JP2015514751A5 - - Google Patents
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- Publication number
- JP2015514751A5 JP2015514751A5 JP2015506529A JP2015506529A JP2015514751A5 JP 2015514751 A5 JP2015514751 A5 JP 2015514751A5 JP 2015506529 A JP2015506529 A JP 2015506529A JP 2015506529 A JP2015506529 A JP 2015506529A JP 2015514751 A5 JP2015514751 A5 JP 2015514751A5
- Authority
- JP
- Japan
- Prior art keywords
- salt
- soluble drug
- measured
- quinolin
- thiophen
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000003839 salts Chemical class 0.000 claims 29
- 239000000203 mixture Substances 0.000 claims 17
- 229940079593 drug Drugs 0.000 claims 16
- 239000003814 drug Substances 0.000 claims 16
- CEUORZQYGODEFX-UHFFFAOYSA-N Aripirazole Chemical compound ClC1=CC=CC(N2CCN(CCCCOC=3C=C4NC(=O)CCC4=CC=3)CC2)=C1Cl CEUORZQYGODEFX-UHFFFAOYSA-N 0.000 claims 10
- 229960004372 aripiprazole Drugs 0.000 claims 10
- ZKIAIYBUSXZPLP-UHFFFAOYSA-N brexpiprazole Chemical compound C1=C2NC(=O)C=CC2=CC=C1OCCCCN(CC1)CCN1C1=CC=CC2=C1C=CS2 ZKIAIYBUSXZPLP-UHFFFAOYSA-N 0.000 claims 10
- 239000000375 suspending agent Substances 0.000 claims 10
- 229920002134 Carboxymethyl cellulose Polymers 0.000 claims 9
- 235000010948 carboxy methyl cellulose Nutrition 0.000 claims 9
- 239000001768 carboxy methyl cellulose Substances 0.000 claims 9
- 239000008112 carboxymethyl-cellulose Substances 0.000 claims 9
- 238000002360 preparation method Methods 0.000 claims 9
- 239000011164 primary particle Substances 0.000 claims 9
- ZIBGPFATKBEMQZ-UHFFFAOYSA-N triethylene glycol Chemical compound OCCOCCOCCO ZIBGPFATKBEMQZ-UHFFFAOYSA-N 0.000 claims 9
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Substances O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 6
- 239000007972 injectable composition Substances 0.000 claims 5
- 238000002347 injection Methods 0.000 claims 5
- 239000007924 injection Substances 0.000 claims 5
- 241001137251 Corvidae Species 0.000 claims 3
- 239000003795 chemical substances by application Substances 0.000 claims 3
- 239000002612 dispersion medium Substances 0.000 claims 3
- 229940071643 prefilled syringe Drugs 0.000 claims 3
- 239000000499 gel Substances 0.000 claims 2
- 239000007788 liquid Substances 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 239000011163 secondary particle Substances 0.000 claims 2
- 208000020925 Bipolar disease Diseases 0.000 claims 1
- 239000011259 mixed solution Substances 0.000 claims 1
- 210000003205 muscle Anatomy 0.000 claims 1
- 230000002265 prevention Effects 0.000 claims 1
- 201000000980 schizophrenia Diseases 0.000 claims 1
- 238000013268 sustained release Methods 0.000 claims 1
- 239000012730 sustained-release form Substances 0.000 claims 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261636938P | 2012-04-23 | 2012-04-23 | |
| US61/636,938 | 2012-04-23 | ||
| US201361792089P | 2013-03-15 | 2013-03-15 | |
| US61/792,089 | 2013-03-15 | ||
| PCT/JP2013/062683 WO2013162048A1 (en) | 2012-04-23 | 2013-04-23 | Injectable preparation |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017206658A Division JP6470378B2 (ja) | 2012-04-23 | 2017-10-25 | 注射製剤 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2015514751A JP2015514751A (ja) | 2015-05-21 |
| JP2015514751A5 true JP2015514751A5 (OSRAM) | 2016-06-09 |
| JP6234996B2 JP6234996B2 (ja) | 2017-11-22 |
Family
ID=48614096
Family Applications (7)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2015506529A Active JP6234996B2 (ja) | 2012-04-23 | 2013-04-23 | 注射製剤 |
