JP6721599B2 - 循環する腫瘍ｄｎａの濃縮方法 - Google Patents

循環する腫瘍ｄｎａの濃縮方法 Download PDF

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JP6721599B2
JP6721599B2 JP2017542357A JP2017542357A JP6721599B2 JP 6721599 B2 JP6721599 B2 JP 6721599B2 JP 2017542357 A JP2017542357 A JP 2017542357A JP 2017542357 A JP2017542357 A JP 2017542357A JP 6721599 B2 JP6721599 B2 JP 6721599B2
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histone
binding agent
nucleosomes
dna
tumor
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JP2017534300A (ja
JP2017534300A5 (enExample
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ビンセント ミカレフ ジャコブ
ビンセント ミカレフ ジャコブ
ヘルゾグ マリエレ
ヘルゾグ マリエレ
エドワード エクレストン マーク
エドワード エクレストン マーク
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ベルジアン ボリション エスピーアールエル
ベルジアン ボリション エスピーアールエル
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Priority claimed from GBGB1419225.6A external-priority patent/GB201419225D0/en
Priority claimed from GB201419299A external-priority patent/GB201419299D0/en
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    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/68—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving proteins, peptides or amino acids
    • G01N33/6875—Nucleoproteins
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N15/00—Mutation or genetic engineering; DNA or RNA concerning genetic engineering, vectors, e.g. plasmids, or their isolation, preparation or purification; Use of hosts therefor
    • C12N15/09—Recombinant DNA-technology
    • C12N15/10—Processes for the isolation, preparation or purification of DNA or RNA
    • C12N15/1003—Extracting or separating nucleic acids from biological samples, e.g. pure separation or isolation methods; Conditions, buffers or apparatuses therefor
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N27/00—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means
    • G01N27/62—Investigating or analysing materials by the use of electric, electrochemical, or magnetic means by investigating the ionisation of gases, e.g. aerosols; by investigating electric discharges, e.g. emission of cathode
    • G01N27/622—Ion mobility spectrometry
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2560/00—Chemical aspects of mass spectrometric analysis of biological material
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/70—Mechanisms involved in disease identification
    • G01N2800/7023—(Hyper)proliferation
    • G01N2800/7028—Cancer

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  • Life Sciences & Earth Sciences (AREA)
  • Health & Medical Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Chemical & Material Sciences (AREA)
  • Biomedical Technology (AREA)
  • Immunology (AREA)
  • Molecular Biology (AREA)
  • Physics & Mathematics (AREA)
  • Urology & Nephrology (AREA)
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  • Biochemistry (AREA)
  • Analytical Chemistry (AREA)
  • Biotechnology (AREA)
  • Microbiology (AREA)
  • Pathology (AREA)
  • General Physics & Mathematics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Cell Biology (AREA)
  • Food Science & Technology (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Organic Chemistry (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • General Engineering & Computer Science (AREA)
  • Biophysics (AREA)
  • Plant Pathology (AREA)
  • Electrochemistry (AREA)
  • Spectroscopy & Molecular Physics (AREA)
  • Crystallography & Structural Chemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
JP2017542357A 2014-10-29 2015-10-29 循環する腫瘍ｄｎａの濃縮方法 Active JP6721599B2 (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
GBGB1419225.6A GB201419225D0 (en) 2014-10-29 2014-10-29 Method for the enrichment of circulating tumor DNA
GB1419225.6 2014-10-29
GB201419299A GB201419299D0 (en) 2014-10-30 2014-10-30 Method for the enrichment of circulating tumour DNA
GB1419299.1 2014-10-30
PCT/GB2015/053238 WO2016067029A1 (en) 2014-10-29 2015-10-29 Method for the enrichment of circulating tumor dna

Publications (3)

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JP2017534300A JP2017534300A (ja) 2017-11-24
JP2017534300A5 JP2017534300A5 (enExample) 2018-11-15
JP6721599B2 true JP6721599B2 (ja) 2020-07-15

