MX359241B - Preparación inyectable que comprende una composición en gel que comprende aripiprazol o brexpiprazol como agentes de suspensión. - Google Patents
Preparación inyectable que comprende una composición en gel que comprende aripiprazol o brexpiprazol como agentes de suspensión.Info
- Publication number
- MX359241B MX359241B MX2014012811A MX2014012811A MX359241B MX 359241 B MX359241 B MX 359241B MX 2014012811 A MX2014012811 A MX 2014012811A MX 2014012811 A MX2014012811 A MX 2014012811A MX 359241 B MX359241 B MX 359241B
- Authority
- MX
- Mexico
- Prior art keywords
- injectable preparation
- composition
- present
- pascal
- viscosity
- Prior art date
Links
- 238000002360 preparation method Methods 0.000 title abstract 4
- 239000000203 mixture Substances 0.000 abstract 3
- 239000002612 dispersion medium Substances 0.000 abstract 2
- 229940079593 drug Drugs 0.000 abstract 2
- 239000003814 drug Substances 0.000 abstract 2
- 239000004480 active ingredient Substances 0.000 abstract 1
- 229940071643 prefilled syringe Drugs 0.000 abstract 1
- 239000000375 suspending agent Substances 0.000 abstract 1
Classifications
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/32—Macromolecular compounds obtained by reactions only involving carbon-to-carbon unsaturated bonds, e.g. carbomers, poly(meth)acrylates, or polyvinyl pyrrolidone
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K31/00—Medicinal preparations containing organic active ingredients
- A61K31/33—Heterocyclic compounds
- A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
- A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
- A61K31/496—Non-condensed piperazines containing further heterocyclic rings, e.g. rifampin, thiothixene or sparfloxacin
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/06—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite
- A61K47/08—Organic compounds, e.g. natural or synthetic hydrocarbons, polyolefins, mineral oil, petrolatum or ozokerite containing oxygen, e.g. ethers, acetals, ketones, quinones, aldehydes, peroxides
- A61K47/10—Alcohols; Phenols; Salts thereof, e.g. glycerol; Polyethylene glycols [PEG]; Poloxamers; PEG/POE alkyl ethers
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K47/00—Medicinal preparations characterised by the non-active ingredients used, e.g. carriers or inert additives; Targeting or modifying agents chemically bound to the active ingredient
- A61K47/30—Macromolecular organic or inorganic compounds, e.g. inorganic polyphosphates
- A61K47/36—Polysaccharides; Derivatives thereof, e.g. gums, starch, alginate, dextrin, hyaluronic acid, chitosan, inulin, agar or pectin
- A61K47/38—Cellulose; Derivatives thereof
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/06—Ointments; Bases therefor; Other semi-solid forms, e.g. creams, sticks, gels
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/10—Dispersions; Emulsions
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/18—Antipsychotics, i.e. neuroleptics; Drugs for mania or schizophrenia
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P25/00—Drugs for disorders of the nervous system
- A61P25/24—Antidepressants
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K9/00—Medicinal preparations characterised by special physical form
- A61K9/0012—Galenical forms characterised by the site of application
- A61K9/0019—Injectable compositions; Intramuscular, intravenous, arterial, subcutaneous administration; Compositions to be administered through the skin in an invasive manner
- A61K9/0024—Solid, semi-solid or solidifying implants, which are implanted or injected in body tissue
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Medicinal Chemistry (AREA)
- Pharmacology & Pharmacy (AREA)
- Life Sciences & Earth Sciences (AREA)
- Animal Behavior & Ethology (AREA)
- General Health & Medical Sciences (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Epidemiology (AREA)
- Engineering & Computer Science (AREA)
- General Chemical & Material Sciences (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Inorganic Chemistry (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Oil, Petroleum & Natural Gas (AREA)
- Dermatology (AREA)
- Neurosurgery (AREA)
- Biomedical Technology (AREA)
- Neurology (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- Organic Chemistry (AREA)
- Psychiatry (AREA)
- Dispersion Chemistry (AREA)
- Pain & Pain Management (AREA)
- Medicinal Preparation (AREA)
- Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
- Infusion, Injection, And Reservoir Apparatuses (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Abstract
Un objeto de la presente invención es brindar una preparación inyectable estable durante el almacenamiento que comprende una composición que comprende un fármaco poco soluble como ingrediente activo, y que además comprende un medio de dispersión. Otro objeto de la presente invención es brindar una jeringa prellenada compacta, liviana mediante el envasado de la preparación inyectable en una jeringa. La presente invención proporciona una preparación inyectable que comprende una composición que comprende un fármaco poco soluble, un medio de dispersión y un agente de suspensión específico, la composición tiene una viscosidad de 40 Pas o más en, al menos, un punto en el rango de velocidad de corte que oscila entre 0.01 y 0.02 s-1 y tiene una viscosidad de 0.2 Pas o inferior, en al menos un punto en el rango de velocidad de corte que oscila entre 900 y 1,000 s-1, como se ha medido.
