JP2016063823A5 - - Google Patents
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- JP2016063823A5 JP2016063823A5 JP2015231313A JP2015231313A JP2016063823A5 JP 2016063823 A5 JP2016063823 A5 JP 2016063823A5 JP 2015231313 A JP2015231313 A JP 2015231313A JP 2015231313 A JP2015231313 A JP 2015231313A JP 2016063823 A5 JP2016063823 A5 JP 2016063823A5
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- Prior art keywords
- reductase
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- 108090000854 Oxidoreductases Proteins 0.000 claims 72
- 102000004316 Oxidoreductases Human genes 0.000 claims 72
- QUCHWTCTBHQQDU-SCSAIBSYSA-N (R)-2-amino-4-oxopentanoic acid zwitterion Chemical compound CC(=O)C[C@@H](N)C(O)=O QUCHWTCTBHQQDU-SCSAIBSYSA-N 0.000 claims 55
- -1 ldh Proteins 0.000 claims 34
- HSJKGGMUJITCBW-UHFFFAOYSA-N 3-hydroxybutanal Chemical compound CC(O)CC=O HSJKGGMUJITCBW-UHFFFAOYSA-N 0.000 claims 28
- 108090000623 proteins and genes Proteins 0.000 claims 25
- 230000015572 biosynthetic process Effects 0.000 claims 22
- 150000001299 aldehydes Chemical class 0.000 claims 20
- PKQIDSVLSKFZQC-UHFFFAOYSA-N 3-oxobutanal Chemical compound CC(=O)CC=O PKQIDSVLSKFZQC-UHFFFAOYSA-N 0.000 claims 16
- 108060008225 Thiolase Proteins 0.000 claims 16
- 102000002932 Thiolase Human genes 0.000 claims 16
- 108090000340 Transaminases Proteins 0.000 claims 16
- 102000014898 transaminase activity proteins Human genes 0.000 claims 16
- 108091000039 acetoacetyl-CoA reductase Proteins 0.000 claims 15
- AXPZIVKEZRHGAS-UHFFFAOYSA-N 3-benzyl-5-[(2-nitrophenoxy)methyl]oxolan-2-one Chemical compound [O-][N+](=O)C1=CC=CC=C1OCC1OC(=O)C(CC=2C=CC=CC=2)C1 AXPZIVKEZRHGAS-UHFFFAOYSA-N 0.000 claims 14
- 230000009615 deamination Effects 0.000 claims 14
- 238000006481 deamination reaction Methods 0.000 claims 14
- 150000002576 ketones Chemical class 0.000 claims 14
- LVSQXDHWDCMMRJ-UHFFFAOYSA-N 4-hydroxybutan-2-one Chemical compound CC(=O)CCO LVSQXDHWDCMMRJ-UHFFFAOYSA-N 0.000 claims 13
- 244000005700 microbiome Species 0.000 claims 13
- 229920001791 ((R)-3-Hydroxybutanoyl)(n-2) Polymers 0.000 claims 12
- QHHKKMYHDBRONY-RMNRSTNRSA-N 3-hydroxybutanoyl-CoA Chemical compound O[C@@H]1[C@H](OP(O)(O)=O)[C@@H](COP(O)(=O)OP(O)(=O)OCC(C)(C)[C@@H](O)C(=O)NCCC(=O)NCCSC(=O)CC(O)C)O[C@H]1N1C2=NC=NC(N)=C2N=C1 QHHKKMYHDBRONY-RMNRSTNRSA-N 0.000 claims 12
- UNRQTHVKJQUDDF-UHFFFAOYSA-N acetylpyruvic acid Chemical compound CC(=O)CC(=O)C(O)=O UNRQTHVKJQUDDF-UHFFFAOYSA-N 0.000 claims 11
- 101150110984 phaB gene Proteins 0.000 claims 11
- LFQSCWFLJHTTHZ-UHFFFAOYSA-N Ethanol Chemical compound CCO LFQSCWFLJHTTHZ-UHFFFAOYSA-N 0.000 claims 10
- 101100297400 Rhizobium meliloti (strain 1021) phaAB gene Proteins 0.000 claims 10
- 230000037361 pathway Effects 0.000 claims 10
- SUVYXKDAVYFUMG-UHFFFAOYSA-N 4-aminobutan-2-one Chemical compound CC(=O)CCN SUVYXKDAVYFUMG-UHFFFAOYSA-N 0.000 claims 9
- 102000004118 Ammonia-Lyases Human genes 0.000 claims 8
- 108090000673 Ammonia-Lyases Proteins 0.000 claims 8
- 101100398755 Escherichia coli (strain K12) ldcC gene Proteins 0.000 claims 8
- FUSUHKVFWTUUBE-UHFFFAOYSA-N buten-2-one Chemical compound CC(=O)C=C FUSUHKVFWTUUBE-UHFFFAOYSA-N 0.000 claims 8
- 102000004190 Enzymes Human genes 0.000 claims 7
- 108090000790 Enzymes Proteins 0.000 claims 7
- 101100280476 Streptococcus pneumoniae (strain ATCC BAA-255 / R6) fabM gene Proteins 0.000 claims 7
- 238000000034 method Methods 0.000 claims 7
- 108020004707 nucleic acids Proteins 0.000 claims 7
- 150000007523 nucleic acids Chemical class 0.000 claims 7
- 102000039446 nucleic acids Human genes 0.000 claims 7
- 108010035023 4-hydroxybutyryl-CoA dehydratase Proteins 0.000 claims 6
- 101100162204 Aspergillus parasiticus (strain ATCC 56775 / NRRL 5862 / SRRC 143 / SU-1) aflH gene Proteins 0.000 claims 6
- 102000011426 Enoyl-CoA hydratase Human genes 0.000 claims 6
- 108010023922 Enoyl-CoA hydratase Proteins 0.000 claims 6
- 101150031227 GDH2 gene Proteins 0.000 claims 6
- 101150099894 GDHA gene Proteins 0.000 claims 6
- 101150024743 adhA gene Proteins 0.000 claims 6
- 230000001419 dependent effect Effects 0.000 claims 6
- 101150069125 fadB gene Proteins 0.000 claims 6
- 101150092019 fadJ gene Proteins 0.000 claims 6
- ZWEHNKRNPOVVGH-UHFFFAOYSA-N 2-Butanone Chemical compound CCC(C)=O ZWEHNKRNPOVVGH-UHFFFAOYSA-N 0.000 claims 4
- SBRVJFMQKPUAGQ-UHFFFAOYSA-N 2-amino-4-hydroxypentanoic acid Chemical compound CC(O)CC(N)C(O)=O SBRVJFMQKPUAGQ-UHFFFAOYSA-N 0.000 claims 4
- 102100032282 26S proteasome non-ATPase regulatory subunit 14 Human genes 0.000 claims 4
- 102100039358 3-hydroxyacyl-CoA dehydrogenase type-2 Human genes 0.000 claims 4
- HFKQINMYQUXOCH-UHFFFAOYSA-N 4-hydroxy-2-oxopentanoic acid Chemical compound CC(O)CC(=O)C(O)=O HFKQINMYQUXOCH-UHFFFAOYSA-N 0.000 claims 4
- 101100171005 Amycolatopsis orientalis dpgB gene Proteins 0.000 claims 4
- 101710088194 Dehydrogenase Proteins 0.000 claims 4
- 101100243777 Dictyostelium discoideum phbB gene Proteins 0.000 claims 4
- 101150019065 HBD gene Proteins 0.000 claims 4
- 101000590281 Homo sapiens 26S proteasome non-ATPase regulatory subunit 14 Proteins 0.000 claims 4
- 101001035740 Homo sapiens 3-hydroxyacyl-CoA dehydrogenase type-2 Proteins 0.000 claims 4
- 101150007959 Lum gene Proteins 0.000 claims 4
- 101100242684 Mesorhizobium japonicum (strain LMG 29417 / CECT 9101 / MAFF 303099) panD1 gene Proteins 0.000 claims 4
- 101100276041 Mycolicibacterium smegmatis (strain ATCC 700084 / mc(2)155) ctpD gene Proteins 0.000 claims 4
- 101100028920 Neurospora crassa (strain ATCC 24698 / 74-OR23-1A / CBS 708.71 / DSM 1257 / FGSC 987) cfp gene Proteins 0.000 claims 4
- 101100063536 Pseudomonas sp. (strain CF600) dmpH gene Proteins 0.000 claims 4
- 101100498625 Selenomonas ruminantium ldc gene Proteins 0.000 claims 4
- 101100398785 Streptococcus agalactiae serotype V (strain ATCC BAA-611 / 2603 V/R) ldhD gene Proteins 0.000 claims 4
- 101100386830 Zymomonas mobilis subsp. mobilis (strain ATCC 31821 / ZM4 / CP4) ddh gene Proteins 0.000 claims 4
- SRUCYNCHUFMZIT-UHFFFAOYSA-N acetyl prop-2-enoate Chemical compound CC(=O)OC(=O)C=C SRUCYNCHUFMZIT-UHFFFAOYSA-N 0.000 claims 4
- 101150014383 adhE gene Proteins 0.000 claims 4
- 101150008667 cadA gene Proteins 0.000 claims 4
- 101150063051 hom gene Proteins 0.000 claims 4
- 101150026107 ldh1 gene Proteins 0.000 claims 4
- 101150041530 ldha gene Proteins 0.000 claims 4
- 101150033534 lysA gene Proteins 0.000 claims 4
- 101150080950 mdlC gene Proteins 0.000 claims 4
- 101150001292 padC gene Proteins 0.000 claims 4
- 101150076071 panD gene Proteins 0.000 claims 4
- 101150014006 thrA gene Proteins 0.000 claims 4
