|
US2187108A
(en)
|
1938-05-27 |
1940-01-16 |
Du Pont |
Process of purifying lead nitrate solutions
|
|
JPS5727375B2
(enExample)
|
1973-06-01 |
1982-06-10 |
|
|
|
US4179337A
(en)
|
1973-07-20 |
1979-12-18 |
Davis Frank F |
Non-immunogenic polypeptides
|
|
DE2712230C2
(de)
|
1977-03-19 |
1985-05-23 |
Bayer Ag, 5090 Leverkusen |
Verzweigte Segmentpolymere
|
|
US4109496A
(en)
|
1977-12-20 |
1978-08-29 |
Norris Industries |
Trapped key mechanism
|
|
US4458066A
(en)
*
|
1980-02-29 |
1984-07-03 |
University Patents, Inc. |
Process for preparing polynucleotides
|
|
US4469863A
(en)
|
1980-11-12 |
1984-09-04 |
Ts O Paul O P |
Nonionic nucleic acid alkyl and aryl phosphonates and processes for manufacture and use thereof
|
|
JPS58129411A
(ja)
|
1982-01-27 |
1983-08-02 |
Nippon Kogaku Kk <Nikon> |
リアフオ−カスコンバ−ジヨンレンズ
|
|
US4522811A
(en)
*
|
1982-07-08 |
1985-06-11 |
Syntex (U.S.A.) Inc. |
Serial injection of muramyldipeptides and liposomes enhances the anti-infective activity of muramyldipeptides
|
|
GB8311018D0
(en)
*
|
1983-04-22 |
1983-05-25 |
Amersham Int Plc |
Detecting mutations in dna
|
|
US4683195A
(en)
*
|
1986-01-30 |
1987-07-28 |
Cetus Corporation |
Process for amplifying, detecting, and/or-cloning nucleic acid sequences
|
|
US5656493A
(en)
|
1985-03-28 |
1997-08-12 |
The Perkin-Elmer Corporation |
System for automated performance of the polymerase chain reaction
|
|
US4965188A
(en)
|
1986-08-22 |
1990-10-23 |
Cetus Corporation |
Process for amplifying, detecting, and/or cloning nucleic acid sequences using a thermostable enzyme
|
|
US4683202A
(en)
*
|
1985-03-28 |
1987-07-28 |
Cetus Corporation |
Process for amplifying nucleic acid sequences
|
|
US4676980A
(en)
*
|
1985-09-23 |
1987-06-30 |
The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Target specific cross-linked heteroantibodies
|
|
US4868103A
(en)
|
1986-02-19 |
1989-09-19 |
Enzo Biochem, Inc. |
Analyte detection by means of energy transfer
|
|
ATE141646T1
(de)
|
1986-04-09 |
1996-09-15 |
Genzyme Corp |
Genetisch transformierte tiere, die ein gewünschtes protein in milch absondern
|
|
US4851331A
(en)
*
|
1986-05-16 |
1989-07-25 |
Allied Corporation |
Method and kit for polynucleotide assay including primer-dependant DNA polymerase
|
|
US5525464A
(en)
|
1987-04-01 |
1996-06-11 |
Hyseq, Inc. |
Method of sequencing by hybridization of oligonucleotide probes
|
|
US5202231A
(en)
*
|
1987-04-01 |
1993-04-13 |
Drmanac Radoje T |
Method of sequencing of genomes by hybridization of oligonucleotide probes
|
|
US4873316A
(en)
|
1987-06-23 |
1989-10-10 |
Biogen, Inc. |
Isolation of exogenous recombinant proteins from the milk of transgenic mammals
|
|
US5080891A
(en)
*
|
1987-08-03 |
1992-01-14 |
Ddi Pharmaceuticals, Inc. |
Conjugates of superoxide dismutase coupled to high molecular weight polyalkylene glycols
|
|
US5048530A
(en)
|
1988-08-17 |
1991-09-17 |
Robert Hurwitz |
Method of using an amniocentesis needle with improved sonographic visibility
|
|
US5720928A
(en)
*
|
1988-09-15 |
1998-02-24 |
New York University |
Image processing and analysis of individual nucleic acid molecules
|
|
WO1990006952A1
(fr)
|
1988-12-22 |
1990-06-28 |
Kirin-Amgen, Inc. |
Facteur de stimulation de colonies de granulocytes modifies chimiquement
|
|
US5075212A
(en)
|
1989-03-27 |
1991-12-24 |
University Of Patents, Inc. |
Methods of detecting picornaviruses in biological fluids and tissues
|
|
US5800992A
(en)
*
|
1989-06-07 |
1998-09-01 |
Fodor; Stephen P.A. |
Method of detecting nucleic acids
|
|
US5143854A
(en)
*
|
1989-06-07 |
1992-09-01 |
Affymax Technologies N.V. |
Large scale photolithographic solid phase synthesis of polypeptides and receptor binding screening thereof
|
|
US5766849A
(en)
*
|
1989-07-11 |
1998-06-16 |
Gen-Probe Incorporated |
Methods of amplifying nucleic acids using promoter-containing primer sequence
|
|
GB2236186B
(en)
*
|
1989-08-22 |
1994-01-05 |
Finnigan Mat Gmbh |
Process and device for laser desorption of analyte molecular ions, especially of biomolecules
|
|
ATE174058T1
(de)
|
1989-11-06 |
1998-12-15 |
Cell Genesys Inc |
Herstellung von proteinen mittels homologer rekombination
|
|
US5641628A
(en)
*
|
1989-11-13 |
1997-06-24 |
Children's Medical Center Corporation |
Non-invasive method for isolation and detection of fetal DNA
|
|
US5272071A
(en)
|
1989-12-22 |
1993-12-21 |
Applied Research Systems Ars Holding N.V. |
Method for the modification of the expression characteristics of an endogenous gene of a given cell line
