SG10201903822XA - Method for the enrichment of circulating tumor dna - Google Patents

Method for the enrichment of circulating tumor dna

Info

Publication number
SG10201903822XA
SG10201903822XA SG10201903822XA SG10201903822XA SG10201903822XA SG 10201903822X A SG10201903822X A SG 10201903822XA SG 10201903822X A SG10201903822X A SG 10201903822XA SG 10201903822X A SG10201903822X A SG 10201903822XA SG 10201903822X A SG10201903822X A SG 10201903822XA
Authority
SG
Singapore
Prior art keywords
circulating tumor
enrichment
tumor dna
relates
binding agents
Prior art date
Application number
SG10201903822XA
Inventor
Jacob Vincent Micallef
Marielle Herzog
Mark Edward Eccleston
Original Assignee
Belgian Volition Sprl
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Family has litigation
First worldwide family litigation filed litigation Critical https://patents.darts-ip.com/?family=54427791&utm_source=google_patent&utm_medium=platform_link&utm_campaign=public_patent_search&patent=SG10201903822X(A) "Global patent litigation dataset” by Darts-ip is licensed under a Creative Commons Attribution 4.0 International License.
Priority claimed from GBGB1419225.6A external-priority patent/GB201419225D0/en
Priority claimed from GB201419299A external-priority patent/GB201419299D0/en
Application filed by Belgian Volition Sprl filed Critical Belgian Volition Sprl
Publication of SG10201903822XA publication Critical patent/SG10201903822XA/en

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

Abstract

METHOD FOR THE ENRICHMENT OF CIRCULATING TUMOR DNA The invention relates to the use of histone binding agents for detecting, isolating and/or purifying cell free nucleosomes of tumor originor circulating tumor DNA from a biological sample. The invention also relates to methods and kits using said histone binding agents. [Figure 5]
SG10201903822XA 2014-10-29 2015-10-29 Method for the enrichment of circulating tumor dna SG10201903822XA (en)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GBGB1419225.6A GB201419225D0 (en) 2014-10-29 2014-10-29 Method for the enrichment of circulating tumor DNA
GB201419299A GB201419299D0 (en) 2014-10-30 2014-10-30 Method for the enrichment of circulating tumour DNA

Publications (1)

Publication Number Publication Date
SG10201903822XA true SG10201903822XA (en) 2019-05-30

Family

ID=54427791

Family Applications (2)

Application Number Title Priority Date Filing Date
SG10201903822XA SG10201903822XA (en) 2014-10-29 2015-10-29 Method for the enrichment of circulating tumor dna
SG11201702978VA SG11201702978VA (en) 2014-10-29 2015-10-29 Method for the enrichment of circulating tumor dna

Family Applications After (1)

Application Number Title Priority Date Filing Date
SG11201702978VA SG11201702978VA (en) 2014-10-29 2015-10-29 Method for the enrichment of circulating tumor dna

Country Status (14)

Country Link
US (2) US20180024141A1 (en)
EP (2) EP3213084B2 (en)
JP (1) JP6721599B2 (en)
CN (2) CN111505305B (en)
AU (1) AU2015340378B2 (en)
CA (1) CA2965752C (en)
DK (1) DK3213084T4 (en)
ES (1) ES2839973T3 (en)
HK (1) HK1243764A1 (en)
IL (1) IL251896A0 (en)
NZ (1) NZ731116A (en)
PL (1) PL3213084T3 (en)
SG (2) SG10201903822XA (en)
WO (1) WO2016067029A1 (en)

