JP2013535952A5 - - Google Patents

Download PDF

Info

Publication number
JP2013535952A5
JP2013535952A5 JP2013509230A JP2013509230A JP2013535952A5 JP 2013535952 A5 JP2013535952 A5 JP 2013535952A5 JP 2013509230 A JP2013509230 A JP 2013509230A JP 2013509230 A JP2013509230 A JP 2013509230A JP 2013535952 A5 JP2013535952 A5 JP 2013535952A5
Authority
JP
Japan
Prior art keywords
sequence
seq
light chain
heavy chain
chain
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Granted
Application number
JP2013509230A
Other languages
English (en)
Japanese (ja)
Other versions
JP6008842B2 (ja
JP2013535952A (ja
Filing date
Publication date
Application filed filed Critical
Priority claimed from PCT/US2011/035231 external-priority patent/WO2011140249A2/en
Publication of JP2013535952A publication Critical patent/JP2013535952A/ja
Publication of JP2013535952A5 publication Critical patent/JP2013535952A5/ja
Application granted granted Critical
Publication of JP6008842B2 publication Critical patent/JP6008842B2/ja
Active legal-status Critical Current
Anticipated expiration legal-status Critical

Links

JP2013509230A 2010-05-04 2011-05-04 Csf1rに結合する抗体 Active JP6008842B2 (ja)

Applications Claiming Priority (3)

Application Number Priority Date Filing Date Title
US33117710P 2010-05-04 2010-05-04
US61/331,177 2010-05-04
PCT/US2011/035231 WO2011140249A2 (en) 2010-05-04 2011-05-04 Antibodies that bind csf1r

Related Child Applications (1)

Application Number Title Priority Date Filing Date
JP2016071180A Division JP6196347B2 (ja) 2010-05-04 2016-03-31 Csf1rに結合する抗体

Publications (3)

Publication Number Publication Date
JP2013535952A JP2013535952A (ja) 2013-09-19
JP2013535952A5 true JP2013535952A5 (he) 2014-04-10
JP6008842B2 JP6008842B2 (ja) 2016-10-19

Family

ID=44902080

Family Applications (6)

Application Number Title Priority Date Filing Date
JP2013509230A Active JP6008842B2 (ja) 2010-05-04 2011-05-04 Csf1rに結合する抗体
JP2016071180A Active JP6196347B2 (ja) 2010-05-04 2016-03-31 Csf1rに結合する抗体
JP2017157498A Active JP6529552B2 (ja) 2010-05-04 2017-08-17 Csf1rに結合する抗体
JP2019091364A Pending JP2019180413A (ja) 2010-05-04 2019-05-14 Csf1rに結合する抗体
JP2021149042A Withdrawn JP2022008382A (ja) 2010-05-04 2021-09-14 Csf1rに結合する抗体
JP2023132563A Withdrawn JP2023144055A (ja) 2010-05-04 2023-08-16 Csf1rに結合する抗体

Family Applications After (5)

Application Number Title Priority Date Filing Date
JP2016071180A Active JP6196347B2 (ja) 2010-05-04 2016-03-31 Csf1rに結合する抗体
JP2017157498A Active JP6529552B2 (ja) 2010-05-04 2017-08-17 Csf1rに結合する抗体
JP2019091364A Pending JP2019180413A (ja) 2010-05-04 2019-05-14 Csf1rに結合する抗体
JP2021149042A Withdrawn JP2022008382A (ja) 2010-05-04 2021-09-14 Csf1rに結合する抗体
JP2023132563A Withdrawn JP2023144055A (ja) 2010-05-04 2023-08-16 Csf1rに結合する抗体

Country Status (26)

Country Link
US (8) US8206715B2 (he)
EP (3) EP2566517B1 (he)
JP (6) JP6008842B2 (he)
KR (3) KR20200044999A (he)
CN (4) CN103179985B (he)
AU (4) AU2011248083B2 (he)
BR (1) BR112012027994B1 (he)
CA (1) CA2797399C (he)
CY (1) CY1121102T1 (he)
DK (1) DK2566517T3 (he)
EA (1) EA036336B1 (he)
ES (2) ES2706412T3 (he)
HR (1) HRP20190047T1 (he)
HU (1) HUE042898T2 (he)
IL (3) IL222629B (he)
LT (1) LT2566517T (he)
MX (2) MX355418B (he)
NZ (3) NZ626610A (he)
PL (1) PL2566517T3 (he)
PT (1) PT2566517T (he)
RS (1) RS58211B1 (he)
SG (3) SG10201604798SA (he)
SI (1) SI2566517T1 (he)
TR (1) TR201900368T4 (he)
TW (5) TWI713942B (he)
WO (1) WO2011140249A2 (he)

