IL254639B - Digital analysis of cancer cells moving in the bloodstream in blood samples - Google Patents
Digital analysis of cancer cells moving in the bloodstream in blood samplesInfo
- Publication number
- IL254639B IL254639B IL254639A IL25463917A IL254639B IL 254639 B IL254639 B IL 254639B IL 254639 A IL254639 A IL 254639A IL 25463917 A IL25463917 A IL 25463917A IL 254639 B IL254639 B IL 254639B
- Authority
- IL
- Israel
- Prior art keywords
- tumor cells
- blood samples
- circulating tumor
- digital analysis
- analysis
- Prior art date
Links
Classifications
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6806—Preparing nucleic acids for analysis, e.g. for polymerase chain reaction [PCR] assay
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6813—Hybridisation assays
- C12Q1/6816—Hybridisation assays characterised by the detection means
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/6851—Quantitative amplification
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6844—Nucleic acid amplification reactions
- C12Q1/686—Polymerase chain reaction [PCR]
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
- C12Q1/68—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving nucleic acids
- C12Q1/6876—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes
- C12Q1/6883—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material
- C12Q1/6886—Nucleic acid products used in the analysis of nucleic acids, e.g. primers or probes for diseases caused by alterations of genetic material for cancer
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/107—Nucleic acid detection characterized by the use of physical, structural and functional properties fluorescence
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- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2563/00—Nucleic acid detection characterized by the use of physical, structural and functional properties
- C12Q2563/159—Microreactors, e.g. emulsion PCR or sequencing, droplet PCR, microcapsules, i.e. non-liquid containers with a range of different permeability's for different reaction components
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2565/00—Nucleic acid analysis characterised by mode or means of detection
- C12Q2565/60—Detection means characterised by use of a special device
- C12Q2565/629—Detection means characterised by use of a special device being a microfluidic device
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/118—Prognosis of disease development
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/158—Expression markers
-
- C—CHEMISTRY; METALLURGY
- C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
- C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
- C12Q2600/00—Oligonucleotides characterized by their use
- C12Q2600/16—Primer sets for multiplex assays
Landscapes
- Chemical & Material Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Organic Chemistry (AREA)
- Health & Medical Sciences (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Engineering & Computer Science (AREA)
- Zoology (AREA)
- Wood Science & Technology (AREA)
- Analytical Chemistry (AREA)
- Genetics & Genomics (AREA)
- Immunology (AREA)
- Molecular Biology (AREA)
- General Health & Medical Sciences (AREA)
- General Engineering & Computer Science (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Biotechnology (AREA)
- Microbiology (AREA)
- Biochemistry (AREA)
- Biophysics (AREA)
- Physics & Mathematics (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Pathology (AREA)
- Hospice & Palliative Care (AREA)
- Oncology (AREA)
- Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
- Investigating Or Analysing Biological Materials (AREA)
Applications Claiming Priority (4)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201562137891P | 2015-03-25 | 2015-03-25 | |
| US201562219339P | 2015-09-16 | 2015-09-16 | |
| US201562253619P | 2015-11-10 | 2015-11-10 | |
| PCT/US2016/024367 WO2016154600A1 (en) | 2015-03-25 | 2016-03-25 | Digital analysis of circulating tumor cells in blood samples |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| IL254639A0 IL254639A0 (en) | 2017-11-30 |
| IL254639B true IL254639B (en) | 2021-10-31 |
Family
ID=56977798
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| IL254639A IL254639B (en) | 2015-03-25 | 2017-09-24 | Digital analysis of cancer cells moving in the bloodstream in blood samples |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US20180057889A1 (enExample) |
