IL254639B - Digital analysis of cancer cells moving in the bloodstream in blood samples - Google Patents
Digital analysis of cancer cells moving in the bloodstream in blood samplesInfo
- Publication number
- IL254639B IL254639B IL254639A IL25463917A IL254639B IL 254639 B IL254639 B IL 254639B IL 254639 A IL254639 A IL 254639A IL 25463917 A IL25463917 A IL 25463917A IL 254639 B IL254639 B IL 254639B
- Authority
- IL
- Israel
- Prior art keywords
- tumor cells
- blood samples
- circulating tumor
- digital analysis
- analysis
- Prior art date
Links
Classifications
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562137891P | 2015-03-25 | 2015-03-25 | |
| US201562219339P | 2015-09-16 | 2015-09-16 | |
| US201562253619P | 2015-11-10 | 2015-11-10 | |
| PCT/US2016/024367 WO2016154600A1 (en) | 2015-03-25 | 2016-03-25 | Digital analysis of circulating tumor cells in blood samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL254639A0 IL254639A0 (en) | 2017-11-30 |
| IL254639B true IL254639B (en) | 2021-10-31 |
Family
ID=56977798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL254639A IL254639B (en) | 2015-03-25 | 2017-09-24 | Digital analysis of cancer cells moving in the bloodstream in blood samples |
Country Status (9)
| Country | Link |
|---|---|
| US (3) | US20180057889A1 (enExample) |
| EP (1) | EP3274476B1 (enExample) |
| JP (2) | JP7144934B2 (enExample) |
| KR (1) | KR102502087B1 (enExample) |
| CN (1) | CN107614698A (enExample) |
| AU (2) | AU2016238253B2 (enExample) |
| ES (1) | ES2954456T3 (enExample) |
| IL (1) | IL254639B (enExample) |
| WO (1) | WO2016154600A1 (enExample) |
Families Citing this family (17)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CN107326085B (zh) | 2012-02-03 | 2022-05-03 | 加州理工学院 | 多路生化测定中信号的编码和解码 |
| EP3274476B1 (en) | 2015-03-25 | 2023-06-07 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| US11371101B2 (en) | 2016-10-27 | 2022-06-28 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
| US20180252722A1 (en) * | 2017-03-05 | 2018-09-06 | Yan Wang | PCR-based Method for Counting Circulating Tumor Cells |
| US11597963B2 (en) * | 2017-11-09 | 2023-03-07 | Biomillenia Sas | Microbial selection system |
| WO2019165242A1 (en) * | 2018-02-23 | 2019-08-29 | Paraskevi Giannakakou | Assay for detection of androgen receptor variants |
| CN108535145A (zh) * | 2018-03-09 | 2018-09-14 | 深圳市瑞图生物技术有限公司 | 快速检测外周血液中网织红细胞数量的方法及装置 |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| CN110456034B (zh) * | 2018-05-07 | 2022-07-22 | 上海市第十人民医院 | 一种循环肿瘤细胞的检测方法 |
| WO2020006404A1 (en) | 2018-06-29 | 2020-01-02 | The General Hospital Corporation | Isolating and analyzing rare brain-derived cells and particles |
| US12203129B2 (en) * | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| KR20210057765A (ko) * | 2018-09-11 | 2021-05-21 | 더 제너럴 하스피탈 코포레이션 | 간 질환을 검출하는 방법 |
| KR102380529B1 (ko) * | 2020-04-29 | 2022-03-31 | 인제대학교 산학협력단 | 전이성 전립선 암의 진단 및 예후 예측을 위한 혈중종양세포 기반 바이오 마커 조성물 |
| CN112662774A (zh) * | 2021-01-12 | 2021-04-16 | 南方医科大学南方医院 | 一种肝癌循环肿瘤细胞标志物及其应用 |
| CN117241878A (zh) | 2021-03-05 | 2023-12-15 | 伊努梅里斯公司 | 用于生成微滴和执行数字分析的系统和方法 |
| CN114395622A (zh) * | 2021-12-13 | 2022-04-26 | 深圳先进技术研究院 | 一种利用数字pcr检测循环肿瘤细胞egfr基因突变的方法及其应用 |
| DE102022211089A1 (de) * | 2022-10-19 | 2024-04-25 | Robert Bosch Gesellschaft mit beschränkter Haftung | Kombinierte Zellspezifische Markierung und Anreicherung von Biomarkern |
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| US20120252015A1 (en) * | 2011-02-18 | 2012-10-04 | Bio-Rad Laboratories | Methods and compositions for detecting genetic material |