Families Citing this family (247)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2009539403A (ja) 2006-06-13 2009-11-19 オンコメッド ファーマシューティカルズ インコーポレイテッド 癌を診断および処置するための組成物および方法
JP5618544B2 (ja) 2007-01-24 2014-11-05 オンコメッドファーマシューティカルズ インコーポレイテッド 癌の診断および処置のための組成物および方法
SI2307051T1 (sl) 2008-07-08 2015-04-30 Oncomed Pharmaceuticals, Inc. Notch-vezavna sredstva in antagonisti ter postopki njihove uporabe
PE20121398A1 (es) 2009-12-10 2012-10-26 Hoffmann La Roche Anticuerpos ligantes preferentemente al dominio extracelular 4 de csf1r humano
US10626399B2 (en) 2010-01-28 2020-04-21 The Board Of Trustees Of The Leland Stanford Junior University Methods of treating cognitive symptoms of an aging-associated impairment by modulating C-C chemokine receptor type 3 (CCR3)
US20160208011A1 (en) 2010-01-28 2016-07-21 The Board Of Trustees Of The Leland Stanford Junior University Ccr3 modulation in the treatment of aging-associated impairments, and compositions for practicing the same
US10487148B2 (en) 2010-01-28 2019-11-26 The Board Of Trustees Of The Leland Stanford Junior University Methods and compositions for treating aging-associated impairments
CN102918060B (zh) 2010-03-05 2016-04-06 霍夫曼-拉罗奇有限公司 抗人csf-1r抗体及其用途
CA2789071C (en) 2010-03-05 2018-03-27 F. Hoffmann-La Roche Ag Antibodies against human csf-1r and uses thereof
SI2566517T1 (sl) 2010-05-04 2019-01-31 Five Prime Therapeutics, Inc. Protitelesa, ki vežejo CSF1R
US9161968B2 (en) 2011-04-08 2015-10-20 The Board Of Trustees Of The Leland Stanford Junior University Methods of neuroprotection involving macrophage colony stimulating factor receptor agonists
CA2841013C (en) 2011-07-18 2020-04-21 Morphosys Ag Use of c-fms antagonists
WO2013059885A2 (en) 2011-10-28 2013-05-02 Cephalon Australia Pty Ltd Polypeptide constructs and uses thereof
MX356337B (es) * 2011-12-15 2018-05-23 Hoffmann La Roche Anticuerpos contra csf-1r humano y sus usos.
JP6416630B2 (ja) * 2012-02-06 2018-10-31 ジェネンテック, インコーポレイテッド Csf1r阻害剤を用いるための組成物及び方法
US9708601B2 (en) 2012-04-26 2017-07-18 Vaccinex, Inc. Fusion proteins to facilitate selection of cells infected with specific immunoglobulin gene recombinant vaccinia virus
AU2015264860B2 (en) * 2012-05-11 2017-03-02 Five Prime Therapeutics, Inc. Method of treating conditions with antibodies that bind colony stimulating factor 1 receptor (CSF1R)
US20130302322A1 (en) * 2012-05-11 2013-11-14 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
RU2670743C9 (ru) * 2012-05-11 2018-12-19 Файв Прайм Терапьютикс, Инк. Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
US20140079699A1 (en) * 2012-08-31 2014-03-20 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
RS57120B1 (sr) * 2012-10-03 2018-06-29 Chiome Bioscience Inc Anti-humano dlk-1 antitelo koje ima in vivo aktivnost protiv tumora
AU2014222509A1 (en) * 2013-02-28 2015-10-01 University Court Of The University Of Edinburgh CSF1 therapeutics
CA2907973A1 (en) 2013-04-12 2014-10-16 Morphosys Ag Antibodies targeting m-csf
AR095882A1 (es) 2013-04-22 2015-11-18 Hoffmann La Roche Terapia de combinación de anticuerpos contra csf-1r humano con un agonista de tlr9
GB201315487D0 (en) * 2013-08-30 2013-10-16 Ucb Pharma Sa Antibodies
AR097584A1 (es) 2013-09-12 2016-03-23 Hoffmann La Roche Terapia de combinación de anticuerpos contra el csf-1r humano y anticuerpos contra el pd-l1 humano
US10905779B2 (en) 2013-12-09 2021-02-02 The Board Of Trustees Of The Leland Stanford Junior University Methods for screening human blood products comprising plasma using immunocompromised rodent models
CN106163530A (zh) 2013-12-09 2016-11-23 小利兰·斯坦福大学托管委员会 用于治疗衰老相关病症的方法和组合物
DK3466949T3 (da) 2013-12-24 2021-03-15 Bristol Myers Squibb Co Tricyklisk forbindelse som anticancermidler
US20170023576A1 (en) * 2014-04-04 2017-01-26 Oncomed Pharmaceuticals, Inc. Notch3 antibodies and uses thereof
HUE047385T2 (hu) 2014-06-06 2020-04-28 Bristol Myers Squibb Co Antitestek glükokortikoid indukált tumornekrózis faktor receptor (GITR) ellen és annak felhasználásai
WO2015188085A1 (en) 2014-06-06 2015-12-10 Flexus Biosciences, Inc. Immunoregulatory agents
MX2016016664A (es) * 2014-06-23 2017-03-20 Five Prime Therapeutics Inc Metodos para tratar condiciones con anticuerpos que enlazan al receptor de factor 1 estimulador de colonias (csf1r).
AU2015339306B2 (en) 2014-10-29 2021-07-22 Bristol-Myers Squibb Company Combination therapy for cancer
AR102537A1 (es) 2014-11-05 2017-03-08 Flexus Biosciences Inc Agentes inmunomoduladores
CA2964276A1 (en) 2014-11-05 2016-05-12 Flexus Biosciences, Inc. Immunoregulatory agents
UY36390A (es) 2014-11-05 2016-06-01 Flexus Biosciences Inc Compuestos moduladores de la enzima indolamina 2,3-dioxigenasa (ido), sus métodos de síntesis y composiciones farmacéuticas que los contienen
TWI758928B (zh) 2014-11-21 2022-03-21 美商必治妥美雅史谷比公司 抗cd73抗體及其用途
CN107257806B (zh) * 2014-12-22 2021-08-10 戊瑞治疗有限公司 用于治疗pvns的抗csf1r抗体
AR103232A1 (es) 2014-12-22 2017-04-26 Bristol Myers Squibb Co ANTAGONISTAS DE TGFbR
JP6180663B2 (ja) 2014-12-23 2017-08-16 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company Tigitに対する抗体
US10983128B2 (en) 2015-02-05 2021-04-20 Bristol-Myers Squibb Company CXCL11 and SMICA as predictive biomarkers for efficacy of anti-CTLA4 immunotherapy
SG11201705484WA (en) * 2015-02-09 2017-08-30 Ucb Biopharma Sprl Pharmaceutical formulation
EP3265454B1 (en) 2015-03-02 2020-02-26 Rigel Pharmaceuticals, Inc. Tgf-beta inhibitors