| EP (1) | EP3274476B1 (enExample) |
| JP (2) | JP7144934B2 (enExample) |
| KR (1) | KR102502087B1 (enExample) |
| CN (1) | CN107614698A (enExample) |
| AU (2) | AU2016238253B2 (enExample) |
| CA (1) | CA2980562A1 (enExample) |
| ES (1) | ES2954456T3 (enExample) |
| IL (1) | IL254639B (enExample) |
| WO (1) | WO2016154600A1 (enExample) |
Families Citing this family (16)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP3544015B1 (en) | 2012-02-03 | 2024-10-23 | California Institute of Technology | Signal encoding and decoding in multiplexed biochemical assays |
| AU2016238253B2 (en) | 2015-03-25 | 2022-06-16 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| WO2018081625A2 (en) * | 2016-10-27 | 2018-05-03 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
| US20180252722A1 (en) * | 2017-03-05 | 2018-09-06 | Yan Wang | PCR-based Method for Counting Circulating Tumor Cells |
| JP2021502098A (ja) * | 2017-11-09 | 2021-01-28 | ビオミレニア ソシエテ パ アクシオンス シンプリフィエ | 微生物選択システム |
| WO2019165242A1 (en) * | 2018-02-23 | 2019-08-29 | Paraskevi Giannakakou | Assay for detection of androgen receptor variants |
| CN108535145A (zh) * | 2018-03-09 | 2018-09-14 | 深圳市瑞图生物技术有限公司 | 快速检测外周血液中网织红细胞数量的方法及装置 |
| CN112424377A (zh) | 2018-04-17 | 2021-02-26 | 克罗玛科德公司 | 用于多重分析的方法和系统 |
| CN110456034B (zh) * | 2018-05-07 | 2022-07-22 | 上海市第十人民医院 | 一种循环肿瘤细胞的检测方法 |
| EP3814775A4 (en) | 2018-06-29 | 2021-09-01 | The General Hospital Corporation | ISOLATION AND ANALYSIS OF CELLS AND RARE PARTICLES DERIVED FROM THE BRAIN |
| US12203129B2 (en) * | 2018-07-03 | 2025-01-21 | ChromaCode, Inc. | Formulations and signal encoding and decoding methods for massively multiplexed biochemical assays |
| JP2022500029A (ja) * | 2018-09-11 | 2022-01-04 | ザ ジェネラル ホスピタル コーポレイション | 肝臓疾患を検出する方法 |
| KR102380529B1 (ko) * | 2020-04-29 | 2022-03-31 | 인제대학교 산학협력단 | 전이성 전립선 암의 진단 및 예후 예측을 위한 혈중종양세포 기반 바이오 마커 조성물 |
| CN112662774A (zh) * | 2021-01-12 | 2021-04-16 | 南方医科大学南方医院 | 一种肝癌循环肿瘤细胞标志物及其应用 |
| CN114395622A (zh) * | 2021-12-13 | 2022-04-26 | 深圳先进技术研究院 | 一种利用数字pcr检测循环肿瘤细胞egfr基因突变的方法及其应用 |
| DE102022211089A1 (de) * | 2022-10-19 | 2024-04-25 | Robert Bosch Gesellschaft mit beschränkter Haftung | Kombinierte Zellspezifische Markierung und Anreicherung von Biomarkern |
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| US20120252015A1 (en) * | 2011-02-18 | 2012-10-04 | Bio-Rad Laboratories | Methods and compositions for detecting genetic material |
| WO2014028378A2 (en) * | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Methods and systems for detecting biological components |
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| US8535A (en) | 1851-11-18 | Stove-geate | ||
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| DE29623597U1 (de) | 1996-11-08 | 1999-01-07 | Eppendorf - Netheler - Hinz Gmbh, 22339 Hamburg | Temperierblock mit Temperiereinrichtungen |
| US20080050393A1 (en) | 1998-12-03 | 2008-02-28 | Tang Y Tom | Novel nucleic acids and polypeptides |
| CA2311201A1 (en) * | 1999-08-05 | 2001-02-05 | Genset S.A. | Ests and encoded human proteins |
| WO2002012328A2 (en) * | 2000-08-03 | 2002-02-14 | Corixa Corporation | Compositions and methods for the therapy and diagnosis of colon cancer |
| JP2004537261A (ja) | 2000-12-08 | 2004-12-16 | イプソゲン | 候補遺伝子のアレイを用いた原発性乳がんの遺伝子発現プロファイリング |
| WO2002092854A2 (en) | 2001-05-16 | 2002-11-21 | Novartis Ag | Genes expressed in breast cancer as prognostic and therapeutic targets |
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| US20090275486A1 (en) * | 2006-05-16 | 2009-11-05 | Nurith Kurn | Nucleic acid separation and purification method based on reversible charge interactions |
| US8372584B2 (en) * | 2006-06-14 | 2013-02-12 | The General Hospital Corporation | Rare cell analysis using sample splitting and DNA tags |
| WO2009051734A1 (en) * | 2007-10-17 | 2009-04-23 | The General Hospital Corporation | Microchip-based devices for capturing circulating tumor cells and methods of their use |
| US9068181B2 (en) | 2008-05-23 | 2015-06-30 | The General Hospital Corporation | Microfluidic droplet encapsulation |
| US9625454B2 (en) * | 2009-09-04 | 2017-04-18 | The Research Foundation For The State University Of New York | Rapid and continuous analyte processing in droplet microfluidic devices |
| US20110166030A1 (en) * | 2009-09-30 | 2011-07-07 | Yixin Wang | Prediction of response to docetaxel therapy based on the presence of TMPRSSG2:ERG fusion in circulating tumor cells |