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US201261636938P | 2012-04-23 | 2012-04-23 | |
| US201361792089P | 2013-03-15 | 2013-03-15 | |
| PCT/JP2013/062683 WO2013162048A1 (en) | 2012-04-23 | 2013-04-23 | Injectable preparation |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| MX2014012811A MX2014012811A (es) | 2015-05-07 |
| MX359241B true MX359241B (es) | 2018-09-20 |
Family
ID=48614096
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018010879A MX387891B (es) | 2012-04-23 | 2013-04-23 | Preparación inyectable que comprende una composición en gel de aripiprazol y polinilpirrolidona como agente de suspensión y el uso de la misma para tratar esquizofrenia, trastorno bipolar o depresión |
| MX2014012811A MX359241B (es) | 2012-04-23 | 2013-04-23 | Preparación inyectable que comprende una composición en gel que comprende aripiprazol o brexpiprazol como agentes de suspensión. |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| MX2018010879A MX387891B (es) | 2012-04-23 | 2013-04-23 | Preparación inyectable que comprende una composición en gel de aripiprazol y polinilpirrolidona como agente de suspensión y el uso de la misma para tratar esquizofrenia, trastorno bipolar o depresión |
Country Status (31)
| Country | Link |
|---|---|
| US (9) | US20150093442A1 (es) |
| EP (2) | EP2841054B2 (es) |
| JP (7) | JP6234996B2 (es) |
| KR (4) | KR102138852B1 (es) |
| CN (3) | CN108186556B (es) |
| AR (1) | AR090776A1 (es) |
| AU (6) | AU2013253374B2 (es) |
| BR (1) | BR112014026307B1 (es) |
| CA (2) | CA2869889C (es) |
| CO (1) | CO7151500A2 (es) |
| CY (1) | CY1122252T1 (es) |
| DK (1) | DK2841054T4 (es) |
| EA (1) | EA026619B1 (es) |
| ES (1) | ES2743706T5 (es) |
| HR (1) | HRP20191366T4 (es) |
| HU (1) | HUE045979T2 (es) |
| IL (1) | IL235299B (es) |
| JO (2) | JOP20200109A1 (es) |
| LT (1) | LT2841054T (es) |
| MX (2) | MX387891B (es) |
| MY (3) | MY198007A (es) |
| NZ (1) | NZ630335A (es) |
| PH (2) | PH12014502379A1 (es) |
| PL (1) | PL2841054T5 (es) |
| PT (1) | PT2841054T (es) |
| SG (3) | SG10201608753UA (es) |
| SI (1) | SI2841054T2 (es) |
| TW (6) | TWI713826B (es) |
| UA (1) | UA115444C2 (es) |
| WO (1) | WO2013162048A1 (es) |
| ZA (1) | ZA201407335B (es) |
Families Citing this family (22)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| TWI562991B (en) * | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
| AR090775A1 (es) * | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| CN105461703B (zh) * | 2014-12-29 | 2019-05-17 | 深圳市泛谷药业股份有限公司 | 一种brexpiprazole的制备方法 |
| JP6513461B2 (ja) * | 2015-04-14 | 2019-05-15 | 帝國製薬株式会社 | ブレクスピプラゾールの経皮吸収製剤 |
| CN104829603A (zh) * | 2015-05-19 | 2015-08-12 | 杭州新博思生物医药有限公司 | A晶型依匹唑派盐酸盐及其制备方法 |