- 101150051977 AAT2 gene Proteins 0.000 claims 3
- 101150046224 ABAT gene Proteins 0.000 claims 3
- 101150014733 ASP5 gene Proteins 0.000 claims 3
- 102100033814 Alanine aminotransferase 2 Human genes 0.000 claims 3
- 101100377784 Arabidopsis thaliana ASP2 gene Proteins 0.000 claims 3
- 101100223316 Arabidopsis thaliana GAD2 gene Proteins 0.000 claims 3
- 101100277697 Bacillus subtilis (strain 168) rocG gene Proteins 0.000 claims 3
- 101100174521 Bradyrhizobium diazoefficiens (strain JCM 10833 / BCRC 13528 / IAM 13628 / NBRC 14792 / USDA 110) fumC2 gene Proteins 0.000 claims 3
- 101150097247 CRT1 gene Proteins 0.000 claims 3
- 101100335626 Caenorhabditis elegans fum-1 gene Proteins 0.000 claims 3
- 101100067649 Caenorhabditis elegans gta-1 gene Proteins 0.000 claims 3
- 101100385314 Clostridioides difficile crt gene Proteins 0.000 claims 3
- 101100338533 Clostridium aminobutyricum abfD gene Proteins 0.000 claims 3
- 101100322572 Clostridium beijerinckii (strain ATCC 51743 / NCIMB 8052) adc gene Proteins 0.000 claims 3
- 101100322573 Clostridium botulinum (strain Eklund 17B / Type B) adc gene Proteins 0.000 claims 3
- 101000636215 Crotalus durissus terrificus Crotamine Proteins 0.000 claims 3
- 101100489862 Danio rerio got2a gene Proteins 0.000 claims 3
- 101100335628 Dictyostelium discoideum fumH gene Proteins 0.000 claims 3
- 101100493587 Escherichia coli (strain K12) avtA gene Proteins 0.000 claims 3
- 101100174518 Escherichia coli (strain K12) fumB gene Proteins 0.000 claims 3
- 101100350700 Escherichia coli (strain K12) paaB gene Proteins 0.000 claims 3
- 101100350709 Escherichia coli (strain K12) paaG gene Proteins 0.000 claims 3
- 101100082381 Escherichia coli (strain K12) patA gene Proteins 0.000 claims 3
- 101100246464 Escherichia coli (strain K12) puuE gene Proteins 0.000 claims 3
- 101150094033 GDH1 gene Proteins 0.000 claims 3
- 101150079757 GPT2 gene Proteins 0.000 claims 3
- 108010050375 Glucose 1-Dehydrogenase Proteins 0.000 claims 3
- 108010000445 Glycerate dehydrogenase Proteins 0.000 claims 3
- 101100277701 Halobacterium salinarum gdhX gene Proteins 0.000 claims 3
- 101100120826 Methylorubrum extorquens (strain ATCC 14718 / DSM 1338 / JCM 2805 / NCIMB 9133 / AM1) fumC gene Proteins 0.000 claims 3
- 101100328158 Mus musculus Clmp gene Proteins 0.000 claims 3
- 101100268515 Mus musculus Serpina1b gene Proteins 0.000 claims 3
- 101100392454 Picrophilus torridus (strain ATCC 700027 / DSM 9790 / JCM 10055 / NBRC 100828) gdh2 gene Proteins 0.000 claims 3
- 101100310885 Pseudomonas aeruginosa (strain ATCC 15692 / DSM 22644 / CIP 104116 / JCM 14847 / LMG 12228 / 1C / PRS 101 / PAO1) spuC gene Proteins 0.000 claims 3
- 101100463818 Pseudomonas oleovorans phaC1 gene Proteins 0.000 claims 3
- 101100332697 Rhodobacter capsulatus (strain ATCC BAA-309 / NBRC 16581 / SB1003) fadB1 gene Proteins 0.000 claims 3
- 101100443340 Ruegeria pomeroyi (strain ATCC 700808 / DSM 15171 / DSS-3) dmdB gene Proteins 0.000 claims 3
- 101100116769 Saccharolobus solfataricus (strain ATCC 35092 / DSM 1617 / JCM 11322 / P2) gdhA-2 gene Proteins 0.000 claims 3
- 101100489854 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) AAT2 gene Proteins 0.000 claims 3
- 101100492609 Talaromyces wortmannii astC gene Proteins 0.000 claims 3
- 101100400217 Thermus thermophilus (strain ATCC BAA-163 / DSM 7039 / HB27) lysN gene Proteins 0.000 claims 3
- 101150004098 UGA1 gene Proteins 0.000 claims 3
- 101100277160 Xenopus laevis odc1-a gene Proteins 0.000 claims 3
- 101150116772 aatA gene Proteins 0.000 claims 3
- 101150006589 adc gene Proteins 0.000 claims 3
- 101150005925 aspC gene Proteins 0.000 claims 3
- 101150056596 azin2 gene Proteins 0.000 claims 3
- 101150100742 dapL gene Proteins 0.000 claims 3
- 101150012368 dmdA gene Proteins 0.000 claims 3
- 101150004244 fumA gene Proteins 0.000 claims 3
- 101150028420 fumC gene Proteins 0.000 claims 3
- 101150116670 gabT gene Proteins 0.000 claims 3
- 108010029645 galactitol 2-dehydrogenase Proteins 0.000 claims 3
- 101150019455 gdh gene Proteins 0.000 claims 3
- 101150098764 gdhA1 gene Proteins 0.000 claims 3
- 101150086595 lat gene Proteins 0.000 claims 3
- 101150056697 nadX gene Proteins 0.000 claims 3
- 101150037784 paaA gene Proteins 0.000 claims 3
- 101150046540 phaA gene Proteins 0.000 claims 3
- 238000000926 separation method Methods 0.000 claims 3
- WWJZWCUNLNYYAU-UHFFFAOYSA-N temephos Chemical compound C1=CC(OP(=S)(OC)OC)=CC=C1SC1=CC=C(OP(=S)(OC)OC)C=C1 WWJZWCUNLNYYAU-UHFFFAOYSA-N 0.000 claims 3
- PUPZLCDOIYMWBV-UHFFFAOYSA-N (+/-)-1,3-Butanediol Chemical compound CC(O)CCO PUPZLCDOIYMWBV-UHFFFAOYSA-N 0.000 claims 2
- 102100034044 All-trans-retinol dehydrogenase [NAD(+)] ADH1B Human genes 0.000 claims 2
- 101710193111 All-trans-retinol dehydrogenase [NAD(+)] ADH4 Proteins 0.000 claims 2
- 101150031273 BDH1 gene Proteins 0.000 claims 2
- 101100098786 Bacillus subtilis (strain 168) tapA gene Proteins 0.000 claims 2
- 101100110009 Caenorhabditis elegans asd-2 gene Proteins 0.000 claims 2
- 101100108227 Cereibacter sphaeroides (strain ATCC 17023 / DSM 158 / JCM 6121 / CCUG 31486 / LMG 2827 / NBRC 12203 / NCIMB 8253 / ATH 2.4.1.) adhI gene Proteins 0.000 claims 2
- 101100269671 Dictyostelium discoideum alrA gene Proteins 0.000 claims 2
- 101100447155 Escherichia coli (strain K12) fre gene Proteins 0.000 claims 2
- 101100350708 Escherichia coli (strain K12) paaF gene Proteins 0.000 claims 2
- 101100082074 Escherichia coli (strain K12) paaZ gene Proteins 0.000 claims 2
- 101100321116 Escherichia coli (strain K12) yqhD gene Proteins 0.000 claims 2
- 101100236497 Klebsiella aerogenes maoC gene Proteins 0.000 claims 2
- 101100456321 Metallosphaera sedula (strain ATCC 51363 / DSM 5348 / JCM 9185 / NBRC 15509 / TH2) Msed_0709 gene Proteins 0.000 claims 2
- 101100269700 Mycolicibacterium smegmatis alr gene Proteins 0.000 claims 2
- 101100350716 Pseudomonas putida paaK gene Proteins 0.000 claims 2
- 101100493797 Thauera butanivorans (strain ATCC 43655 / DSM 2080 / JCM 20651 / NBRC 103042 / IAM 12574 / Bu B1211) bdh gene Proteins 0.000 claims 2
- 101100056949 Wolinella succinogenes (strain ATCC 29543 / DSM 1740 / LMG 7466 / NCTC 11488 / FDC 602W) ansA gene Proteins 0.000 claims 2
- 101150079502 acr1 gene Proteins 0.000 claims 2
- 238000005576 amination reaction Methods 0.000 claims 2
- 101150082095 ansB gene Proteins 0.000 claims 2
- 101150008745 bphG gene Proteins 0.000 claims 2
- 238000004821 distillation Methods 0.000 claims 2
- 101150041588 eutE gene Proteins 0.000 claims 2
- 238000000605 extraction Methods 0.000 claims 2
- 101150004992 fadA gene Proteins 0.000 claims 2
- 101150027774 fadI gene Proteins 0.000 claims 2