| JP2017206658A Active JP6470378B2 (ja) | 2012-04-23 | 2017-10-25 | 注射製剤 |
| JP2019005031A Pending JP2019070028A (ja) | 2012-04-23 | 2019-01-16 | 注射製剤 |
| JP2020172902A Pending JP2021008512A (ja) | 2012-04-23 | 2020-10-14 | 注射製剤 |
| JP2022004098A Active JP7293412B2 (ja) | 2012-04-23 | 2022-01-14 | 注射製剤 |
| JP2023092924A Active JP7612758B2 (ja) | 2012-04-23 | 2023-06-06 | 注射製剤 |
| JP2024226861A Pending JP2025041805A (ja) | 2012-04-23 | 2024-12-24 | 注射製剤 |
Family Applications After (6)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2017206658A Active JP6470378B2 (ja) | 2012-04-23 | 2017-10-25 | 注射製剤 |
| JP2019005031A Pending JP2019070028A (ja) | 2012-04-23 | 2019-01-16 | 注射製剤 |
| JP2020172902A Pending JP2021008512A (ja) | 2012-04-23 | 2020-10-14 | 注射製剤 |
| JP2022004098A Active JP7293412B2 (ja) | 2012-04-23 | 2022-01-14 | 注射製剤 |
| JP2023092924A Active JP7612758B2 (ja) | 2012-04-23 | 2023-06-06 | 注射製剤 |
| JP2024226861A Pending JP2025041805A (ja) | 2012-04-23 | 2024-12-24 | 注射製剤 |
Country Status (31)
| Country | Link |
|---|---|
| US (9) | US20150093442A1 (OSRAM) |
| EP (2) | EP2841054B2 (OSRAM) |
| JP (7) | JP6234996B2 (OSRAM) |
| KR (4) | KR20240068788A (OSRAM) |
| CN (3) | CN104470499B (OSRAM) |
| AR (1) | AR090776A1 (OSRAM) |
| AU (6) | AU2013253374B2 (OSRAM) |
| BR (1) | BR112014026307B1 (OSRAM) |
| CA (2) | CA2869889C (OSRAM) |
| CO (1) | CO7151500A2 (OSRAM) |
| CY (1) | CY1122252T1 (OSRAM) |
| DK (1) | DK2841054T4 (OSRAM) |
| EA (1) | EA026619B1 (OSRAM) |
| ES (1) | ES2743706T5 (OSRAM) |
| HR (1) | HRP20191366T4 (OSRAM) |
| HU (1) | HUE045979T2 (OSRAM) |
| IL (1) | IL235299B (OSRAM) |
| JO (2) | JOP20200109A1 (OSRAM) |
| LT (1) | LT2841054T (OSRAM) |
| MX (2) | MX387891B (OSRAM) |
| MY (3) | MY198007A (OSRAM) |
| NZ (1) | NZ630335A (OSRAM) |
| PH (2) | PH12014502379B1 (OSRAM) |
| PL (1) | PL2841054T5 (OSRAM) |
| PT (1) | PT2841054T (OSRAM) |
| SG (3) | SG10201913425VA (OSRAM) |
| SI (1) | SI2841054T2 (OSRAM) |
| TW (6) | TW202313036A (OSRAM) |
| UA (1) | UA115444C2 (OSRAM) |
| WO (1) | WO2013162048A1 (OSRAM) |
| ZA (1) | ZA201407335B (OSRAM) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| AR090775A1 (es) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| CN105461703B (zh) * | 2014-12-29 | 2019-05-17 | 深圳市泛谷药业股份有限公司 | 一种brexpiprazole的制备方法 |
| JP6513461B2 (ja) * | 2015-04-14 | 2019-05-15 | 帝國製薬株式会社 | ブレクスピプラゾールの経皮吸収製剤 |
| CN104829603A (zh) * | 2015-05-19 | 2015-08-12 | 杭州新博思生物医药有限公司 | A晶型依匹唑派盐酸盐及其制备方法 |
| US10501450B2 (en) | 2016-02-01 | 2019-12-10 | Hexal Ag | Anhydrate-free polymorphically pure micronized crystalline brexpiprazole di-hydrate for use in intramuscular injectable sustained release formulations |
| JP6901571B2 (ja) * | 2017-01-26 | 2021-07-14 | 四川瀛瑞医薬科技有限公司Ｓｉｃｈｕａｎ Ｙｉｎｇｒｕｉ Ｐｈａｒｍａｃｅｕｔｉｃａｌ Ｔｅｃｈｎｏｌｏｇｙ Ｃｏｍｐａｎｙ | ナノ炭素−鉄複合システム及びその組成物、調製方法並びに使用 |
| US10987303B2 (en) | 2018-05-02 | 2021-04-27 | LifeMax Laboratories, Inc. | Extended release suspension formulation of lurasidone |
| WO2020089942A2 (en) * | 2018-11-02 | 2020-05-07 | Amaterasu Lifesciences Llp | A liquid injectable composition |
| WO2021199076A1 (en) * | 2020-03-30 | 2021-10-07 | Cipla Limited | Injectable aripiprazole formulation |
| CA3163321C (en) * | 2020-04-01 | 2023-12-19 | Otsuka Pharmaceutical Co., Ltd. | Methods for dose initiation of aripiprazole treatments |
| US20230372317A1 (en) * | 2020-10-27 | 2023-11-23 | Pts Consulting, Llc | A liquid injectable composition of donepezil |
| US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