| WO2017134038A1 (en) * | 2016-02-01 | 2017-08-10 | Hexal Ag | Anhydrate-free polymorphically pure micronized crystalline brexpiprazole dihydrate for use in intramuscular injectable sustained release formulations |
| WO2018137708A1 (zh) * | 2017-01-26 | 2018-08-02 | 重庆莱美药业股份有限公司 | 一种纳米炭-铁复合体系及其组合物、制备方法和用途 |
| US10987303B2 (en) | 2018-05-02 | 2021-04-27 | LifeMax Laboratories, Inc. | Extended release suspension formulation of lurasidone |
| WO2020089942A2 (en) * | 2018-11-02 | 2020-05-07 | Amaterasu Lifesciences Llp | A liquid injectable composition |
| US20230310417A1 (en) * | 2020-03-30 | 2023-10-05 | Cipla Limited | Injectable aripiprazole formulation |
| CA3212191A1 (en) * | 2020-04-01 | 2021-10-07 | Otsuka Pharmaceutical Co., Ltd. | Methods for dose initiation of aripiprazole treatments |
| US20230372317A1 (en) * | 2020-10-27 | 2023-11-23 | Pts Consulting, Llc | A liquid injectable composition of donepezil |
| US11229644B1 (en) * | 2020-12-31 | 2022-01-25 | Lake O'hara Llc | Methods of treating psychiatric disorders in obese patients with brexpiprazole |
| US11910794B2 (en) * | 2021-03-08 | 2024-02-27 | Monsanto Technology Llc | Solutions and methods for long-term pollen storage |
| WO2023067664A1 (ja) * | 2021-10-18 | 2023-04-27 | 大塚製薬株式会社 | ベンゾチオフェン化合物の新規結晶形及びその製造方法 |
| US20250090476A1 (en) * | 2022-06-16 | 2025-03-20 | Wisdom Pharmaceutical Co., Ltd. | Pharmaceutical composition and brexpiprazole orally soluable film |
| CN115969785A (zh) * | 2022-12-30 | 2023-04-18 | 辰欣药业股份有限公司 | 一种阿立哌唑注射剂及其制备方法 |
| WO2024194955A1 (en) * | 2023-03-17 | 2024-09-26 | Otsuka Pharmaceutical Co., Ltd. | Methods of dispersing aripiprazole injectable preparations |
| CN120957722A (zh) | 2023-04-26 | 2025-11-14 | 大塚制药株式会社 | 用阿立哌唑治疗精神分裂症或i型双相障碍的剂量启动 |
| WO2025051281A1 (zh) * | 2023-09-08 | 2025-03-13 | 广州玻思韬控释药业有限公司 | 注射用依匹哌唑凝胶 |
| WO2025183016A1 (ja) * | 2024-02-26 | 2025-09-04 | 大塚製薬株式会社 | Ｑｕａｂｏｄｅｐｉｓｔａｔ含有組成物 |
Family Cites Families (62)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| GB864100A (en) * | 1957-04-09 | 1961-03-29 | Pfizer & Co C | Therapeutic pencillin compositions and the preparation thereof |
| JPS5913714A (ja) | 1982-07-13 | 1984-01-24 | Taito Pfizer Kk | 外用消炎鎮痛剤 |
| US5006528A (en) | 1988-10-31 | 1991-04-09 | Otsuka Pharmaceutical Co., Ltd. | Carbostyril derivatives |
| US5192802A (en) | 1991-09-25 | 1993-03-09 | Mcneil-Ppc, Inc. | Bioadhesive pharmaceutical carrier |
| JP4012994B2 (ja) | 1996-05-08 | 2007-11-28 | 大塚製薬株式会社 | 抗不安薬 |
| US20020076437A1 (en) | 2000-04-12 | 2002-06-20 | Sanjeev Kothari | Flashmelt oral dosage formulation |
| US6495164B1 (en) | 2000-05-25 | 2002-12-17 | Alkermes Controlled Therapeutics, Inc. I | Preparation of injectable suspensions having improved injectability |
| AR032641A1 (es) | 2001-01-29 | 2003-11-19 | Otsuka Pharma Co Ltd | Agonista de subtipo de receptor 5-ht 1a. |