| WO2014028378A2 (en) * | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Methods and systems for detecting biological components |
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| US889A (en) | 1838-08-20 | Mode of constructing metal bench-vises | ||
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| US20080050393A1 (en) | 1998-12-03 | 2008-02-28 | Tang Y Tom | Novel nucleic acids and polypeptides |
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| US20110166030A1 (en) * | 2009-09-30 | 2011-07-07 | Yixin Wang | Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells |
| JP5934657B2 (ja) | 2010-02-12 | 2016-06-15 | レインダンス テクノロジーズ， インコーポレイテッド | デジタル検体分析 |
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| RU2016148441A (ru) | 2014-05-21 | 2018-06-22 | Ф. Хоффманн-Ля Рош Аг | Способ лечения pr-положительного люминального а-типа рака молочной железы ингибитором pi3k пиктилисибом |
| JP6782698B2 (ja) | 2014-12-12 | 2020-11-11 | セルキュイティー インコーポレイテッド | がん患者を診断および処置するためのｅｒｂｂシグナル伝達経路活性の測定方法 |
| WO2016131924A1 (en) | 2015-02-20 | 2016-08-25 | Comelz S.P.A. | Method for cutting natural hides and the like |
| KR20170136525A (ko) | 2015-03-12 | 2017-12-11 | 얀센 파마슈티카 엔.브이. | 전립선암을 예측하기 위한 전혈 기반 mRNA 마커 및 그의 검출 방법 |
| EP3274476B1 (en) | 2015-03-25 | 2023-06-07 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| US11371101B2 (en) | 2016-10-27 | 2022-06-28 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
-
2016
- 2016-03-25 EP EP16769818.2A patent/EP3274476B1/en active Active
- 2016-03-25 WO PCT/US2016/024367 patent/WO2016154600A1/en not_active Ceased
- 2016-03-25 CN CN201680029396.XA patent/CN107614698A/zh active Pending
- 2016-03-25 JP JP2017549623A patent/JP7144934B2/ja active Active
- 2016-03-25 KR KR1020177030104A patent/KR102502087B1/ko active Active
- 2016-03-25 ES ES16769818T patent/ES2954456T3/es active Active
- 2016-03-25 AU AU2016238253A patent/AU2016238253B2/en active Active
- 2016-03-25 US US15/560,324 patent/US20180057889A1/en not_active Abandoned
-
2017
- 2017-09-24 IL IL254639A patent/IL254639B/en unknown
-
2020
- 2020-10-08 US US17/065,889 patent/US11898209B2/en active Active
-
2021
- 2021-01-28 JP JP2021012116A patent/JP7203128B2/ja active Active
-
2022
- 2022-09-15 AU AU2022231734A patent/AU2022231734A1/en not_active Abandoned
-
2023
- 2023-12-26 US US18/396,156 patent/US20240132969A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120252015A1 (en) * | 2011-02-18 | 2012-10-04 | Bio-Rad Laboratories | Methods and compositions for detecting genetic material |
| WO2014028378A2 (en) * | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Methods and systems for detecting biological components |
Also Published As
| Publication number | Publication date |
|---|---|
| ES2954456T3 (es) | 2023-11-22 |
| AU2016238253B2 (en) | 2022-06-16 |
| US20240132969A1 (en) | 2024-04-25 |
| JP7203128B2 (ja) | 2023-01-12 |
| AU2016238253A1 (en) | 2017-10-19 |
| JP2021087428A (ja) | 2021-06-10 |
| US20210189501A1 (en) | 2021-06-24 |
| KR20170131516A (ko) | 2017-11-29 |
| AU2022231734A1 (en) | 2022-11-10 |
| US11898209B2 (en) | 2024-02-13 |
| KR102502087B1 (ko) | 2023-02-20 |
| US20180057889A1 (en) | 2018-03-01 |
| EP3274476A1 (en) | 2018-01-31 |
| IL254639A0 (en) | 2017-11-30 |
| EP3274476A4 (en) | 2018-08-29 |
| JP7144934B2 (ja) | 2022-09-30 |
| JP2018513679A (ja) | 2018-05-31 |
| CN107614698A (zh) | 2018-01-19 |
| WO2016154600A1 (en) | 2016-09-29 |
| HK1249553A1 (en) | 2018-11-02 |
| EP3274476B1 (en) | 2023-06-07 |
| CA2980562A1 (en) | 2016-09-29 |
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