CN102648292A - 基于甲基化从母体样品中富集胎儿核酸的可用于无创性产前诊断的方法和组合物 - Google Patents

基于甲基化从母体样品中富集胎儿核酸的可用于无创性产前诊断的方法和组合物 Download PDF

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CN102648292A
CN102648292A CN2010800527486A CN201080052748A CN102648292A CN 102648292 A CN102648292 A CN 102648292A CN 2010800527486 A CN2010800527486 A CN 2010800527486A CN 201080052748 A CN201080052748 A CN 201080052748A CN 102648292 A CN102648292 A CN 102648292A
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nucleic acid
fetal
dna
maternal
methylation
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M·埃里希
A·O·H·尼格伦
T·J·詹森
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Sequenom Inc
Sequenom Center for Molecular Medicine LLC
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Sequenom Inc
Sequenom Center for Molecular Medicine LLC
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CN2010800527486A 2009-09-16 2010-03-18 基于甲基化从母体样品中富集胎儿核酸的可用于无创性产前诊断的方法和组合物 Pending CN102648292A (zh)

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US12/561,241 US8476013B2 (en) 2008-09-16 2009-09-16 Processes and compositions for methylation-based acid enrichment of fetal nucleic acid from a maternal sample useful for non-invasive prenatal diagnoses
US12/561,241 2009-09-16
PCT/US2010/027879 WO2011034631A1 (en) 2009-09-16 2010-03-18 Processes and compositions for methylation-based enrichment of fetal nucleic acid from a maternal sample useful for non invasive prenatal diagnoses

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US (7) US8476013B2 (enExample)
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JP (7) JP5873434B2 (enExample)
CN (1) CN102648292A (enExample)
AU (1) AU2010295968B2 (enExample)
CA (3) CA3024967C (enExample)
ES (1) ES2650666T3 (enExample)
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CN107002122A (zh) * 2014-07-25 2017-08-01 华盛顿大学 确定导致无细胞dna的产生的组织和/或细胞类型的方法以及使用其鉴定疾病或紊乱的方法
CN107223159A (zh) * 2014-05-09 2017-09-29 科戴克斯生命股份公司 源自特定细胞类型的dna的检测及相关方法
CN107451419A (zh) * 2017-07-14 2017-12-08 浙江大学 一种通过计算机程序模拟产生简化dna甲基化测序数据的方法
WO2018072705A1 (en) * 2016-10-19 2018-04-26 The Chinese University Of Hong Kong Gestational age assessment by methylation and size profiling of maternal plasma dna
CN109689896A (zh) * 2015-11-10 2019-04-26 科戴克斯生命股份公司 使用在胎儿和怀孕雌性动物之间差异甲基化的dna区域检测胎儿染色体非整倍性
CN110325650A (zh) * 2016-12-22 2019-10-11 夸登特健康公司 用于分析核酸分子的方法和系统
CN111065746A (zh) * 2018-03-19 2020-04-24 伊鲁米纳公司 用于用重组核酸酶选择性切割核酸的方法和组合物
CN111593119A (zh) * 2020-06-28 2020-08-28 成都市妇女儿童中心医院 用于检测母体血液中胎儿游离DNA β-地中海贫血突变的探针及试剂盒
CN113061653A (zh) * 2021-05-07 2021-07-02 济南国科医工科技发展有限公司 用于产前无创检测21三体综合征的pcr扩增组合物及检测试剂盒
US11773443B2 (en) 2014-05-09 2023-10-03 Eurofins Lifecodexx Gmbh Multiplex detection of DNA that originates from a specific cell-type

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