JP2018516238A (ja) 2015-04-03 2018-06-21 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company 癌の治療のためのインドールアミン−2,3−ジオキシゲナーゼの阻害剤およびそれらの使用方法
WO2016162505A1 (en) 2015-04-08 2016-10-13 F-Star Biotechnology Limited Her2 binding agent therapies
HUE053903T2 (hu) 2015-04-13 2021-07-28 Five Prime Therapeutics Inc Kombinációs terápia rák ellen
EP3294736B1 (en) 2015-05-11 2020-07-22 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
US9725449B2 (en) 2015-05-12 2017-08-08 Bristol-Myers Squibb Company Tricyclic compounds as anticancer agents
US10174024B2 (en) 2015-05-12 2019-01-08 Bristol-Myers Squibb Company 5H-pyrido[3,2-B]indole compounds as anticancer agents
EP3303390A1 (en) * 2015-05-27 2018-04-11 UCB Biopharma SPRL Method for the treatment of neurological disease
WO2016196228A1 (en) 2015-05-29 2016-12-08 Bristol-Myers Squibb Company Antibodies against ox40 and uses thereof
CN113855804A (zh) 2015-06-15 2021-12-31 小利兰·斯坦福大学托管委员会 用于治疗衰老相关病症的方法和组合物
JP6621252B2 (ja) * 2015-06-17 2019-12-18 国立大学法人北海道大学 治療耐性がんに対する治療耐性低減剤
WO2017004016A1 (en) 2015-06-29 2017-01-05 The Rockefeller University Antibodies to cd40 with enhanced agonist activity
US10399987B2 (en) 2015-07-28 2019-09-03 Bristol-Myer Squibb Company TGF beta receptor antagonists
EP3341372A1 (en) 2015-08-25 2018-07-04 Bristol-Myers Squibb Company Tgf beta receptor antagonists
KR20180054701A (ko) * 2015-09-16 2018-05-24 아블렉시스, 엘엘씨 항-cd115 항체
US10584160B2 (en) 2015-09-23 2020-03-10 Bristol-Myers Squibb Company Glypican-3-binding fibronectin based scaffold molecules
WO2017087678A2 (en) 2015-11-19 2017-05-26 Bristol-Myers Squibb Company Antibodies against glucocorticoid-induced tumor necrosis factor receptor (gitr) and uses thereof
KR20180094036A (ko) 2015-12-15 2018-08-22 브리스톨-마이어스 스큅 컴퍼니 Cxcr4 수용체 길항제
SG10201913033UA (en) 2016-03-04 2020-03-30 Bristol Myers Squibb Co Combination therapy with anti-cd73 antibodies
WO2017184619A2 (en) 2016-04-18 2017-10-26 Celldex Therapeutics, Inc. Agonistic antibodies that bind human cd40 and uses thereof
EP3995141B1 (en) 2016-04-28 2024-01-03 Alkahest, Inc. Plasma fractions as therapy for thymic cancer
JP2019519485A (ja) 2016-05-04 2019-07-11 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company インドールアミン2,3−ジオキシゲナーゼ阻害剤およびその使用方法
KR20190004743A (ko) 2016-05-04 2019-01-14 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
CN109414421A (zh) 2016-05-04 2019-03-01 百时美施贵宝公司 吲哚胺2,3-双加氧酶的抑制剂及其使用方法
CN109348714A (zh) 2016-05-04 2019-02-15 百时美施贵宝公司 吲哚胺2,3-双加氧酶的抑制剂及其使用方法
KR20190004742A (ko) 2016-05-04 2019-01-14 브리스톨-마이어스 스큅 컴퍼니 인돌아민 2,3-디옥시게나제의 억제제 및 그의 사용 방법
US11623958B2 (en) 2016-05-20 2023-04-11 Harpoon Therapeutics, Inc. Single chain variable fragment CD3 binding proteins
US10994033B2 (en) 2016-06-01 2021-05-04 Bristol-Myers Squibb Company Imaging methods using 18F-radiolabeled biologics
RU2756236C2 (ru) 2016-06-20 2021-09-28 Кимаб Лимитед PD-L1 специфические антитела
PE20190418A1 (es) 2016-07-14 2019-03-19 Bristol Myers Squibb Co Anticuerpos contra proteina 3 que contiene el dominio de mucina e inmunoglobulina de linfocitos t (tim3) y sus usos
US20190292179A1 (en) 2016-07-21 2019-09-26 Bristol-Myers Squibb Company TGF Beta RECEPTOR ANTAGONISTS
JP7128177B2 (ja) 2016-08-02 2022-08-30 バクシネックス インコーポレーティッド ワクシニアウイルス/真核細胞においてポリヌクレオチドライブラリを生成するための改善された方法
EP3504239B1 (en) 2016-08-25 2024-05-29 F. Hoffmann-La Roche AG Intermittent dosing of an anti-csf-1r antibody in combination with macrophage activating agent
EP3503916A1 (en) 2016-08-26 2019-07-03 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
JP2019528301A (ja) 2016-08-26 2019-10-10 ブリストル−マイヤーズ スクイブ カンパニーBristol−Myers Squibb Company インドールアミン2,3−ジオキシゲナーゼの阻害剤およびその使用方法
EA039316B1 (ru) 2016-10-24 2022-01-12 Алкахест, Инк. Фракции плазмы крови в качестве лечения когнитивных расстройств, связанных со старением
US10660909B2 (en) 2016-11-17 2020-05-26 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists
WO2018115051A1 (en) 2016-12-22 2018-06-28 F. Hoffmann-La Roche Ag Treatment of tumors with an anti-csf-1r antibody in combination with an anti-pd-l1 antibody after failure of anti-pd-l1/pd1 treatment
WO2018132279A1 (en) 2017-01-05 2018-07-19 Bristol-Myers Squibb Company Tgf beta receptor antagonists
US10399962B2 (en) 2017-01-20 2019-09-03 Arcus Biosciences, Inc. Azolopyrimidine for the treatment of cancer-related disorders
JP2017125040A (ja) * 2017-02-28 2017-07-20 ファイブ プライム セラピューティックス インコーポレイテッド コロニー刺激因子1受容体(csf1r)を結合させる抗体を用いて状態を治療する方法
CN110709101B (zh) * 2017-03-23 2024-05-07 宾夕法尼亚大学理事会 抗C5a抗体及其应用
WO2018183366A1 (en) 2017-03-28 2018-10-04 Syndax Pharmaceuticals, Inc. Combination therapies of csf-1r or csf-1 antibodies and a t-cell engaging therapy
CN110709420A (zh) * 2017-03-31 2020-01-17 戊瑞治疗有限公司 使用抗gitr抗体的癌症组合疗法
TWI788340B (zh) 2017-04-07 2023-01-01 美商必治妥美雅史谷比公司 抗icos促效劑抗體及其用途
AU2018256406A1 (en) 2017-04-19 2019-10-17 Marengo Therapeutics, Inc. Multispecific molecules and uses thereof
CA3059939A1 (en) 2017-04-21 2018-10-25 Kyn Therapeutics Indole ahr inhibitors and uses thereof
EP4299129A3 (en) 2017-04-26 2024-03-20 Alkahest, Inc. Dosing regimen for treatment of cognitive impairments with blood plasma products
US11040068B2 (en) 2017-04-26 2021-06-22 Alkahest, Inc. Dosing regimen for treatment of cognitive and motor impairments with blood plasma and blood plasma products