|
|
EP0594584A1
(en)
*
|
1990-01-12 |
1994-05-04 |
The Scripps Research Institute |
Nucleic acid enzymes for cleaving dna
|
|
US6013431A
(en)
*
|
1990-02-16 |
2000-01-11 |
Molecular Tool, Inc. |
Method for determining specific nucleotide variations by primer extension in the presence of mixture of labeled nucleotides and terminators
|
|
US5321131A
(en)
*
|
1990-03-08 |
1994-06-14 |
Hybridon, Inc. |
Site-specific functionalization of oligodeoxynucleotides for non-radioactive labelling
|
|
US5210015A
(en)
*
|
1990-08-06 |
1993-05-11 |
Hoffman-La Roche Inc. |
Homogeneous assay system using the nuclease activity of a nucleic acid polymerase
|
|
US6004744A
(en)
|
1991-03-05 |
1999-12-21 |
Molecular Tool, Inc. |
Method for determining nucleotide identity through extension of immobilized primer
|
|
US5719262A
(en)
*
|
1993-11-22 |
1998-02-17 |
Buchardt, Deceased; Ole |
Peptide nucleic acids having amino acid side chains
|
|
DK51092D0
(da)
|
1991-05-24 |
1992-04-15 |
Ole Buchardt |
Oligonucleotid-analoge betegnet pna, monomere synthoner og fremgangsmaade til fremstilling deraf samt anvendelser deraf
|
|
DE4214112A1
(de)
*
|
1991-08-02 |
1993-02-04 |
Europ Lab Molekularbiolog |
Neues verfahren zur sequenzierung von nukleinsaeuren
|
|
US5700922A
(en)
|
1991-12-24 |
1997-12-23 |
Isis Pharmaceuticals, Inc. |
PNA-DNA-PNA chimeric macromolecules
|
|
CA2087413A1
(en)
*
|
1992-01-17 |
1993-07-18 |
Joseph R. Lakowicz |
Fluorescent energy transfer immunoassay
|
|
GB9208733D0
(en)
|
1992-04-22 |
1992-06-10 |
Medical Res Council |
Dna sequencing method
|
|
GB9211979D0
(en)
*
|
1992-06-05 |
1992-07-15 |
Buchard Ole |
Uses of nucleic acid analogues
|
|
AU678769B2
(en)
*
|
1992-07-27 |
1997-06-12 |
Hybridon, Inc. |
Oligonucleotide alkylphosphonothioates
|
|
CA2148252C
(en)
|
1992-10-30 |
2007-06-12 |
Roger Brent |
Interaction trap system for isolating novel proteins
|
|
CA2153387A1
(en)
|
1993-01-07 |
1994-07-21 |
Hubert Koester |
Dna sequencing by mass spectrometry
|
|
US5605798A
(en)
*
|
1993-01-07 |
1997-02-25 |
Sequenom, Inc. |
DNA diagnostic based on mass spectrometry
|
|
US6194144B1
(en)
*
|
1993-01-07 |
2001-02-27 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry
|
|
WO1994017091A2
(en)
*
|
1993-01-21 |
1994-08-04 |
Hybridon Inc. |
Foldback triplex-forming oligonucleotides
|
|
US6045996A
(en)
*
|
1993-10-26 |
2000-04-04 |
Affymetrix, Inc. |
Hybridization assays on oligonucleotide arrays
|
|
US6156501A
(en)
|
1993-10-26 |
2000-12-05 |
Affymetrix, Inc. |
Arrays of modified nucleic acid probes and methods of use
|
|
EP0765401B1
(en)
|
1993-11-17 |
2001-02-21 |
Amersham Pharmacia Biotech UK Limited |
Primer extension mass spectroscopy nucleic acid sequencing method
|
|
DE69531542T2
(de)
|
1994-02-07 |
2004-06-24 |
Beckman Coulter, Inc., Fullerton |
Ligase/polymerase-vermittelte analyse genetischer elemente von einzelnukleotid-polymorphismen und ihre verwendung in der genetischen analyse
|
|
US5637684A
(en)
*
|
1994-02-23 |
1997-06-10 |
Isis Pharmaceuticals, Inc. |
Phosphoramidate and phosphorothioamidate oligomeric compounds
|
|
US5851770A
(en)
|
1994-04-25 |
1998-12-22 |
Variagenics, Inc. |
Detection of mismatches by resolvase cleavage using a magnetic bead support
|
|
WO1995029251A1
(en)
|
1994-04-25 |
1995-11-02 |
Applied Technology Genetics Corporation |
Detection of mutation by resolvase cleavage
|
|
US5834189A
(en)
|
1994-07-08 |
1998-11-10 |
Visible Genetics Inc. |
Method for evaluation of polymorphic genetic sequences, and the use thereof in identification of HLA types
|
|
WO1996002634A1
(en)
*
|
1994-07-15 |
1996-02-01 |
Cephalon, Inc. |
Active calpain expressed by baculovirus
|
|
US5849483A
(en)
|
1994-07-28 |
1998-12-15 |
Ig Laboratories, Inc. |
High throughput screening method for sequences or genetic alterations in nucleic acids
|
|
US5589330A
(en)
|
1994-07-28 |
1996-12-31 |
Genzyme Corporation |
High-throughput screening method for sequence or genetic alterations in nucleic acids using elution and sequencing of complementary oligonucleotides
|
|
US5662813A
(en)
*
|
1994-10-21 |
1997-09-02 |
Bioseparations, Inc. |
Method for separation of nucleated fetal erythrocytes from maternal blood samples
|
|
US5807718A
(en)
|
1994-12-02 |
1998-09-15 |
The Scripps Research Institute |
Enzymatic DNA molecules
|
|
MX9705172A
(es)
|
1995-01-09 |
1997-10-31 |
Boehringer Ingelheim Int |
Polipeptido asociado a il-2r y moleculas de adn que codifican el mismo.
