|
US3687808A
(en)
|
1969-08-14 |
1972-08-29 |
Univ Leland Stanford Junior |
Synthetic polynucleotides
|
|
US4235871A
(en)
|
1978-02-24 |
1980-11-25 |
Papahadjopoulos Demetrios P |
Method of encapsulating biologically active materials in lipid vesicles
|
|
US4201860A
(en)
|
1978-05-09 |
1980-05-06 |
Bristol-Myers Company |
Purine derivatives
|
|
US4415732A
(en)
|
1981-03-27 |
1983-11-15 |
University Patents, Inc. |
Phosphoramidite compounds and processes
|
|
US4426330A
(en)
|
1981-07-20 |
1984-01-17 |
Lipid Specialties, Inc. |
Synthetic phospholipid compounds
|
|
US5023243A
(en)
|
1981-10-23 |
1991-06-11 |
Molecular Biosystems, Inc. |
Oligonucleotide therapeutic agent and method of making same
|
|
US4501728A
(en)
|
1983-01-06 |
1985-02-26 |
Technology Unlimited, Inc. |
Masking of liposomes from RES recognition
|
|
US5643889A
(en)
|
1984-07-11 |
1997-07-01 |
Temple University-Of The Commonwealth System Of Pennsylvania |
Cholesterol conjugates of 2'5'-oligoadenylate derivatives and antiviral uses thereof
|
|
US4810646A
(en)
|
1984-11-28 |
1989-03-07 |
Massachusetts Institute Of Technology |
Glucan compositions and process for preparation thereof
|
|
US5028703A
(en)
|
1988-03-11 |
1991-07-02 |
Massachusetts Institute Of Technology |
Glucan composition and process for preparation thereof
|
|
US4992540A
(en)
|
1984-11-28 |
1991-02-12 |
Massachusetts Institute Of Technology |
Glucan composition and process for preparation thereof
|
|
US5082936A
(en)
|
1984-11-28 |
1992-01-21 |
Massachusetts Institute Of Technology |
Glucan composition and process for preparation thereof
|
|
US4897355A
(en)
|
1985-01-07 |
1990-01-30 |
Syntex (U.S.A.) Inc. |
N[ω,(ω-1)-dialkyloxy]- and N-[ω,(ω-1)-dialkenyloxy]-alk-1-yl-N,N,N-tetrasubstituted ammonium lipids and uses therefor
|
|
DE3529497A1
(de)
|
1985-08-17 |
1987-02-26 |
Boehringer Mannheim Gmbh |
N(pfeil hoch)6(pfeil hoch)-disubstituierte purinderivate, verfahren zu deren herstellung sowie diese verbindungen enthaltende arzneimittel
|
|
US4737323A
(en)
|
1986-02-13 |
1988-04-12 |
Liposome Technology, Inc. |
Liposome extrusion method
|
|
EP0260032B1
(en)
|
1986-09-08 |
1994-01-26 |
Ajinomoto Co., Inc. |
Compounds for the cleavage at a specific position of RNA, oligomers employed for the formation of said compounds, and starting materials for the synthesis of said oligomers
|
|
US4837028A
(en)
|
1986-12-24 |
1989-06-06 |
Liposome Technology, Inc. |
Liposomes with enhanced circulation time
|
|
US5264423A
(en)
|
1987-03-25 |
1993-11-23 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US5276019A
(en)
|
1987-03-25 |
1994-01-04 |
The United States Of America As Represented By The Department Of Health And Human Services |
Inhibitors for replication of retroviruses and for the expression of oncogene products
|
|
US4904582A
(en)
|
1987-06-11 |
1990-02-27 |
Synthetic Genetics |
Novel amphiphilic nucleic acid conjugates
|
|
US4924624A
(en)
|
1987-10-22 |
1990-05-15 |
Temple University-Of The Commonwealth System Of Higher Education |
2,',5'-phosphorothioate oligoadenylates and plant antiviral uses thereof
|
|
US5188897A
(en)
|
1987-10-22 |
1993-02-23 |
Temple University Of The Commonwealth System Of Higher Education |
Encapsulated 2',5'-phosphorothioate oligoadenylates
|
|
DE3738460A1
(de)
|
1987-11-12 |
1989-05-24 |
Max Planck Gesellschaft |
Modifizierte oligonukleotide
|
|
US5750666A
(en)
|
1988-05-26 |
1998-05-12 |
Competitve Technologies, Inc. |
Polynucleotide phosphorodithioate compounds
|
|
US5278302A
(en)
|
1988-05-26 |
1994-01-11 |
University Patents, Inc. |
Polynucleotide phosphorodithioates
|
|
ZA902710B
(en)
|
1989-05-22 |
1991-12-24 |
Univ Georgia Res Found |
Enzyme luminescence assay
|
|
US4958013A
(en)
|
1989-06-06 |
1990-09-18 |
Northwestern University |
Cholesteryl modified oligonucleotides
|
|
US5032401A
(en)
|
1989-06-15 |
1991-07-16 |
Alpha Beta Technology |
Glucan drug delivery system and adjuvant
|
|
JPH05503952A
(ja)
|
1989-09-08 |
1993-06-24 |
アルファ ベータ テクノロジー,インコーポレイティッド |
可溶性グルカン類の製造方法
|
|
CA2067159A1
(en)
|
1989-09-08 |
1991-03-09 |
Spiros Jamas |
Method for immune system activation
|
|
US5591722A
(en)
|
1989-09-15 |
1997-01-07 |
Southern Research Institute |
2'-deoxy-4'-thioribonucleosides and their antiviral activity
|
|
JPH05504552A
(ja)
|
1989-10-24 |
1993-07-15 |
ギリアド サイエンシズ,インコーポレイテッド |
2’位が改変されたオリゴヌクレオチド
|
|
US5264562A
(en)
|
1989-10-24 |
1993-11-23 |
Gilead Sciences, Inc. |
Oligonucleotide analogs with novel linkages
|
|
US5495009A
(en)
|
1989-10-24 |
1996-02-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs containing thioformacetal linkages
|
|
US5486603A
(en)
|
1990-01-08 |
1996-01-23 |
Gilead Sciences, Inc. |
Oligonucleotide having enhanced binding affinity
|
|
US5670633A
(en)
|
1990-01-11 |
1997-09-23 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides that detect and modulate gene expression
|
|
US5578718A
(en)
|
1990-01-11 |
1996-11-26 |
Isis Pharmaceuticals, Inc. |
Thiol-derivatized nucleosides
|
|
US5646265A
(en)
|
1990-01-11 |
1997-07-08 |
Isis Pharmceuticals, Inc. |
Process for the preparation of 2'-O-alkyl purine phosphoramidites
|
|
US6153737A
(en)
|
1990-01-11 |
2000-11-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US6358931B1
(en)
|
1990-01-11 |
2002-03-19 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for modulating RNA
|
|
US5514786A
(en)
|
1990-01-11 |
1996-05-07 |
Isis Pharmaceuticals, Inc. |
Compositions for inhibiting RNA activity
|
|
US5914396A
(en)
|
1990-01-11 |
1999-06-22 |
Isis Pharmaceuticals, Inc. |
2'-O-modified nucleosides and phosphoramidites
|
|
US5681941A
(en)
|
1990-01-11 |
1997-10-28 |
Isis Pharmaceuticals, Inc. |
Substituted purines and oligonucleotide cross-linking
|
|
US6395492B1
(en)
|
1990-01-11 |
2002-05-28 |
Isis Pharmaceuticals, Inc. |
Derivatized oligonucleotides having improved uptake and other properties
|
|
US5459255A
(en)
|
1990-01-11 |
1995-10-17 |
Isis Pharmaceuticals, Inc. |
N-2 substituted purines
|
|
US6005087A
(en)
|
1995-06-06 |
1999-12-21 |
Isis Pharmaceuticals, Inc. |
2'-modified oligonucleotides
|