US11066392B2 (en) 2017-05-12 2021-07-20 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
JP7090347B2 (ja) 2017-05-12 2022-06-24 ハープーン セラピューティクス,インク. メソテリン結合タンパク質
WO2018213377A1 (en) 2017-05-17 2018-11-22 Arcus Biosciences, Inc. Quinazoline-pyrazole derivatives for the treatment of cancer-related disorders
JP2020520943A (ja) 2017-05-19 2020-07-16 シンダックス ファーマシューティカルズ, インコーポレイテッド 併用療法
WO2019006283A1 (en) 2017-06-30 2019-01-03 Bristol-Myers Squibb Company AMORPHOUS AND CRYSTALLINE FORMS OF IDO INHIBITORS
KR20200032180A (ko) 2017-07-28 2020-03-25 브리스톨-마이어스 스큅 컴퍼니 항암제로서의 시클릭 디뉴클레오티드
AU2018319016B2 (en) 2017-08-17 2023-08-31 Ikena Oncology, Inc. AHR inhibitors and uses thereof
SG11202000387YA (en) 2017-08-25 2020-03-30 Five Prime Therapeutics Inc B7-h4 antibodies and methods of use thereof
US11667663B2 (en) 2017-08-31 2023-06-06 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
ES2945140T3 (es) 2017-08-31 2023-06-28 Bristol Myers Squibb Co Dinucleótidos cíclicos como agentes anticancerosos
EP3676279B1 (en) 2017-08-31 2021-12-01 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
CA3073531A1 (en) * 2017-09-13 2019-03-21 Five Prime Therapeutics, Inc. Combination anti-csf1r and anti-pd-1 antibody combination therapy for pancreatic cancer
IL273432B (he) 2017-09-22 2022-09-01 Kymera Therapeutics Inc מפרקי חלבון ושימושים בהם
EP3684366A4 (en) 2017-09-22 2021-09-08 Kymera Therapeutics, Inc. CRBN LIGANDS AND USES OF THE LATEST
US11649212B2 (en) 2017-10-09 2023-05-16 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US11203592B2 (en) 2017-10-09 2021-12-21 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
KR20200061399A (ko) 2017-10-10 2020-06-02 브리스톨-마이어스 스큅 컴퍼니 항암제로서의 시클릭 디뉴클레오티드
WO2019075090A1 (en) 2017-10-10 2019-04-18 Tilos Therapeutics, Inc. ANTI-LAP ANTIBODIES AND USES THEREOF
AU2018346955A1 (en) 2017-10-13 2020-04-30 Harpoon Therapeutics, Inc. B cell maturation antigen binding proteins
US11427610B2 (en) 2017-10-16 2022-08-30 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
WO2019080889A1 (zh) * 2017-10-26 2019-05-02 江苏恒瑞医药股份有限公司 抗csf-1r抗体、其抗原结合片段及其医药用途
CN111542544A (zh) 2017-11-01 2020-08-14 百时美施贵宝公司 用于治疗癌症的免疫刺激性激动性抗体
ES2925450T3 (es) 2017-11-06 2022-10-18 Bristol Myers Squibb Co Compuestos de isofuranona útiles como inhibidores de HPK1
US20200377571A1 (en) 2017-12-08 2020-12-03 Elstar Therapeutics, Inc. Multispecific molecules and uses thereof
SG11202005912PA (en) 2017-12-26 2020-07-29 Kymera Therapeutics Inc Irak degraders and uses thereof
JP7284759B2 (ja) 2017-12-27 2023-05-31 ブリストル-マイヤーズ スクイブ カンパニー 抗cd40抗体およびその使用
US11447449B2 (en) 2018-01-05 2022-09-20 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US11485743B2 (en) 2018-01-12 2022-11-01 Kymera Therapeutics, Inc. Protein degraders and uses thereof
WO2019140387A1 (en) 2018-01-12 2019-07-18 Kymera Therapeutics, Inc. Crbn ligands and uses thereof
EP3737700A1 (en) 2018-01-12 2020-11-18 Bristol-Myers Squibb Company Antibodies against tim3 and uses thereof
CN108276495B (zh) * 2018-01-24 2022-03-18 博生吉医药科技(苏州)有限公司 靶向csf1r嵌合抗原受体修饰的nk92mi细胞和t细胞及其制法和应用
WO2019147982A1 (en) 2018-01-26 2019-08-01 Celldex Therapeutics, Inc. Methods of treating cancer with dendritic cell mobilizing agents
TWI816742B (zh) 2018-01-29 2023-10-01 美商維泰克斯製藥公司 Gcn2抑制劑及其用途
CN111867581B (zh) 2018-01-29 2023-12-26 默克专利股份有限公司 Gcn2抑制剂及其用途
US10519187B2 (en) 2018-02-13 2019-12-31 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
WO2019165315A1 (en) 2018-02-23 2019-08-29 Syntrix Biosystems Inc. Method for treating cancer using chemokine antagonists alone or in combination
GB201803226D0 (en) 2018-02-28 2018-04-11 Ultrahuman Twelve Ltd CSF1R Binding agents
EA202091810A1 (ru) 2018-03-02 2021-01-29 Файв Прайм Терапьютикс, Инк. Антитела к b7-h4 и способы их применения
US11945834B2 (en) 2018-03-08 2024-04-02 Bristol-Myers Squibb Company Cyclic dinucleotides as anticancer agents
JP2021518133A (ja) 2018-03-21 2021-08-02 ファイブ プライム セラピューティクス, インコーポレイテッド 酸性pHでVISTAに結合する抗体
CN111886256A (zh) 2018-03-23 2020-11-03 百时美施贵宝公司 抗mica和/或micb抗体及其用途
AU2019244091B2 (en) 2018-03-28 2023-12-07 Bristol-Myers Squibb Company Interleukin-2/Interleukin-2 receptor alpha fusion proteins and methods of use
MX2020010604A (es) 2018-04-12 2020-10-20 Bristol Myers Squibb Co Terapia de combinacion anticancer con anticuerpo antagonista del grupo de diferenciacion 73 (cd73) y anticuerpo antagonista del eje proteina de muerte programada 1 (pd-1)/ligando de muerte programada 1 (pd-l1).
AU2019255196A1 (en) 2018-04-16 2020-11-12 Arrys Therapeutics, Inc. EP4 inhibitors and use thereof
AU2019256460A1 (en) * 2018-04-19 2020-11-12 The Board Of Trustees Of The University Of Illinois Methods and compositions of inhibiting CSF1R for treating allergic inflammation
US20230339891A1 (en) 2018-05-03 2023-10-26 Bristol-Myers Squibb Company Uracil derivatives as mer-axl inhibitors
US11180531B2 (en) 2018-06-22 2021-11-23 Bicycletx Limited Bicyclic peptide ligands specific for Nectin-4
SI3814348T1 (sl) 2018-06-27 2023-10-30 Bristol-Myers Squibb Company Substituirane naftiridinonske spojine, uporabne kot aktivatorji t celic
EP3814347B1 (en) 2018-06-27 2023-05-03 Bristol-Myers Squibb Company Naphthyridinone compounds useful as t cell activators
WO2020010177A1 (en) 2018-07-06 2020-01-09 Kymera Therapeutics, Inc. Tricyclic crbn ligands and uses thereof
MX2021000009A (es) 2018-07-09 2021-03-09 Five Prime Therapeutics Inc Anticuerpos de union a transcripcion tipo inmunoglobulina 4 (ilt4).