|
|
US6239273B1
(en)
*
|
1995-02-27 |
2001-05-29 |
Affymetrix, Inc. |
Printing molecular library arrays
|
|
DE19515552A1
(de)
|
1995-04-27 |
1996-10-31 |
Europ Lab Molekularbiolog |
Simultane Sequenzierung von Nukleinsäuren
|
|
US5614622A
(en)
*
|
1995-06-01 |
1997-03-25 |
Hybridon, Inc. |
5-pentenoyl moiety as a nucleoside-amino protecting group, 4-pentenoyl-protected nucleotide synthons, and related oligonucleotide syntheses
|
|
US6140482A
(en)
|
1995-06-01 |
2000-10-31 |
Hybridon, Inc. |
Primary phosphoramidate internucleoside linkages and oligonucleotides containing the same
|
|
US5955599A
(en)
|
1995-06-01 |
1999-09-21 |
Hybridon, Inc. |
Process for making oligonucleotides containing o- and s- methylphosphotriester internucleoside linkages
|
|
US5962674A
(en)
|
1995-06-01 |
1999-10-05 |
Hybridon, Inc. |
Synthesis of oligonucleotides containing alkylphosphonate internucleoside linkages
|
|
US5981186A
(en)
|
1995-06-30 |
1999-11-09 |
Visible Genetics, Inc. |
Method and apparatus for DNA-sequencing using reduced number of sequencing mixtures
|
|
US5637683A
(en)
*
|
1995-07-13 |
1997-06-10 |
Cornell Research Foundation, Inc. |
Nucleic acid analog with amide linkage and method of making that analog
|
|
US5652356A
(en)
*
|
1995-08-17 |
1997-07-29 |
Hybridon, Inc. |
Inverted chimeric and hybrid oligonucleotides
|
|
JP3193301B2
(ja)
*
|
1995-09-14 |
2001-07-30 |
麒麟麦酒株式会社 |
生理活性タンパク質ｐ１６０
|
|
US5869242A
(en)
*
|
1995-09-18 |
1999-02-09 |
Myriad Genetics, Inc. |
Mass spectrometry to assess DNA sequence polymorphisms
|
|
GB9519638D0
(en)
*
|
1995-09-26 |
1995-11-29 |
Dynal As |
Method
|
|
AU2069597A
(en)
|
1996-03-04 |
1997-09-22 |
Genetrace Systems, Inc. |
Methods of screening nucleic acids using mass spectrometry
|
|
WO1997037041A2
(en)
|
1996-03-18 |
1997-10-09 |
Sequenom, Inc. |
Dna sequencing by mass spectrometry
|
|
ES2347854T5
(es)
|
1996-03-26 |
2014-07-24 |
Michael S. Kopreski |
Método que permite el uso de RNA extracelular extraído de plasma o suero para detectar, monitorizar o evaluar un cáncer
|
|
US6759217B2
(en)
|
1996-03-26 |
2004-07-06 |
Oncomedx, Inc. |
Method enabling use of extracellular RNA extracted from plasma or serum to detect, monitor or evaluate cancer
|
|
IL126544A
(en)
*
|
1996-04-25 |
2004-08-31 |
Genicon Sciences Inc |
Analyte assay using scattered-light detectable particles
|
|
US5928906A
(en)
*
|
1996-05-09 |
1999-07-27 |
Sequenom, Inc. |
Process for direct sequencing during template amplification
|
|
US5786146A
(en)
*
|
1996-06-03 |
1998-07-28 |
The Johns Hopkins University School Of Medicine |
Method of detection of methylated nucleic acid using agents which modify unmethylated cytosine and distinguishing modified methylated and non-methylated nucleic acids
|
|
WO1997047761A1
(en)
|
1996-06-14 |
1997-12-18 |
Sarnoff Corporation |
Method for polynucleotide sequencing
|
|
WO1998008858A1
(en)
|
1996-08-26 |
1998-03-05 |
Hybridon, Inc. |
Improved reagents and process for synthesis of oligonucleotides containing phosphorodithioate internucleoside linkages
|
|
US5849546A
(en)
|
1996-09-13 |
1998-12-15 |
Epicentre Technologies Corporation |
Methods for using mutant RNA polymerases with reduced discrimination between non-canonical and canonical nucleoside triphosphates
|
|
US5886165A
(en)
*
|
1996-09-24 |
1999-03-23 |
Hybridon, Inc. |
Mixed backbone antisense oligonucleotides containing 2'-5'-ribonucleotide- and 3'-5'-deoxyribonucleotides segments
|
|
GB9620209D0
(en)
*
|
1996-09-27 |
1996-11-13 |
Cemu Bioteknik Ab |
Method of sequencing DNA
|
|
US6057134A
(en)
|
1996-10-07 |
2000-05-02 |
Ambion, Inc. |
Modulating the efficiency of nucleic acid amplification reactions with 3' modified oligonucleotides
|
|
US6024925A
(en)
*
|
1997-01-23 |
2000-02-15 |
Sequenom, Inc. |
Systems and methods for preparing low volume analyte array elements
|
|
EP1460083B1
(en)
|
1996-11-06 |
2006-01-18 |
Sequenom, Inc. |
Analysing method and apparatus
|
|
US6140053A
(en)
|
1996-11-06 |
2000-10-31 |
Sequenom, Inc. |
DNA sequencing by mass spectrometry via exonuclease degradation
|
|
US7285422B1
(en)
|
1997-01-23 |
2007-10-23 |
Sequenom, Inc. |
Systems and methods for preparing and analyzing low volume analyte array elements
|
|
US6043060A
(en)
|
1996-11-18 |
2000-03-28 |
Imanishi; Takeshi |
Nucleotide analogues
|
|
US6017702A
(en)
*
|
1996-12-05 |
2000-01-25 |
The Perkin-Elmer Corporation |
Chain-termination type nucleic acid sequencing method including 2'-deoxyuridine-5'-triphosphate
|
|
US5876934A
(en)
*
|
1996-12-18 |
1999-03-02 |
Pharmacia Biotech Inc. |
DNA sequencing method
|
|
US6046005A
(en)
*
|
1997-01-15 |
2000-04-04 |