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JP2017542357A Active JP6721599B2 (ja) 2014-10-29 2015-10-29 循環する腫瘍ｄｎａの濃縮方法

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US (2) US20180024141A1 (enExample)
EP (2) EP3213084B2 (enExample)
JP (1) JP6721599B2 (enExample)
CN (2) CN107209190B (enExample)
AU (1) AU2015340378B2 (enExample)
CA (1) CA2965752C (enExample)
DK (1) DK3213084T4 (enExample)
ES (1) ES2839973T3 (enExample)
IL (1) IL251896A0 (enExample)
PL (1) PL3213084T3 (enExample)
SG (2) SG10201903822XA (enExample)
WO (1) WO2016067029A1 (enExample)

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US9605313B2 (en) 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
EP2971100A1 (en) 2013-03-13 2016-01-20 Sequenom, Inc. Primers for dna methylation analysis
US11365447B2 (en) 2014-03-13 2022-06-21 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
CN106544341A (zh) * 2017-01-17 2017-03-29 上海亿康医学检验所有限公司 高效检测样本中的ctDNA的方法
IL273413B2 (en) * 2017-09-18 2024-05-01 Santersus Ag Method and device for purification of blood from circulating cell free dna
CN109932224A (zh) * 2017-12-18 2019-06-25 中国科学院大连化学物理研究所 一种富集提取循环肿瘤dna的方法
WO2019175876A2 (en) * 2018-03-13 2019-09-19 Yissum Research Development Company Of The Hebrew University Of Jerusalem Ltd. Diagnostic use of cell free dna chromatin immunoprecipitation
US20210198747A1 (en) * 2018-05-18 2021-07-01 The Johns Hopkins University Cell-free dna for assessing and/or treating cancer
GB201818965D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Method for the detection of colorectal cancer
GB201818963D0 (en) 2018-11-21 2019-01-09 Belgian Volition Sprl Methof for the detection of prostate cancer
CN109841265B (zh) * 2019-02-22 2021-09-21 清华大学 使用片段化模式确定血浆游离核酸分子组织来源的方法和系统及应用
GB201906199D0 (en) 2019-05-02 2019-06-19 Belgian Volition Sprl Method for the detection of cancer
GB201906201D0 (en) 2019-05-02 2019-06-19 Belgian Voltion Sprl Method for the detection of protate cancer
US20220290252A1 (en) * 2019-08-27 2022-09-15 Belgian Volition Srl Method of isolating circulating nucleosomes
WO2021064463A1 (en) * 2019-10-04 2021-04-08 Santersus Ag Method for isolating and analyzing cell free dna
JP7349104B2 (ja) * 2019-11-13 2023-09-22 株式会社島津製作所 ベロ毒素の検出方法
AU2020395504A1 (en) 2019-12-02 2022-06-23 Belgian Volition Srl Use of cell free nucleosomes as biomarkers
AU2021276524A1 (en) * 2020-05-22 2023-01-05 Aqtual, Inc. Methods for characterizing cell-free nucleic acid fragments
GB202117799D0 (en) 2021-12-09 2022-01-26 Belgian Volition Srl Method for the detection of blood cancer
EP4453241A1 (en) * 2021-12-21 2024-10-30 Guardant Health, Inc. Methods and systems for combinatorial chromatin-ip sequencing
US12053567B2 (en) 2021-12-27 2024-08-06 Santersus Ag Method and device for removal of circulating cell free DNA
US20250197944A1 (en) 2022-03-11 2025-06-19 Belgian Volition Srl Differential diagnosis method
EP4577833A1 (en) * 2022-08-25 2025-07-02 Belgian Volition SRL Method for measuring cell free chromatin
WO2024148280A1 (en) 2023-01-06 2024-07-11 Ideaya Biosciences, Inc. Treatment of er+ breast cancer comprising homologous recombination deficiency using parc inhibitor
WO2024223947A1 (en) 2023-04-28 2024-10-31 Belgian Volition Srl Use of cell free nucleosomes as biomarkers of carcinomas
GB202307768D0 (en) 2023-05-24 2023-07-05 Belgian Volition Srl Use of cell free nucleosomes as biomarkers
GB202310137D0 (en) 2023-07-03 2023-08-16 Belgian Volition Srl Method for the detection of cancer
WO2025012440A1 (en) 2023-07-13 2025-01-16 Belgian Volition Srl Method for detection of the potential of a body fluid sample to produce extracellular traps
WO2025061853A1 (en) 2023-09-19 2025-03-27 Belgian Volition Srl Lateral flow test device
WO2025073909A1 (en) 2023-10-04 2025-04-10 Belgian Volition Srl Pcr method for detecting ctcf occupied cfdna fragments
WO2025093747A1 (en) 2023-11-02 2025-05-08 Belgian Volition Srl Novel rapid high-throughput method of netosis induction and inhibition with physiologically relevant molecules