- 101150115959 fadR gene Proteins 0.000 claims 2
- 101150056881 mcr gene Proteins 0.000 claims 2
- 101150031436 sucD gene Proteins 0.000 claims 2
- VLSWXZBMRYEYQX-UHFFFAOYSA-N 4-aminobutan-2-one azane Chemical compound N.NCCC(C)=O VLSWXZBMRYEYQX-UHFFFAOYSA-N 0.000 claims 1
- 101100455775 Geobacillus stearothermophilus lysDH gene Proteins 0.000 claims 1
- 101150010646 ODC1 gene Proteins 0.000 claims 1
- 108010065064 acetaldehyde dehydrogenase (acylating) Proteins 0.000 claims 1
- 238000005377 adsorption chromatography Methods 0.000 claims 1
- 238000005119 centrifugation Methods 0.000 claims 1
- 238000002425 crystallisation Methods 0.000 claims 1
- 230000008025 crystallization Effects 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 238000000909 electrodialysis Methods 0.000 claims 1
- 238000001914 filtration Methods 0.000 claims 1
- 239000001963 growth medium Substances 0.000 claims 1
- 238000004255 ion exchange chromatography Methods 0.000 claims 1
- 101150004610 kdd gene Proteins 0.000 claims 1
- 238000000622 liquid--liquid extraction Methods 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000002609 medium Substances 0.000 claims 1
- 239000012528 membrane Substances 0.000 claims 1
- 238000005374 membrane filtration Methods 0.000 claims 1
- 101150064028 ortA gene Proteins 0.000 claims 1
- 101150007368 ortB gene Proteins 0.000 claims 1
- 238000005373 pervaporation Methods 0.000 claims 1
- 238000001223 reverse osmosis Methods 0.000 claims 1
- 238000000638 solvent extraction Methods 0.000 claims 1
- 101150000850 thrC gene Proteins 0.000 claims 1
- 238000000108 ultra-filtration Methods 0.000 claims 1
Priority Applications (1)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| JP2018078301A JP6899793B2 (ja) | 2009-04-30 | 2018-04-16 | １，３−ブタンジオールの産生のための生物 |
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US17447309P | 2009-04-30 | 2009-04-30 | |
| US61/174,473 | 2009-04-30 |
Related Parent Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508804A Division JP5876822B2 (ja) | 2009-04-30 | 2010-04-30 | １，３−ブタンジオールの産生のための生物 |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018078301A Division JP6899793B2 (ja) | 2009-04-30 | 2018-04-16 | １，３−ブタンジオールの産生のための生物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2016063823A JP2016063823A (ja) | 2016-04-28 |
| JP2016063823A5 true JP2016063823A5 (https=) | 2016-06-16 |
| JP6326398B2 JP6326398B2 (ja) | 2018-05-16 |
Family
ID=43032812
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508804A Active JP5876822B2 (ja) | 2009-04-30 | 2010-04-30 | １，３−ブタンジオールの産生のための生物 |
| JP2015231313A Active JP6326398B2 (ja) | 2009-04-30 | 2015-11-27 | １，３−ブタンジオールの産生のための生物 |
| JP2018078301A Expired - Fee Related JP6899793B2 (ja) | 2009-04-30 | 2018-04-16 | １，３−ブタンジオールの産生のための生物 |
| JP2020104368A Pending JP2020156507A (ja) | 2009-04-30 | 2020-06-17 | １，３−ブタンジオールの産生のための生物 |
| JP2023051610A Pending JP2023082077A (ja) | 2009-04-30 | 2023-03-28 | １，３－ブタンジオールの産生のための生物 |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012508804A Active JP5876822B2 (ja) | 2009-04-30 | 2010-04-30 | １，３−ブタンジオールの産生のための生物 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2018078301A Expired - Fee Related JP6899793B2 (ja) | 2009-04-30 | 2018-04-16 | １，３−ブタンジオールの産生のための生物 |
| JP2020104368A Pending JP2020156507A (ja) | 2009-04-30 | 2020-06-17 | １，３−ブタンジオールの産生のための生物 |
| JP2023051610A Pending JP2023082077A (ja) | 2009-04-30 | 2023-03-28 | １，３－ブタンジオールの産生のための生物 |
Country Status (13)
| Country | Link |
|---|---|
| US (5) | US9017983B2 (https=) |
| EP (6) | EP4321615A3 (https=) |
| JP (5) | JP5876822B2 (https=) |
| KR (6) | KR102115497B1 (https=) |
| CN (2) | CN106119113A (https=) |
| AU (1) | AU2010242789B2 (https=) |
| BR (1) | BRPI1013426A2 (https=) |
| CA (2) | CA2759994C (https=) |
| ES (1) | ES2593117T3 (https=) |
| LT (1) | LT2424975T (https=) |
| MY (1) | MY176050A (https=) |
| WO (1) | WO2010127319A2 (https=) |
| ZA (1) | ZA201107806B (https=) |
Families Citing this family (71)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| EP2373781A4 (en) | 2008-12-16 | 2012-10-10 | Genomatica Inc | MICRO-ORGANISMS AND METHODS OF CONVERTING SYNGAS AND OTHER CARBON RESOURCES IN USEFUL PRODUCTS |
| EP4321615A3 (en) | 2009-04-30 | 2024-02-21 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
| EP2440669A4 (en) | 2009-06-10 | 2013-08-28 | Genomatica Inc | MICROOGANISMS AND PROCEDURES FOR THE CARBON EFFECTIVE BIOSYNTHESIS MEK AND 2-BUTANOL |
| WO2011052718A1 (ja) * | 2009-10-30 | 2011-05-05 | ダイセル化学工業株式会社 | １，３－ブタンジオール生産機能を付与された遺伝子組換え微生物及びその利用 |
| US8268607B2 (en) | 2009-12-10 | 2012-09-18 | Genomatica, Inc. | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
| US8637286B2 (en) | 2010-02-23 | 2014-01-28 | Genomatica, Inc. | Methods for increasing product yields |
| KR101814648B1 (ko) | 2010-05-05 | 2018-01-04 | 게노마티카 인코포레이티드 | 부타디엔을 생합성하기 위한 미생물 및 방법 |
| CN102533870B (zh) * | 2010-12-23 | 2014-04-16 | 中国科学院青岛生物能源与过程研究所 | 一种生物法合成异戊二烯的方法、酶系统和重组细胞及其应用 |
| WO2012106516A1 (en) * | 2011-02-02 | 2012-08-09 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of butadiene |
| US9169486B2 (en) | 2011-06-22 | 2015-10-27 | Genomatica, Inc. | Microorganisms for producing butadiene and methods related thereto |
| AU2012273177A1 (en) | 2011-06-22 | 2013-05-02 | Genomatica, Inc. | Microorganisms for producing 1,3-butanediol and methods related thereto |
| EP2744906B1 (en) * | 2011-08-19 | 2019-05-22 | Genomatica, Inc. | Microorganisms and methods for producing 2,4-pentadienoate, butadiene, propylene, 1,3-butanediol and related alcohols |
| WO2013173711A1 (en) | 2012-05-18 | 2013-11-21 | Novozymes A/S | Bacterial mutants with improved transformation efficiency |
| BR112015004488A2 (pt) * | 2012-08-28 | 2018-11-21 | Braskem Sa | método de coprodução de um terpeno e pelo menos um coproduto a partir de uma fonte de carbono fermentável |
| WO2014045781A1 (ja) * | 2012-09-24 | 2014-03-27 | 昭和電工株式会社 | ブタンジオール類の製造方法 |
| EP2899273A4 (en) | 2012-09-24 | 2016-03-02 | Showa Denko Kk | GEN, MICROORGANISM, CONVERSION METHOD AND METHOD OF MANUFACTURE |
| US20150218567A1 (en) | 2012-09-27 | 2015-08-06 | Novozymes A/S | Bacterial Mutants with Improved Transformation Efficiency |
| JP6012371B2 (ja) * | 2012-09-27 | 2016-10-25 | 株式会社日本触媒 | ４−ヒドロキシ−２−ブタノンまたはブタノールの製造方法 |
| JP6208146B2 (ja) | 2012-12-05 | 2017-10-04 | 昭和電工株式会社 | １，４−ブタンジオールの製造方法、微生物及び遺伝子 |
| WO2014152665A1 (en) | 2013-03-15 | 2014-09-25 | Genomatica, Inc. | Process and systems for obtaining 1,4-butanediol from fermentation broths |
| EP2971023B1 (en) * | 2013-03-15 | 2024-12-11 | Kiverdi, Inc. | Methods of using natural and engineered organisms to produce small molecules for industrial application |
