DK3142751T3 - Anti-B7-H1- og anti-CTLA-4-antistoffer til behandling af ikke-småcellet lungecancer - Google Patents

Anti-B7-H1- og anti-CTLA-4-antistoffer til behandling af ikke-småcellet lungecancer

Info

Publication number
DK3142751T3
DK3142751T3 DK15722195.3T DK15722195T DK3142751T3 DK 3142751 T3 DK3142751 T3 DK 3142751T3 DK 15722195 T DK15722195 T DK 15722195T DK 3142751 T3 DK3142751 T3 DK 3142751T3
Authority
DK
Denmark
Prior art keywords
ctla
antibodies
treatment
lung cancer
small cell
Prior art date
Application number
DK15722195.3T
Other languages
English (en)
Inventor
Rajesh Narwal
Paul Robbins
Joyson Karakunnel
Mohammed M Dar
Original Assignee
Medimmune Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Medimmune Ltd filed Critical Medimmune Ltd
Application granted granted Critical
Publication of DK3142751T3 publication Critical patent/DK3142751T3/da

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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/39558—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against tumor tissues, cells, antigens
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A61K39/39533—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals
    • A61K39/3955—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum against materials from animals against proteinaceous materials, e.g. enzymes, hormones, lymphokines
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2818—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against CD28 or CD152
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K39/395—Antibodies; Immunoglobulins; Immune serum, e.g. antilymphocytic serum
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A61P35/04—Antineoplastic agents specific for metastasis
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
    • C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
    • C07K16/28—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants
    • C07K16/2803—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily
    • C07K16/2827—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against receptors, cell surface antigens or cell surface determinants against the immunoglobulin superfamily against B7 molecules, e.g. CD80, CD86
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
    • A61K2039/507—Comprising a combination of two or more separate antibodies
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/54—Medicinal preparations containing antigens or antibodies characterised by the route of administration
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/545—Medicinal preparations containing antigens or antibodies characterised by the dose, timing or administration schedule
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K39/00—Medicinal preparations containing antigens or antibodies
    • A61K2039/58—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation
    • A61K2039/585—Medicinal preparations containing antigens or antibodies raising an immune response against a target which is not the antigen used for immunisation wherein the target is cancer
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/20—Immunoglobulins specific features characterized by taxonomic origin
    • C07K2317/21—Immunoglobulins specific features characterized by taxonomic origin from primates, e.g. man
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07K—PEPTIDES
    • C07K2317/00—Immunoglobulins specific features
    • C07K2317/90—Immunoglobulins specific features characterized by (pharmaco)kinetic aspects or by stability of the immunoglobulin
    • C07K2317/94—Stability, e.g. half-life, pH, temperature or enzyme-resistance

Landscapes

  • Health & Medical Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Immunology (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Organic Chemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Animal Behavior & Ethology (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Biophysics (AREA)
  • Biochemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Molecular Biology (AREA)
  • Genetics & Genomics (AREA)
  • General Chemical & Material Sciences (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Epidemiology (AREA)
  • Microbiology (AREA)
  • Mycology (AREA)
  • Oncology (AREA)
  • Endocrinology (AREA)
  • Biomedical Technology (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
  • Peptides Or Proteins (AREA)
  • Micro-Organisms Or Cultivation Processes Thereof (AREA)
  • Preparation Of Compounds By Using Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
DK15722195.3T 2014-05-13 2015-05-12 Anti-B7-H1- og anti-CTLA-4-antistoffer til behandling af ikke-småcellet lungecancer DK3142751T3 (da)

Applications Claiming Priority (4)

Application Number Priority Date Filing Date Title
US201461992658P 2014-05-13 2014-05-13
US201562105992P 2015-01-21 2015-01-21
US201562114336P 2015-02-10 2015-02-10
PCT/EP2015/060523 WO2015173267A1 (en) 2014-05-13 2015-05-12 Anti-b7-h1 and anti-ctla-4 antibodies for treating non-small cell lung cancer

Publications (1)

Publication Number Publication Date
DK3142751T3 true DK3142751T3 (da) 2019-10-14

Family

ID=53175516

Family Applications (1)