|
US6399754B1
(en)
|
1991-12-24 |
2002-06-04 |
Isis Pharmaceuticals, Inc. |
Sugar modified oligonucleotides
|
|
WO1991013080A1
(en)
|
1990-02-20 |
1991-09-05 |
Gilead Sciences, Inc. |
Pseudonucleosides and pseudonucleotides and their polymers
|
|
US5658731A
(en)
|
1990-04-09 |
1997-08-19 |
Europaisches Laboratorium Fur Molekularbiologie |
2'-O-alkylnucleotides as well as polymers which contain such nucleotides
|
|
US5470967A
(en)
|
1990-04-10 |
1995-11-28 |
The Dupont Merck Pharmaceutical Company |
Oligonucleotide analogs with sulfamate linkages
|
|
US5264618A
(en)
|
1990-04-19 |
1993-11-23 |
Vical, Inc. |
Cationic lipids for intracellular delivery of biologically active molecules
|
|
US5151510A
(en)
|
1990-04-20 |
1992-09-29 |
Applied Biosystems, Inc. |
Method of synethesizing sulfurized oligonucleotide analogs
|
|
WO1991017424A1
(en)
|
1990-05-03 |
1991-11-14 |
Vical, Inc. |
Intracellular delivery of biologically active substances by means of self-assembling lipid complexes
|
|
CA2040374C
(en)
|
1990-07-06 |
1998-06-16 |
Gunnar Rorstad |
Process for enhancing the resistance of aquatic animals to disease
|
|
US5602240A
(en)
|
1990-07-27 |
1997-02-11 |
Ciba Geigy Ag. |
Backbone modified oligonucleotide analogs
|
|
US5386023A
(en)
|
1990-07-27 |
1995-01-31 |
Isis Pharmaceuticals |
Backbone modified oligonucleotide analogs and preparation thereof through reductive coupling
|
|
US5489677A
(en)
|
1990-07-27 |
1996-02-06 |
Isis Pharmaceuticals, Inc. |
Oligonucleoside linkages containing adjacent oxygen and nitrogen atoms
|
|
US5614617A
(en)
|
1990-07-27 |
1997-03-25 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant, pyrimidine modified oligonucleotides that detect and modulate gene expression
|
|
US5623070A
(en)
|
1990-07-27 |
1997-04-22 |
Isis Pharmaceuticals, Inc. |
Heteroatomic oligonucleoside linkages
|
|
DE69133511T2
(de)
|
1990-08-13 |
2006-09-28 |
Isis Pharmaceuticals, Inc., Carlsbad |
Zuckermodifizierte oligonukleotide zum erkennen und steuern der genexpression
|
|
JP3256539B2
(ja)
|
1990-08-28 |
2002-02-12 |
エポック・ファーマシューティカルズ・インコーポレイテッド |
連結分子を介する3’―尾分子付オリゴヌクレオチドの固体支持体合成
|
|
US5512667A
(en)
|
1990-08-28 |
1996-04-30 |
Reed; Michael W. |
Trifunctional intermediates for preparing 3'-tailed oligonucleotides
|
|
US5561225A
(en)
|
1990-09-19 |
1996-10-01 |
Southern Research Institute |
Polynucleotide analogs containing sulfonate and sulfonamide internucleoside linkages
|
|
AU662298B2
(en)
|
1990-09-20 |
1995-08-31 |
Gilead Sciences, Inc. |
Modified internucleoside linkages
|
|
US5432272A
(en)
|
1990-10-09 |
1995-07-11 |
Benner; Steven A. |
Method for incorporating into a DNA or RNA oligonucleotide using nucleotides bearing heterocyclic bases
|
|
GB9022560D0
(en)
|
1990-10-17 |
1990-11-28 |
G B Biotechnology Limited |
Processing of waste
|
|
WO1994008003A1
(en)
|
1991-06-14 |
1994-04-14 |
Isis Pharmaceuticals, Inc. |
ANTISENSE OLIGONUCLEOTIDE INHIBITION OF THE ras GENE
|
|
US5419966A
(en)
|
1991-06-10 |
1995-05-30 |
Microprobe Corporation |
Solid support for synthesis of 3'-tailed oligonucleotides
|
|
US5214135A
(en)
|
1991-08-30 |
1993-05-25 |
Chemgenes Corporation |
N-protected-2'-O-methyl-ribonucleosides and N-protected 2'-O-methyl-3'-cyanoethyl-N-,N-diisopropyl phosphoramidite ribonucleosides
|
|
US5770209A
(en)
|
1991-08-30 |
1998-06-23 |
University Of South Florida |
Acceleration of wound healing using connective tissue growth factor
|
|
US7384634B2
(en)
|
1991-08-30 |
2008-06-10 |
University Of South Florida |
Connective tissue growth factor
|
|
US5525719A
(en)
|
1991-08-30 |
1996-06-11 |
Chemgenes Corporation |
N-protected-2'-O-methyl-and N-protected-3'-O-methyl-ribonucleosides and their phosphoramidite derivatives
|
|
US5661134A
(en)
|
1991-10-15 |
1997-08-26 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating Ha-ras or Ki-ras having phosphorothioate linkages of high chiral purity
|
|
US5599797A
(en)
|
1991-10-15 |
1997-02-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having phosphorothioate linkages of high chiral purity
|
|
US5607923A
(en)
|
1991-10-15 |
1997-03-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides for modulating cytomegalovirus having phosphorothioate linkages of high chiral purity
|
|
US6335434B1
(en)
|
1998-06-16 |
2002-01-01 |
Isis Pharmaceuticals, Inc., |
Nucleosidic and non-nucleosidic folate conjugates
|
|
US5594121A
(en)
|
1991-11-07 |
1997-01-14 |
Gilead Sciences, Inc. |
Enhanced triple-helix and double-helix formation with oligomers containing modified purines
|
|
TW393513B
(en)
|
1991-11-26 |
2000-06-11 |
Isis Pharmaceuticals Inc |
Enhanced triple-helix and double-helix formation with oligomers containing modified pyrimidines
|
|
US5359044A
(en)
|
1991-12-13 |
1994-10-25 |
Isis Pharmaceuticals |
Cyclobutyl oligonucleotide surrogates
|
|
US5856455A
(en)
|
1991-12-24 |
1999-01-05 |
Isis Pharmaceuticals, Inc. |
Gapped 2'-modified oligonucleotides
|
|
FI115214B
(fi)
|
1992-01-22 |
2005-03-31 |
Hoechst Ag |
Menetelmä oligonukleotidianalogien valmistamiseksi ja niiden käyttö
|
|
US5633360A
(en)
|
1992-04-14 |
1997-05-27 |
Gilead Sciences, Inc. |
Oligonucleotide analogs capable of passive cell membrane permeation
|
|
US5817781A
(en)
|
1992-06-01 |
1998-10-06 |
Gilead Sciences, Inc. |
Modified internucleoside linkages (II)
|
|
EP0577558A2
(de)
|
1992-07-01 |
1994-01-05 |
Ciba-Geigy Ag |
Carbocyclische Nukleoside mit bicyclischen Ringen, Oligonukleotide daraus, Verfahren zu deren Herstellung, deren Verwendung und Zwischenproduckte
|
|
US6346614B1
(en)
|
1992-07-23 |
2002-02-12 |
Hybridon, Inc. |
Hybrid oligonucleotide phosphorothioates
|
|
JP3351476B2
(ja)
|
1993-01-22 |
2002-11-25 |
三菱化学株式会社 |
リン脂質誘導体及びそれを含有するリポソーム
|
|
WO1994022891A1
(en)
|
1993-03-31 |
1994-10-13 |
Sterling Winthrop Inc. |
Oligonucleotides with amide linkages replacing phosphodiester linkages
|
|
CN1124980A
(zh)
|
1993-03-31 |
1996-06-19 |
海布里顿公司 |
具有改良抗流感活性的经修饰寡核苷酸
|
|
FR2705099B1
(fr)
|
1993-05-12 |
1995-08-04 |
Centre Nat Rech Scient |
Oligonucléotides phosphorothioates triesters et procédé de préparation.