Family Cites Families (13)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
GB0319376D0 (en) * 2003-08-18 2003-09-17 Chroma Therapeutics Ltd Histone modification detection
US20060115482A1 (en) * 2004-04-27 2006-06-01 The Regents Of The University Of California Modifications of histone proteins as indicators of cell proliferation and differentiation
WO2007121276A2 (en) * 2006-04-12 2007-10-25 Biocept, Inc. Enrichment of circulating fetal dna
EP2062912A1 (en) * 2007-11-26 2009-05-27 Koninklijke Philips Electronics N.V. Selective enrichment of post-translationally modified proteins and/or peptides
US20100240054A1 (en) * 2008-09-22 2010-09-23 Biocept, Inc. Identification and isolation of fetal cells and nucleic acid
WO2010120942A2 (en) * 2009-04-14 2010-10-21 The Regents Of The University Of California Histone modification patterns for clinical diagnosis and prognosis of cancer
US20140213475A1 (en) * 2011-07-14 2014-07-31 University Of Massachusetts Methods of diagnosing cancer using epigenetic biomarkers
GB201115098D0 (en) † 2011-09-01 2011-10-19 Belgian Volition Sa Method for detecting nucleosomes containing histone variants
GB201115095D0 (en) * 2011-09-01 2011-10-19 Singapore Volition Pte Ltd Method for detecting nucleosomes containing nucleotides
WO2013075237A1 (en) † 2011-11-21 2013-05-30 The Royal Institution For The Advancement Of Learning / Mcgill University Mutations of histone proteins associated with proliferative disorders
EP4092415A1 (en) * 2011-12-07 2022-11-23 Belgian Volition Srl Method for detecting nucleosome adducts
US9605313B2 (en) * 2012-03-02 2017-03-28 Sequenom, Inc. Methods and processes for non-invasive assessment of genetic variations
US9388213B2 (en) * 2012-09-10 2016-07-12 The Rockefeller University Polycomb repressive complex 2 (PRC2) inhibitors and uses thereof

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Publication number Publication date
WO2016067029A1 (en) 2016-05-06
SG10201903822XA (en) 2019-05-30
NZ731116A (en) 2024-03-22
EP3213084A1 (en) 2017-09-06
AU2015340378B2 (en) 2021-08-12
EP3213084B2 (en) 2023-12-13
EP3213084B1 (en) 2020-11-25
US20180024141A1 (en) 2018-01-25
SG11201702978VA (en) 2017-05-30
CN107209190A (zh) 2017-09-26
CN111505305A (zh) 2020-08-07
DK3213084T4 (da) 2024-03-18
CN111505305B (zh) 2023-10-17
EP3809140A1 (en) 2021-04-21
CA2965752A1 (en) 2016-05-06
AU2015340378A1 (en) 2017-05-11
DK3213084T3 (da) 2021-01-18
CA2965752C (en) 2024-04-02
CN107209190B (zh) 2021-07-16
IL251896A0 (en) 2017-06-29
PL3213084T3 (pl) 2021-07-26
JP2017534300A (ja) 2017-11-24
ES2839973T3 (es) 2021-07-06
US20220334128A1 (en) 2022-10-20
HK1243764A1 (en) 2018-07-20

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