| BR112015020904A2 (pt) | 2013-03-15 | 2017-10-10 | Genomatica Inc | microrganismos e métodos para produção de butadieno e compostos relacionados por assimilação de formiato |
| US11814664B2 (en) | 2013-05-24 | 2023-11-14 | Genomatica, Inc. | Microorganisms and methods for producing (3R)-hydroxybutyl (3R)-hydroxybutyrate |
| EP4296364B1 (en) | 2013-12-03 | 2025-12-03 | Genomatica, Inc. | Microorganisms and methods for improving product yields on methanol using acetyl-coa synthesis |
| CA3114049C (en) | 2013-12-05 | 2023-06-13 | REG Life Sciences, LLC | Microbial production of fatty amines |
| ITMI20132069A1 (it) | 2013-12-11 | 2015-06-12 | Versalis Spa | Procedimento per la produzione di zuccheri da biomassa |
| US10597684B2 (en) | 2013-12-27 | 2020-03-24 | Genomatica, Inc. | Methods and organisms with increased carbon flux efficiencies |
| HUE059279T2 (hu) | 2014-05-16 | 2022-11-28 | Versalis Spa | Eljárás alkének elõállítására és azok felhasználása 1,3-butadién elõállításához |
| US10487342B2 (en) * | 2014-07-11 | 2019-11-26 | Genomatica, Inc. | Microorganisms and methods for the production of butadiene using acetyl-CoA |
| EP3741865B1 (en) | 2014-09-18 | 2024-03-13 | Genomatica, Inc. | Non-natural microbial organisms with improved energetic efficiency |
| WO2016094526A1 (en) * | 2014-12-11 | 2016-06-16 | Ciris Energy Inc. | Genetically modified microbes for the biological conversion of carbonaceous materials to diols |
| DK3230236T3 (da) | 2014-12-12 | 2024-05-13 | Versalis Spa | Fremgangsmåde til fremstilling af 1,3-butadien fra 1,3-butandiol |
| MX2017010570A (es) | 2015-02-23 | 2017-12-07 | Versalis Spa | Proceso para la deshidratacion de compuestos oxigenados. |
| AU2016222830B2 (en) | 2015-02-24 | 2021-02-25 | Bioatla Llc | Conditionally active biological proteins |
| CN108026214B (zh) | 2015-05-30 | 2021-03-02 | 基因组股份公司 | 乙烯基异构酶-脱水酶、烯醇脱水酶、芳樟醇脱水酶和/或巴豆醇脱水酶及其制备和使用 |
| MX386450B (es) * | 2015-06-12 | 2025-03-12 | Basf Se | Microorganismo recombinante para la producción mejorada de productos químicos finos. |
| US20170009263A1 (en) * | 2015-07-08 | 2017-01-12 | Invista North America S.A.R.L. | Methods and host cells for enhancing production of 1, 3-butanediol |
| US10626423B2 (en) * | 2015-07-21 | 2020-04-21 | The Governing Council Of The University Of Toronto | Methods and microorganisms for the production of 1,3-butanediol |
| US11441128B2 (en) | 2015-10-30 | 2022-09-13 | Genomatica, Inc. | Methanol dehydrogenase fusion proteins |
| GB201605354D0 (en) | 2016-03-30 | 2016-05-11 | Zuvasyntha Ltd | Modified enzyme |
| IT201600105178A1 (it) | 2016-10-19 | 2018-04-19 | Versalis Spa | Procedimento per la produzione di dieni |
| US20210101855A1 (en) * | 2017-03-31 | 2021-04-08 | Genomatica, Inc. | Process and systems for obtaining 1,3-butanediol from fermentation broths |
| CA3058219A1 (en) | 2017-03-31 | 2018-10-04 | Genomatica, Inc. | Aldehyde dehydrogenase variants and methods of use |
| CN110691847A (zh) | 2017-03-31 | 2020-01-14 | 基因组股份公司 | 3-羟基丁酰基-CoA脱氢酶变体以及使用方法 |
| CN108728471B (zh) * | 2017-04-14 | 2020-01-31 | 中国科学院微生物研究所 | 产3-羟基丙酸的重组菌及其制备方法与应用 |
| CN108728469B (zh) * | 2017-04-14 | 2022-03-01 | 中国科学院微生物研究所 | 重组大肠杆菌工程菌的构建及其在生产β-丙氨酸中的应用 |
| US20210079334A1 (en) | 2018-01-30 | 2021-03-18 | Genomatica, Inc. | Fermentation systems and methods with substantially uniform volumetric uptake rate of a reactive gaseous component |
| CN108690851B (zh) * | 2018-05-30 | 2020-11-06 | 青岛农业大学 | 一种丁二烯生产菌及其生产丁二烯的方法 |
| US11541105B2 (en) | 2018-06-01 | 2023-01-03 | The Research Foundation For The State University Of New York | Compositions and methods for disrupting biofilm formation and maintenance |
| WO2020006058A2 (en) | 2018-06-26 | 2020-01-02 | Genomatica, Inc. | Engineered microorganisms with g3p---> 3pg enzyme and/or fructose-1,6-bisphosphatase including those having synthetic or enhanced methylotrophy |
| CA3101934A1 (en) * | 2018-07-03 | 2020-01-09 | Global Bioenergies | 3-methylcrotonic acid decarboxylase (mdc) variants |
| JP7390369B2 (ja) | 2018-09-21 | 2023-12-01 | ベルサリス エッセ．ピー．アー． | 発酵ブロスからバイオ－１，３－ブタンジオールを精製する方法 |
| EP3856896A1 (en) | 2018-09-26 | 2021-08-04 | Genomatica, Inc. | Aldehyde dehydrogenase variants and methods of using same |
| CN112280722B (zh) * | 2019-07-23 | 2022-03-08 | 清华大学 | 用于生产光学纯1,3-丁二醇的重组菌及其应用 |
| CN110643556A (zh) * | 2019-08-23 | 2020-01-03 | 浙江工业大学 | 一种共表达烯醛还原酶和葡萄糖脱氢酶的重组基因工程菌及其应用 |
| IT201900015069A1 (it) | 2019-08-27 | 2021-02-27 | Versalis Spa | Catalizzatore comprendente coke e procedimento per la produzione di dieni. |
| KR102682257B1 (ko) | 2019-09-05 | 2024-07-08 | 주식회사 다이셀 | 1,3-부틸렌 글리콜 제품 |
| JP7376041B2 (ja) * | 2019-09-11 | 2023-11-08 | 公益財団法人地球環境産業技術研究機構 | 形質転換体及びそれを用いる１，３－ブタンジオールの製造方法 |
| IT201900025000A1 (it) | 2019-12-20 | 2021-06-20 | Versalis Spa | Procedimento per la produzione di dieni. |
| JP7475598B2 (ja) * | 2020-03-04 | 2024-04-30 | 大阪瓦斯株式会社 | １，３－ブタンジオールの製造方法 |
| WO2021198273A1 (en) * | 2020-03-31 | 2021-10-07 | Technische Universität Hamburg | Biologic synthesis of diols from amino acids |
| IT202000013243A1 (it) | 2020-06-04 | 2021-12-04 | Novamont Spa | Processo per la purificazione di una miscela di dioli |
| IT202000031979A1 (it) | 2020-12-22 | 2022-06-22 | Novamont Spa | Processo di purificazione di una miscela comprendente dioli e acetali |
| IT202100006419A1 (it) | 2021-03-17 | 2022-09-17 | Novamont Spa | Recupero di dioli da una miscela |
| IT202100030572A1 (it) | 2021-12-02 | 2023-06-02 | Novamont Spa | 1,3-butandiolo purificato da una miscela di dioli |
| CN118804980A (zh) * | 2022-01-21 | 2024-10-18 | 大象株式会社 | 生产1,4-丁二醇的微生物及利用其的1,4-丁二醇的生产方法 |
| EP4472605A1 (en) | 2022-01-31 | 2024-12-11 | Givaudan SA | Solvent mixtures comprising 1,3-butylene glycol and triethyl- citrate |
| WO2023201208A1 (en) * | 2022-04-11 | 2023-10-19 | Genomatica, Inc. | 1,3-butylene glycol compositions and methods of use |
| IT202300019440A1 (it) | 2023-09-21 | 2025-03-21 | Novamont Spa | Idrolizzato proteico di cellule di escherichia coli residue da un processo di fermentazione |
| CN119082061B (zh) * | 2024-09-05 | 2025-04-22 | 福建生物工程职业技术学院 | 一种高酶活的苯丙酮酸还原酶突变体及其应用 |
Family Cites Families (193)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3513209A (en) | 1968-08-19 | 1970-05-19 | Du Pont | Method of making 1,4-cyclohexadiene |
| US4076948A (en) | 1968-10-10 | 1978-02-28 | El Paso Products Company | Process for treatment of adipic acid mother liquor |
| GB1230276A (https=) | 1968-12-09 | 1971-04-28 | ||
| US3965182A (en) | 1969-10-02 | 1976-06-22 | Ethyl Corporation | Preparation of aniline from phenol and ammonia |