US20220073617A1 (en) 2018-07-11 2022-03-10 Five Prime Therapeutics, Inc. Antibodies Binding to Vista at Acidic pH
CN108948199B (zh) * 2018-07-18 2019-06-21 博奥信生物技术(南京)有限公司 抗人csf-1r单克隆抗体及其用途
CN109053887B (zh) * 2018-07-18 2019-07-23 博奥信生物技术(南京)有限公司 一种抗人csf-1r单克隆抗体及用途
CN108948198B (zh) * 2018-07-18 2020-09-01 博奥信生物技术(南京)有限公司 抗人csf-1r单克隆抗体及其应用
US20210299126A1 (en) 2018-07-23 2021-09-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US20210355113A1 (en) 2018-07-23 2021-11-18 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
JP2021534101A (ja) 2018-08-09 2021-12-09 ヴェルソー セラピューティクス, インコーポレイテッド Ccr2及びcsf1rを標的とするためのオリゴヌクレオチド組成物ならびにその使用
US10959986B2 (en) 2018-08-29 2021-03-30 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
US11253525B2 (en) 2018-08-29 2022-02-22 Bristol-Myers Squibb Company Inhibitors of indoleamine 2,3-dioxygenase and methods of their use
EP3846793B1 (en) 2018-09-07 2024-01-24 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
JP7425049B2 (ja) 2018-09-25 2024-01-30 ハープーン セラピューティクス,インク. Dll3結合タンパク質および使用方法
CN113164777A (zh) 2018-09-27 2021-07-23 马伦戈治疗公司 Csf1r/ccr2多特异性抗体
CN113164780A (zh) 2018-10-10 2021-07-23 泰洛斯治疗公司 抗lap抗体变体及其用途
JP2022505915A (ja) 2018-10-26 2022-01-14 アルカヘスト,インコーポレイテッド 疼痛、創傷治癒及び術後回復の改善のための血漿及び血漿画分の使用
KR20210092769A (ko) 2018-11-16 2021-07-26 브리스톨-마이어스 스큅 컴퍼니 항-nkg2a 항체 및 그의 용도
US11352350B2 (en) 2018-11-30 2022-06-07 Kymera Therapeutics, Inc. IRAK degraders and uses thereof
US20220016168A1 (en) 2018-12-11 2022-01-20 Celldex Therapeutics, Inc. Methods of using cd27 antibodies as conditioning treatment for adoptive cell therapy
CN113301960A (zh) * 2018-12-13 2021-08-24 财团法人生物技术开发中心 抗人类csf-1r抗体和其用途
EP3670659A1 (en) 2018-12-20 2020-06-24 Abivax Biomarkers, and uses in treatment of viral infections, inflammations, or cancer
JP2019089840A (ja) * 2019-02-22 2019-06-13 ファイブ プライム セラピューティックス インコーポレイテッド コロニー刺激因子1受容体(csf1r)を結合させる抗体を用いて状態を治療する方法
AU2020242284A1 (en) 2019-03-19 2021-09-16 Fundació Privada Institut D'investigació Oncològica De Vall Hebron Combination therapy for the treatment of cancer
AU2020253990A1 (en) 2019-04-02 2021-10-28 Bicycletx Limited Bicycle toxin conjugates and uses thereof
MA55565A (fr) 2019-04-05 2022-02-09 Kymera Therapeutics Inc Agents de dégradation de stat et leurs utilisations
WO2020231766A1 (en) 2019-05-13 2020-11-19 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
US20230242478A1 (en) 2019-05-13 2023-08-03 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
US20220363760A1 (en) 2019-05-30 2022-11-17 Bristol-Myers Squibb Company Multi-tumor gene signature for suitability to immuno-oncology therapy
EP3976832A1 (en) 2019-05-30 2022-04-06 Bristol-Myers Squibb Company Methods of identifying a subject suitable for an immuno-oncology (i-o) therapy
EP3977132A1 (en) 2019-05-30 2022-04-06 Bristol-Myers Squibb Company Cell localization signature and combination therapy
CN114502540A (zh) 2019-05-31 2022-05-13 医肯纳肿瘤学公司 Tead抑制剂和其用途
CN112300277A (zh) * 2019-07-25 2021-02-02 苏州丁孚靶点生物技术有限公司 Csf1r抗体、基因、载体、宿主细胞和csf1r拮抗剂
WO2021024020A1 (en) 2019-08-06 2021-02-11 Astellas Pharma Inc. Combination therapy involving antibodies against claudin 18.2 and immune checkpoint inhibitors for treatment of cancer
US20220306630A1 (en) 2019-08-06 2022-09-29 Bristol-Myers Squibb Company AGONISTS OF ROR GAMMAt
AR119821A1 (es) 2019-08-28 2022-01-12 Bristol Myers Squibb Co Compuestos de piridopirimidinonilo sustituidos útiles como activadores de células t
MX2022002877A (es) 2019-09-13 2022-08-08 Nimbus Saturn Inc Antagonistas de cinasa progenitora hematopoyetica 1 (hpk1) y sus usos.
JP2022548292A (ja) 2019-09-19 2022-11-17 ブリストル-マイヤーズ スクイブ カンパニー 酸性pHでVISTAと結合する抗体
JP2022550069A (ja) 2019-09-26 2022-11-30 エフ.ホフマン-ラ ロシュ アーゲー 抗csf-1r抗体
US11548870B2 (en) 2019-11-19 2023-01-10 Bristol-Myers Squibb Company Compounds useful as inhibitors of helios protein
MX2022006308A (es) 2019-11-26 2022-06-22 Ikena Oncology Inc Derivados de carbazol polimorfos y usos de los mismos.
IL293357A (he) 2019-11-26 2022-07-01 Bristol Myers Squibb Co מלחים/קוריסטלים של (r)-n-(4-כלורופניל)-2-((1s,4s)-4-(6-fluoroquinolin-4-yl)cyclohexyl)propanamide
BR112022011651A2 (pt) 2019-12-17 2022-08-23 Kymera Therapeutics Inc Degradadores de irak e usos dos mesmos
EP4076524A4 (en) 2019-12-17 2023-11-29 Kymera Therapeutics, Inc. IRAQ DEGRADERS AND USES THEREOF
WO2021133752A1 (en) 2019-12-23 2021-07-01 Bristol-Myers Squibb Company Substituted heteroaryl compounds useful as t cell activators
CN115175907A (zh) 2019-12-23 2022-10-11 百时美施贵宝公司 可用作t细胞激活剂的经取代的哌嗪衍生物
TW202136242A (zh) 2019-12-23 2021-10-01 美商凱麥拉醫療公司 Smarca降解劑及其用途
EP4081516A1 (en) 2019-12-23 2022-11-02 Bristol-Myers Squibb Company Substituted quinazolinyl compounds useful as t cell activators
AR120823A1 (es) 2019-12-23 2022-03-23 Bristol Myers Squibb Co Compuestos bicíclicos sustituidos útiles como activadores de células t
WO2021133748A1 (en) 2019-12-23 2021-07-01 Bristol-Myers Squibb Company Substituted quinolinonyl piperazine compounds useful as t cell activators
KR20220117320A (ko) * 2019-12-24 2022-08-23 아다젠 (수저우) 리미티드 항 csf1r 분자 및 이의 용도
WO2021139682A1 (en) 2020-01-07 2021-07-15 Hifibio (Hk) Limited Anti-galectin-9 antibody and uses thereof
AU2021230289A1 (en) 2020-03-03 2022-09-29 PIC Therapeutics, Inc. eIF4E inhibitors and uses thereof
EP4118118A1 (en) 2020-03-09 2023-01-18 Bristol-Myers Squibb Company Antibodies to cd40 with enhanced agonist activity