| MY129350A (en) | 2001-04-25 | 2007-03-30 | Bristol Myers Squibb Co | Aripiprazole oral solution |
| PE20030445A1 (es) * | 2001-09-25 | 2003-07-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| AR033485A1 (es) | 2001-09-25 | 2003-12-26 | Otsuka Pharma Co Ltd | Sustancia medicinal de aripiprazol de baja higroscopicidad y proceso para la preparacion de la misma |
| JP2003171264A (ja) * | 2001-12-07 | 2003-06-17 | Taiyo Yakuhin Kogyo Kk | マイクロカプセル及びその製造方法 |
| JP2003238393A (ja) | 2002-02-15 | 2003-08-27 | Otsuka Pharmaceut Co Ltd | 施錠性が改善された錠剤及びその製造方法 |
| UA79984C2 (en) | 2002-08-20 | 2007-08-10 | Bristol Myers Squibb Co | Preparation on the basis of aripiprazole complex and use thereof |
| RU2356554C2 (ru) | 2002-12-27 | 2009-05-27 | Оцука Фармасьютикал Ко., Лтд. | Производные карбостирила и ингибиторы обратного захвата серотонина для лечения эмоциональных расстройств |
| DK1480953T4 (da) | 2003-01-09 | 2010-11-15 | Otsuka Pharma Co Ltd | Fremgangsmåde til fremstilling af aripiprazol |
| WO2004064752A2 (en) | 2003-01-22 | 2004-08-05 | Alkermes Controlled Therapeutics, Inc. | Method of preparing sustained release microparticles |
| CA2523484A1 (en) * | 2003-05-02 | 2004-11-11 | Rimon Therapeutics Ltd. | Thermally reversible implant |
| DK1626721T3 (en) | 2003-05-23 | 2017-01-23 | Otsuka Pharma Co Ltd | CARBOSTYRIL DERIVATIVES AND Mood Stabilizers for the Treatment of Mood Disorders |
| US6987111B2 (en) | 2003-08-06 | 2006-01-17 | Alkermes Controlled Therapeutics, Ii | Aripiprazole, olanzapine and haloperidol pamoate salts |
| US20050032811A1 (en) | 2003-08-06 | 2005-02-10 | Josiah Brown | Methods for administering aripiprazole |
| AU2004285448C1 (en) | 2003-10-23 | 2021-08-19 | Otsuka Pharmaceutical Co., Ltd. | Controlled release sterile injectable aripiprazole formulation and method |
| TWI371274B (en) | 2003-10-23 | 2012-09-01 | Bristol Myers Squibb Co | Process for making sterile aripiprazole of desired mean particle size |
| ATE424816T1 (de) | 2003-10-27 | 2009-03-15 | Dow Corning | Zubereitungen für die topische anwendung und verfahren zur abgabe eines wirkstoffs an ein substrat |
| CA2553254C (en) * | 2004-01-12 | 2013-12-17 | The Trustees Of The University Of Pennsylvania | Long-term delivery formulations and methods of use thereof |
| JP2006219380A (ja) * | 2005-02-08 | 2006-08-24 | Minofuaagen Seiyaku:Kk | グリチルリチン皮下注射製剤 |
| TWI320783B (en) | 2005-04-14 | 2010-02-21 | Otsuka Pharma Co Ltd | Heterocyclic compound |
| EP1933814A2 (en) | 2005-09-15 | 2008-06-25 | Elan Pharma International Limited | Nanoparticulate aripiprazole formulations |
| CA2629300C (en) | 2005-11-17 | 2014-07-08 | Zogenix, Inc. | Delivery of viscous formulations by needle-free injection |