Families Citing this family (19)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP3597774A1 (en) 2013-03-13 2020-01-22 Sequenom, Inc. Primers for dna methylation analysis
EP3117011B1 (en) 2014-03-13 2020-05-06 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN106544341A (en) * 2017-01-17 2017-03-29 上海亿康医学检验所有限公司 The method of the ctDNA in efficient detection sample
US11724015B2 (en) * 2017-09-18 2023-08-15 Santersus Ag Method and device for purification of blood from circulating cell free DNA
CN109932224A (en) * 2017-12-18 2019-06-25 中国科学院大连化学物理研究所 A method of Circulating tumor DNA is extracted in enrichment
CN112119166A (en) 2018-03-13 2020-12-22 耶路撒冷希伯来大学伊萨姆研发有限公司 Diagnostic use of cell-free DNA chromatin immunoprecipitation
GB201818965D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Method for the detection of colorectal cancer
GB201818963D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Methof for the detection of prostate cancer
CN109841265B (en) * 2019-02-22 2021-09-21 清华大学 Method and system for determining tissue source of plasma free nucleic acid molecules by using fragmentation mode and application
GB201906199D0 (en) 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
GB201906201D0 (en) 2019-05-02 2019-06-19 Belgian Voltion Sprl Method for the detection of protate cancer
EP4041914A1 (en) * 2019-10-04 2022-08-17 Santersus AG Method for isolating and analyzing cell free dna
JP7349104B2 (en) * 2019-11-13 2023-09-22 株式会社島津製作所 How to detect verotoxin
CA3163181A1 (en) 2019-12-02 2021-06-10 Belgian Volition Srl Use of cell free nucleosomes as biomarkers
GB202117799D0 (en) 2021-12-09 2022-01-26 Belgian Volition Srl Method for the detection of blood cancer
WO2023122623A1 (en) * 2021-12-21 2023-06-29 Guardant Health, Inc. Methods and systems for combinatorial chromatin-ip sequencing
WO2023170298A1 (en) 2022-03-11 2023-09-14 Belgian Volition Srl Differential diagnosis method
WO2024042210A1 (en) * 2022-08-25 2024-02-29 Belgian Volition Srl Method for measuring cell free chromatin

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0319376D0 (en) 2003-08-18 2003-09-17 Chroma Therapeutics Ltd Histone modification detection
US20060115482A1 (en) * 2004-04-27 2006-06-01 The Regents Of The University Of California Modifications of histone proteins as indicators of cell proliferation and differentiation
WO2007121276A2 (en) * 2006-04-12 2007-10-25 Biocept, Inc. Enrichment of circulating fetal dna
EP2062912A1 (en) * 2007-11-26 2009-05-27 Koninklijke Philips Electronics N.V. Selective enrichment of post-translationally modified proteins and/or peptides
US20100240054A1 (en) * 2008-09-22 2010-09-23 Biocept, Inc. Identification and isolation of fetal cells and nucleic acid
AU2010236415A1 (en) * 2009-04-14 2011-12-01 The Regents Of The University Of California Histone modification patterns for clinical diagnosis and prognosis of cancer
WO2013010181A2 (en) * 2011-07-14 2013-01-17 University Of Massachusetts Methods of diagnosing cancer using epigenetic biomarkers
GB201115095D0 (en) * 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
GB201115098D0 (en) * 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants
US9494591B2 (en) * 2011-11-21 2016-11-15 The Royal Institution For The Advancement Of Learning/Mcgill University Mutations of histone proteins associated with proliferative disorders
EP2788767B1 (en) 2011-12-07 2017-09-06 Belgian Volition SPRL Method for detecting nucleosome adducts
US9605313B2 (en) * 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9388213B2 (en) * 2012-09-10 2016-07-12 The Rockefeller University Polycomb repressive complex 2 (PRC2) inhibitors and uses thereof

Also Published As

Publication number Publication date
NZ731116A (en) 2024-03-22
US20180024141A1 (en) 2018-01-25
EP3809140A1 (en) 2021-04-21
CA2965752A1 (en) 2016-05-06
AU2015340378A1 (en) 2017-05-11
JP2017534300A (en) 2017-11-24
DK3213084T3 (en) 2021-01-18
JP6721599B2 (en) 2020-07-15
DK3213084T4 (en) 2024-03-18
EP3213084B1 (en) 2020-11-25
US20220334128A1 (en) 2022-10-20
EP3213084A1 (en) 2017-09-06
PL3213084T3 (en) 2021-07-26
CN111505305B (en) 2023-10-17
EP3213084B2 (en) 2023-12-13
CA2965752C (en) 2024-04-02
IL251896A0 (en) 2017-06-29
CN107209190B (en) 2021-07-16
ES2839973T3 (en) 2021-07-06
HK1243764A1 (en) 2018-07-20
WO2016067029A1 (en) 2016-05-06
SG11201702978VA (en) 2017-05-30
CN111505305A (en) 2020-08-07
AU2015340378B2 (en) 2021-08-12
CN107209190A (en) 2017-09-26

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