|
|
DE59407895D1
(de)
|
1993-05-12 |
1999-04-15 |
Novartis Ag |
Nukleoside und Oligonukleotide mit 2'-Ethergruppen
|
|
US6015886A
(en)
|
1993-05-24 |
2000-01-18 |
Chemgenes Corporation |
Oligonucleotide phosphate esters
|
|
US5428149A
(en)
|
1993-06-14 |
1995-06-27 |
Washington State University Research Foundation |
Method for palladium catalyzed carbon-carbon coulping and products
|
|
US5580972A
(en)
|
1993-06-14 |
1996-12-03 |
Nexstar Pharmaceuticals, Inc. |
Purine nucleoside modifications by palladium catalyzed methods
|
|
US5534259A
(en)
|
1993-07-08 |
1996-07-09 |
Liposome Technology, Inc. |
Polymer compound and coated particle composition
|
|
US5532130A
(en)
|
1993-07-20 |
1996-07-02 |
Dyad Pharmaceutical Corporation |
Methods and compositions for sequence-specific hybridization of RNA by 2'-5' oligonucleotides
|
|
US5417978A
(en)
|
1993-07-29 |
1995-05-23 |
Board Of Regents, The University Of Texas System |
Liposomal antisense methyl phosphonate oligonucleotides and methods for their preparation and use
|
|
US5614621A
(en)
|
1993-07-29 |
1997-03-25 |
Isis Pharmaceuticals, Inc. |
Process for preparing oligonucleotides using silyl-containing diamino phosphorous reagents
|
|
WO1995006731A2
(en)
|
1993-09-02 |
1995-03-09 |
Ribozyme Pharmaceuticals, Inc. |
Non-nucleotide containing enzymatic nucleic acid
|
|
DE69433036T2
(de)
|
1993-09-03 |
2004-05-27 |
Isis Pharmaceuticals, Inc., Carlsbad |
Aminoderivatisierte nukleoside und oligonukleoside
|
|
US5502177A
(en)
|
1993-09-17 |
1996-03-26 |
Gilead Sciences, Inc. |
Pyrimidine derivatives for labeled binding partners
|
|
JPH09504297A
(ja)
|
1993-10-27 |
1997-04-28 |
リボザイム・ファーマシューティカルズ・インコーポレーテッド |
2′−アミドおよび2′−ペプチド修飾オリゴヌクレオチド
|
|
EP0735899A4
(en)
|
1993-11-16 |
1998-10-21 |
Genta Inc |
SYNTHETIC OLIGOMERS COMPRISING INTERNUCLEOSIDYL PHOSPHONATE BINDINGS OF INDEFINED CHIRALITY MIXED WITH NON-PHOSPHONATE INTERNUCLEOSIDYLE LINKS
|
|
JPH09505057A
(ja)
|
1993-11-19 |
1997-05-20 |
ザ・ユニバーシティ・オブ・シドニー |
白内障を予防または制御するための方法
|
|
US5652359A
(en)
|
1993-12-02 |
1997-07-29 |
Epoch Pharmaceuticals, Inc. |
Oligonucleotides containing n-methyl thiolated bases having antiviral activity
|
|
JPH09510954A
(ja)
|
1993-12-17 |
1997-11-04 |
ジ・オハイオ・ステイト・ユニバーシティー |
エイコサノイド生成を抑制するアンチセンスオリゴヌクレオチド
|
|
CA2181546A1
(en)
|
1994-02-18 |
1995-08-24 |
Robert E. Kilkuskie |
Oligonucleotides with anti-respiratory syncytial virus activity
|
|
US5646126A
(en)
|
1994-02-28 |
1997-07-08 |
Epoch Pharmaceuticals |
Sterol modified oligonucleotide duplexes having anticancer activity
|
|
US5596091A
(en)
|
1994-03-18 |
1997-01-21 |
The Regents Of The University Of California |
Antisense oligonucleotides comprising 5-aminoalkyl pyrimidine nucleotides
|
|
US5651981A
(en)
|
1994-03-29 |
1997-07-29 |
Northwestern University |
Cationic phospholipids for transfection
|
|
US5625050A
(en)
|
1994-03-31 |
1997-04-29 |
Amgen Inc. |
Modified oligonucleotides and intermediates useful in nucleic acid therapeutics
|
|
US5777153A
(en)
|
1994-07-08 |
1998-07-07 |
Gilead Sciences, Inc. |
Cationic lipids
|
|
US5580731A
(en)
|
1994-08-25 |
1996-12-03 |
Chiron Corporation |
N-4 modified pyrimidine deoxynucleotides and oligonucleotide probes synthesized therewith
|
|
US5591721A
(en)
|
1994-10-25 |
1997-01-07 |
Hybridon, Inc. |
Method of down-regulating gene expression
|
|
US5681940A
(en)
|
1994-11-02 |
1997-10-28 |
Icn Pharmaceuticals |
Sugar modified nucleosides and oligonucleotides
|
|
US5767099A
(en)
|
1994-12-09 |
1998-06-16 |
Genzyme Corporation |
Cationic amphiphiles containing amino acid or dervatized amino acid groups for intracellular delivery of therapeutic molecules
|
|
US5948767A
(en)
|
1994-12-09 |
1999-09-07 |
Genzyme Corporation |
Cationic amphiphile/DNA complexes
|
|
US5716824A
(en)
|
1995-04-20 |
1998-02-10 |
Ribozyme Pharmaceuticals, Inc. |
2'-O-alkylthioalkyl and 2-C-alkylthioalkyl-containing enzymatic nucleic acids (ribozymes)
|
|
US5830430A
(en)
|
1995-02-21 |
1998-11-03 |
Imarx Pharmaceutical Corp. |
Cationic lipids and the use thereof
|
|
AUPN166195A0
(en)
|
1995-03-13 |
1995-04-06 |
Norvet Research Pty Limited |
Process for glucan extraction
|
|
US6420549B1
(en)
|
1995-06-06 |
2002-07-16 |
Isis Pharmaceuticals, Inc. |
Oligonucleotide analogs having modified dimers
|
|
US5981501A
(en)
|
1995-06-07 |
1999-11-09 |
Inex Pharmaceuticals Corp. |
Methods for encapsulating plasmids in lipid bilayers
|
|
AU723163B2
(en)
|
1995-06-07 |
2000-08-17 |
Tekmira Pharmaceuticals Corporation |
Lipid-nucleic acid particles prepared via a hydrophobic lipid-nucleic acid complex intermediate and use for gene transfer
|
|
US5736392A
(en)
|
1995-06-07 |
1998-04-07 |
Life Technologies, Inc. |
Peptide-enhanced cationic lipid transfections
|
|
US6221911B1
(en)
|
1995-06-07 |
2001-04-24 |
Karo Bio Ab |
Uses for thyroid hormone compounds or thyroid hormone-like compounds
|
|
US5851548A
(en)
|
1995-06-07 |
1998-12-22 |
Gen-Probe Incorporated |
Liposomes containing cationic lipids and vitamin D
|
|
AUPN398295A0
(en)
|
1995-07-05 |
1995-07-27 |
Carlton And United Breweries Limited |
Chemical compounds and processes for their production
|
|
US5734041A
(en)
|
1995-10-20 |
1998-03-31 |
Mcgill University |
Preparation of chiral phosphorothioate oligomers
|
|
US5705621A
(en)
|
1995-11-17 |
1998-01-06 |
Isis Pharmaceuticals, Inc. |
Oligomeric phosphite, phosphodiester, Phosphorothioate and phosphorodithioate compounds and intermediates for preparing same
|
|
US5684143A
(en)
|
1996-02-21 |
1997-11-04 |
Lynx Therapeutics, Inc. |
Oligo-2'-fluoronucleotide N3'->P5' phosphoramidates
|
|
US6331617B1
(en)
|
1996-03-21 |
2001-12-18 |
University Of Iowa Research Foundation |
Positively charged oligonucleotides as regulators of gene expression