Incyte Pharmaceuticals, Inc. |
Nucleic acid sequencing with solid phase capturable terminators comprising a cleavable linking group
|
|
US20010051341A1
(en)
|
1997-03-04 |
2001-12-13 |
Isis Innovation Limited |
Non-invasive prenatal diagnosis
|
|
GB9704444D0
(en)
|
1997-03-04 |
1997-04-23 |
Isis Innovation |
Non-invasive prenatal diagnosis
|
|
JP3756313B2
(ja)
|
1997-03-07 |
2006-03-15 |
武 今西 |
新規ビシクロヌクレオシド及びオリゴヌクレオチド類縁体
|
|
US5849497A
(en)
|
1997-04-03 |
1998-12-15 |
The Research Foundation Of State University Of New York |
Specific inhibition of the polymerase chain reaction using a non-extendable oligonucleotide blocker
|
|
US6143496A
(en)
|
1997-04-17 |
2000-11-07 |
Cytonix Corporation |
Method of sampling, amplifying and quantifying segment of nucleic acid, polymerase chain reaction assembly having nanoliter-sized sample chambers, and method of filling assembly
|
|
US5739314A
(en)
*
|
1997-04-25 |
1998-04-14 |
Hybridon, Inc. |
Method for synthesizing 2'-O-substituted pyrimidine nucleosides
|
|
DK0920539T3
(da)
|
1997-05-30 |
2006-07-24 |
Xenomics |
Fremgangsmåder til detektion af nukleinsyresekvenser i urin
|
|
WO1999005574A1
(en)
*
|
1997-07-25 |
1999-02-04 |
Affymetrix, Inc. |
Method and system for providing a probe array chip design database
|
|
EP1019536B1
(en)
*
|
1997-08-15 |
2004-10-20 |
Affymetrix, Inc. |
Polymorphism detection utilizing clustering analysis
|
|
DE19754482A1
(de)
*
|
1997-11-27 |
1999-07-01 |
Epigenomics Gmbh |
Verfahren zur Herstellung komplexer DNA-Methylierungs-Fingerabdrücke
|
|
US5998143A
(en)
|
1997-12-05 |
1999-12-07 |
The Perkin-Elmer Corporation |
Cycle sequencing thermal profiles
|
|
CA2319712A1
(en)
|
1998-02-04 |
1999-08-12 |
Variagenics, Inc. |
Mismatch detection techniques
|
|
SG71920A1
(en)
*
|
1998-04-27 |
2000-04-18 |
Texas Instruments Inc |
Method and apparatus for driving a polyphase brushless dc motor
|
|
US6183958B1
(en)
*
|
1998-05-06 |
2001-02-06 |
Variagenics, Inc. |
Probes for variance detection
|
|
US6723564B2
(en)
|
1998-05-07 |
2004-04-20 |
Sequenom, Inc. |
IR MALDI mass spectrometry of nucleic acids using liquid matrices
|
|
US20030022207A1
(en)
*
|
1998-10-16 |
2003-01-30 |
Solexa, Ltd. |
Arrayed polynucleotides and their use in genome analysis
|
|
US6140054A
(en)
|
1998-09-30 |
2000-10-31 |
University Of Utah Research Foundation |
Multiplex genotyping using fluorescent hybridization probes
|
|
US6610492B1
(en)
|
1998-10-01 |
2003-08-26 |
Variagenics, Inc. |
Base-modified nucleotides and cleavage of polynucleotides incorporating them
|
|
NO986133D0
(no)
*
|
1998-12-23 |
1998-12-23 |
Preben Lexow |
FremgangsmÕte for DNA-sekvensering
|
|
US6136541A
(en)
|
1999-02-22 |
2000-10-24 |
Vialogy Corporation |
Method and apparatus for analyzing hybridized biochip patterns using resonance interactions employing quantum expressor functions
|
|
US6142681A
(en)
|
1999-02-22 |
2000-11-07 |
Vialogy Corporation |
Method and apparatus for interpreting hybridized bioelectronic DNA microarray patterns using self-scaling convergent reverberant dynamics
|
|
DK1163250T3
(da)
|
1999-03-24 |
2006-11-13 |
Exiqon As |
Forbedret syntese af [2.2.1]bicyclonukleosider
|
|
US6368834B1
(en)
*
|
1999-04-06 |
2002-04-09 |
Genome Technologies, Llc |
PCR genome walking with synthetic primer
|
|
WO2000066771A2
(en)
|
1999-04-30 |
2000-11-09 |
Methexis N.V. |
Diagnostic sequencing by a combination of specific cleavage and mass spectrometry
|
|
KR20010001577A
(ko)
|
1999-06-07 |
2001-01-05 |
윤종용 |
고분자 광산발생제를 이용한 올리고펩티드 핵산 탐침의 제조방법
|
|
NZ533466A
(en)
*
|
1999-06-28 |
2005-10-28 |
California Inst Of Techn |
Microfabricated elastomeric valve and pump systems
|
|
US6440706B1
(en)
|
1999-08-02 |
2002-08-27 |
Johns Hopkins University |
Digital amplification
|
|
AU6629200A
(en)
|
1999-08-25 |
2001-03-19 |
Philip P Garner |
Alpha-helical peptide nucleic acid alpha-pna
|
|
US20050287592A1
(en)
|
2000-08-29 |
2005-12-29 |
Yeda Research And Development Co. Ltd. |
Template-dependent nucleic acid polymerization using oligonucleotide triphosphates building blocks
|
|
US6274320B1
(en)
|
1999-09-16 |
2001-08-14 |
Curagen Corporation |
Method of sequencing a nucleic acid
|
|
AU7751600A
(en)
|
1999-10-06 |
2001-05-10 |
Amersham Biosciences Corp. |
Method for detecting mutations using arrayed primer extension
|
|
US6297016B1
(en)
|
1999-10-08 |
2001-10-02 |
Applera Corporation |
Template-dependent ligation with PNA-DNA chimeric probes
|
|
WO2001027327A2
(en)
|
1999-10-08 |
2001-04-19 |
Protogene Laboratories, Inc. |
Method and apparatus for performing large numbers of reactions using array assembly
|
|
US6221600B1
(en)
|
1999-10-08 |
2001-04-24 |
