JP2018513679A5 - - Google Patents
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- JP2018513679A5 JP2018513679A5 JP2017549623A JP2017549623A JP2018513679A5 JP 2018513679 A5 JP2018513679 A5 JP 2018513679A5 JP 2017549623 A JP2017549623 A JP 2017549623A JP 2017549623 A JP2017549623 A JP 2017549623A JP 2018513679 A5 JP2018513679 A5 JP 2018513679A5
- Authority
- JP
- Japan
- Prior art keywords
- cancer
- cdna
- ctcs
- droplet
- ctc
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 239000002299 complementary DNA Substances 0.000 claims 22
- 238000000034 method Methods 0.000 claims 17
- 210000005266 circulating tumour cell Anatomy 0.000 claims 15
- 206010006187 Breast cancer Diseases 0.000 claims 11
- 208000026310 Breast neoplasm Diseases 0.000 claims 11
- 208000005443 Circulating Neoplastic Cells Diseases 0.000 claims 11
- 206010028980 Neoplasm Diseases 0.000 claims 11
- 239000008280 blood Substances 0.000 claims 11
- 210000004369 blood Anatomy 0.000 claims 11
- 206010058467 Lung neoplasm malignant Diseases 0.000 claims 10
- 201000005202 lung cancer Diseases 0.000 claims 10
- 208000020816 lung neoplasm Diseases 0.000 claims 10
- 239000000523 sample Substances 0.000 claims 9
- 229920002477 rna polymer Polymers 0.000 claims 7
- 201000011510 cancer Diseases 0.000 claims 6
- 238000003384 imaging method Methods 0.000 claims 6
- 201000007270 liver cancer Diseases 0.000 claims 6
- 208000014018 liver neoplasm Diseases 0.000 claims 6
- 238000012360 testing method Methods 0.000 claims 6
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 5
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 5
- 201000001441 melanoma Diseases 0.000 claims 5
- 201000002528 pancreatic cancer Diseases 0.000 claims 5
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 5
- 125000006853 reporter group Chemical group 0.000 claims 5
- 108700020796 Oncogene Proteins 0.000 claims 3
- 206010060862 Prostate cancer Diseases 0.000 claims 3
- 208000000236 Prostatic Neoplasms Diseases 0.000 claims 3
- 210000004027 cell Anatomy 0.000 claims 3
- 239000000356 contaminant Substances 0.000 claims 3
- 238000003752 polymerase chain reaction Methods 0.000 claims 3
- 230000001225 therapeutic effect Effects 0.000 claims 3
- 108020004635 Complementary DNA Proteins 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000012544 monitoring process Methods 0.000 claims 2
- 238000010839 reverse transcription Methods 0.000 claims 2
- 239000004215 Carbon black (E152) Substances 0.000 claims 1
- 102000043276 Oncogene Human genes 0.000 claims 1
- 239000012807 PCR reagent Substances 0.000 claims 1
- 239000011324 bead Substances 0.000 claims 1
- 239000007850 fluorescent dye Substances 0.000 claims 1
- 229930195733 hydrocarbon Natural products 0.000 claims 1
- 150000002430 hydrocarbons Chemical class 0.000 claims 1
- 230000003100 immobilizing effect Effects 0.000 claims 1
- 210000004185 liver Anatomy 0.000 claims 1
- 239000002480 mineral oil Substances 0.000 claims 1
- 239000003921 oil Substances 0.000 claims 1
- 238000004393 prognosis Methods 0.000 claims 1
- 210000002307 prostate Anatomy 0.000 claims 1
- 108090000623 proteins and genes Proteins 0.000 claims 1
- 230000002441 reversible effect Effects 0.000 claims 1
- 230000035945 sensitivity Effects 0.000 claims 1
- 229920002545 silicone oil Polymers 0.000 claims 1
- 239000007790 solid phase Substances 0.000 claims 1