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| AU2015268617A1 (en) | 2010-03-31 | 2016-01-07 | Sividon Diagnostics Gmbh | Method for breast cancer recurrence prediction under endocrine treatment |
| JP5940517B2 (ja) | 2010-03-31 | 2016-06-29 | ジヴィドン ダイアグノスティックス ゲゼルシャフト ミット ベシュレンクテル ハフツング | 内分泌治療下における乳癌再発を予測するための方法 |
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| EP2606353A4 (en) | 2010-08-18 | 2014-10-15 | Caris Life Sciences Luxembourg Holdings | CIRCULATING BIOMARKERS FOR DISEASES |
| WO2012115885A1 (en) | 2011-02-22 | 2012-08-30 | Caris Life Sciences Luxembourg Holdings, S.A.R.L. | Circulating biomarkers |
| WO2012135397A2 (en) | 2011-03-29 | 2012-10-04 | Lisanti Michael P | Lactate-and ketones-induced gene signatures and use the same for diagnosing disease and predicting clinical outcome |
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| KR20160058774A (ko) | 2013-08-12 | 2016-05-25 | 토카이 파마슈티컬, 아이엔씨. | 안드로겐-표적 치료제를 이용하는 종양 질환 치료를 위한 바이오마커 |
| WO2015058206A1 (en) | 2013-10-18 | 2015-04-23 | The General Hosptial Corporation | Microfluidic sorting using high gradient magnetic fields |
| RU2016137150A (ru) | 2014-03-13 | 2018-04-18 | Ф. Хоффманн-Ля Рош Аг | Способы и композиции для модулирования мутантов эстрогеновых рецепторов |
| WO2015177184A1 (en) | 2014-05-21 | 2015-11-26 | F. Hoffmann-La Roche Ag | Methods of treating pr-positive, luminal a breast cancer with pi3k inhibitor, pictilisib |
| CN107003300B (zh) | 2014-12-12 | 2020-02-07 | 凯尔科迪股份有限公司 | 测量erbb信号传导通路活性以诊断和治疗癌症患者的方法 |
| ES2719206T3 (es) | 2015-02-20 | 2019-07-09 | Comelz Spa | Procedimiento para cortar pieles naturales |
| RS62972B1 (sr) | 2015-03-12 | 2022-03-31 | Janssen Pharmaceutica Nv | Mrnk markeri na bazi pune krvi za predviđivanje raka prostate i metode otkrivanja istog |
| AU2016238253B2 (en) | 2015-03-25 | 2022-06-16 | The General Hospital Corporation | Digital analysis of circulating tumor cells in blood samples |
| WO2018081625A2 (en) | 2016-10-27 | 2018-05-03 | The General Hospital Corporation | Digital analysis of blood samples to determine efficacy of cancer therapies for specific cancers |
-
2016
- 2016-03-25 AU AU2016238253A patent/AU2016238253B2/en active Active
- 2016-03-25 WO PCT/US2016/024367 patent/WO2016154600A1/en not_active Ceased
- 2016-03-25 JP JP2017549623A patent/JP7144934B2/ja active Active
- 2016-03-25 KR KR1020177030104A patent/KR102502087B1/ko active Active
- 2016-03-25 CA CA2980562A patent/CA2980562A1/en active Pending
- 2016-03-25 EP EP16769818.2A patent/EP3274476B1/en active Active
- 2016-03-25 CN CN201680029396.XA patent/CN107614698A/zh active Pending
- 2016-03-25 ES ES16769818T patent/ES2954456T3/es active Active
- 2016-03-25 US US15/560,324 patent/US20180057889A1/en not_active Abandoned
-
2017
- 2017-09-24 IL IL254639A patent/IL254639B/en unknown
-
2020
- 2020-10-08 US US17/065,889 patent/US11898209B2/en active Active
-
2021
- 2021-01-28 JP JP2021012116A patent/JP7203128B2/ja active Active
-
2022
- 2022-09-15 AU AU2022231734A patent/AU2022231734A1/en not_active Abandoned
-
2023
- 2023-12-26 US US18/396,156 patent/US20240132969A1/en active Pending
Patent Citations (2)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20120252015A1 (en) * | 2011-02-18 | 2012-10-04 | Bio-Rad Laboratories | Methods and compositions for detecting genetic material |
| WO2014028378A2 (en) * | 2012-08-13 | 2014-02-20 | The Regents Of The University Of California | Methods and systems for detecting biological components |
Also Published As
| Publication number | Publication date |
|---|---|
| US20180057889A1 (en) | 2018-03-01 |
| EP3274476A4 (en) | 2018-08-29 |
| JP2018513679A (ja) | 2018-05-31 |
| US20210189501A1 (en) | 2021-06-24 |
| WO2016154600A1 (en) | 2016-09-29 |
| CA2980562A1 (en) | 2016-09-29 |
| EP3274476A1 (en) | 2018-01-31 |
| JP2021087428A (ja) | 2021-06-10 |
| IL254639A0 (en) | 2017-11-30 |
| KR102502087B1 (ko) | 2023-02-20 |
| US11898209B2 (en) | 2024-02-13 |
| EP3274476B1 (en) | 2023-06-07 |
| CN107614698A (zh) | 2018-01-19 |
| JP7203128B2 (ja) | 2023-01-12 |
| AU2016238253A1 (en) | 2017-10-19 |
| HK1249553A1 (en) | 2018-11-02 |
| KR20170131516A (ko) | 2017-11-29 |
| AU2022231734A1 (en) | 2022-11-10 |
| US20240132969A1 (en) | 2024-04-25 |
| ES2954456T3 (es) | 2023-11-22 |
| JP7144934B2 (ja) | 2022-09-30 |
| AU2016238253B2 (en) | 2022-06-16 |
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