|
|
US6444806B1
(en)
|
1996-04-30 |
2002-09-03 |
Hisamitsu Pharmaceutical Co., Inc. |
Conjugates and methods of forming conjugates of oligonucleotides and carbohydrates
|
|
US5898031A
(en)
|
1996-06-06 |
1999-04-27 |
Isis Pharmaceuticals, Inc. |
Oligoribonucleotides for cleaving RNA
|
|
US5789416B1
(en)
|
1996-08-27 |
1999-10-05 |
Cv Therapeutics Inc |
N6 mono heterocyclic substituted adenosine derivatives
|
|
US6111085A
(en)
|
1996-09-13 |
2000-08-29 |
Isis Pharmaceuticals, Inc. |
Carbamate-derivatized nucleosides and oligonucleosides
|
|
US5849902A
(en)
|
1996-09-26 |
1998-12-15 |
Oligos Etc. Inc. |
Three component chimeric antisense oligonucleotides
|
|
US6248878B1
(en)
|
1996-12-24 |
2001-06-19 |
Ribozyme Pharmaceuticals, Inc. |
Nucleoside analogs
|
|
US7504493B2
(en)
|
1997-01-23 |
2009-03-17 |
The John Hopkins University |
Characterization of the yeast transcriptome
|
|
DE69841002D1
(de)
|
1997-05-14 |
2009-09-03 |
Univ British Columbia |
Hochwirksame verkapselung von nukleinsäuren in lipidvesikeln
|
|
US6333152B1
(en)
|
1997-05-21 |
2001-12-25 |
The Johnshopkins University |
Gene expression profiles in normal and cancer cells
|
|
EA003832B1
(ru)
|
1997-09-15 |
2003-10-30 |
Дженетик Иммьюнити, Ллс. |
Ген-доставочный комплекс для чрескожной доставки чужеродного генетического материала в антиген-презентирующие клетки и способы его использования
|
|
US6028183A
(en)
|
1997-11-07 |
2000-02-22 |
Gilead Sciences, Inc. |
Pyrimidine derivatives and oligonucleotides containing same
|
|
WO1999031073A1
(en)
|
1997-12-15 |
1999-06-24 |
Yamanouchi Pharmaceutical Co., Ltd. |
Novel pyrimidine-5-carboxamide derivatives
|
|
US6506559B1
(en)
|
1997-12-23 |
2003-01-14 |
Carnegie Institute Of Washington |
Genetic inhibition by double-stranded RNA
|
|
US6562618B1
(en)
|
1997-12-25 |
2003-05-13 |
Japan Tobacco, Inc. |
Monoclonal antibody against connective tissue growth factor and medicinal uses thereof
|
|
US6020475A
(en)
|
1998-02-10 |
2000-02-01 |
Isis Pharmeuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
WO1999054459A2
(en)
|
1998-04-20 |
1999-10-28 |
Ribozyme Pharmaceuticals, Inc. |
Nucleic acid molecules with novel chemical compositions capable of modulating gene expression
|
|
US20040241845A1
(en)
|
1998-05-22 |
2004-12-02 |
Luc Desgroseillers |
Mammalian staufen and use thereof
|
|
US6277967B1
(en)
|
1998-07-14 |
2001-08-21 |
Isis Pharmaceuticals, Inc. |
Carbohydrate or 2′-modified oligonucleotides having alternating internucleoside linkages
|
|
US6242589B1
(en)
|
1998-07-14 |
2001-06-05 |
Isis Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides having modified internucleoside linkages
|
|
US6271358B1
(en)
|
1998-07-27 |
2001-08-07 |
Isis Pharmaceuticals, Inc. |
RNA targeted 2′-modified oligonucleotides that are conformationally preorganized
|
|
US20040009938A1
(en)
|
1998-08-07 |
2004-01-15 |
Muthiah Manoharan |
Methods of enhancing renal uptake of oligonucleotides
|
|
US6043352A
(en)
|
1998-08-07 |
2000-03-28 |
Isis Pharmaceuticals, Inc. |
2'-O-Dimethylaminoethyloxyethyl-modified oligonucleotides
|
|
US6344323B1
(en)
*
|
1998-09-16 |
2002-02-05 |
Vitagenix, Inc. |
Compositions and methods for inhibiting cox-2 expression and treating cox-2 associated disorders by using cox-2 antisense oligonucleotides
|
|
US6020483A
(en)
|
1998-09-25 |
2000-02-01 |
Nexstar Pharmaceuticals, Inc. |
Nucleoside modifications by palladium catalyzed methods
|
|
US6475490B1
(en)
|
1998-10-19 |
2002-11-05 |
Fordham University |
Compositions and methods for promoting tissue repair using heat shock proteins
|
|
US7115390B1
(en)
|
1998-12-14 |
2006-10-03 |
Fibrogen, Inc. |
Connective tissue growth factor fragments and methods and uses thereof
|
|
KR100664625B1
(ko)
|
1998-12-14 |
2007-01-04 |
유니버시티 오브 마이애미 |
결합 조직 성장인자 단편, 그의 제조 방법 및 그의 용도
|
|
US6455586B1
(en)
|
1998-12-15 |
2002-09-24 |
Leonard L. Kaplan |
Topical immunomodulating compositions for treatment of aids, Hepatitis B & C, other infectious diseases, and cancer
|
|
DK2314321T3
(da)
|
1999-01-27 |
2014-09-08 |
Coda Therapeutics Inc |
Formuleringer, der omfatter antisense-nukleotider til connexiner
|
|
DE19956568A1
(de)
|
1999-01-30 |
2000-08-17 |
Roland Kreutzer |
Verfahren und Medikament zur Hemmung der Expression eines vorgegebenen Gens
|
|
US6465628B1
(en)
|
1999-02-04 |
2002-10-15 |
Isis Pharmaceuticals, Inc. |
Process for the synthesis of oligomeric compounds
|
|
US6207819B1
(en)
|
1999-02-12 |
2001-03-27 |
Isis Pharmaceuticals, Inc. |
Compounds, processes and intermediates for synthesis of mixed backbone oligomeric compounds
|
|
ATE287897T2
(de)
|
1999-02-12 |
2005-02-15 |
Sankyo Co |
Analoga von nukleosiden und oligonukleotiden
|
|
US6121437A
(en)
|
1999-03-16 |
2000-09-19 |
Isis Pharmaceuticals, Inc. |
Phosphate and thiophosphate protecting groups
|
|
US6706491B1
(en)
|
1999-04-09 |
2004-03-16 |
The Board Of Trustees Of The University Of Illinois |
Reagents and methods for identifying and modulating expression of genes regulated by p21
|
|
US6492497B1
(en)
|
1999-04-30 |
2002-12-10 |
Cambridge Antibody Technology Limited |
Specific binding members for TGFbeta1
|
|
EP1190044A2
(en)
|
1999-06-16 |
2002-03-27 |
The John Hopkins University |
Characterization of the yeast transcriptome
|
|
US6593466B1
(en)
|
1999-07-07 |
2003-07-15 |
Isis Pharmaceuticals, Inc. |
Guanidinium functionalized nucleotides and precursors thereof
|
|
GB9925459D0
(en)
|
1999-10-27 |
1999-12-29 |
Plant Bioscience Ltd |
Gene silencing
|
|
US8017742B2
(en)
|
1999-11-10 |
2011-09-13 |
Japan Science And Technology Agency |
Gene carrier
|
|
JP2001206899A
(ja)
|
1999-11-18 |
2001-07-31 |
Japan Tobacco Inc |
TGF−βII型受容体に対するヒトモノクローナル抗体及びその医薬用途
|
|
US20040072785A1
(en)
|