IL295569A (he) 2020-03-19 2022-10-01 Arcus Biosciences Inc תרכובות טטרלין וטטרהידרוקינולין כמעכבות של hif-2alpha
JP2023518423A (ja) 2020-03-19 2023-05-01 カイメラ セラピューティクス, インコーポレイテッド Mdm2分解剤およびそれらの使用
TW202140441A (zh) 2020-03-23 2021-11-01 美商必治妥美雅史谷比公司 經取代之側氧基異吲哚啉化合物
US20230272056A1 (en) 2020-04-09 2023-08-31 Merck Sharp & Dohme Llc Affinity matured anti-lap antibodies and uses thereof
US20230192867A1 (en) 2020-05-15 2023-06-22 Bristol-Myers Squibb Company Antibodies to garp
MX2022015157A (es) 2020-06-02 2023-01-16 Arcus Biosciences Inc Anticuerpos para tigit.
TW202210483A (zh) 2020-06-03 2022-03-16 美商凱麥拉醫療公司 Irak降解劑之結晶型
AU2021292195A1 (en) 2020-06-17 2023-01-05 Arcus Biosciences, Inc. Crystalline forms of a CD73 inhibitor and uses thereof
JP2023532768A (ja) 2020-07-07 2023-07-31 バイオエヌテック エスエー Hpv陽性癌の治療用rna
US11857535B2 (en) 2020-07-30 2024-01-02 Kymera Therapeutics, Inc. Methods of treating mutant lymphomas
KR20230074721A (ko) 2020-08-17 2023-05-31 바이사이클티엑스 리미티드 Nectin-4에 특이적인 이환 콘쥬게이트 및 이의 용도
US20230303700A1 (en) 2020-08-31 2023-09-28 Bristol-Myers Squibb Company Cell localization signature and immunotherapy
IL303376A (he) 2020-12-02 2023-08-01 Ikena Oncology Inc מעכבי tead ושימושיהם
WO2022120353A1 (en) 2020-12-02 2022-06-09 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2022120179A1 (en) 2020-12-03 2022-06-09 Bristol-Myers Squibb Company Multi-tumor gene signatures and uses thereof
WO2022135666A1 (en) 2020-12-21 2022-06-30 BioNTech SE Treatment schedule for cytokine proteins
WO2022135667A1 (en) 2020-12-21 2022-06-30 BioNTech SE Therapeutic rna for treating cancer
TW202245808A (zh) 2020-12-21 2022-12-01 德商拜恩迪克公司 用於治療癌症之治療性rna
TW202241488A (zh) 2021-01-11 2022-11-01 英商拜斯科技技術開發有限公司 治療癌症之方法
MX2023009059A (es) 2021-02-02 2023-09-15 Liminal Biosciences Ltd Antagonistas de gpr84 y usos de estos.
AU2022216810A1 (en) 2021-02-02 2023-08-24 Liminal Biosciences Limited Gpr84 antagonists and uses thereof
US20240109899A1 (en) 2021-02-04 2024-04-04 Bristol-Myers Squibb Company Benzofuran compounds as sting agonists
KR20230145446A (ko) 2021-02-15 2023-10-17 카이메라 쎄라퓨틱스 인코포레이티드 Irak4 분해제 및 이의 용도
CN117295737A (zh) 2021-03-05 2023-12-26 林伯士萨顿公司 Hpk1拮抗剂和其用途
US11918582B2 (en) 2021-03-15 2024-03-05 Rapt Therapeutics, Inc. Pyrazole pyrimidine compounds and uses thereof
EP4314068A1 (en) 2021-04-02 2024-02-07 The Regents Of The University Of California Antibodies against cleaved cdcp1 and uses thereof
AU2022253450A1 (en) 2021-04-05 2023-11-16 Bristol-Myers Squibb Company Pyridinyl substituted oxoisoindoline compounds for the treatment of cancer
BR112023020077A2 (pt) 2021-04-06 2023-11-14 Bristol Myers Squibb Co Compostos de oxoisoindolina substituída por piridinila
EP4323066A1 (en) 2021-04-16 2024-02-21 Ikena Oncology, Inc. Mek inhibitors and uses thereof
TW202313602A (zh) 2021-05-21 2023-04-01 美商阿克思生物科學有限公司 Axl化合物
EP4341262A1 (en) 2021-05-21 2024-03-27 Arcus Biosciences, Inc. Axl inhibitor compounds
EP4370552A1 (en) 2021-07-13 2024-05-22 BioNTech SE Multispecific binding agents against cd40 and cd137 in combination therapy for cancer
WO2023028235A1 (en) 2021-08-25 2023-03-02 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
US20230134932A1 (en) 2021-08-25 2023-05-04 PIC Therapeutics, Inc. Eif4e inhibitors and uses thereof
TW202333802A (zh) 2021-10-11 2023-09-01 德商拜恩迪克公司 用於肺癌之治療性rna(二)
WO2023077046A1 (en) 2021-10-29 2023-05-04 Arcus Biosciences, Inc. Inhibitors of hif-2alpha and methods of use thereof
WO2023114984A1 (en) 2021-12-17 2023-06-22 Ikena Oncology, Inc. Tead inhibitors and uses thereof
WO2023150186A1 (en) 2022-02-01 2023-08-10 Arvinas Operations, Inc. Dgk targeting compounds and uses thereof
WO2023173053A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023173057A1 (en) 2022-03-10 2023-09-14 Ikena Oncology, Inc. Mek inhibitors and uses thereof
WO2023178329A1 (en) 2022-03-18 2023-09-21 Bristol-Myers Squibb Company Methods of isolating polypeptides
WO2023211889A1 (en) 2022-04-25 2023-11-02 Ikena Oncology, Inc. Polymorphic compounds and uses thereof
WO2023215719A1 (en) 2022-05-02 2023-11-09 Arcus Biosciences, Inc. Anti-tigit antibodies and uses of the same
WO2023230205A1 (en) 2022-05-25 2023-11-30 Ikena Oncology, Inc. Mek inhibitors and uses thereof
US20240124490A1 (en) 2022-07-15 2024-04-18 Arcus Biosciences, Inc. Inhibitors of hpk1 and methods of use thereof
WO2024020034A1 (en) 2022-07-20 2024-01-25 Arcus Biosciences, Inc. Cbl-b inhibitors and methods of use thereof
WO2024028364A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Aryl-triazolyl and related gpr84 antagonists and uses thereof
WO2024028365A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Substituted pyridone gpr84 antagonists and uses thereof
WO2024028363A1 (en) 2022-08-02 2024-02-08 Liminal Biosciences Limited Heteroaryl carboxamide and related gpr84 antagonists and uses thereof
WO2024036100A1 (en) 2022-08-08 2024-02-15 Bristol-Myers Squibb Company Substituted tetrazolyl compounds useful as t cell activators
WO2024036101A1 (en) 2022-08-09 2024-02-15 Bristol-Myers Squibb Company Tertiary amine substituted bicyclic compounds useful as t cell activators
WO2024081385A1 (en) 2022-10-14 2024-04-18 Arcus Biosciences, Inc. Hpk1 inhibitors and methods of use thereof
WO2024086718A1 (en) 2022-10-20 2024-04-25 Arcus Biosciences, Inc. Lyophilized formulations of cd73 compounds