| JPS506776Y1 (https=) | 1969-12-27 | 1975-02-26 | ||
| JPS4831084B1 (https=) | 1970-09-04 | 1973-09-26 | ||
| GB1344557A (en) | 1972-06-23 | 1974-01-23 | Mitsubishi Petrochemical Co | Process for preparing 1,4-butanediol |
| JPS5543759B2 (https=) | 1972-06-28 | 1980-11-07 | ||
| DE2455617C3 (de) | 1974-11-23 | 1982-03-18 | Basf Ag, 6700 Ludwigshafen | Verfahren zur Herstellung von Butandiol und/oder Tetrahydrofuran über die Zwischenstufe des γ-Butyrolactons |
| DE2501499A1 (de) | 1975-01-16 | 1976-07-22 | Hoechst Ag | Verfahren zur herstellung von butandiol-(1.4) |
| US4190495A (en) | 1976-09-27 | 1980-02-26 | Research Corporation | Modified microorganisms and method of preparing and using same |
| US4301077A (en) | 1980-12-22 | 1981-11-17 | Standard Oil Company | Process for the manufacture of 1-4-butanediol and tetrahydrofuran |
| IT1190783B (it) | 1981-04-29 | 1988-02-24 | Davy Mckee Oil & Chem | Processo per l'idrogenolisi di esteri di acidi carbossilici |
| JPS60114197A (ja) | 1983-11-25 | 1985-06-20 | Agency Of Ind Science & Technol | 微生物によるジカルボン酸の製造法 |
| US4871667A (en) | 1984-11-26 | 1989-10-03 | Agency Of Industrial Science & Technology | Process for preparing muconic acid |
| US4652685A (en) | 1985-11-15 | 1987-03-24 | General Electric Company | Hydrogenation of lactones to glycols |
| US5143834A (en) | 1986-06-11 | 1992-09-01 | Glassner David A | Process for the production and purification of succinic acid |
| EP0249773B1 (en) | 1986-06-11 | 1992-12-16 | Michigan Biotechnology Institute | A process for the production of succinic acid by anaerobic fermentation |
| US5168055A (en) | 1986-06-11 | 1992-12-01 | Rathin Datta | Fermentation and purification process for succinic acid |
| US5182199A (en) | 1987-05-27 | 1993-01-26 | Hartley Brian S | Thermophilic ethanol production in a two-stage closed system |
| US5229279A (en) | 1987-06-29 | 1993-07-20 | Massachusetts Institute Of Technology | Method for producing novel polyester biopolymers |
| EP0556387B1 (en) | 1988-04-27 | 1995-08-09 | Daicel Chemical Industries, Ltd. | Process for preparing optically active 1,3-butanediol |
| JP2731589B2 (ja) * | 1988-04-27 | 1998-03-25 | ダイセル化学工業株式会社 | 光学活性１，３―ブタンジオールの製造方法 |
| WO1990012888A1 (en) | 1989-04-27 | 1990-11-01 | Biocontrol Systems, Incorporated | Precipitate test for microorganisms |
| JPH05506983A (ja) | 1990-03-09 | 1993-10-14 | バスフ ケイ アンド エフ コーポレイション | 天然長鎖アルコールの製造方法 |
| US5192673A (en) | 1990-04-30 | 1993-03-09 | Michigan Biotechnology Institute | Mutant strain of C. acetobutylicum and process for making butanol |
| US5079143A (en) | 1990-05-02 | 1992-01-07 | The Upjohn Company | Method of indentifying compounds useful as antiparasitic drugs |
| EP0769557B1 (en) | 1990-10-15 | 2000-11-15 | Daicel Chemical Industries, Ltd. | Process for producing optically active 1,3-butanediol |
| US5173429A (en) | 1990-11-09 | 1992-12-22 | The Board Of Trustees Of The University Of Arkansas | Clostridiumm ljungdahlii, an anaerobic ethanol and acetate producing microorganism |
| IL100572A (en) | 1991-01-03 | 1997-01-10 | Lepetit Spa | Amides of antibiotic ge 2270 factors their preparation and pharmaceutical compositions containing them |
| GB9115245D0 (en) | 1991-07-16 | 1991-08-28 | Ici Plc | Production of polyalkanoate |
| US5416020A (en) | 1992-09-29 | 1995-05-16 | Bio-Technical Resources | Lactobacillus delbrueckii ssp. bulgaricus strain and fermentation process for producing L-(+)-lactic acid |
| US5807722A (en) | 1992-10-30 | 1998-09-15 | Bioengineering Resources, Inc. | Biological production of acetic acid from waste gases with Clostridium ljungdahlii |
| US6136577A (en) | 1992-10-30 | 2000-10-24 | Bioengineering Resources, Inc. | Biological production of ethanol from waste gases with Clostridium ljungdahlii |
| FR2702492B1 (fr) | 1993-03-12 | 1995-05-24 | Rhone Poulenc Chimie | Procédé de production par fermentation d'acide itaconique. |
| US5487987A (en) | 1993-09-16 | 1996-01-30 | Purdue Research Foundation | Synthesis of adipic acid from biomass-derived carbon sources |
| US5521075A (en) | 1994-12-19 | 1996-05-28 | Michigan Biotechnology Institute | Method for making succinic acid, anaerobiospirillum succiniciproducens variants for use in process and methods for obtaining variants |
| US5504004A (en) | 1994-12-20 | 1996-04-02 | Michigan Biotechnology Institute | Process for making succinic acid, microorganisms for use in the process and methods of obtaining the microorganisms |
| US5700934A (en) | 1995-03-01 | 1997-12-23 | Dsm N.V. | Process for the preparation of epsilon-caprolactam and epsilon-caprolactam precursors |
| US5478952A (en) | 1995-03-03 | 1995-12-26 | E. I. Du Pont De Nemours And Company | Ru,Re/carbon catalyst for hydrogenation in aqueous solution |
| US5863782A (en) | 1995-04-19 | 1999-01-26 | Women's And Children's Hospital | Synthetic mammalian sulphamidase and genetic sequences encoding same |
| US5686276A (en) | 1995-05-12 | 1997-11-11 | E. I. Du Pont De Nemours And Company | Bioconversion of a fermentable carbon source to 1,3-propanediol by a single microorganism |
| FR2736927B1 (fr) | 1995-07-18 | 1997-10-17 | Rhone Poulenc Fibres & Polymer | Enzymes a activite amidase, outils genetiques et microorganismes hotes permettant leur obtention et procede d'hydrolyse mettant en oeuvre lesdites enzymes |
| US5573931A (en) | 1995-08-28 | 1996-11-12 | Michigan Biotechnology Institute | Method for making succinic acid, bacterial variants for use in the process, and methods for obtaining variants |
| US5770435A (en) | 1995-11-02 | 1998-06-23 | University Of Chicago | Mutant E. coli strain with increased succinic acid production |
| US5869301A (en) | 1995-11-02 | 1999-02-09 | Lockhead Martin Energy Research Corporation | Method for the production of dicarboxylic acids |
| US5908924A (en) | 1996-02-27 | 1999-06-01 | Michigan State University | Cloning and expression of the gene encoding thermoanaerobacter ethanolicus 39E secondary-alcohol dehydrogenase and enzyme biochemical characterization |
| US5958745A (en) | 1996-03-13 | 1999-09-28 | Monsanto Company | Methods of optimizing substrate pools and biosynthesis of poly-β-hydroxybutyrate-co-poly-β-hydroxyvalerate in bacteria and plants |
| KR100387301B1 (ko) | 1996-07-01 | 2003-06-12 | 바이오 엔지니어링 리소스 인코포레이티드 | 폐가스로부터의 생성물의 생물학적 제조방법 |
| KR100459818B1 (ko) | 1996-09-02 | 2004-12-03 | 이. 아이. 두퐁 드 느무르 앤드 컴퍼니 | ε-카프로락탐의 제조방법 |
| EP0977865A1 (en) | 1997-02-13 | 2000-02-09 | James Madison University | Methods of making polyhydroxyalkanoates comprising 4-hydroxybutyrate monomer units |
| KR100516986B1 (ko) | 1997-02-19 | 2005-09-26 | 코닌클리즈케 디에스엠 엔.브이. | 6-아미노카프론산 유도체를 과열 수증기와 접촉시킴으로써 촉매 없이 카프로락탐을 제조하는 방법 |