- 238000002560 therapeutic procedure Methods 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562137891P | 2015-03-25 | 2015-03-25 | |
| US62/137,891 | 2015-03-25 | ||
| US201562219339P | 2015-09-16 | 2015-09-16 | |
| US62/219,339 | 2015-09-16 | ||
| US201562253619P | 2015-11-10 | 2015-11-10 | |
| US62/253,619 | 2015-11-10 | ||
| PCT/US2016/024367 WO2016154600A1 (en) | 2015-03-25 | 2016-03-25 | Digital analysis of circulating tumor cells in blood samples |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012116A Division JP7203128B2 (ja) | 2015-03-25 | 2021-01-28 | 血液試料中の循環腫瘍細胞のデジタル分析 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2018513679A JP2018513679A (ja) | 2018-05-31 |
| JP2018513679A5 true JP2018513679A5 (enExample) | 2019-05-09 |
| JP7144934B2 JP7144934B2 (ja) | 2022-09-30 |
Family
ID=56977798
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017549623A Active JP7144934B2 (ja) | 2015-03-25 | 2016-03-25 | 血液試料中の循環腫瘍細胞のデジタル分析 |
| JP2021012116A Active JP7203128B2 (ja) | 2015-03-25 | 2021-01-28 | 血液試料中の循環腫瘍細胞のデジタル分析 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2021012116A Active JP7203128B2 (ja) | 2015-03-25 | 2021-01-28 | 血液試料中の循環腫瘍細胞のデジタル分析 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20180057889A1 (enExample) |
| EP (1) | EP3274476B1 (enExample) |
| JP (2) | JP7144934B2 (enExample) |
| KR (1) | KR102502087B1 (enExample) |
| CN (1) | CN107614698A (enExample) |
| AU (2) | AU2016238253B2 (enExample) |
| CA (1) | CA2980562A1 (enExample) |
| ES (1) | ES2954456T3 (enExample) |
| IL (1) | IL254639B (enExample) |
| WO (1) | WO2016154600A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN104271767B (zh) | 2012-02-03 | 2017-08-25 | 加州理工学院 | 多路生化测定中信号的编码和解码 |
| EP3274476B1 (en) | 2015-03-25 | 2023-06-07 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| EP3985127A1 (en) * | 2016-10-27 | 2022-04-20 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
| US20180252722A1 (en) * | 2017-03-05 | 2018-09-06 | Yan Wang | PCR-based Method for Counting Circulating Tumor Cells |
| WO2019092213A1 (en) * | 2017-11-09 | 2019-05-16 | Biomillenia Sas | Microbial selection system |
| US20200399681A1 (en) * | 2018-02-23 | 2020-12-24 | Cornell University | Assay for detection of androgen receptor variants |
| CN108535145A (zh) * | 2018-03-09 | 2018-09-14 | 深圳市瑞图生物技术有限公司 | 快速检测外周血液中网织红细胞数量的方法及装置 |
| WO2019204357A1 (en) | 2018-04-17 | 2019-10-24 | ChromaCode, Inc. | Methods and systems for multiplex analysis |
| CN110456034B (zh) * | 2018-05-07 | 2022-07-22 | 上海市第十人民医院 | 一种循环肿瘤细胞的检测方法 |
| EP3814775A4 (en) | 2018-06-29 | 2021-09-01 | The General Hospital Corporation | ISOLATION AND ANALYSIS OF CELLS AND RARE PARTICLES DERIVED FROM THE BRAIN |
| US12203129B2 (en) * | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| CN112996928A (zh) * | 2018-09-11 | 2021-06-18 | 总医院公司 | 用于检测肝脏疾病的方法 |
| KR102380529B1 (ko) | 2020-04-29 | 2022-03-31 | 인제대학교 산학협력단 | 전이성 전립선 암의 진단 및 예후 예측을 위한 혈중종양세포 기반 바이오 마커 조성물 |
| CN112662774A (zh) * | 2021-01-12 | 2021-04-16 | 南方医科大学南方医院 | 一种肝癌循环肿瘤细胞标志物及其应用 |
| CN114395622A (zh) * | 2021-12-13 | 2022-04-26 | 深圳先进技术研究院 | 一种利用数字pcr检测循环肿瘤细胞egfr基因突变的方法及其应用 |
| DE102022211089A1 (de) * | 2022-10-19 | 2024-04-25 | Robert Bosch Gesellschaft mit beschränkter Haftung | Kombinierte Zellspezifische Markierung und Anreicherung von Biomarkern |
Family Cites Families (45)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US889A (en) | 1838-08-20 | Mode of constructing metal bench-vises | ||