1999-11-23 |
2004-04-15 |
Wolff Jon A. |
Intravascular delivery of non-viral nucleic acid
|
|
US7829693B2
(en)
|
1999-11-24 |
2010-11-09 |
Alnylam Pharmaceuticals, Inc. |
Compositions and methods for inhibiting expression of a target gene
|
|
DE10160151A1
(de)
|
2001-01-09 |
2003-06-26 |
Ribopharma Ag |
Verfahren zur Hemmung der Expression eines vorgegebenen Zielgens
|
|
US7098030B2
(en)
|
1999-12-31 |
2006-08-29 |
Mirus Bio Corporation |
Polyampholytes for delivering polyions to a cell
|
|
US20050032733A1
(en)
|
2001-05-18 |
2005-02-10 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (SiNA)
|
|
AU2001245793A1
(en)
|
2000-03-16 |
2001-09-24 |
Cold Spring Harbor Laboratory |
Methods and compositions for rna interference
|
|
AU2001249622B2
(en)
|
2000-03-30 |
2007-06-07 |
Massachusetts Institute Of Technology |
RNA sequence-specific mediators of RNA interference
|
|
WO2001085941A2
(en)
|
2000-05-11 |
2001-11-15 |
Academisch Ziekenhuis Bij De Universiteit Van Amsterdam |
Myc targets
|
|
US7108721B2
(en)
|
2000-05-11 |
2006-09-19 |
Massachusetts Institute Of Technology |
Tissue regrafting
|
|
AU2001276934A1
(en)
|
2000-07-18 |
2002-02-05 |
Joslin Diabetes Center Inc. |
Methods of modulating fibrosis
|
|
WO2002008205A1
(en)
|
2000-07-24 |
2002-01-31 |
Krenitsky Pharmaceuticals, Inc. |
Substituted 5-alkynyl pyrimidines having neurotrophic activity
|
|
WO2002010217A2
(en)
|
2000-08-02 |
2002-02-07 |
The Johns Hopkins University |
Endothelial cell expression patterns
|
|
WO2002012348A2
(en)
|
2000-08-03 |
2002-02-14 |
Abac R & D Gmbh |
Isolation of glucan particles and uses thereof
|
|
US6794137B2
(en)
|
2000-09-08 |
2004-09-21 |
New York University |
Gene markers useful for detecting skin damage in response to ultraviolet radiation
|
|
US6753321B2
(en)
|
2000-09-15 |
2004-06-22 |
Genvec, Inc. |
Method of modulating neovascularization
|
|
US20020132788A1
(en)
|
2000-11-06 |
2002-09-19 |
David Lewis |
Inhibition of gene expression by delivery of small interfering RNA to post-embryonic animal cells in vivo
|
|
US6476003B1
(en)
|
2000-11-06 |
2002-11-05 |
Immusonic, Inc. |
Method for preparing small particle size glucan in a dry material
|
|
EP1873259B1
(en)
|
2000-12-01 |
2012-01-25 |
Max-Planck-Gesellschaft zur Förderung der Wissenschaften e.V. |
RNA interference mediated by 21 and 22nt RNAs
|
|
FR2818642B1
(fr)
|
2000-12-26 |
2005-07-15 |
Hoechst Marion Roussel Inc |
Nouveaux derives de la purine, leur procede de preparation, leur application a titre de medicaments, compositions pharmaceutiques et nouvelle utilistion
|
|
WO2002059300A2
(en)
|
2000-12-28 |
2002-08-01 |
J & J Research Pty Ltd |
Double-stranded rna-mediated gene suppression
|
|
DE10100127A1
(de)
|
2001-01-03 |
2002-10-02 |
Henkel Kgaa |
Verfahren zur Bestimmung der Homeostase der Haut
|
|
DE10100121A1
(de)
|
2001-01-03 |
2002-08-01 |
Henkel Kgaa |
Verfahren zur Bestimmung des Hautstreß oder der Hautalterung in vitro
|
|
US7044945B2
(en)
|
2001-03-30 |
2006-05-16 |
Sand Bruce J |
Prevention of regression in thermal ciliary muscle tendinoplasty
|
|
CA2443995C
(en)
|
2001-04-11 |
2014-06-03 |
The Johns Hopkins University |
Endothelial cell expression patterns
|
|
US20030077829A1
(en)
|
2001-04-30 |
2003-04-24 |
Protiva Biotherapeutics Inc.. |
Lipid-based formulations
|
|
AU2004266311B2
(en)
|
2001-05-18 |
2009-07-23 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (siNA)
|
|
US20060211642A1
(en)
|
2001-05-18 |
2006-09-21 |
Sirna Therapeutics, Inc. |
RNA inteference mediated inhibition of hepatitis C virus (HVC) gene expression using short interfering nucleic acid (siNA)
|
|
US20070032441A1
(en)
|
2001-05-18 |
2007-02-08 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of gene expression using chemically modified short interfering nucleic acid (sina)
|
|
US20050233997A1
(en)
|
2001-05-18 |
2005-10-20 |
Sirna Therapeutics, Inc. |
RNA interference mediated inhibition of matrix metalloproteinase 13 (MMP13) gene expression using short interfering nucleic acid (siNA)
|
|
DE10131458A1
(de)
|
2001-06-29 |
2003-01-09 |
Aventis Pharma Gmbh |
Verfahren zur Identifizierung von Verbindungen zur Therapie von Alterungsprozessen des Herz-Kreislauf Systems
|
|
US20030158403A1
(en)
|
2001-07-03 |
2003-08-21 |
Isis Pharmaceuticals, Inc. |
Nuclease resistant chimeric oligonucleotides
|
|
DE10133858A1
(de)
|
2001-07-12 |
2003-02-06 |
Aventis Pharma Gmbh |
Synthetische doppelsträngige Oligonucleotide zur gezielten Hemmung der Genexpression
|
|
WO2003012052A2
(en)
|
2001-07-30 |
2003-02-13 |
The Government Of The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services |
Specific inhibition of gene expression by small double stranded rnas
|
|
EP1434993B1
(en)
*
|
2001-09-18 |
2013-04-24 |
Fibrogen, Inc. |
Methods of assaying connective tissue growth factor
|
|
US7786094B2
(en)
|
2001-10-09 |
2010-08-31 |
Biopolymer Engineering, Inc. |
Use of beta-glucans against biological warfare weapons and pathogens including anthrax
|
|
WO2003035876A1
(de)
|
2001-10-26 |
2003-05-01 |
Ribopharma Ag |
Verwendung einer doppelsträngigen ribonukleinsäure zur behandlung einer infektion mit einem (+)-strang-rna-virus
|
|
WO2003035868A1
(de)
*
|
2001-10-26 |
2003-05-01 |
Ribopharma Ag |
Medikament zur erhöhung der wirksamkeit eines rezeptor-vermittelt apoptose in tumorzellen auslösenden arzeimittels
|
|
US20030157030A1
(en)
|
2001-11-02 |
2003-08-21 |
Insert Therapeutics, Inc. |
Methods and compositions for therapeutic use of rna interference
|
|
US20040063654A1
(en)
|
2001-11-02 |
2004-04-01 |
Davis Mark E. |
Methods and compositions for therapeutic use of RNA interference
|
|
US6965025B2
(en)
|
2001-12-10 |
2005-11-15 |
Isis Pharmaceuticals, Inc. |