| US6274790B1 (en) | 1997-04-14 | 2001-08-14 | The University Of British Columbia | Nucleic acids encoding a plant enzyme involved in very long chain fatty acid synthesis |
| KR19990013007A (ko) | 1997-07-31 | 1999-02-25 | 박원훈 | 형질전환된 대장균 ｓｓ373(ｋｃｔｃ 8818ｐ)과 이를 이용한숙신산의 생산방법 |
| IT1294728B1 (it) * | 1997-09-12 | 1999-04-12 | Biopolo S C A R L | Ceppi di lievito per la riproduzione di acido lattico |
| JPH11103863A (ja) | 1997-10-08 | 1999-04-20 | Nippon Shokubai Co Ltd | マレイン酸異性化酵素遺伝子 |
| US6280986B1 (en) | 1997-12-01 | 2001-08-28 | The United States Of America As Represented By The Secretary Of Agriculture | Stabilization of pet operon plasmids and ethanol production in bacterial strains lacking lactate dehydrogenase and pyruvate formate lyase activities |
| US20030087381A1 (en) | 1998-04-13 | 2003-05-08 | University Of Georgia Research Foundation, Inc. | Metabolically engineered organisms for enhanced production of oxaloacetate-derived biochemicals |
| WO1999053035A1 (en) | 1998-04-13 | 1999-10-21 | The University Of Georgia Research Foundation, Inc. | Pyruvate carboxylase overexpression for enhanced production of oxaloacetate-derived biochemicals in microbial cells |
| US6159738A (en) | 1998-04-28 | 2000-12-12 | University Of Chicago | Method for construction of bacterial strains with increased succinic acid production |
| US6432686B1 (en) | 1998-05-12 | 2002-08-13 | E. I. Du Pont De Nemours And Company | Method for the production of 1,3-propanediol by recombinant organisms comprising genes for vitamin B12 transport |
| US6444784B1 (en) | 1998-05-29 | 2002-09-03 | Exxonmobil Research & Engineering Company | Wax crystal modifiers (LAW657) |
| CA2331327A1 (en) | 1998-06-26 | 2000-01-06 | Iowa State University Research Foundation, Inc. | Materials and methods for the alteration of enzyme and acetyl coa levels in plants |
| US6531303B1 (en) | 1998-07-06 | 2003-03-11 | Arkion Life Sciences Llc | Method of producing geranylgeraniol |
| DE19856136C2 (de) | 1998-12-04 | 2002-10-24 | Pasteur Institut | Verfahren und Vorrichtung zur Selektion beschleunigter Proliferation lebender Zellen in Suspension |
| US6835820B2 (en) | 1999-01-07 | 2004-12-28 | The University Of Massachusetts | Polyhydroxyalkanoate biosynthesis associated proteins and coding region in bacillus megaterium |
| WO2000046405A2 (en) | 1999-02-02 | 2000-08-10 | Bernhard Palsson | Methods for identifying drug targets based on genomic sequence data |
| US6686310B1 (en) | 1999-02-09 | 2004-02-03 | E. I. Du Pont De Nemours And Company | High surface area sol-gel route prepared hydrogenation catalysts |
| US6365376B1 (en) | 1999-02-19 | 2002-04-02 | E. I. Du Pont De Nemours And Company | Genes and enzymes for the production of adipic acid intermediates |
| US6448473B1 (en) | 1999-03-05 | 2002-09-10 | Monsanto Technology Llc | Multigene expression vectors for the biosynthesis of products via multienzyme biological pathways |
| US6485947B1 (en) | 1999-05-21 | 2002-11-26 | Cargill Dow Polymers, Llc | Production of lactate using crabtree negative organisms in varying culture conditions |
| DE60030403D1 (de) | 1999-08-30 | 2006-10-12 | Wisconsin Alumni Res Found | Herstellung von 3-hydroxypropionsäure in rekombinanten organismen |
| US6852517B1 (en) | 1999-08-30 | 2005-02-08 | Wisconsin Alumni Research Foundation | Production of 3-hydroxypropionic acid in recombinant organisms |
| US6660857B2 (en) | 2000-02-03 | 2003-12-09 | Dsm N.V. | Process for the preparation of ε-caprolactam |
| US6878861B2 (en) | 2000-07-21 | 2005-04-12 | Washington State University Research Foundation | Acyl coenzyme A thioesterases |
| DK1303629T3 (da) | 2000-07-25 | 2006-10-30 | Emmaus Foundation Inc | Fremgangsmåde til forögelse af ethanolproduktion fra mikrobiel fermetering |
| CA2429039A1 (en) | 2000-11-20 | 2002-05-30 | Cargill, Incorporated | 3-hydroxypropionic acid and other organic compounds |
| US7109010B2 (en) | 2000-11-22 | 2006-09-19 | Nature Works Llc | Methods and materials for the synthesis of organic products |
| CN1358841A (zh) | 2000-12-11 | 2002-07-17 | 云南省微生物研究所 | 云南链霉菌 |
| US7501268B2 (en) | 2000-12-28 | 2009-03-10 | Toyota Jidosha Kabushiki Kaisha | Methods of producing prenyl alcohols |
| JP4776146B2 (ja) | 2001-01-10 | 2011-09-21 | ザ・ペン・ステート・リサーチ・ファンデーション | 細胞代謝をモデル化する方法及びシステム |
| US7127379B2 (en) | 2001-01-31 | 2006-10-24 | The Regents Of The University Of California | Method for the evolutionary design of biochemical reaction networks |
| CA2439260C (en) | 2001-03-01 | 2012-10-23 | The Regents Of The University Of California | Models and methods for determining systemic properties of regulated reaction networks |
| US6743610B2 (en) | 2001-03-30 | 2004-06-01 | The University Of Chicago | Method to produce succinic acid from raw hydrolysates |
| DE60226229T2 (de) | 2001-05-07 | 2009-05-28 | Cargill, Inc., Wayzata | Verfahren zur herstellung von carbonsäuren und deren derivaten |
| JP4630486B2 (ja) * | 2001-05-28 | 2011-02-09 | ダイセル化学工業株式会社 | 新規な（ｒ）−２，３−ブタンジオール脱水素酵素、その製造方法、及びこれを利用した光学活性アルコールの製造方法 |
| EP1409702A1 (en) | 2001-07-20 | 2004-04-21 | Youming Zhang | Improved rect or recet cloning and subcloning method |
| US6998471B2 (en) | 2001-07-25 | 2006-02-14 | E.I. Du Pont De Nemours And Company | Polynucleotides encoding an acetyl-CoA acetyltransferase from Hevea brasiliensis, related products, and methods |
| CA2356540A1 (en) | 2001-08-30 | 2003-02-28 | Emory University | Expressed dna sequences involved in mitochondrial functions |
| MXPA04004194A (es) | 2001-11-02 | 2005-03-31 | Rice University | Sistema de recirculacion para la manipulacion de disponibilidad de nadh intracelular. |
| ES2329778T3 (es) | 2002-01-18 | 2009-12-01 | Novozymes A/S | 2,3-aminomutasa de alanina. |
| WO2003066863A1 (fr) | 2002-02-06 | 2003-08-14 | Showa Denko K.K. | Gene reductase d'un compose carbonyle alpha-substitue-alpha, beta-insature |
| US20030224363A1 (en) | 2002-03-19 | 2003-12-04 | Park Sung M. | Compositions and methods for modeling bacillus subtilis metabolism |
| CA2480216A1 (en) | 2002-03-29 | 2003-10-09 | Genomatica, Inc. | Human metabolic models and methods |
| JPWO2003095651A1 (ja) | 2002-05-10 | 2005-09-15 | 協和醗酵工業株式会社 | メバロン酸の製造方法 |
| US7856317B2 (en) | 2002-06-14 | 2010-12-21 | Genomatica, Inc. | Systems and methods for constructing genomic-based phenotypic models |
| DE60313866T2 (de) | 2002-06-14 | 2008-04-17 | Dsm Ip Assets B.V. | Polypeptide mit alpha-h alpha amino acid amide racemase aktivitität und nukleinsäuren kodierend dafür |
| US7826975B2 (en) | 2002-07-10 | 2010-11-02 | The Penn State Research Foundation | Method for redesign of microbial production systems |