| US8535A (en) | 1851-11-18 | Stove-geate | ||
| DE29623597U1 (de) | 1996-11-08 | 1999-01-07 | Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg | Temperierblock mit Temperiereinrichtungen |
| US20080050393A1 (en) | 1998-12-03 | 2008-02-28 | Tang Y Tom | Novel nucleic acids and polypeptides |
| CA2311201A1 (en) * | 1999-08-05 | 2001-02-05 | Genset S.A. | Ests and encoded human proteins |
| CA2417866A1 (en) * | 2000-08-03 | 2002-02-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| JP2004537261A (ja) | 2000-12-08 | 2004-12-16 | イプソゲン | 候補遺伝子のアレイを用いた原発性乳がんの遺伝子発現プロファイリング |
| WO2002092854A2 (en) | 2001-05-16 | 2002-11-21 | Novartis Ag | Genes expressed in breast cancer as prognostic and therapeutic targets |
| US20030073623A1 (en) | 2001-07-30 | 2003-04-17 | Drmanac Radoje T. | Novel nucleic acid sequences obtained from various cDNA libraries |
| US20040142325A1 (en) | 2001-09-14 | 2004-07-22 | Liat Mintz | Methods and systems for annotating biomolecular sequences |
| US20060275794A1 (en) | 2005-03-07 | 2006-12-07 | Invitrogen Corporation | Collections of matched biological reagents and methods for identifying matched reagents |
| US20070026417A1 (en) * | 2005-07-29 | 2007-02-01 | Martin Fuchs | Devices and methods for enrichment and alteration of circulating tumor cells and other particles |
| WO2006121991A2 (en) | 2005-05-06 | 2006-11-16 | Diadexus, Inc. | Compositions and methods for detection, prognosis and treatment of breast cancer |
| EP2079838A1 (en) * | 2006-05-16 | 2009-07-22 | NuGEN Technologies, Inc. | Nucleic acid separation and purification method based on reversible charge interactions |
| EP2589668A1 (en) * | 2006-06-14 | 2013-05-08 | Verinata Health, Inc | Rare cell analysis using sample splitting and DNA tags |
| WO2009051734A1 (en) | 2007-10-17 | 2009-04-23 | The General Hospital Corporation | Microchip-based devices for capturing circulating tumor cells and methods of their use |
| US9068181B2 (en) | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
| US20120252015A1 (en) * | 2011-02-18 | 2012-10-04 | Bio-Rad Laboratories | Methods and compositions for detecting genetic material |
| US9625454B2 (en) * | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
| US20110166030A1 (en) * | 2009-09-30 | 2011-07-07 | Yixin Wang | Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells |
| EP3392349A1 (en) | 2010-02-12 | 2018-10-24 | Raindance Technologies, Inc. | Digital analyte analysis |
| US20120329061A1 (en) * | 2010-03-11 | 2012-12-27 | Board Of Regents, The University Of Texas System | Quantitative rt-pcr detection for genes involved in epithelial mesenchymal transition in peripheral blood of cancer patients |
| AU2015268617A1 (en) | 2010-03-31 | 2016-01-07 | Sividon Diagnostics Gmbh | Method for breast cancer recurrence prediction under endocrine treatment |
| US20130065786A1 (en) | 2010-03-31 | 2013-03-14 | Sividon Diagnostics Gmbh | Method for breast cancer recurrence prediction under endocrine treatment |
| US9650629B2 (en) * | 2010-07-07 | 2017-05-16 | Roche Molecular Systems, Inc. | Clonal pre-amplification in emulsion |
| US20140148350A1 (en) | 2010-08-18 | 2014-05-29 | David Spetzler | Circulating biomarkers for disease |
| EP2678448A4 (en) | 2011-02-22 | 2014-10-01 | Caris Life Sciences Luxembourg Holdings S A R L | CIRCULATING BIOMARKERS |