Antisense modulation of connective tissue growth factor expression
|
|
WO2003049773A1
(en)
|
2001-12-11 |
2003-06-19 |
Fibrogen, Inc. |
Methods for inhibiting ocular processes
|
|
US20060009409A1
(en)
|
2002-02-01 |
2006-01-12 |
Woolf Tod M |
Double-stranded oligonucleotides
|
|
ATE443133T1
(de)
|
2002-02-01 |
2009-10-15 |
Life Technologies Corp |
Oligonukleotidzusammensetzungen mit verbesserter effizienz
|
|
ATE416183T1
(de)
|
2002-02-01 |
2008-12-15 |
Univ Mcgill |
Oligonukleotide mit alternierenden segmenten und deren verwendungen
|
|
US20030166282A1
(en)
|
2002-02-01 |
2003-09-04 |
David Brown |
High potency siRNAS for reducing the expression of target genes
|
|
AU2003216255A1
(en)
|
2002-02-20 |
2003-09-09 |
Ribozyme Pharmaceuticals, Inc. |
RNA INTERFERENCE MEDIATED INHIBITION OF MDR P-GLYCOPROTEIN GENE EXPRESSION USING SHORT INTERFERING NUCLEIC ACID (siNA)
|
|
US6923833B2
(en)
|
2002-04-09 |
2005-08-02 |
Ray C. Wasielewski |
Biologically reabsorbable acetabular constraining components and materials for use with a hip replacement prosthesis and bioreabsorbable materials to augment hip replacement stability and function
|
|
WO2003099840A1
(en)
|
2002-05-24 |
2003-12-04 |
Isis Pharmaceuticals, Inc. |
Oligonucleotides having modified nucleoside units
|
|
FR2840217B1
(fr)
|
2002-06-03 |
2005-06-24 |
Oreal |
Compositions cosmetiques comprenant au moins un oligonucleotide d'arn double brin (dsrna)et leurs utilisations
|
|
US20040022707A1
(en)
*
|
2002-06-05 |
2004-02-05 |
Exxonmobil Research And Engineering Company |
Oxidation of NOx's with sodium chlorite in combination with a thermal NOx removal process
|
|
EP3222724B1
(en)
|
2002-08-05 |
2018-10-31 |
Silence Therapeutics GmbH |
Further novel forms of interfering rna molecules
|
|
DE10238298A1
(de)
|
2002-08-21 |
2004-03-04 |
Beiersdorf Ag |
Verwendung von Antisense-Oligonucleotiden zur Behandlung von degenerativen Hauterscheinungen
|
|
AU2003273336A1
(en)
|
2002-09-18 |
2004-04-08 |
Isis Pharmaceuticals, Inc. |
Efficient reduction of target rna's by single- and double-stranded oligomeric compounds
|
|
ATE513843T1
(de)
|
2002-09-25 |
2011-07-15 |
Univ Massachusetts |
Abstellen von genen in vivo durch chemischmodifizierte und stabile sirna
|
|
AU2003284323A1
(en)
|
2002-10-18 |
2004-05-04 |
Alnylam Pharmaceuticals Inc |
Double-stranded rna structures and constructs, and methods for generating and using the same
|
|
US7309361B2
(en)
|
2002-10-23 |
2007-12-18 |
Wasielewski Ray C |
Biologic modular tibial and femoral component augments for use with total knee arthroplasty
|
|
AU2003304386A1
(en)
|
2002-10-30 |
2005-02-25 |
The Center For Blood Research, Inc. |
Methods for treating and preventing apoptosis-related diseases using rna interfering agents
|
|
AU2003290586B2
(en)
|
2002-11-04 |
2009-07-02 |
University Of Massachusetts |
Allele-specific RNA interference
|
|
US9150605B2
(en)
|
2002-11-05 |
2015-10-06 |
Isis Pharmaceuticals, Inc. |
Compositions comprising alternating 2′-modified nucleosides for use in gene modulation
|
|
EP2314691A3
(en)
|
2002-11-14 |
2012-01-18 |
Dharmacon, Inc. |
Fuctional and hyperfunctional siRNA
|
|
WO2006006948A2
(en)
*
|
2002-11-14 |
2006-01-19 |
Dharmacon, Inc. |
METHODS AND COMPOSITIONS FOR SELECTING siRNA OF IMPROVED FUNCTIONALITY
|
|
US7655785B1
(en)
|
2002-11-14 |
2010-02-02 |
Rosetta Genomics Ltd. |
Bioinformatically detectable group of novel regulatory oligonucleotides and uses thereof
|
|
DE10254214A1
(de)
|
2002-11-20 |
2004-06-09 |
Beiersdorf Ag |
Oligoribonukleotide zur Behandlung von degenerativen Hauterscheinungen durch RNA-Interferenz
|
|
EP1585756B1
(en)
|
2002-11-26 |
2010-04-21 |
University of Massachusetts |
Delivery of sirnas
|
|
US7217807B2
(en)
|
2002-11-26 |
2007-05-15 |
Rosetta Genomics Ltd |
Bioinformatically detectable group of novel HIV regulatory genes and uses thereof
|
|
WO2004065600A2
(en)
|
2003-01-17 |
2004-08-05 |
MAX-PLANCK-Gesellschaft zur Förderung der Wissenschaften e.V. |
Rna interference by palindromic or modified rna molecules
|
|
DE10302421A1
(de)
|
2003-01-21 |
2004-07-29 |
Ribopharma Ag |
Doppelsträngige Ribonukleinsäure mit verbesserter Wirksamkeit
|
|
CA2514912A1
(en)
|
2003-02-05 |
2004-08-26 |
University Of Massachusetts |
Rnai targeting of viruses
|
|
US20040162235A1
(en)
|
2003-02-18 |
2004-08-19 |
Trubetskoy Vladimir S. |
Delivery of siRNA to cells using polyampholytes
|
|
US20040167090A1
(en)
|
2003-02-21 |
2004-08-26 |
Monahan Sean D. |
Covalent modification of RNA for in vitro and in vivo delivery
|
|
US20050026286A1
(en)
|
2003-03-05 |
2005-02-03 |
Jen-Tsan Chi |
Methods and compositions for selective RNAi mediated inhibition of gene expression in mammal cells
|
|
ATE479752T1
(de)
|
2003-03-07 |
2010-09-15 |
Alnylam Pharmaceuticals Inc |
Therapeutische zusammensetzungen
|
|
US20070054271A1
(en)
|
2003-03-20 |
2007-03-08 |
Dana-Farber Cancer Institute, Inc. |
Gene expression in breast cancer
|
|
JP4605799B2
(ja)
|
2003-04-02 |
2011-01-05 |
ダーマコン, インコーポレイテッド |
Rna干渉において使用するための修飾ポリヌクレオチド
|
|
DK1620544T3
(en)
|
2003-04-17 |
2019-01-14 |
Alnylam Pharmaceuticals Inc |
MODIFIED iRNA AGENTS
|
|
WO2004099372A2
(en)
|
2003-05-01 |
2004-11-18 |
University Of Florida |
Anti-scarring ribozymes and methods
|
|
US20060178327A1
(en)
|
2003-05-30 |
2006-08-10 |
Yeung Wah Hin A |
Inhibition of gene expression by delivery of specially selected double stranded or other forms of small interfering RNA precursors enabling the formation and function of small interfering RNA in vivo and in vitro
|
|
EP1633890B2
(en)
|
2003-06-02 |
2020-11-18 |
University of Massachusetts |
METHODS AND COMPOSITIONS FOR ENHANCING THE EFFICACY AND SPECIFICITY OF FNAi
|
|
US7750144B2
(en)
|
2003-06-02 |
2010-07-06 |