| AU2003256480B2 (en) | 2002-07-10 | 2008-03-06 | The Penn State Research Foundation | Method for determining gene knockout strategies |
| US7413878B2 (en) | 2002-07-15 | 2008-08-19 | Kosan Biosciences, Inc. | Recombinant host cells expressing atoAD and capable of making a polyketide using a starter unit |
| KR101148255B1 (ko) | 2002-10-04 | 2012-08-08 | 다니스코 유에스 인크. | 고수율을 갖는 1,3-프로판디올의 생물학적 제조 방법 |
| US7734420B2 (en) | 2002-10-15 | 2010-06-08 | The Regents Of The University Of California | Methods and systems to identify operational reaction pathways |
| AU2003287625A1 (en) | 2002-11-06 | 2004-06-03 | University Of Florida | Materials and methods for the efficient production of acetate and other products |
| WO2004074495A1 (ja) | 2003-02-24 | 2004-09-02 | Research Institute Of Innovative Technology For The Earth | 微生物による高効率水素製造方法 |
| US20040199941A1 (en) | 2003-03-24 | 2004-10-07 | Rice University | Increased bacterial CoA and acetyl-CoA pools |
| RU2268300C2 (ru) | 2003-04-07 | 2006-01-20 | Закрытое акционерное общество "Научно-исследовательский институт Аджиномото-Генетика" | СПОСОБ ПОЛУЧЕНИЯ L-АМИНОКИСЛОТ С ИСПОЛЬЗОВАНИЕМ БАКТЕРИЙ, ОБЛАДАЮЩИХ ПОВЫШЕННОЙ ЭКСПРЕССИЕЙ ГЕНА pckA |
| DE10316109A1 (de) | 2003-04-09 | 2004-10-21 | Degussa Ag | Verfahren zur fermentativen Herstellung von L-Aminosäuren unter Verwendung von Stämmen der Familie Enterobacteriaceae |
| US7927859B2 (en) | 2003-08-22 | 2011-04-19 | Rice University | High molar succinate yield bacteria by increasing the intracellular NADH availability |
| EP1672067B1 (en) | 2003-09-17 | 2015-11-11 | Mitsubishi Chemical Corporation | Process for producing non-amino organic acid |
| WO2005026338A1 (en) | 2003-09-18 | 2005-03-24 | Ciba Specialty Chemicals Holding Inc. | Alcohol dehydrogenases with increased solvent and temperature stability |
| FR2862068B1 (fr) | 2003-11-06 | 2007-10-12 | Metabolic Explorer Sa | Souches de microorganismes optimisees pour des voies de biosyntheses consommatrices de nadph |
| US7244610B2 (en) | 2003-11-14 | 2007-07-17 | Rice University | Aerobic succinate production in bacteria |
| AU2004320598A1 (en) | 2003-12-18 | 2005-12-22 | Basf Aktiengesellschaft | Methods for the preparation of a fine chemical by fermentation |
| AU2004299728A1 (en) | 2003-12-18 | 2005-06-30 | Basf Aktiengesellschaft | Methods for the preparation of a fine chemical by fermentation |
| US20080032374A1 (en) | 2003-12-18 | 2008-02-07 | Basf Aktiengesellschaft | Method for the Preparation of Lysine by Fermentation of Corynebacterium Glutamicum |
| FR2864967B1 (fr) | 2004-01-12 | 2006-05-19 | Metabolic Explorer Sa | Microorganisme evolue pour la production de 1,2-propanediol |
| BRPI0506942B1 (pt) | 2004-01-19 | 2015-07-28 | Dsm Ip Assets B.V. | Síntese bioquímica de ácido 6-amino capróico |
| US7608700B2 (en) | 2004-03-08 | 2009-10-27 | North Carolina State University | Lactobacillus acidophilus nucleic acid sequences encoding stress-related proteins and uses therefor |
| DE102004031177A1 (de) | 2004-06-29 | 2006-01-19 | Henkel Kgaa | Neue Geruchsstoffe bildende Genprodukte von Bacillus licheniformis und darauf aufbauende verbesserte biotechnologische Produktionsverfahren |
| WO2006020663A2 (en) | 2004-08-09 | 2006-02-23 | Rice University | Aerobic succinate production in bacteria |
| KR101245428B1 (ko) | 2004-08-27 | 2013-03-19 | 라이스 유니버시티 | 숙신산 생산이 증가된 돌연변이 대장균 균주 |
| JP4712716B2 (ja) | 2004-09-09 | 2011-06-29 | 財団法人地球環境産業技術研究機構 | プロモーター機能を有するｄｎａ断片 |
| JP2008513023A (ja) | 2004-09-17 | 2008-05-01 | ライス ユニバーシティー | 高コハク酸生産細菌 |
| WO2006069174A2 (en) | 2004-12-22 | 2006-06-29 | Rice University | Simultaneous anaerobic production of isoamyl acetate and succinic acid |
| JP2006204255A (ja) | 2005-01-31 | 2006-08-10 | Canon Inc | アセチル−ＣｏＡアシルトランスフェラーゼ遺伝子破壊ポリヒドロキシアルカノエート生産菌、またこれを利用したポリヒドロキシアルカノエート生産方法 |
| WO2006109312A2 (en) | 2005-04-15 | 2006-10-19 | Vascular Biogenics Ltd. | Compositions containing beta 2-glycoprotein i-derived peptides for the prevention and/or treatment of vascular disease |
| WO2007001982A1 (en) | 2005-06-20 | 2007-01-04 | Archer-Daniels-Midland Company | Altered glyoxylate shunt for improved production of aspartate-derived amino acids and chemicals |
| US20090053797A1 (en) * | 2005-08-19 | 2009-02-26 | Yoichiro Shiba | Genetically modified host cells and use of same for producing isoprenoid compounds |
| KR100676160B1 (ko) | 2005-08-19 | 2007-02-01 | 한국과학기술원 | 말릭효소를 코딩하는 유전자로 형질전환된 재조합 미생물 및 이를 이용한 숙신산의 제조방법 |
| KR100679638B1 (ko) | 2005-08-19 | 2007-02-06 | 한국과학기술원 | 포메이트 디하이드로게나제 ｄ 또는 ｅ를 코딩하는 유전자로 형질전환된 미생물 및 이를 이용한 숙신산의 제조방법 |
| JP2009507493A (ja) | 2005-09-09 | 2009-02-26 | ジェノマティカ・インコーポレイテッド | 増殖連動型のコハク酸塩生成のための方法と生物 |
| US9297028B2 (en) | 2005-09-29 | 2016-03-29 | Butamax Advanced Biofuels Llc | Fermentive production of four carbon alcohols |
| RU2394913C2 (ru) | 2005-10-26 | 2010-07-20 | Е.И.Дюпон Де Немур Энд Компани | Ферментативное получение четырехуглеродных спиртов |
| CN100392071C (zh) * | 2005-12-05 | 2008-06-04 | 中国农业大学 | 产乳酸途径缺失的工程菌及其构建方法与应用 |
| CA2650505A1 (en) | 2006-05-01 | 2008-02-14 | University Of Florida Research Foundation, Inc. | Ethanol production in non-recombinant hosts |
| US8206970B2 (en) | 2006-05-02 | 2012-06-26 | Butamax(Tm) Advanced Biofuels Llc | Production of 2-butanol and 2-butanone employing aminobutanol phosphate phospholyase |
| DE102006025821A1 (de) | 2006-06-02 | 2007-12-06 | Degussa Gmbh | Ein Enzym zur Herstellung von Mehylmalonatsemialdehyd oder Malonatsemialdehyd |
| WO2008013996A2 (en) | 2006-07-27 | 2008-01-31 | Gevo Inc. | Engineered microorganisms for increasing product yield in biotransformations, related methods and systems |
| RU2311231C1 (ru) | 2006-08-15 | 2007-11-27 | ООО "Объединенный центр исследований и разработок" | Катализатор для получения эфиров акриловой кислоты по реакции метатезиса диалкилмалеатов (варианты) и каталитическая композиция на его основе |
| BRPI0716212A2 (pt) | 2006-08-30 | 2013-10-15 | Cargill Inc | Beta-alanina/alfa-cetoglutarato aminotransferase para produção de ácido 3-hidroxipropiônico |
| WO2008052991A2 (en) | 2006-10-31 | 2008-05-08 | Dsm Ip Assets B.V. | Butanol production in a eukaryotic cell |
| BRPI0719748A2 (pt) | 2006-12-01 | 2013-12-10 | Gevo Inc | Microrganismo modificados por engenharia para produzir n-butanol e métodos relacionados |
| US8017364B2 (en) | 2006-12-12 | 2011-09-13 | Butamax(Tm) Advanced Biofuels Llc | Solvent tolerant microorganisms |
| WO2008072920A1 (en) * | 2006-12-15 | 2008-06-19 | Biofuelchem Co., Ltd. | Method for preparing butanol through butyryl-coa as an intermediate using bacteria |