| JP4373983B2 (ja) | 2006-01-27 | 2009-11-25 | 三菱電機インフォメーションシステムズ株式会社 | 流通経路管理装置及び流通経路管理プログラム |
| GB0618879D0 (en) * | 2006-09-26 | 2006-11-01 | Zysis Ltd | Pharmaceutical compositions |
| AU2007303794A1 (en) * | 2006-10-05 | 2008-04-10 | Panacea Biotec Ltd. | Injectable depot composition and its' process of preparation |
| JP4540700B2 (ja) | 2006-10-13 | 2010-09-08 | 大塚製薬株式会社 | 医薬 |
| KR101141185B1 (ko) | 2007-01-26 | 2012-07-12 | 오쓰까 세이야꾸 가부시키가이샤 | 치료의 제안된 효능 검출용 마커 |
| WO2009001697A2 (en) | 2007-06-25 | 2008-12-31 | Otsuka Pharmaceutical Co., Ltd. | Microspheres having core/shell structure |
| JP4879349B2 (ja) * | 2007-07-31 | 2012-02-22 | 大塚製薬株式会社 | アリピプラゾール懸濁液及び凍結乾燥製剤の製造方法 |
| EP2185112A4 (en) * | 2007-08-21 | 2012-01-18 | Harbor Biosciences Inc | Stabilized therapeutic compositions and formulations |
| JP2011136906A (ja) * | 2008-04-18 | 2011-07-14 | Otsuka Pharmaceut Co Ltd | 複素環化合物 |
| JP2009286740A (ja) | 2008-05-30 | 2009-12-10 | Otsuka Pharmaceut Co Ltd | アリピプラゾールを含有する逆耐性抑制剤 |
| TR200809200A1 (tr) | 2008-12-01 | 2009-12-21 | Sanovel �La� Sanay� Ve T�Caret Anon�M ��Rket� | Meloksikam içeren farmasötik formülasyonlar |
| WO2010138539A2 (en) | 2009-05-27 | 2010-12-02 | Elan Pharma International Ltd. | Reduction of flake-like aggregation in nanoparticulate active agent compositions |
| RU2555760C2 (ru) | 2009-09-11 | 2015-07-10 | Оцука Фармасьютикал Ко., Лтд. | Терапевтический агент против хронической боли |
| NZ603076A (en) * | 2010-08-24 | 2014-12-24 | Otsuka Pharma Co Ltd | Suspension and cake composition containing carbostyril derivative and silicone oil and/or silicone oil derivative |
| WO2012053654A1 (en) * | 2010-10-18 | 2012-04-26 | Dainippon Sumitomo Pharma Co., Ltd. | Sustained-release formulation for injection |
| AR083884A1 (es) | 2010-11-16 | 2013-03-27 | Otsuka Pharma Co Ltd | Jeringa prellenable de doble camara y relleno de aripiprazol en la jeringa |
| JP2012121850A (ja) | 2010-12-09 | 2012-06-28 | Otsuka Pharmaceut Co Ltd | アリピプラゾールの経口速溶性組成物 |
| ES2884825T3 (es) | 2011-01-24 | 2021-12-13 | Otsuka Pharma Co Ltd | Dispositivo médico que contiene una composición de torta que comprende aripiprazol como principio activo y composición de torta que comprende aripiprazol como principio activo |
| JOP20120083B1 (ar) | 2011-04-05 | 2021-08-17 | Otsuka Pharma Co Ltd | توليفات تشتمل على بريكس ببرازول أو ملح منه وعقار ثاني للاستخدام في علاج اضطراب cns |
| JP2012232958A (ja) † | 2011-05-09 | 2012-11-29 | Otsuka Pharmaceut Co Ltd | 注射製剤 |
| JO3410B1 (ar) | 2011-06-07 | 2019-10-20 | Otsuka Pharma Co Ltd | تركيبة أريبيبرازول مجفف بالتبريد |
| JP6034377B2 (ja) | 2011-06-27 | 2016-11-30 | シャンハイ チョンシ ファーマシューティカル コーポレイション | アリピプラゾール医薬製剤及びその調製方法 |