| WO2012135397A2 (en) | 2011-03-29 | 2012-10-04 | Lisanti Michael P | Lactate-and ketones-induced gene signatures and use the same for diagnosing disease and predicting clinical outcome |
| US8841071B2 (en) | 2011-06-02 | 2014-09-23 | Raindance Technologies, Inc. | Sample multiplexing |
| CN104011543B (zh) * | 2011-10-24 | 2016-06-15 | 通用医疗公司 | 癌症的生物标记 |
| WO2014008155A1 (en) | 2012-07-02 | 2014-01-09 | The General Hospital Corporation | Diagnosis and monitoring treatment of prostate cancer |
| EP4001426A1 (en) * | 2012-08-13 | 2022-05-25 | The Regents of The University of California | Methods and systems for detecting biological components |
| CA2884820A1 (en) | 2012-09-14 | 2014-03-20 | Memorial Sloan-Kettering Cancer Center | Genes associated with dasatinib sensitivity |
| WO2014047285A1 (en) | 2012-09-19 | 2014-03-27 | Paraskevi Giannakakou | Identifying taxane sensitivity in prostate cancer patients |
| WO2014075067A1 (en) | 2012-11-12 | 2014-05-15 | Nanostring Technologies, Inc. | Methods to predict breast cancer outcome |
| US20140303005A1 (en) | 2013-04-05 | 2014-10-09 | Raindance Technologies, Inc. | Rare cell analysis after negative selection |
| KR20160058774A (ko) | 2013-08-12 | 2016-05-25 | 토카이 파마슈티컬, 아이엔씨. | 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커 |
| EP3058316B1 (en) | 2013-10-18 | 2019-03-13 | The General Hospital Corporation | Microfluidic sorting using high gradient magnetic fields |
| CA2941161A1 (en) | 2014-03-13 | 2015-09-17 | F.Hoffmann-La Roche Ag | Methods and compositions for modulating estrogen receptor mutants |
| CA2945068A1 (en) | 2014-05-21 | 2015-11-26 | F. Hoffmann-La Roche Ag | Methods of treating pr-positive, luminal a breast cancer with pi3k inhibitor, pictilisib |
| EP3699589A1 (en) | 2014-12-12 | 2020-08-26 | Celcuity Inc. | Methods of measuring erbb signaling pathway activity to diagnose and treat cancer patients |
| ES2719206T3 (es) | 2015-02-20 | 2019-07-09 | Comelz Spa | Procedimiento para cortar pieles naturales |
| EP3268493B1 (en) | 2015-03-12 | 2022-01-05 | Janssen Pharmaceutica NV | Whole blood based mrna markers for predicting prostate cancer and methods of detecting the same |
| EP3274476B1 (en) | 2015-03-25 | 2023-06-07 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| EP3985127A1 (en) | 2016-10-27 | 2022-04-20 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
-
2016
- 2016-03-25 EP EP16769818.2A patent/EP3274476B1/en active Active
- 2016-03-25 ES ES16769818T patent/ES2954456T3/es active Active
- 2016-03-25 CN CN201680029396.XA patent/CN107614698A/zh active Pending
- 2016-03-25 CA CA2980562A patent/CA2980562A1/en active Pending
- 2016-03-25 US US15/560,324 patent/US20180057889A1/en not_active Abandoned
- 2016-03-25 JP JP2017549623A patent/JP7144934B2/ja active Active
- 2016-03-25 WO PCT/US2016/024367 patent/WO2016154600A1/en not_active Ceased
- 2016-03-25 AU AU2016238253A patent/AU2016238253B2/en active Active
- 2016-03-25 KR KR1020177030104A patent/KR102502087B1/ko active Active
-
2017
- 2017-09-24 IL IL254639A patent/IL254639B/en unknown
-
2020
- 2020-10-08 US US17/065,889 patent/US11898209B2/en active Active
-
2021
- 2021-01-28 JP JP2021012116A patent/JP7203128B2/ja active Active
-
2022
- 2022-09-15 AU AU2022231734A patent/AU2022231734A1/en not_active Abandoned
-
2023
- 2023-12-26 US US18/396,156 patent/US20240132969A1/en active Pending
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