JP2017534300A5 - - Google Patents
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- JP2017534300A5 JP2017534300A5 JP2017542357A JP2017542357A JP2017534300A5 JP 2017534300 A5 JP2017534300 A5 JP 2017534300A5 JP 2017542357 A JP2017542357 A JP 2017542357A JP 2017542357 A JP2017542357 A JP 2017542357A JP 2017534300 A5 JP2017534300 A5 JP 2017534300A5
- Authority
- JP
- Japan
- Prior art keywords
- configuration
- binding agent
- sample
- histone
- nucleosomes
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000011230 binding agent Substances 0.000 description 24
- 108010047956 Nucleosomes Proteins 0.000 description 17
- 238000000034 method Methods 0.000 description 17
- 210000001623 nucleosome Anatomy 0.000 description 17
- 239000000523 sample Substances 0.000 description 11
- 102100034535 Histone H3.1 Human genes 0.000 description 9
- 102100033636 Histone H3.2 Human genes 0.000 description 9
- 101710195400 Histone H3.3 Proteins 0.000 description 9
- 206010028980 Neoplasm Diseases 0.000 description 9
- 102100034536 Histone H3.1t Human genes 0.000 description 8
- 101710195388 Histone H3.1 Proteins 0.000 description 7
- 101710195387 Histone H3.2 Proteins 0.000 description 7
- 239000012472 biological sample Substances 0.000 description 7
- 108010033040 Histones Proteins 0.000 description 6
- 101001067844 Homo sapiens Histone H3.1 Proteins 0.000 description 3
- 238000003018 immunoassay Methods 0.000 description 3
- 230000004048 modification Effects 0.000 description 3
- 238000012986 modification Methods 0.000 description 3
- 238000001712 DNA sequencing Methods 0.000 description 2
- 102000001708 Protein Isoforms Human genes 0.000 description 2
- 108010029485 Protein Isoforms Proteins 0.000 description 2
- 238000004458 analytical method Methods 0.000 description 2
- 230000001973 epigenetic effect Effects 0.000 description 2
- 238000004949 mass spectrometry Methods 0.000 description 2
- 125000003729 nucleotide group Chemical group 0.000 description 2
- LRSASMSXMSNRBT-UHFFFAOYSA-N 5-methylcytosine Chemical compound CC1=CNC(=O)N=C1N LRSASMSXMSNRBT-UHFFFAOYSA-N 0.000 description 1
- 238000001261 affinity purification Methods 0.000 description 1
- 230000003321 amplification Effects 0.000 description 1
- 239000008280 blood Substances 0.000 description 1
- 210000004369 blood Anatomy 0.000 description 1
- 201000011510 cancer Diseases 0.000 description 1
- 238000004925 denaturation Methods 0.000 description 1
- 230000036425 denaturation Effects 0.000 description 1
- 238000007847 digital PCR Methods 0.000 description 1
- 238000003199 nucleic acid amplification method Methods 0.000 description 1
- 210000002381 plasma Anatomy 0.000 description 1
- 230000008707 rearrangement Effects 0.000 description 1
- 210000002966 serum Anatomy 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| GBGB1419225.6A GB201419225D0 (en) | 2014-10-29 | 2014-10-29 | Method for the enrichment of circulating tumor DNA |
| GB1419225.6 | 2014-10-29 | ||
| GB201419299A GB201419299D0 (en) | 2014-10-30 | 2014-10-30 | Method for the enrichment of circulating tumour DNA |
| GB1419299.1 | 2014-10-30 | ||
| PCT/GB2015/053238 WO2016067029A1 (en) | 2014-10-29 | 2015-10-29 | Method for the enrichment of circulating tumor dna |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2017534300A JP2017534300A (ja) | 2017-11-24 |
| JP2017534300A5 true JP2017534300A5 (enExample) | 2018-11-15 |
| JP6721599B2 JP6721599B2 (ja) | 2020-07-15 |
Family
ID=54427791
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017542357A Active JP6721599B2 (ja) | 2014-10-29 | 2015-10-29 | 循環する腫瘍ｄｎａの濃縮方法 |
Country Status (12)