| TW201309651A (zh) | 2011-06-29 | 2013-03-01 | Otsuka Pharma Co Ltd | 阿立哌唑（ａｒｉｐｉｐｒａｚｏｌｅ）無水物Ｂ形結晶微粒子之製造方法 |
| EP2736894B1 (en) | 2011-07-28 | 2016-08-31 | Otsuka Pharmaceutical Co., Ltd. | Method for producing benzo[b] thiophene compounds |
| JO3227B1 (ar) | 2011-09-08 | 2018-03-08 | Otsuka Pharma Co Ltd | مشتقات بنزو ثيوفين بها استبدال ببرازين كعوامل مضادة للذهان |
| JO3753B1 (ar) | 2011-10-14 | 2021-01-31 | Otsuka Pharma Co Ltd | قرص يتألف من 7-[4-(4-بينزو[بي]ثيوفين-4-ايل-ببرازين-1-1ايل)بوتكسيل]-1اتش-كوينولين-2-وان أو ملح منه |
| TWI679977B (zh) | 2011-10-19 | 2019-12-21 | 大塚製藥股份有限公司 | 口服溶液 |
| TW201332572A (zh) | 2011-12-28 | 2013-08-16 | Otsuka Pharma Co Ltd | 具有經取代的β－環糊精之藥物製劑 |
| JP2013139441A (ja) | 2011-12-28 | 2013-07-18 | Otsuka Pharmaceut Co Ltd | マイクロスフェア |
| AR090245A1 (es) | 2012-03-06 | 2014-10-29 | Otsuka Pharma Co Ltd | Preparacion solida oral de liberacion sostenida, metodo de preparacion |
| JOP20200109A1 (ar) | 2012-04-23 | 2017-06-16 | Otsuka Pharma Co Ltd | مستحضر قابل للحقن |
| AR090775A1 (es) | 2012-04-23 | 2014-12-03 | Otsuka Pharma Co Ltd | Preparado inyectable |
| TWI562991B (en) | 2012-04-23 | 2016-12-21 | Otsuka Pharma Co Ltd | Dihydrate of benzothiophene compound or of a salt thereof, and process for producing the same |
-
2012
- 2012-04-23 JO JOP/2020/0109A patent/JOP20200109A1/ar unknown
-
2013
- 2013-04-22 AR ARP130101321A patent/AR090776A1/es not_active Application Discontinuation
- 2013-04-23 JP JP2015506529A patent/JP6234996B2/ja active Active
- 2013-04-23 SG SG10201608753UA patent/SG10201608753UA/en unknown
- 2013-04-23 SG SG10201913425VA patent/SG10201913425VA/en unknown
- 2013-04-23 TW TW107109282A patent/TWI713826B/zh active
- 2013-04-23 CA CA2869889A patent/CA2869889C/en active Active
- 2013-04-23 TW TW109130917A patent/TW202126303A/zh unknown
- 2013-04-23 HR HRP20191366TT patent/HRP20191366T4/hr unknown
- 2013-04-23 SI SI201331550T patent/SI2841054T2/sl unknown
- 2013-04-23 UA UAA201411954A patent/UA115444C2/uk unknown
- 2013-04-23 ES ES13728542T patent/ES2743706T5/es active Active
- 2013-04-23 CN CN201810143716.5A patent/CN108186556B/zh active Active
- 2013-04-23 SG SG11201406451SA patent/SG11201406451SA/en unknown
- 2013-04-23 PT PT13728542T patent/PT2841054T/pt unknown
- 2013-04-23 CN CN202210169142.5A patent/CN114344259B/zh active Active
- 2013-04-23 BR BR112014026307-8A patent/BR112014026307B1/pt active IP Right Grant
- 2013-04-23 CN CN201380021440.9A patent/CN104470499B/zh active Active
- 2013-04-23 HU HUE13728542A patent/HUE045979T2/hu unknown
- 2013-04-23 MX MX2018010879A patent/MX387891B/es unknown
- 2013-04-23 AU AU2013253374A patent/AU2013253374B2/en active Active
- 2013-04-23 MY MYPI2018001894A patent/MY198007A/en unknown
- 2013-04-23 KR KR1020147032714A patent/KR102138852B1/ko active Active