Family Cites Families (65)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US4816567A (en) 1983-04-08 1989-03-28 Genentech, Inc. Recombinant immunoglobin preparations
AU2728588A (en) 1987-10-23 1989-05-23 Genetics Institute Inc. Composition and method for treating cancers characterized by over-expression of the c-fms proto-oncogene
GB8823869D0 (en) 1988-10-12 1988-11-16 Medical Res Council Production of antibodies
US5530101A (en) 1988-12-28 1996-06-25 Protein Design Labs, Inc. Humanized immunoglobulins
US6713610B1 (en) 1990-01-12 2004-03-30 Raju Kucherlapati Human antibodies derived from immunized xenomice
US6673986B1 (en) 1990-01-12 2004-01-06 Abgenix, Inc. Generation of xenogeneic antibodies
US5877397A (en) 1990-08-29 1999-03-02 Genpharm International Inc. Transgenic non-human animals capable of producing heterologous antibodies of various isotypes
US5874299A (en) 1990-08-29 1999-02-23 Genpharm International, Inc. Transgenic non-human animals capable of producing heterologous antibodies
US5545806A (en) 1990-08-29 1996-08-13 Genpharm International, Inc. Ransgenic non-human animals for producing heterologous antibodies
US6255458B1 (en) 1990-08-29 2001-07-03 Genpharm International High affinity human antibodies and human antibodies against digoxin
US6300129B1 (en) 1990-08-29 2001-10-09 Genpharm International Transgenic non-human animals for producing heterologous antibodies
JPH08507916A (ja) 1992-06-09 1996-08-27 カイロン コーポレイション M−csfの結晶化
US20020193575A1 (en) 1993-09-07 2002-12-19 Smithkline Beecham P.L.C. Recombinant IL4 antibodies useful in treatment of IL4 mediated disorders
US6972323B1 (en) * 1997-04-01 2005-12-06 Sankyo Company, Limited Anti-Fas antibodies
US6342220B1 (en) 1997-08-25 2002-01-29 Genentech, Inc. Agonist antibodies
WO1999029345A1 (en) 1997-12-05 1999-06-17 La Jolla Institute For Experimental Medicine Inhibition of tumor growth by macrophage intervention
WO2000025803A1 (fr) 1998-10-30 2000-05-11 Takeda Chemical Industries, Ltd. Preparations contenant une proteine betacelluline
AU783063B2 (en) 1999-10-28 2005-09-22 Seyedhossein Aharinejad Use of CSF-1 inhibitors
AU1759501A (en) 1999-11-08 2001-06-06 Government of The United States of America, as represented by The Secretary Department of Health & Human Services, The National Institutes of Health, The Method of treating a viral infection using antagonists of macrophage colony stimulating factor
US7108852B2 (en) 2000-03-20 2006-09-19 Warner-Lambert Company Llc Methods of treating inflammation using antibodies to M-CSF
US7455836B2 (en) 2000-05-08 2008-11-25 The University Of Melbourne Method of treatment and agents useful for same
US6773895B2 (en) 2000-09-01 2004-08-10 Boehringer Ingelheim Pharma Kg Method for identifying substances which positively influence inflammatory conditions of chronic inflammatory airway diseases
US7247618B2 (en) 2001-04-30 2007-07-24 Tripathi Rajavashisth Methods for inhibiting macrophage colony stimulating factor and c-FMS-dependent cell signaling
AU2002314495A1 (en) 2001-06-20 2003-01-02 Prochon Biotech Ltd. Antibodies that block receptor protein tyrosine kinase activation, methods of screening for and uses thereof
CA2492671C (en) 2002-03-22 2012-04-17 Aprogen, Inc. Humanized antibody and process for preparing same
EP2246363A1 (en) 2002-11-15 2010-11-03 Novartis Vaccines and Diagnostics, Inc. Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
US7807389B2 (en) 2003-03-14 2010-10-05 University Of Rochester Methods and compositions related to joint inflammation diseases
AR045563A1 (es) * 2003-09-10 2005-11-02 Warner Lambert Co Anticuerpos dirigidos a m-csf
EP1678314B1 (en) 2003-10-22 2012-09-05 Keck Graduate Institute Methods of synthesizing heteromultimeric polypeptides in yeast using a haploid mating strategy
GB0325836D0 (en) 2003-11-05 2003-12-10 Celltech R&D Ltd Biological products
EP1706137A2 (en) 2004-01-21 2006-10-04 Chiron Corporation M-csf muteins and uses thereof
AU2005245896A1 (en) 2004-05-14 2005-12-01 Receptor Biologix, Inc. Cell surface receptor isoforms and methods of identifying and using the same
WO2006012451A2 (en) 2004-07-22 2006-02-02 Five Prime Therapeutics, Inc. Compositions and methods of use for mgd-csf in disease treatment
WO2006076288A2 (en) 2005-01-11 2006-07-20 Five Prime Therapeutics, Inc. Dna constructs for long-term expression of intravascularly injected naked dna
EP1841874B1 (en) 2005-01-27 2010-01-06 Five Prime Therapeutics, Inc. Leader sequences for directing secretion of polypeptides and methods for production thereof