Application Number Title Priority Date Filing Date
DK15722195.3T DK3142751T3 (da) 2014-05-13 2015-05-12 Anti-B7-H1- og anti-CTLA-4-antistoffer til behandling af ikke-småcellet lungecancer

Country Status (26)

Country Link
US (3) US10232040B2 (da)
EP (2) EP3603748A1 (da)
JP (4) JP6648038B2 (da)
KR (4) KR20210149870A (da)
CN (2) CN113230398A (da)
AU (3) AU2015260962B2 (da)
BR (2) BR112016026197A2 (da)
CA (1) CA2947471A1 (da)
CY (1) CY1122642T1 (da)
DK (1) DK3142751T3 (da)
ES (1) ES2749098T3 (da)
GB (1) GB2531094A (da)
HR (1) HRP20191449T1 (da)
HU (1) HUE045965T2 (da)
IL (2) IL248528B (da)
LT (1) LT3142751T (da)
ME (1) ME03493B (da)
MX (1) MX2016014189A (da)
PL (1) PL3142751T3 (da)
PT (1) PT3142751T (da)
RS (1) RS59134B1 (da)
RU (1) RU2702332C2 (da)
SG (2) SG10201810108PA (da)
SI (1) SI3142751T1 (da)
TW (3) TW202123967A (da)
WO (1) WO2015173267A1 (da)

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HUE045965T2 (hu) 2020-01-28
RU2016148645A (ru) 2018-06-19
KR102333658B1 (ko) 2021-12-01
US10232040B2 (en) 2019-03-19
LT3142751T (lt) 2019-09-25
CA2947471A1 (en) 2015-11-19
ME03493B (me) 2020-01-20
AU2015260962A1 (en) 2016-11-24
ES2749098T3 (es) 2020-03-19
US20190240324A1 (en) 2019-08-08
CN113230398A (zh) 2021-08-10
US11446377B2 (en) 2022-09-20
KR20220162844A (ko) 2022-12-08
IL248528B (en) 2020-08-31
IL248528A0 (en) 2016-12-29
TWI707692B (zh) 2020-10-21
CN106456756A (zh) 2017-02-22
KR20230165876A (ko) 2023-12-05
RU2702332C2 (ru) 2019-10-08
HRP20191449T1 (hr) 2019-11-15
GB201508097D0 (en) 2015-06-24
JP2023052607A (ja) 2023-04-11
KR20210149870A (ko) 2021-12-09
RU2019129614A3 (da) 2021-12-27
EP3142751A1 (en) 2017-03-22
SG10201810108PA (en) 2018-12-28
SI3142751T1 (sl) 2019-09-30
JP2020090509A (ja) 2020-06-11
JP6648038B2 (ja) 2020-02-14
IL276481B (en) 2022-06-01
PL3142751T3 (pl) 2019-12-31
CN106456756B (zh) 2021-04-23
BR112016026197A2 (pt) 2018-02-20
IL276481A (en) 2020-09-30
AU2023204286A1 (en) 2023-07-27
PT3142751T (pt) 2019-10-25
TWI780994B (zh) 2022-10-11
RU2019129614A (ru) 2020-07-16
CY1122642T1 (el) 2021-03-12
SG11201609285SA (en) 2016-12-29
EP3142751B1 (en) 2019-08-07
AU2015260962B2 (en) 2020-06-11
US20150328311A1 (en) 2015-11-19
TW201545759A (zh) 2015-12-16
BR122023025321A2 (pt) 2024-02-20
AU2020230309A1 (en) 2020-10-01
RS59134B1 (sr) 2019-09-30
TW202123967A (zh) 2021-07-01
AU2020230309B2 (en) 2023-04-20
JP2021098734A (ja) 2021-07-01
EP3603748A1 (en) 2020-02-05
RU2016148645A3 (da) 2018-12-21
JP2017520520A (ja) 2017-07-27
US20230115328A1 (en) 2023-04-13
TW202233239A (zh) 2022-09-01
MX2016014189A (es) 2017-05-04
WO2015173267A1 (en) 2015-11-19
GB2531094A (en) 2016-04-13
KR20170003575A (ko) 2017-01-09

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