- 2013-04-23 TW TW102114410A patent/TWI637752B/zh active
- 2013-04-23 US US14/396,380 patent/US20150093442A1/en not_active Abandoned
- 2013-04-23 MX MX2014012811A patent/MX359241B/es active IP Right Grant
- 2013-04-23 DK DK13728542.5T patent/DK2841054T4/da active
- 2013-04-23 KR KR1020207015451A patent/KR102498075B1/ko active Active
- 2013-04-23 PL PL13728542.5T patent/PL2841054T5/pl unknown
- 2013-04-23 TW TW112130297A patent/TW202425992A/zh unknown
- 2013-04-23 EP EP13728542.5A patent/EP2841054B2/en active Active
- 2013-04-23 TW TW111116460A patent/TW202313036A/zh unknown
- 2013-04-23 JO JOP/2013/0116A patent/JO3632B1/ar active
- 2013-04-23 KR KR1020247015029A patent/KR20240068788A/ko not_active Ceased
- 2013-04-23 CA CA3120297A patent/CA3120297A1/en active Pending
- 2013-04-23 EA EA201491685A patent/EA026619B1/ru not_active IP Right Cessation
- 2013-04-23 WO PCT/JP2013/062683 patent/WO2013162048A1/en not_active Ceased
- 2013-04-23 LT LTEP13728542.5T patent/LT2841054T/lt unknown
- 2013-04-23 EP EP19169193.0A patent/EP3539534A1/en active Pending
- 2013-04-23 TW TW113144877A patent/TW202535396A/zh unknown
- 2013-04-23 MY MYPI2014002932A patent/MY178573A/en unknown
- 2013-04-23 MY MYPI2023004225A patent/MY210484A/en unknown
- 2013-04-23 KR KR1020217029406A patent/KR20210116702A/ko not_active Ceased
- 2013-04-23 NZ NZ630335A patent/NZ630335A/en unknown
-
2014
- 2014-10-09 ZA ZA2014/07335A patent/ZA201407335B/en unknown
- 2014-10-23 PH PH12014502379A patent/PH12014502379A1/en unknown
- 2014-10-23 IL IL235299A patent/IL235299B/en active IP Right Grant
- 2014-11-21 CO CO14256422A patent/CO7151500A2/es unknown
-
2017
- 2017-09-11 US US15/701,202 patent/US20180055941A1/en not_active Abandoned
- 2017-09-14 AU AU2017228608A patent/AU2017228608C1/en active Active
- 2017-10-25 JP JP2017206658A patent/JP6470378B2/ja active Active
-
2018
- 2018-10-10 US US16/156,958 patent/US10517951B2/en active Active
-
2019
- 2019-01-07 AU AU2019200060A patent/AU2019200060A1/en not_active Abandoned
- 2019-01-16 JP JP2019005031A patent/JP2019070028A/ja active Pending
- 2019-03-07 PH PH12019500498A patent/PH12019500498A1/en unknown
- 2019-07-17 US US16/514,973 patent/US20190336607A1/en not_active Abandoned
- 2019-08-28 CY CY20191100912T patent/CY1122252T1/el unknown
-
2020
- 2020-02-07 US US16/785,268 patent/US20200179517A1/en not_active Abandoned
- 2020-06-24 AU AU2020204200A patent/AU2020204200B2/en active Active
- 2020-10-14 JP JP2020172902A patent/JP2021008512A/ja active Pending
- 2020-12-01 US US17/108,939 patent/US11097007B2/en active Active
-
2021
- 2021-08-04 US US17/444,469 patent/US11638757B2/en active Active
-
2022
- 2022-01-14 JP JP2022004098A patent/JP7293412B2/ja active Active
- 2022-09-27 AU AU2022241491A patent/AU2022241491B2/en active Active