Board Of Regents, The University Of Texas System |
Combinatorial oligonucleotide PCR: a method for rapid, global expression analysis
|
|
US20030190644A1
(en)
|
1999-10-13 |
2003-10-09 |
Andreas Braun |
Methods for generating databases and databases for identifying polymorphic genetic markers
|
|
US6709816B1
(en)
|
1999-10-18 |
2004-03-23 |
Affymetrix, Inc. |
Identification of alleles
|
|
AU2001268468A1
(en)
|
2000-06-13 |
2001-12-24 |
The Trustees Of Boston University |
Use of nucleotide analogs in the analysis of oligonucleotide mixtures and in highly multiplexed nucleic acid sequencing
|
|
WO2002018616A1
(en)
|
2000-09-01 |
2002-03-07 |
Hitachi Chemical Co., Ltd. |
Adjusting the efficiency of nucleic acid template amplification by attenuated pcr with template-mimic oligonucleotides
|
|
US6664056B2
(en)
|
2000-10-17 |
2003-12-16 |
The Chinese University Of Hong Kong |
Non-invasive prenatal monitoring
|
|
US6929911B2
(en)
|
2000-11-01 |
2005-08-16 |
The Board Of Trustees Of The Leland Stanford Junior University |
Method for determining genetic affiliation, substructure and gene flow within human populations
|
|
US20060136142A1
(en)
*
|
2000-11-02 |
2006-06-22 |
Kurt Berlin |
Systems, methods and computer program products for guiding selection of a therapeutic treatment regimen based on the methylation status of the DNA
|
|
DE10061348C2
(de)
*
|
2000-12-06 |
2002-10-24 |
Epigenomics Ag |
Verfahren zur Quantifizierung von Cytosin-Methylierungen in komplex amplifizierter genomischer DNA
|
|
EP1229128A1
(en)
*
|
2001-01-31 |
2002-08-07 |
Boehringer Mannheim Gmbh |
New method for genotype determination
|
|
DE10112515B4
(de)
*
|
2001-03-09 |
2004-02-12 |
Epigenomics Ag |
Verfahren zum Nachweis von Cytosin-Methylierungsmustern mit hoher Sensitivität
|
|
US20050064406A1
(en)
*
|
2001-04-20 |
2005-03-24 |
Eugene Zabarovsky |
Methods for high throughput genome analysis using restriction site tagged microarrays
|
|
DE10130800B4
(de)
*
|
2001-06-22 |
2005-06-23 |
Epigenomics Ag |
Verfahren zum Nachweis von Cytosin-Methylierung mit hoher Sensitivität
|
|
US20050037388A1
(en)
*
|
2001-06-22 |
2005-02-17 |
University Of Geneva |
Method for detecting diseases caused by chromosomal imbalances
|
|
US20030054386A1
(en)
|
2001-06-22 |
2003-03-20 |
Stylianos Antonarakis |
Method for detecting diseases caused by chromosomal imbalances
|
|
KR20040036900A
(ko)
*
|
2001-07-15 |
2004-05-03 |
켁크 그래주에이트 인스티튜트 |
닉킹제를 사용한 핵산 단편의 증폭
|
|
DK1421215T3
(da)
*
|
2001-07-25 |
2011-06-27 |
Oncomedx Inc |
Fremgangsmåder til evaluering af patologiske tilstande under anvendelse af ekstracellulært RNA
|
|
JPWO2003016569A1
(ja)
*
|
2001-08-20 |
2004-12-02 |
タカラバイオ株式会社 |
核酸の増幅方法
|
|
US6927028B2
(en)
|
2001-08-31 |
2005-08-09 |
Chinese University Of Hong Kong |
Non-invasive methods for detecting non-host DNA in a host using epigenetic differences between the host and non-host DNA
|
|
DE10201138B4
(de)
*
|
2002-01-08 |
2005-03-10 |
Epigenomics Ag |
Verfahren zum Nachweis von Cytosin-Methylierungsmustern durch exponentielle Ligation hybridisierter Sondenoligonukleotide (MLA)
|
|
JP2005514956A
(ja)
*
|
2002-01-18 |
2005-05-26 |
ジェンザイム・コーポレーション |
胎児ｄｎａの検出および対立遺伝子の定量化のための方法
|
|
US6977162B2
(en)
|
2002-03-01 |
2005-12-20 |
Ravgen, Inc. |
Rapid analysis of variations in a genome
|
|
NZ535044A
(en)
|
2002-03-01 |
2008-12-24 |
Ravgen Inc |
Non-invasive method to determine the genetic sequence of foetal DNA from a sample from a pregnant female thereby detecting any alternation in gene sequence as compared with the wild type sequence
|
|
EP1487999B1
(en)
|
2002-03-15 |
2006-12-27 |
Epigenomics AG |
Discovery and diagnostic methods using 5-methylcytosine dna glycosylase
|
|
US6908755B2
(en)
*
|
2002-03-21 |
2005-06-21 |
Ken-Shwo Dai |
Human megakaryocyte-associated tyrosine kinase (MATK)-related gene variant associated with lung cancers
|
|
US20050164193A1
(en)
|
2002-03-25 |
2005-07-28 |
Epigenomics Ag |
Method for the analysis of methylation patterns within nucleic acids by means of mass spectrometry
|
|
US7081339B2
(en)
|
2002-04-12 |
2006-07-25 |
Primera Biosystems, Inc. |
Methods for variation detection
|
|
US7442506B2
(en)
|
2002-05-08 |
2008-10-28 |
Ravgen, Inc. |
Methods for detection of genetic disorders
|
|
US20030211483A1
(en)
*
|
2002-05-09 |
2003-11-13 |
Schroeder Benjamin G. |
Methods for the enrichment of low-abundance polynucleotides
|
|
WO2004013284A2
(en)
|
2002-08-02 |
2004-02-12 |
Tufts University |
A method to assess genomic dna methylation using high-performance liquid chromatography-electospray ionization mass spectrometry
|
|
CN1703521B
(zh)
*
|
2002-09-06 |