| US11910794B2 (en) * | 2021-03-08 | 2024-02-27 | Monsanto Technology Llc | Solutions and methods for long-term pollen storage |
| WO2023067664A1 (ja) * | 2021-10-18 | 2023-04-27 | 大塚製薬株式会社 | ベンゾチオフェン化合物の新規結晶形及びその製造方法 |
| JP7760615B2 (ja) * | 2022-06-16 | 2025-10-27 | ウィズダム・ファーマスーティカル・カンパニー・リミテッド | 薬物組成物及びブレクスピプラゾール口腔内溶解フィルム |
| CN115969785A (zh) * | 2022-12-30 | 2023-04-18 | 辰欣药业股份有限公司 | 一种阿立哌唑注射剂及其制备方法 |
| WO2024194955A1 (en) * | 2023-03-17 | 2024-09-26 | Otsuka Pharmaceutical Co., Ltd. | Methods of dispersing aripiprazole injectable preparations |
| WO2024225441A1 (en) | 2023-04-26 | 2024-10-31 | Otsuka Pharmaceutical Co., Ltd. | Dose initiation for schizophrenia or bipolar i disorder treatment with aripiprazole |
| WO2025051282A1 (zh) * | 2023-09-08 | 2025-03-13 | 广州玻思韬控释药业有限公司 | 注射用凝胶 |
| WO2025183016A1 (ja) * | 2024-02-26 | 2025-09-04 | 大塚製薬株式会社 | Ｑｕａｂｏｄｅｐｉｓｔａｔ含有組成物 |
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| JO3753B1 (ar) | 2011-10-14 | 2021-01-31 | Otsuka Pharma Co Ltd | قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه |
| TWI679977B (zh) | 2011-10-19 | 2019-12-21 | 大塚製藥股份有限公司 | 口服溶液 |
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| AR090245A1 (es) | 2012-03-06 | 2014-10-29 | Otsuka Pharma Co Ltd | Preparacion solida oral de liberacion sostenida, metodo de preparacion |
| AR090775A1 (es) | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| TWI562991B (en) | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
-
2012
- 2012-04-23 JO JOP/2020/0109A patent/JOP20200109A1/ar unknown
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2013
- 2013-04-22 AR ARP130101321A patent/AR090776A1/es not_active Application Discontinuation
- 2013-04-23 KR KR1020247015029A patent/KR20240068788A/ko not_active Ceased
- 2013-04-23 HR HRP20191366TT patent/HRP20191366T4/hr unknown
- 2013-04-23 SG SG10201913425VA patent/SG10201913425VA/en unknown
- 2013-04-23 CN CN201380021440.9A patent/CN104470499B/zh active Active
- 2013-04-23 EP EP13728542.5A patent/EP2841054B2/en active Active
- 2013-04-23 SG SG11201406451SA patent/SG11201406451SA/en unknown
- 2013-04-23 ES ES13728542T patent/ES2743706T5/es active Active
- 2013-04-23 LT LTEP13728542.5T patent/LT2841054T/lt unknown
- 2013-04-23 TW TW111116460A patent/TW202313036A/zh unknown
- 2013-04-23 AU AU2013253374A patent/AU2013253374B2/en active Active
- 2013-04-23 US US14/396,380 patent/US20150093442A1/en not_active Abandoned
- 2013-04-23 CA CA2869889A patent/CA2869889C/en active Active
- 2013-04-23 MX MX2018010879A patent/MX387891B/es unknown
- 2013-04-23 TW TW107109282A patent/TWI713826B/zh active
- 2013-04-23 SI SI201331550T patent/SI2841054T2/sl unknown
- 2013-04-23 PT PT13728542T patent/PT2841054T/pt unknown
- 2013-04-23 KR KR1020207015451A patent/KR102498075B1/ko active Active
- 2013-04-23 EA EA201491685A patent/EA026619B1/ru not_active IP Right Cessation
- 2013-04-23 TW TW102114410A patent/TWI637752B/zh active
- 2013-04-23 DK DK13728542.5T patent/DK2841054T4/da active
- 2013-04-23 KR KR1020147032714A patent/KR102138852B1/ko active Active
- 2013-04-23 BR BR112014026307-8A patent/BR112014026307B1/pt active IP Right Grant
- 2013-04-23 SG SG10201608753UA patent/SG10201608753UA/en unknown
- 2013-04-23 CN CN201810143716.5A patent/CN108186556B/zh active Active
- 2013-04-23 MY MYPI2018001894A patent/MY198007A/en unknown
- 2013-04-23 MX MX2014012811A patent/MX359241B/es active IP Right Grant
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