| Country | Link |
|---|---|
| US (2) | US20180024141A1 (enExample) |
| EP (2) | EP3809140A1 (enExample) |
| JP (1) | JP6721599B2 (enExample) |
| CN (2) | CN107209190B (enExample) |
| AU (1) | AU2015340378B2 (enExample) |
| CA (1) | CA2965752C (enExample) |
| DK (1) | DK3213084T4 (enExample) |
| ES (1) | ES2839973T3 (enExample) |
| IL (1) | IL251896A0 (enExample) |
| PL (1) | PL3213084T3 (enExample) |
| SG (2) | SG10201903822XA (enExample) |
| WO (1) | WO2016067029A1 (enExample) |
Families Citing this family (31)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP2820129A1 (en) | 2012-03-02 | 2015-01-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| EP2971100A1 (en) | 2013-03-13 | 2016-01-20 | Sequenom, Inc. | Primers for dna methylation analysis |
| EP3736344A1 (en) | 2014-03-13 | 2020-11-11 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| CN106544341A (zh) * | 2017-01-17 | 2017-03-29 | 上海亿康医学检验所有限公司 | 高效检测样本中的ctDNA的方法 |
| ES2913665T3 (es) * | 2017-09-18 | 2022-06-03 | Santersus Ag | Método y dispositivo para la purificación de sangre a partir de ADN celular libre en circulación |
| CN109932224A (zh) * | 2017-12-18 | 2019-06-25 | 中国科学院大连化学物理研究所 | 一种富集提取循环肿瘤dna的方法 |
| CN112119166B (zh) * | 2018-03-13 | 2025-08-22 | 耶路撒冷希伯来大学伊萨姆研发有限公司 | 无细胞dna染色质免疫沉淀的诊断应用 |
| EP3794348A4 (en) * | 2018-05-18 | 2022-03-09 | The Johns Hopkins University | Cell-free dna for assessing and/or treating cancer |
| GB201818963D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Methof for the detection of prostate cancer |
| GB201818965D0 (en) | 2018-11-21 | 2019-01-09 | Belgian Volition Sprl | Method for the detection of colorectal cancer |
| CN109841265B (zh) * | 2019-02-22 | 2021-09-21 | 清华大学 | 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用 |
| GB201906201D0 (en) | 2019-05-02 | 2019-06-19 | Belgian Voltion Sprl | Method for the detection of protate cancer |
| GB201906199D0 (en) * | 2019-05-02 | 2019-06-19 | Belgian Volition Sprl | Method for the detection of cancer |
| AU2020336928A1 (en) * | 2019-08-27 | 2022-03-24 | Belgian Volition Srl | Method of isolating circulating nucleosomes |
| WO2021064463A1 (en) * | 2019-10-04 | 2021-04-08 | Santersus Ag | Method for isolating and analyzing cell free dna |
| JP7349104B2 (ja) * | 2019-11-13 | 2023-09-22 | 株式会社島津製作所 | ベロ毒素の検出方法 |
| PL4070111T3 (pl) * | 2019-12-02 | 2025-02-03 | Belgian Volition Srl | Zastosowanie wolnych pozakomórkowych nukleosomsów jako biomarkerów |
| CN116018646A (zh) * | 2020-05-22 | 2023-04-25 | 阿克图尔公司 | 用于表征无细胞核酸片段的方法 |
| GB202117799D0 (en) | 2021-12-09 | 2022-01-26 | Belgian Volition Srl | Method for the detection of blood cancer |
| WO2023122623A1 (en) * | 2021-12-21 | 2023-06-29 | Guardant Health, Inc. | Methods and systems for combinatorial chromatin-ip sequencing |
| US12053567B2 (en) | 2021-12-27 | 2024-08-06 | Santersus Ag | Method and device for removal of circulating cell free DNA |
| US20250197944A1 (en) | 2022-03-11 | 2025-06-19 | Belgian Volition Srl | Differential diagnosis method |
| US20260072040A1 (en) * | 2022-08-25 | 2026-03-12 | Belgian Volition Srl | Method for measuring cell free chromatin |
| EP4646208A1 (en) | 2023-01-06 | 2025-11-12 | Ideaya Biosciences, Inc. | Treatment of er+ breast cancer comprising homologous recombination deficiency using parg inhibitor |
| WO2024223947A1 (en) | 2023-04-28 | 2024-10-31 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers of carcinomas |
| GB202307768D0 (en) | 2023-05-24 | 2023-07-05 | Belgian Volition Srl | Use of cell free nucleosomes as biomarkers |
| GB202310137D0 (en) | 2023-07-03 | 2023-08-16 | Belgian Volition Srl | Method for the detection of cancer |