2011-11-16 |
波士顿大学信托人 |
基因表达的定量
|
|
CA2507189C
(en)
*
|
2002-11-27 |
2018-06-12 |
Sequenom, Inc. |
Fragmentation-based methods and systems for sequence variation detection and discovery
|
|
WO2004065629A1
(en)
|
2003-01-17 |
2004-08-05 |
The Chinese University Of Hong Kong |
Circulating mrna as diagnostic markers for pregnancy-related disorders
|
|
CA2513889A1
(en)
|
2003-01-29 |
2004-08-19 |
454 Corporation |
Double ended sequencing
|
|
AU2003268333A1
(en)
|
2003-02-28 |
2004-09-28 |
Ravgen, Inc. |
Methods for detection of genetic disorders
|
|
AU2003900944A0
(en)
|
2003-02-28 |
2003-03-13 |
The University Of Queensland |
Cell isolation & enrichment
|
|
WO2004078999A1
(en)
|
2003-03-05 |
2004-09-16 |
Genetic Technologies Limited |
Identification of fetal dna and fetal cell markers in maternal plasma or serum
|
|
US20050009059A1
(en)
|
2003-05-07 |
2005-01-13 |
Affymetrix, Inc. |
Analysis of methylation status using oligonucleotide arrays
|
|
CA2531105C
(en)
*
|
2003-07-05 |
2015-03-17 |
The Johns Hopkins University |
Method and compositions for detection and enumeration of genetic variations
|
|
EP2107129B1
(en)
*
|
2003-07-31 |
2012-08-22 |
Sequenom, Inc. |
Methods for high level multiplexed polymerase chain reactions and homogeneous mass extension reactions for genotyping of polymorhisms
|
|
AU2003263660A1
(en)
|
2003-08-29 |
2005-03-16 |
Pantarhei Bioscience B.V. |
Prenatal diagnosis of down syndrome by detection of fetal rna markers in maternal blood
|
|
EP1664077B1
(en)
|
2003-09-05 |
2016-04-13 |
Trustees of Boston University |
Method for non-invasive prenatal diagnosis
|
|
AU2004274724B2
(en)
*
|
2003-09-22 |
2009-09-10 |
Trisogen Biotechnology Limited Partnership |
Methods and kits useful for detecting an alteration in a locus copy number
|
|
EP1689884A4
(en)
|
2003-10-08 |
2007-04-04 |
Univ Boston |
PROCESS FOR THE PRENATAL DIAGNOSIS OF CHROMOSOMAL ABNORMALITIES
|
|
DE60328193D1
(de)
|
2003-10-16 |
2009-08-13 |
Sequenom Inc |
Nicht invasiver Nachweis fötaler genetischer Merkmale
|
|
ATE553218T1
(de)
|
2003-10-21 |
2012-04-15 |
Orion Genomics Llc |
Differentielle enzymatische fragmetierung
|
|
US20070111233A1
(en)
*
|
2003-10-30 |
2007-05-17 |
Bianchi Diana W |
Prenatal diagnosis using cell-free fetal DNA in amniotic fluid
|
|
WO2005044086A2
(en)
|
2003-10-30 |
2005-05-19 |
Tufts-New England Medical Center |
Prenatal diagnosis using cell-free fetal dna in amniotic fluid
|
|
WO2006019407A2
(en)
*
|
2004-02-18 |
2006-02-23 |
The Trustees Of Boston University |
Method for detecting and quantifying rare mutations/polymorphisms
|
|
US20100216153A1
(en)
|
2004-02-27 |
2010-08-26 |
Helicos Biosciences Corporation |
Methods for detecting fetal nucleic acids and diagnosing fetal abnormalities
|
|
JP4492156B2
(ja)
|
2004-03-03 |
2010-06-30 |
ニプロ株式会社 |
血清アルブミンドメインを含む蛋白質
|
|
US7608394B2
(en)
|
2004-03-26 |
2009-10-27 |
Sequenom, Inc. |
Methods and compositions for phenotype identification based on nucleic acid methylation
|
|
US9249456B2
(en)
|
2004-03-26 |
2016-02-02 |
Agena Bioscience, Inc. |
Base specific cleavage of methylation-specific amplification products in combination with mass analysis
|
|
US7468249B2
(en)
|
2004-05-05 |
2008-12-23 |
Biocept, Inc. |
Detection of chromosomal disorders
|
|
DE602005017781D1
(de)
|
2004-06-01 |
2009-12-31 |
Univ North Carolina |
Rekonstituierter histon-methyltransferase-komplex und verfahren zur identifizierung von modulatoren dafür
|
|
US7709194B2
(en)
*
|
2004-06-04 |
2010-05-04 |
The Chinese University Of Hong Kong |
Marker for prenatal diagnosis and monitoring
|
|
US20060166228A1
(en)
|
2004-07-30 |
2006-07-27 |
Page David C |
Markers of alterations in the Y chromosome and uses therefor
|
|
EP1799861A2
(en)
*
|
2004-09-20 |
2007-06-27 |
Proteogenix, Inc. |
Diagnosis of fetal aneuploidy
|
|
US7415644B2
(en)
|
2004-10-22 |
2008-08-19 |
International Business Machines Corporation |
Self-repairing of microprocessor array structures
|
|
CN102220412B
(zh)
|
2004-11-29 |
2016-04-13 |
塞昆纳姆股份有限公司 |
用于检测甲基化dna的试剂盒和方法
|
|
WO2006056480A2
(en)
|
2004-11-29 |
2006-06-01 |
Klinikum Der Universität Regensburg |
Means and methods for detecting methylated dna
|
|
US7645576B2
(en)
|
2005-03-18 |
2010-01-12 |
The Chinese University Of Hong Kong |
Method for the detection of chromosomal aneuploidies
|
|
CA2894337C
(en)
|
2005-03-18 |
2018-08-28 |
The Chinese University Of Hong Kong |
Markers for prenatal diagnosis of trisomy 18
|
|
US20070048755A1
(en)
*
|
2005-03-22 |
2007-03-01 |
New York University |
Assay for determining the sex of primates
|
|
EP1910574A2
(en)
|
2005-08-02 |
2008-04-16 |
Sequenom, Inc. |