| CA2715092A1 (en) | 2006-12-21 | 2008-07-03 | Gevo, Inc. | Butanol production by metabolically engineered yeast |
| WO2008097064A1 (en) | 2007-02-08 | 2008-08-14 | Biofuelchem Co., Ltd. | Method for preparing butanol through butyryl-coa as an intermediate using yeast |
| LT2821494T (lt) | 2007-03-16 | 2017-04-25 | Genomatica, Inc. | 1,4-butandiolio ir jo pirmtakų biosintezės būdai ir kompozicijos |
| WO2008124523A1 (en) | 2007-04-04 | 2008-10-16 | The Regents Of The University Of California | Butanol production by recombinant microorganisms |
| WO2008131286A1 (en) | 2007-04-18 | 2008-10-30 | Gevo, Inc. | Engineered microorganisms for producing isopropanol |
| US8426174B2 (en) | 2007-05-02 | 2013-04-23 | Butamax(Tm) Advanced Biofuels Llc | Method for the production of 2-butanol |
| US20080274522A1 (en) | 2007-05-02 | 2008-11-06 | Bramucci Michael G | Method for the production of 2-butanone |
| WO2008144060A2 (en) | 2007-05-17 | 2008-11-27 | Tetravitae Bioscience, Inc. | Methods and compositions for producing solvents |
| US20090004715A1 (en) | 2007-06-01 | 2009-01-01 | Solazyme, Inc. | Glycerol Feedstock Utilization for Oil-Based Fuel Manufacturing |
| KR20100049012A (ko) | 2007-06-15 | 2010-05-11 | 에보니크 데구사 게엠베하 | 비타민 ｂ１２ 시스템이 탈조절된 미생물 |
| EP2017344A1 (en) | 2007-07-20 | 2009-01-21 | Nederlandse Organisatie voor toegepast- natuurwetenschappelijk onderzoek TNO | Production of itaconic acid |
| US20100205857A1 (en) | 2007-07-23 | 2010-08-19 | Einte-Karst Dijk | Butanol production in a eukaryotic cell |
| US20100248233A1 (en) | 2007-07-23 | 2010-09-30 | Dsm Ip Assets B.V. | Acetyl-coa producing enzymes in yeast |
| KR101114918B1 (ko) | 2007-08-09 | 2012-02-15 | 주식회사 엘지화학 | 재조합 미생물을 이용한 광학활성（ｓ）-3-하이드록시부탄산 및（ｓ）-3-하이드록시부티레이트 에스테르의 제조방법 |
| US7947483B2 (en) | 2007-08-10 | 2011-05-24 | Genomatica, Inc. | Methods and organisms for the growth-coupled production of 1,4-butanediol |
| KR101042242B1 (ko) | 2007-09-07 | 2011-06-17 | 한국과학기술원 | 1,4-부탄디올 생성능을 가지는 변이체 및 이를 이용한1,4-부탄디올의 제조방법 |
| WO2009046370A2 (en) | 2007-10-04 | 2009-04-09 | Bio Architecture Lab, Inc. | Biofuel production |
| EP2198039A4 (en) | 2007-10-12 | 2012-05-09 | Univ California | MODIFIED MICROORGANISMS FOR THE MANUFACTURE OF ISOPROPANOL |
| CN101918572A (zh) | 2007-10-26 | 2010-12-15 | 阿伯燃料公司 | 正丁醇的生产方法 |
| US8455239B2 (en) | 2007-12-23 | 2013-06-04 | Gevo, Inc. | Yeast organism producing isobutanol at a high yield |
| CN101978042B (zh) | 2008-01-22 | 2017-03-08 | 基因组股份公司 | 利用合成气或其它气态碳源和甲醇的方法和有机体 |
| US20090203089A1 (en) | 2008-01-28 | 2009-08-13 | Bio Architecture Lab, Inc. | Isolated alcohol dehydrogenase enzymes and uses thereof |
| WO2009103026A1 (en) | 2008-02-15 | 2009-08-20 | Gevo, Inc. | Engineered microorganisms for producing isopropanol |
| CA2728285A1 (en) | 2008-03-03 | 2009-09-11 | Joule Unlimited, Inc. | Engineered co2 fixing microorganisms producing carbon-based products of interest |
| US8673599B2 (en) | 2008-03-11 | 2014-03-18 | Dsm Ip Assets B.V. | Preparation of 6-aminocaproic acid from 5-formylvaleric acid |
| US9096873B2 (en) | 2008-03-11 | 2015-08-04 | Genomatica, Inc. | Adipate (ester or thioester) synthesis |
| CN102066551B (zh) | 2008-03-27 | 2013-10-09 | 基因组股份公司 | 用于产生己二酸和其他化合物的微生物 |
| US20090286294A1 (en) | 2008-04-04 | 2009-11-19 | University Of Massachusetts | Methods and Compositions for Improving the Production of Fuels in Microorganisms |
| KR20110021797A (ko) | 2008-04-25 | 2011-03-04 | 자이단호우진 치큐칸쿄 산교기쥬츠 켄큐키코 | 이소프로판올을 제조할 수 있는 유전자 변형된 코리네형 세균 |
| US8188250B2 (en) | 2008-04-28 | 2012-05-29 | Butamax(Tm) Advanced Biofuels Llc | Butanol dehydrogenase enzyme from the bacterium Achromobacter xylosoxidans |
| BRPI0909989A2 (pt) | 2008-06-05 | 2021-06-22 | Butamax Advanced Biofuels Llc | célula de levedura recombinante e método para a produção de um produto |
| US8129154B2 (en) | 2008-06-17 | 2012-03-06 | Genomatica, Inc. | Microorganisms and methods for the biosynthesis of fumarate, malate, and acrylate |
| US7858350B2 (en) * | 2008-09-10 | 2010-12-28 | Genomatica, Inc. | Microorganisms for the production of 1,4-butanediol |
| CA2738574A1 (en) | 2008-09-26 | 2010-04-01 | Kesen Ma | Thermostable alcohol dehydrogenase derived from thermococcus guaymasensis |
| US8354563B2 (en) | 2008-10-16 | 2013-01-15 | Maverick Biofuels, Inc. | Methods and apparatus for synthesis of alcohols from syngas |
| CN103396978A (zh) | 2008-12-12 | 2013-11-20 | 麦特波力克斯公司 | 用于制备聚(5-羟基戊酸)和5碳化合物的绿色工艺和组合物 |
| EP2373781A4 (en) | 2008-12-16 | 2012-10-10 | Genomatica Inc | MICRO-ORGANISMS AND METHODS OF CONVERTING SYNGAS AND OTHER CARBON RESOURCES IN USEFUL PRODUCTS |
| US8455225B2 (en) | 2008-12-29 | 2013-06-04 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving high osmolarity/glycerol response pathway |
| US8795992B2 (en) | 2008-12-29 | 2014-08-05 | Butamax Advanced Biofuels Llc | Yeast with increased butanol tolerance involving cell wall integrity pathway |
| US8557562B2 (en) | 2008-12-29 | 2013-10-15 | Butamax(Tm) Advanced Biofuels Llc | Yeast with increased butanol tolerance involving filamentous growth response |
| US20100086981A1 (en) | 2009-06-29 | 2010-04-08 | Qteros, Inc. | Compositions and methods for improved saccharification of biomass |
| US9034616B2 (en) | 2009-04-06 | 2015-05-19 | Syracuse University | Butanal production using engineered Streptomyces coelicolor |
| EP4321615A3 (en) | 2009-04-30 | 2024-02-21 | Genomatica, Inc. | Organisms for the production of 1,3-butanediol |
| JP4760951B2 (ja) | 2009-05-08 | 2011-08-31 | トヨタ自動車株式会社 | ブタノール生産能を有する組換え微生物及びブタノールの製造方法 |
| BR112012006939A2 (pt) | 2009-09-29 | 2015-09-08 | Butamax Tm Advanced Biofuels | célula hospedeira de produção de levedura recombinante e método para a produção de um produto selecionado do grupo que consiste em 2,3-butanodiol, isobutanol, 2-butanol, 1-butanol, 2-butanona, valina, leucina, ácido lático, ácido málico, álcool, isoampilico e isoprenoides |
| US20110137088A1 (en) | 2009-12-03 | 2011-06-09 | Bp Corporation North America Inc. | Methods and Apparatuses for Producing Renewable Materials From Inhibiting Compounds |
| US8268607B2 (en) | 2009-12-10 | 2012-09-18 | Genomatica, Inc. | Methods and organisms for converting synthesis gas or other gaseous carbon sources and methanol to 1,3-butanediol |
| WO2011081658A2 (en) | 2009-12-15 | 2011-07-07 | Qteros, Inc. | Methods and compositions for producing chemical products from c. phytofermentants |
| BR112012020261B8 (pt) | 2010-02-12 | 2020-04-14 | California Inst Of Techn | saccharomyces cerevisiae recombinante e método de produção de isobutanol |
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