| WO2025012440A1 (en) | 2023-07-13 | 2025-01-16 | Belgian Volition Srl | Method for detection of the potential of a body fluid sample to produce extracellular traps |
| WO2025061853A1 (en) | 2023-09-19 | 2025-03-27 | Belgian Volition Srl | Lateral flow test device |
| TW202530419A (zh) | 2023-10-04 | 2025-08-01 | 比利時商比利時意志有限公司 | Pcr方法 |
| WO2025093747A1 (en) | 2023-11-02 | 2025-05-08 | Belgian Volition Srl | Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules |
Family Cites Families (13)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB0319376D0 (en) * | 2003-08-18 | 2003-09-17 | Chroma Therapeutics Ltd | Histone modification detection |
| US20060115482A1 (en) * | 2004-04-27 | 2006-06-01 | The Regents Of The University Of California | Modifications of histone proteins as indicators of cell proliferation and differentiation |
| WO2007121276A2 (en) * | 2006-04-12 | 2007-10-25 | Biocept, Inc. | Enrichment of circulating fetal dna |
| EP2062912A1 (en) * | 2007-11-26 | 2009-05-27 | Koninklijke Philips Electronics N.V. | Selective enrichment of post-translationally modified proteins and/or peptides |
| US20100240054A1 (en) * | 2008-09-22 | 2010-09-23 | Biocept, Inc. | Identification and isolation of fetal cells and nucleic acid |
| WO2010120942A2 (en) * | 2009-04-14 | 2010-10-21 | The Regents Of The University Of California | Histone modification patterns for clinical diagnosis and prognosis of cancer |
| WO2013010181A2 (en) * | 2011-07-14 | 2013-01-17 | University Of Massachusetts | Methods of diagnosing cancer using epigenetic biomarkers |
| GB201115095D0 (en) | 2011-09-01 | 2011-10-19 | Singapore Volition Pte Ltd | Method for detecting nucleosomes containing nucleotides |
| GB201115098D0 (en) * | 2011-09-01 | 2011-10-19 | Belgian Volition Sa | Method for detecting nucleosomes containing histone variants |
| WO2013075237A1 (en) * | 2011-11-21 | 2013-05-30 | The Royal Institution For The Advancement Of Learning / Mcgill University | Mutations of histone proteins associated with proliferative disorders |
| AU2012349855B2 (en) * | 2011-12-07 | 2017-12-07 | Belgian Volition Sprl | Method for detecting nucleosome adducts |
| EP2820129A1 (en) * | 2012-03-02 | 2015-01-07 | Sequenom, Inc. | Methods and processes for non-invasive assessment of genetic variations |
| US9388213B2 (en) * | 2012-09-10 | 2016-07-12 | The Rockefeller University | Polycomb repressive complex 2 (PRC2) inhibitors and uses thereof |
-
2015
- 2015-10-29 WO PCT/GB2015/053238 patent/WO2016067029A1/en not_active Ceased
- 2015-10-29 CN CN201580058989.4A patent/CN107209190B/zh active Active
- 2015-10-29 US US15/523,280 patent/US20180024141A1/en not_active Abandoned
- 2015-10-29 PL PL15790214T patent/PL3213084T3/pl unknown
- 2015-10-29 EP EP20203154.8A patent/EP3809140A1/en not_active Withdrawn
- 2015-10-29 SG SG10201903822XA patent/SG10201903822XA/en unknown
- 2015-10-29 DK DK15790214.9T patent/DK3213084T4/da active
- 2015-10-29 JP JP2017542357A patent/JP6721599B2/ja active Active
- 2015-10-29 CN CN202010018617.1A patent/CN111505305B/zh active Active
- 2015-10-29 CA CA2965752A patent/CA2965752C/en active Active
- 2015-10-29 AU AU2015340378A patent/AU2015340378B2/en active Active
- 2015-10-29 EP EP15790214.9A patent/EP3213084B2/en active Active
- 2015-10-29 SG SG11201702978VA patent/SG11201702978VA/en unknown
- 2015-10-29 ES ES15790214T patent/ES2839973T3/es active Active
-
2017
- 2017-04-25 IL IL251896A patent/IL251896A0/en active IP Right Grant
-
2022
- 2022-06-07 US US17/834,701 patent/US20220334128A1/en active Pending
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