University Of Massachusetts |
Methods and compositions for enhancing the efficacy and specificity of RNA silencing
|
|
US7405274B2
(en)
|
2003-06-04 |
2008-07-29 |
Fibrogen, Inc. |
Connective tissue growth factor antibodies
|
|
EP3604537B1
(en)
*
|
2003-06-13 |
2021-12-08 |
Alnylam Europe AG |
Double-stranded ribonucleic acid with increased effectiveness in an organism
|
|
US20050026823A1
(en)
|
2003-06-20 |
2005-02-03 |
Biomarin Pharmaceutical Inc. |
Use of the chaperone receptor-associated protein (RAP) for the delivery of therapeutic compounds to the brain and other tissues
|
|
JP4951338B2
(ja)
|
2003-07-16 |
2012-06-13 |
プロチバ バイオセラピューティクス インコーポレイティッド |
脂質に封入された干渉rna
|
|
US20050106594A1
(en)
|
2003-08-22 |
2005-05-19 |
Andrew Ellington |
In vitro selection of aptamer beacons
|
|
US20050118625A1
(en)
|
2003-10-02 |
2005-06-02 |
Mounts William M. |
Nucleic acid arrays for detecting gene expression associated with human osteoarthritis and human proteases
|
|
US8258105B2
(en)
|
2003-10-07 |
2012-09-04 |
Isis Pharmaceuticals, Inc. |
Antisense oligonucleotides optimized for kidney targeting
|
|
CN101507822B
(zh)
|
2003-11-24 |
2012-06-06 |
坎吉有限公司 |
皮肤瘢痕形成的减少
|
|
EP1694840A2
(en)
*
|
2003-12-19 |
2006-08-30 |
Antisense Pharma GmbH |
Combination therapy associating a tgf-beta antagonist with a chemotherapeutic agent
|
|
US20080254487A1
(en)
|
2004-01-16 |
2008-10-16 |
Fibrogen, Inc. |
Connective Tissue Growth Factor Signaling
|
|
US20070269889A1
(en)
|
2004-02-06 |
2007-11-22 |
Dharmacon, Inc. |
Stabilized siRNAs as transfection controls and silencing reagents
|
|
WO2005079533A2
(en)
|
2004-02-17 |
2005-09-01 |
University Of Massachusetts |
Methods and compositions for mediating gene silencing
|
|
US20080071068A1
(en)
|
2004-02-20 |
2008-03-20 |
Hideki Oba |
Cytoplasmic Localization Dna and Rna
|
|
WO2005085443A2
(en)
|
2004-03-01 |
2005-09-15 |
Massachusetts Institute Of Technology |
Rnai-based therapeutics for allergic rhinitis and asthma
|
|
US8569474B2
(en)
|
2004-03-09 |
2013-10-29 |
Isis Pharmaceuticals, Inc. |
Double stranded constructs comprising one or more short strands hybridized to a longer strand
|
|
US20080300147A1
(en)
|
2004-03-26 |
2008-12-04 |
Nasser Chegini |
Detection and Treatment of Fibrotic Disorders
|
|
KR101147147B1
(ko)
|
2004-04-01 |
2012-05-25 |
머크 샤프 앤드 돔 코포레이션 |
Rna 간섭의 오프 타겟 효과 감소를 위한 변형된폴리뉴클레오타이드
|
|
US20050265957A1
(en)
|
2004-04-08 |
2005-12-01 |
Monahan Sean D |
Polymerized formamides for use in delivery of compounds to cells
|
|
EP2145957B1
(en)
|
2004-04-20 |
2013-12-25 |
Marina Biotech, Inc. |
Compositions for enhancing delivery of double-stranded RNA to regulate gene expression in mammalian cells
|
|
US8168600B2
(en)
|
2004-04-23 |
2012-05-01 |
Isis Pharmaceuticals, Inc. |
Compositions and methods for topical delivery of oligonucleotides
|
|
US7687616B1
(en)
|
2004-05-14 |
2010-03-30 |
Rosetta Genomics Ltd |
Small molecules modulating activity of micro RNA oligonucleotides and micro RNA targets and uses thereof
|
|
CN1997446B
(zh)
|
2004-05-20 |
2012-01-04 |
伊顿研究有限公司 |
含有包封萜成分的中空葡聚糖颗粒或细胞壁颗粒的组合物、其制备和使用方法
|
|
EP1766071A4
(en)
|
2004-06-03 |
2009-11-11 |
Isis Pharmaceuticals Inc |
DOUBLE-STRONG COMPOSITIONS WITH DIFFERENTLY MODIFIED STRANDS FOR USE IN GENE MODULATION
|
|
AU2005252273B2
(en)
|
2004-06-07 |
2011-04-28 |
Arbutus Biopharma Corporation |
Lipid encapsulated interfering RNA
|
|
US7740861B2
(en)
|
2004-06-16 |
2010-06-22 |
University Of Massachusetts |
Drug delivery product and methods
|
|
ES2632913T3
(es)
|
2004-08-23 |
2017-09-18 |
Sylentis S.A.U. |
Tratamiento con ARNpi de trastornos oculares caracterizados por una presión intraocular elevada
|
|
US20060211766A1
(en)
|
2004-09-30 |
2006-09-21 |
Kaplan Leonard L |
Gelled immunomodulating topical compositions and a method of treating warts and other human papilloma virus skin infections
|
|
JP2008514242A
(ja)
|
2004-10-01 |
2008-05-08 |
ノバルティス ヴァクシンズ アンド ダイアグノスティクス, インコーポレイテッド |
改変型の小さい干渉rna分子および使用方法
|
|
US20100069620A1
(en)
|
2004-12-02 |
2010-03-18 |
Rxi Pharmaceuticals Corp. |
Novel compositions of chemically modified small interfering rna
|
|
EP1827436A4
(en)
|
2004-12-15 |
2011-08-10 |
Merck Sharp & Dohme |
INHIBITORS OF ACT ACTIVITY
|
|
US20060142228A1
(en)
|
2004-12-23 |
2006-06-29 |
Ambion, Inc. |
Methods and compositions concerning siRNA's as mediators of RNA interference
|
|
TWI386225B
(zh)
|
2004-12-23 |
2013-02-21 |
Alcon Inc |
用於治療眼睛病症的結締組織生長因子(CTGF)RNA干擾(RNAi)抑制技術
|
|
US20060171943A1
(en)
|
2005-02-01 |
2006-08-03 |
Amgen Inc. |
Compositions and methods of treating fibrotic disorders
|
|
WO2006128141A2
(en)
|
2005-05-27 |
2006-11-30 |
Sirna Therapeutics, Inc. |
Rna interference mediated inhibition of stromal cell-derived factor-1 (sdf-1) gene expression using short interfering nucleic acid (sina)
|
|
WO2007030167A1
(en)
|
2005-09-02 |
2007-03-15 |
Nastech Pharmaceutical Company Inc. |
Modification of double-stranded ribonucleic acid molecules
|
|
US20090209624A1
(en)
|
2005-10-24 |
2009-08-20 |
University Of Massachusetts |
Compositions and their uses for gene therapy of bone conditions
|
|
CN101300033A
(zh)
|
2005-11-07 |
2008-11-05 |
泰坦医药品公司 |
用镓对不良肝脏病症的治疗和预防
|
|
FR2894582B1
(fr)
|
2005-12-12 |
2008-02-22 |
Fabre Pierre Dermo Cosmetique |
Sirna anti myosine va et depigmentation de la peau
|
|
EP1968643A2
(en)
*
|
2005-12-16 |
2008-09-17 |
Diatos |
Cell penetrating peptide conjugates for delivering of nucleic acids into a cell
|
|
US20120115923A1
(en)
|
2005-12-30 |
2012-05-10 |
Intradigm Corporation |
Sirna Compositions Promoting Scar-Free Wound Healing of Skin and Methods for Wound Treatment
|
|
CN101374528A
(zh)
*
|
2006-01-20 |
2009-02-25 |
夸克医药公司 |
Rtp801的治疗用途
|
|
US7825099B2
(en)
*
|
