptable
peptide
acceptable salt
antibacterial peptide
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CN106232616B (zh
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刘克良
邹存彬
孟庆斌
刘兴东
王晨宏
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Academy of Military Medical Sciences AMMS of PLA
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Institute of Pharmacology and Toxicology of AMMS
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    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/04Peptides having up to 20 amino acids in a fully defined sequence; Derivatives thereof
    • A61K38/10Peptides having 12 to 20 amino acids
    • AHUMAN NECESSITIES
    • A61MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61KPREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K38/00Medicinal preparations containing peptides
    • A61K38/16Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K14/00Peptides having more than 20 amino acids; Gastrins; Somatostatins; Melanotropins; Derivatives thereof
    • CCHEMISTRY; METALLURGY
    • C07ORGANIC CHEMISTRY
    • C07KPEPTIDES
    • C07K7/00Peptides having 5 to 20 amino acids in a fully defined sequence; Derivatives thereof
    • C07K7/04Linear peptides containing only normal peptide links
    • C07K7/08Linear peptides containing only normal peptide links having 12 to 20 amino acids
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/11DNA or RNA fragments; Modified forms thereof; Non-coding nucleic acids having a biological activity
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09Recombinant DNA-technology
    • C12N15/63Introduction of foreign genetic material using vectors; Vectors; Use of hosts therefor; Regulation of expression
    • CCHEMISTRY; METALLURGY
    • C12BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12NMICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N5/00Undifferentiated human, animal or plant cells, e.g. cell lines; Tissues; Cultivation or maintenance thereof; Culture media therefor
    • C12N5/10Cells modified by introduction of foreign genetic material

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Genetics & Genomics (AREA)
  • Engineering & Computer Science (AREA)
  • Organic Chemistry (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • General Health & Medical Sciences (AREA)
  • Biomedical Technology (AREA)
  • Wood Science & Technology (AREA)
  • Zoology (AREA)
  • Biotechnology (AREA)
  • Molecular Biology (AREA)
  • Biochemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Biophysics (AREA)
  • Microbiology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Physics & Mathematics (AREA)
  • Immunology (AREA)
  • Plant Pathology (AREA)
  • Cell Biology (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Peptides Or Proteins (AREA)

Abstract

本发明属于生物医药领域,提供了一类具有自由巯基或其二聚体的抗菌肽、其药物组合物及用途。

Description

PCT国内申请,说明书已公开。

Claims (19)

  1. PCT国内申请,权利要求书已公开。
CN201580020639.9A 2014-04-24 2015-04-24 两亲性合成抗菌肽、其药物组合物及其用途 Active CN106232616B (zh)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
CN2014101666541 2014-04-24
CN201410166654 2014-04-24
PCT/CN2015/077337 WO2015161820A1 (zh) 2014-04-24 2015-04-24 两亲性合成抗菌肽、其药物组合物及其用途

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CN106232616A true CN106232616A (zh) 2016-12-14
CN106232616B CN106232616B (zh) 2019-10-25

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CN (1) CN106232616B (zh)
WO (1) WO2015161820A1 (zh)

Cited By (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110128544A (zh) * 2019-04-03 2019-08-16 中国农业大学 一种具有免疫调节和抗炎功能的杂合肽及其制备方法与应用
WO2021129779A1 (zh) * 2019-12-26 2021-07-01 李瑛� 一种新型两亲性蛋白、其制备方法及用途
CN114805821A (zh) * 2022-04-28 2022-07-29 上海摩漾生物科技有限公司 一种基于纤维素的可降解抗菌肽及其制备方法
CN116332777A (zh) * 2023-02-20 2023-06-27 华中科技大学 二芳基苯甲胺类化合物、制备及作为载体合成多肽的应用

Families Citing this family (4)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
WO2017165452A1 (en) 2016-03-21 2017-09-28 Rhode Island Council On Postsecondary Education pH-SENSITIVE PEPTIDES
EP3615549A1 (en) 2017-04-25 2020-03-04 Universiteit Utrecht Holding B.V. Antimicrobial peptides and their use
WO2021003413A2 (en) * 2019-07-02 2021-01-07 Fred Hutchinson Cancer Research Center Self-assembling circular tandem repeat proteins with increased stability
CN114989254B (zh) * 2022-06-17 2023-11-03 中山大学 一种多肽及其设计方法和在制备抑制具核梭杆菌产品或预防结直肠癌药物中的应用

Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040848A (zh) * 2007-04-19 2007-09-26 上海交通大学 两亲性聚合物载药纳米粒子的制备方法
CN101570569A (zh) * 2008-04-29 2009-11-04 昆山博青生物科技有限公司 合成抗菌肽、其制备方法及应用
CN102079821A (zh) * 2009-10-07 2011-06-01 强生消费者公司 含有超亲水两亲性共聚物的组合物及其应用方法

Family Cites Families (2)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US7960339B2 (en) * 2006-07-10 2011-06-14 Österreichische Akademie der Wissenschaften Antimicrobial peptides
DE102007036128A1 (de) * 2007-07-23 2009-02-12 Universität Leipzig Antibiotische Peptide

Patent Citations (3)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN101040848A (zh) * 2007-04-19 2007-09-26 上海交通大学 两亲性聚合物载药纳米粒子的制备方法
CN101570569A (zh) * 2008-04-29 2009-11-04 昆山博青生物科技有限公司 合成抗菌肽、其制备方法及应用
CN102079821A (zh) * 2009-10-07 2011-06-01 强生消费者公司 含有超亲水两亲性共聚物的组合物及其应用方法

Cited By (6)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN110128544A (zh) * 2019-04-03 2019-08-16 中国农业大学 一种具有免疫调节和抗炎功能的杂合肽及其制备方法与应用
CN110128544B (zh) * 2019-04-03 2020-12-01 中国农业大学 一种具有免疫调节和抗炎功能的杂合肽及其制备方法与应用
WO2021129779A1 (zh) * 2019-12-26 2021-07-01 李瑛� 一种新型两亲性蛋白、其制备方法及用途
CN114805821A (zh) * 2022-04-28 2022-07-29 上海摩漾生物科技有限公司 一种基于纤维素的可降解抗菌肽及其制备方法
CN114805821B (zh) * 2022-04-28 2023-02-03 上海摩漾生物科技有限公司 一种基于纤维素的可降解抗菌肽及其制备方法
CN116332777A (zh) * 2023-02-20 2023-06-27 华中科技大学 二芳基苯甲胺类化合物、制备及作为载体合成多肽的应用

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CN106232616B (zh) 2019-10-25

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Inventor after: Meng Qingbin

Inventor after: Zou Cunbin

Inventor after: Liu Xingdong

Inventor after: Wang Chenhong

Inventor after: Liu Keliang

Inventor before: Liu Keliang

Inventor before: Zou Cunbin

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