US8003108B2 (en) * 2005-05-03 2011-08-23 Amgen Inc. Sclerostin epitopes
EP1945662A2 (en) 2005-11-10 2008-07-23 Receptor Biologix, Inc. Methods for production of receptor and ligand isoforms
WO2007075933A2 (en) 2005-12-21 2007-07-05 Cell Signaling Technology, Inc. Translocation and mutant csf1r kinase in human leukemia
JP2009521685A (ja) 2005-12-22 2009-06-04 ノバルティス アーゲー 可溶性ヒトm−csf受容体およびその使用
EP2705854A1 (en) 2006-01-05 2014-03-12 Novartis AG Methods for preventing and treating cancer metastasis and bone loss associated with cancer metastasis
US20100036091A1 (en) 2006-11-10 2010-02-11 Amgen Inc. Antibody-based diagnostics and therapeutics
EP2089049A4 (en) 2006-11-17 2011-11-16 Biogen Idec Inc SYSTEMIC ADMINISTRATION OF COLONIAL STIMULATING FACTORS TO TREAT AMYLOID ASSOCIATED DISEASES
DE602008004296D1 (de) 2007-02-14 2011-02-17 Vaccinex Inc Humanisierte anti-cd100-antikörper
WO2008124858A2 (en) 2007-04-11 2008-10-23 F-Star Biotechnologische Forschungs- Und Entwicklungsges. M.B.H. Targeted receptor
US20100298217A1 (en) 2007-05-30 2010-11-25 Evan Richard Stanley Csf-1r mutants
CA2696761C (en) 2007-08-21 2017-02-14 Amgen Inc. Human c-fms antigen binding proteins
US7981415B2 (en) 2007-09-07 2011-07-19 Cisthera, Inc. Humanized PAI-1 antibodies
AU2008313727A1 (en) 2007-10-18 2009-04-23 Novartis Ag CSF-1R inhibitors for treatment of cancer and bone diseases
WO2009058968A2 (en) 2007-10-31 2009-05-07 Janssen Pharmaceutica N.V. Biomarker for assessing response to fms treatment
US20110262425A1 (en) 2007-12-12 2011-10-27 National Cancer Center Therapeutic agent for mll leukemia and moz leukemia of which molecular target is m-csf receptor, and use thereof
ES2567298T3 (es) * 2008-03-14 2016-04-21 Transgene Sa Anticuerpo contra el CSF-1R
US8470977B2 (en) 2008-03-14 2013-06-25 Transgene S.A. Antibody against the CSF-1R
WO2010062401A2 (en) 2008-11-26 2010-06-03 Five Prime Therapeutics, Inc. Treatment of osteolytic disorders and cancer using csf1r extracellular domain fusion molecules
WO2010062399A2 (en) 2008-11-26 2010-06-03 Five Prime Therapeutics, Inc. Csf1r extracellular domain fusion molecules and treatments using same
PE20121398A1 (es) 2009-12-10 2012-10-26 Hoffmann La Roche Anticuerpos ligantes preferentemente al dominio extracelular 4 de csf1r humano
CN102918060B (zh) 2010-03-05 2016-04-06 霍夫曼-拉罗奇有限公司 抗人csf-1r抗体及其用途
CA2789071C (en) 2010-03-05 2018-03-27 F. Hoffmann-La Roche Ag Antibodies against human csf-1r and uses thereof
AR080698A1 (es) 2010-04-01 2012-05-02 Imclone Llc Anticuerpo o fragmento del mismo que especificamente enlaza la variante de csf -1r humano, composicion farmaceutica que lo comprende, su uso para la manufactura de un medicamento util para el tratamiento de cancer y metodo para determinar si un sujeto es candidato para tratamiento de cancer basado e
SI2566517T1 (sl) 2010-05-04 2019-01-31 Five Prime Therapeutics, Inc. Protitelesa, ki vežejo CSF1R
TW201307845A (zh) 2010-12-13 2013-02-16 Novartis Ag 預測方法及利用il-17拮抗劑治療關節炎的方法
CA2852800A1 (en) 2011-10-21 2013-04-25 Inserm (Institut National De La Sante Et De La Recherche Medicale) A m-dc8+ monocyte depleting agent for the prevention or the treatment of a condition associated with a chronic hyperactivation of the immune system
BR112014008540A2 (pt) 2011-10-21 2020-12-01 Transgène S.A. método para aumentar agrupamento de macrófagos m1 em um paciente
US20130302322A1 (en) 2012-05-11 2013-11-14 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)
RU2670743C9 (ru) 2012-05-11 2018-12-19 Файв Прайм Терапьютикс, Инк. Способы лечения состояний антителами, которые связывают рецептор колониестимулирующего фактора 1 (csf1r)
US20140079699A1 (en) 2012-08-31 2014-03-20 Five Prime Therapeutics, Inc. Methods of treating conditions with antibodies that bind colony stimulating factor 1 receptor (csf1r)

Similar Documents

Publication Publication Date Title
JP2013535952A5 (he)
CA2797399A1 (en) Antibodies that bind csf1r
JP2022008382A5 (he)
JP6986965B2 (ja) 抗pd−1抗体
JP2014534242A5 (he)
JP2020510422A5 (he)
JP2015504306A5 (he)
JP2016512551A5 (he)
JP2018503365A5 (he)
RU2019128134A (ru) Антитело против gprc5d и молекула, содержащая антитело
JP2016511277A5 (he)
JP2019536806A5 (he)
JP2012530496A5 (he)
RU2017118225A (ru) Антитела к PD-1 и способы их применения
JP2012526558A5 (he)
JP2014519317A5 (he)
JP2015517300A5 (he)
JP2010500876A5 (he)
CA2896548A1 (en) Multivalent binding protein compositions
JP2012513214A5 (he)
SG191716A1 (en) Neutralizing anti-ccl20 antibodies
JP2008542321A5 (he)
JP2013520984A5 (he)
CN110167592A (zh) 抗il-37抗体
JP2010509931A5 (he)