Methods and compositions for disease prognosis based on nucleic acid methylation
|
|
US20070122823A1
(en)
|
2005-09-01 |
2007-05-31 |
Bianchi Diana W |
Amniotic fluid cell-free fetal DNA fragment size pattern for prenatal diagnosis
|
|
HUE030215T2
(en)
|
2006-02-02 |
2017-04-28 |
Univ Leland Stanford Junior |
Non-invasive fetal genetic screening by digital analysis
|
|
US7799531B2
(en)
|
2006-02-28 |
2010-09-21 |
University Of Louisville Research Foundation |
Detecting fetal chromosomal abnormalities using tandem single nucleotide polymorphisms
|
|
CN101421410A
(zh)
*
|
2006-03-06 |
2009-04-29 |
纽约市哥伦比亚大学托管会 |
从混合的胎儿-母体来源中特异性扩增胎儿dna序列
|
|
US20070243549A1
(en)
|
2006-04-12 |
2007-10-18 |
Biocept, Inc. |
Enrichment of circulating fetal dna
|
|
US7754428B2
(en)
*
|
2006-05-03 |
2010-07-13 |
The Chinese University Of Hong Kong |
Fetal methylation markers
|
|
US7901884B2
(en)
|
2006-05-03 |
2011-03-08 |
The Chinese University Of Hong Kong |
Markers for prenatal diagnosis and monitoring
|
|
EP3260556B1
(en)
|
2006-05-31 |
2019-07-31 |
Sequenom, Inc. |
Methods for the extraction of nucleic acid from a sample
|
|
EP2029779A4
(en)
*
|
2006-06-14 |
2010-01-20 |
Living Microsystems Inc |
HIGHLY PARALLEL SNP GENOTYPING UTILIZATION FOR FETAL DIAGNOSIS
|
|
AU2007260750A1
(en)
|
2006-06-16 |
2007-12-21 |
Sequenom, Inc. |
Methods and compositions for the amplification, detection and quantification of nucleic acid from a sample
|
|
US7902345B2
(en)
*
|
2006-12-05 |
2011-03-08 |
Sequenom, Inc. |
Detection and quantification of biomolecules using mass spectrometry
|
|
US8133701B2
(en)
|
2006-12-05 |
2012-03-13 |
Sequenom, Inc. |
Detection and quantification of biomolecules using mass spectrometry
|
|
US8262900B2
(en)
*
|
2006-12-14 |
2012-09-11 |
Life Technologies Corporation |
Methods and apparatus for measuring analytes using large scale FET arrays
|
|
CA2677517C
(en)
|
2007-02-08 |
2015-11-03 |
Sequenom, Inc. |
Nucleic acid-based tests for rhd typing, gender determination and nucleic acid quantification
|
|
WO2008103761A2
(en)
|
2007-02-20 |
2008-08-28 |
Sequenom, Inc. |
Methods and compositions for cancer diagnosis and treatment based on nucleic acid methylation
|
|
GB0703996D0
(en)
|
2007-03-01 |
2007-04-11 |
Oxitec Ltd |
Nucleic acid detection
|
|
AU2008230813B2
(en)
|
2007-03-26 |
2014-01-30 |
Sequenom, Inc. |
Restriction endonuclease enhanced polymorphic sequence detection
|
|
WO2008157264A2
(en)
|
2007-06-15 |
2008-12-24 |
Sequenom, Inc. |
Combined methods for the detection of chromosomal aneuploidy
|
|
HUE061020T2
(hu)
|
2007-07-23 |
2023-05-28 |
Univ Hong Kong Chinese |
Nukleinsav-szekvencia kiegyensúlyozatlanságának meghatározására
|
|
WO2009032779A2
(en)
|
2007-08-29 |
2009-03-12 |
Sequenom, Inc. |
Methods and compositions for the size-specific seperation of nucleic acid from a sample
|
|
US9404150B2
(en)
|
2007-08-29 |
2016-08-02 |
Sequenom, Inc. |
Methods and compositions for universal size-specific PCR
|
|
US8748100B2
(en)
*
|
2007-08-30 |
2014-06-10 |
The Chinese University Of Hong Kong |
Methods and kits for selectively amplifying, detecting or quantifying target DNA with specific end sequences
|
|
KR20100061539A
(ko)
*
|
2007-09-21 |
2010-06-07 |
바이오셉트 인코포레이티드 |
태아 세포 및 핵산의 동정 및 단리
|
|
US20100331195A1
(en)
|
2007-10-04 |
2010-12-30 |
William Andregg |
Sequencing Nucleic Acid Polymers with Electron Microscopy
|
|
JP5535921B2
(ja)
*
|
2007-10-04 |
2014-07-02 |
コモンウェルス サイエンティフィック アンドインダストリアル リサーチ オーガナイゼーション |
核酸増幅
|
|
US8093063B2
(en)
*
|
2007-11-29 |
2012-01-10 |
Quest Diagnostics Investments Incorporated |
Assay for detecting genetic abnormalities in genomic nucleic acids
|
|
WO2009091934A1
(en)
|
2008-01-17 |
2009-07-23 |
Sequenom, Inc. |
Single molecule nucleic acid sequence analysis processes and compositions
|
|
WO2009114543A2
(en)
|
2008-03-11 |
2009-09-17 |
Sequenom, Inc. |
Nucleic acid-based tests for prenatal gender determination
|
|
US8206926B2
(en)
|
2008-03-26 |
2012-06-26 |
Sequenom, Inc. |
Restriction endonuclease enhanced polymorphic sequence detection
|
|
EP2307540B1
(en)
|
2008-07-07 |
2017-04-19 |
Oxford Nanopore Technologies Limited |
Enzyme-pore constructs
|
|
US20110178719A1
(en)
|
2008-08-04 |
2011-07-21 |
Gene Security Network, Inc. |
Methods for Allele Calling and Ploidy Calling
|
|
US8962247B2
(en)
|
2008-09-16 |
2015-02-24 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
|
|
US8476013B2
(en)
|
2008-09-16 |
2013-07-02 |
Sequenom, Inc. |
Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
|
CA2737200C
(en)
|
2008-09-16 |
2020-03-31 |
Sequenom Center For Molecular Medicine |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