- 2022-12-30 US US18/148,860 patent/US12016927B2/en active Active
-
2023
- 2023-06-06 JP JP2023092924A patent/JP7612758B2/ja active Active
-
2024
- 2024-05-13 US US18/662,049 patent/US20250121065A1/en active Pending
- 2024-12-24 JP JP2024226861A patent/JP2025041805A/ja active Pending
-
2025
- 2025-01-13 AU AU2025200229A patent/AU2025200229A1/en active Pending
Also Published As
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| PH12019500498A1 (en) | Injectable preparation | |
| MY161022A (en) | Dexmedetomidine premix formulation | |
| SG196810A1 (en) | Controlled release pharmaceutical or foodformulation and process for its preparation | |
| JO2944B1 (en) | Long-acting formulations of insulin | |
| MX2013002932A (es) | Formulaciones agricolas liquidas de estabilidad mejorada. | |
| BR112015017246A8 (pt) | composição farmacêutica aquosa, seu uso e seringa | |
| EA201590805A1 (ru) | Композиция с немедленным и пролонгированным высвобождением | |
| JO3508B1 (ar) | جهاز طبي محتوي على تركيبة عجينة مشتملة على أريببرازول كمكون فعال وتركيبة عجينة مشتملة على أريببرازول كمكون فعال | |
| MX2016005395A (es) | Formulacion estable de insulina glulisina. | |
| MX385093B (es) | Formulaciones de espuma y aparatos para su suministro. | |
| MX2017000764A (es) | Formulacion acuosa que comprende paracetamol e ibuprofeno. | |
| MX2016001422A (es) | Composicion farmaceutica de fingolimod. | |
| MX346467B (es) | Una composicion que comprende por lo menos un alginato para el uso en el tratamiento y/o prevencion de sobrepeso. | |
| MX2015015075A (es) | Dispositivo de administracion de farmaco y metodo de ensamblaje del mismo. | |
| MX2021015921A (es) | Preparacion inyectable. | |
| PH12013500727A1 (en) | Sustained-release pharmaceutical composition | |
| LV15003A (lv) | Farmaceitiska kompozīcija ķermeņa masas pieauguma kontrolei | |
| EA027609B9 (ru) | Способ получения интерферона бета-1альфа и фармацевтическая композиция, содержащая интерферон бета-1альфа | |
| IN2013CH01615A (es) | ||
| TH157429A (th) | สารเตรียมชนิดฉีดได้ | |
| MY187672A (en) | Pharmaceutical preparation for anaesthetic use and associated preparation process | |
| GR1008039B (el) | Σταθερο ενεσιμο φαρμακευτικο σκευασμα ενος αγωνιστη των υποδοχεων της βιταμινης d και μεθοδος για την παρασκευη αυτου | |
| BR112015022000A8 (pt) | preparação de combinação farmacêutica, composição farmacêutica e uso da preparação de combinação | |
| PL414785A1 (pl) | Kwas 3-dodecylosulfanylomasłowy do zastosowania jako lek, zwłaszcza do zapobiegania rozwojowi insulinooporności oraz kompozycja farmaceutyczna zawierająca kwas 3-dodecylosulfanylomasłowy jako substancję czynną |
Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| FG | Grant or registration |