|
ES2620012T3
(es)
|
2008-09-20 |
2017-06-27 |
The Board Of Trustees Of The Leland Stanford Junior University |
Diagnóstico no invasivo de la aneuploidia fetal por secuenciación
|
|
US20100240054A1
(en)
|
2008-09-22 |
2010-09-23 |
Biocept, Inc. |
Identification and isolation of fetal cells and nucleic acid
|
|
CA2743211A1
(en)
*
|
2008-11-12 |
2010-05-20 |
Caris Life Sciences Luxembourg Holdings, S.A.R.L. |
Methods and systems of using exosomes for determining phenotypes
|
|
WO2010065470A2
(en)
|
2008-12-01 |
2010-06-10 |
Consumer Genetics, Inc. |
Compositions and methods for detecting background male dna during fetal sex determination
|
|
US20100279295A1
(en)
|
2009-03-18 |
2010-11-04 |
Sequenom, Inc. |
Use of thermostable endonucleases for generating reporter molecules
|
|
EP2414545B1
(en)
|
2009-04-03 |
2017-01-11 |
Sequenom, Inc. |
Nucleic acid preparation compositions and methods
|
|
US8211735B2
(en)
*
|
2009-06-08 |
2012-07-03 |
International Business Machines Corporation |
Nano/microwire solar cell fabricated by nano/microsphere lithography
|
|
US8563242B2
(en)
|
2009-08-11 |
2013-10-22 |
The Chinese University Of Hong Kong |
Method for detecting chromosomal aneuploidy
|
|
AU2015252141A1
(en)
|
2009-09-16 |
2015-12-03 |
Sequenom Center For Molecular Medicine |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses
|
|
SMT202300034T1
(it)
|
2009-11-05 |
2023-03-17 |
Sequenom Inc |
Analisi genomica fetale da un campione biologico materno
|
|
EA034241B1
(ru)
|
2009-11-06 |
2020-01-21 |
Те Чайниз Юниверсити Ов Гонконг |
Способ пренатальной диагностики дисбаланса последовательности
|
|
DK2516680T3
(en)
|
2009-12-22 |
2016-05-02 |
Sequenom Inc |
Method and kits to identify aneuploidy
|
|
AU2011207561B2
(en)
|
2010-01-19 |
2014-02-20 |
Verinata Health, Inc. |
Partition defined detection methods
|
|
AU2010343277B2
(en)
|
2010-01-19 |
2015-05-28 |
Verinata Health, Inc. |
Method for determining copy number variations
|
|
DK2529032T3
(en)
|
2010-01-26 |
2017-05-01 |
Nipd Genetics Ltd |
METHODS AND COMPOSITIONS FOR NON-INVASIVE PRE-NATIONAL DIAGNOSTICATION OF Fetal ANEUPLOIDITIES
|
|
US8940487B2
(en)
|
2010-02-09 |
2015-01-27 |
UmiTaq Bio |
Methods and compositions for universal detection of nucleic acids
|
|
US20140186827A1
(en)
|
2010-05-14 |
2014-07-03 |
Fluidigm, Inc. |
Assays for the detection of genotype, mutations, and/or aneuploidy
|
|
SG185544A1
(en)
|
2010-05-14 |
2012-12-28 |
Fluidigm Corp |
Nucleic acid isolation methods
|
|
US8825412B2
(en)
|
2010-05-18 |
2014-09-02 |
Natera, Inc. |
Methods for non-invasive prenatal ploidy calling
|
|
US8603742B2
(en)
|
2010-07-06 |
2013-12-10 |
University of Pittsburgh—of the Commonwealth System of Higher Education |
Methods for the diagnosis of fetal disease
|
|
CN103069006A
(zh)
|
2010-07-23 |
2013-04-24 |
艾索特里克斯遗传实验室有限责任公司 |
区别表达的胚胎或母源基因组区的鉴定及其用途
|
|
US20120184449A1
(en)
|
2010-12-23 |
2012-07-19 |
Sequenom, Inc. |
Fetal genetic variation detection
|
|
US20120219950A1
(en)
|
2011-02-28 |
2012-08-30 |
Arnold Oliphant |
Assay systems for detection of aneuploidy and sex determination
|
|
EP2702168B1
(en)
|
2011-04-29 |
2018-01-17 |
Sequenom, Inc. |
Quantification of a minority nucleic acid species
|
|
WO2013019361A1
(en)
|
2011-07-07 |
2013-02-07 |
Life Technologies Corporation |
Sequencing methods
|
|
US9367663B2
(en)
|
2011-10-06 |
2016-06-14 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
EP3922731A3
(en)
|
2011-10-06 |
2022-01-05 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
CA2851537C
(en)
|
2011-10-11 |
2020-12-29 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
US9605313B2
(en)
|
2012-03-02 |
2017-03-28 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
US20150284783A1
(en)
|
2012-05-21 |
2015-10-08 |
Agena Bioscience, Inc. |
Methods and compositions for analyzing nucleic acid
|
|
ES2902401T3
(es)
|
2012-05-21 |
2022-03-28 |
Sequenom Inc |
Métodos y procesos para la evaluación no invasiva de variaciones genéticas
|
|
US9920361B2
(en)
|
2012-05-21 |
2018-03-20 |
Sequenom, Inc. |
Methods and compositions for analyzing nucleic acid
|
|
EP2872648B1
(en)
|
2012-07-13 |
2019-09-04 |
Sequenom, Inc. |
Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
|
|
WO2014168711A1
(en)
|
2013-03-13 |
2014-10-16 |
Sequenom, Inc. |
Primers for dna methylation analysis
|
|
US11365447B2
(en)
|
2014-03-13 |
2022-06-21 |
Sequenom, Inc. |
Methods and processes for non-invasive assessment of genetic variations
|
|
CN106544407B
(zh)
|
2015-09-18 |
2019-11-08 |
广州华大基因医学检验所有限公司 |
确定受体cfDNA样本中供体来源cfDNA比例的方法
|
|
JP6447765B1
(ja)
|
2017-11-21 |
2019-01-09 |
株式会社リコー |
検査デバイス及びデバイス
|