2006-01-20 |
2010-11-02 |
Quark Pharmaceuticals, Inc. |
Treatment or prevention of oto-pathologies by inhibition of pro-apoptotic genes
|
|
JP2009523823A
(ja)
|
2006-01-23 |
2009-06-25 |
アボット・ラボラトリーズ |
siRNA送達のための化学的に修飾されたポリカチオンポリマー
|
|
EP1986609A2
(en)
|
2006-01-26 |
2008-11-05 |
University of Massachusetts |
Rna silencing agents for use in therapy and nanotransporters for efficient delivery of same
|
|
CA2638622A1
(en)
|
2006-03-09 |
2007-09-09 |
University Of Rochester |
Peripheral and neural inflammatory crosstalk
|
|
EA201100813A1
(ru)
|
2006-04-03 |
2012-06-29 |
Сантарис Фарма А/С |
Фармацевтическая композиция
|
|
EP2015758B1
(en)
|
2006-05-05 |
2014-04-02 |
Isis Pharmaceuticals, Inc. |
Compounds and methods for modulating expression apob
|
|
ES2610703T3
(es)
|
2006-06-23 |
2017-05-03 |
Engeneic Molecular Delivery Pty Ltd. |
Administración dirigida de fármacos, ácidos nucleicos terapéuticos y ácidos nucleicos funcionales a células mamíferas mediante células bacterianas muertas intactas
|
|
US20080039415A1
(en)
|
2006-08-11 |
2008-02-14 |
Gregory Robert Stewart |
Retrograde transport of sirna and therapeutic uses to treat neurologic disorders
|
|
KR101133799B1
(ko)
|
2006-08-18 |
2012-04-24 |
에프. 호프만-라 로슈 아게 |
폴리뉴클레오타이드의 생체내 전달을 위한 다가접합체
|
|
US8252755B2
(en)
|
2006-09-22 |
2012-08-28 |
Dharmacon, Inc. |
Duplex oligonucleotide complexes and methods for gene silencing by RNA interference
|
|
JP2010507387A
(ja)
|
2006-10-25 |
2010-03-11 |
クアーク・ファーマスーティカルス、インコーポレイテッド |
新規のsiRNAおよびその使用方法
|
|
US20080193443A1
(en)
|
2006-10-30 |
2008-08-14 |
Oxana Beskrovnaya |
Methods and compositions for the treatment of polycystic diseases
|
|
US8039010B2
(en)
|
2006-11-03 |
2011-10-18 |
Allergan, Inc. |
Sustained release intraocular drug delivery systems comprising a water soluble therapeutic agent and a release modifier
|
|
US20090010948A1
(en)
|
2006-12-15 |
2009-01-08 |
The University Of Hong Kong |
Anti-tumor vaccines delivered by dendritic cells devoid of interleukin-10
|
|
WO2008109353A1
(en)
|
2007-03-02 |
2008-09-12 |
Mdrna, Inc. |
Nucleic acid compounds for inhibiting map2k gene expression and uses thereof
|
|
US20080311040A1
(en)
|
2007-03-06 |
2008-12-18 |
Flagship Ventures |
METHODS AND COMPOSITIONS FOR IMPROVED THERAPEUTIC EFFECTS WITH siRNA
|
|
CA2692320A1
(en)
|
2007-07-02 |
2009-01-08 |
Wyeth |
Methods of treating bone disorders with modulators of axl
|
|
US9884899B2
(en)
|
2007-07-06 |
2018-02-06 |
Promedior, Inc. |
Methods for treating fibrosis using CRP antagonists
|
|
WO2009020344A2
(en)
|
2007-08-06 |
2009-02-12 |
Postech Acad Ind Found |
Small interfering rnas (sirnas) controlling multiple target genes and method for preparing the same
|
|
US20090043367A1
(en)
|
2007-08-09 |
2009-02-12 |
Yitzhak Zilberman |
Apparatus and methods for removing an electronic implant from a body
|
|
EP2192920A4
(en)
|
2007-08-21 |
2010-09-01 |
Univ Virginia Commonwealth |
METHOD AND COMPOSITIONS FOR TREATING OR PREVENTING RADIATION-INDUCED FIBROSIS
|
|
EP3121281B1
(en)
|
2007-08-27 |
2021-03-31 |
1Globe Health Institute LLC |
Compositions of asymmetric interfering rna and uses thereof
|
|
JP5296081B2
(ja)
*
|
2007-10-02 |
2013-09-25 |
テレフオンアクチーボラゲット エル エム エリクソン(パブル) |
通信システムの方法及び装置
|
|
EP2205740A2
(en)
|
2007-10-02 |
2010-07-14 |
Rxi Pharmaceuticals Corp. |
Tripartite rnai constructs
|
|
AU2008306455C1
(en)
|
2007-10-03 |
2014-04-17 |
Quark Pharmaceuticals, Inc. |
Novel siRNA structures
|
|
CA2910760C
(en)
|
2007-12-04 |
2019-07-09 |
Muthiah Manoharan |
Targeting lipids
|
|
KR100949791B1
(ko)
|
2007-12-18 |
2010-03-30 |
이동기 |
오프-타겟 효과를 최소화하고 RNAi 기구를 포화시키지않는 신규한 siRNA 구조 및 그 용도
|
|
EP2245039A4
(en)
|
2008-01-31 |
2012-06-06 |
Alnylam Pharmaceuticals Inc |
OPTIMIZED METHODS FOR EXPORING DSRNA TO TARGET THE PCSK9 GEN
|
|
AU2009213147A1
(en)
*
|
2008-02-11 |
2009-08-20 |
Rxi Pharmaceuticals Corp. |
Modified RNAi polynucleotides and uses thereof
|
|
US8361980B2
(en)
|
2008-03-07 |
2013-01-29 |
Santaris Pharma A/S |
Pharmaceutical compositions for treatment of microRNA related diseases
|
|
WO2009126933A2
(en)
|
2008-04-11 |
2009-10-15 |
Alnylam Pharmaceuticals, Inc. |
Site-specific delivery of nucleic acids by combining targeting ligands with endosomolytic components
|
|
WO2010006237A2
(en)
|
2008-07-11 |
2010-01-14 |
Alnylam Pharmaceuticals, Inc. |
Phosphorothioate oligonucleotides non-nucleosidic phosphorothiotes as delivery agents for irna agents
|
|
CN102089429A
(zh)
*
|
2008-07-15 |
2011-06-08 |
弗·哈夫曼-拉罗切有限公司 |
用于抑制TGF-β受体基因表达的组合物和方法
|
|
US8815818B2
(en)
|
2008-07-18 |
2014-08-26 |
Rxi Pharmaceuticals Corporation |
Phagocytic cell delivery of RNAI
|
|
WO2010011346A1
(en)
|
2008-07-24 |
2010-01-28 |
Rxi Pharmaceuticals Corporation |
Rnai constructs and uses therof
|
|
US8946172B2
(en)
|
2008-08-25 |
2015-02-03 |
Excaliard Pharmaceuticals, Inc. |
Method for reducing scarring during wound healing using antisense compounds directed to CTGF
|
|
WO2010027830A2
(en)
|
2008-08-25 |
2010-03-11 |
Excaliard Pharmaceuticals, Inc. |
Methods for modulation of connective tissue growth factor expression by administering antisense oligonucleotides through a delivery system so as to reduce scarring from wound healing and threat fibrotic diseases
|
|
ES2657696T3
(es)
|
2008-08-25 |
2018-03-06 |
Excaliard Pharmaceuticals, Inc. |
Método para reducir la cicatrización durante la curación de una herida utilizando compuestos antisentido dirigidos al CTGF
|
|
GB2465902B
(en)
|
2008-08-25 |
2010-12-08 |
Excaliard Pharmaceuticals Inc |
Antisense oligonucleotides directed against connective tissue growth factor and uses thereof
|
|
JP2012502991A
(ja)
|
2008-09-22 |
2012-02-02 |
アールエックスアイ ファーマシューティカルズ コーポレーション |
皮膚適用におけるrna干渉
|
|
US8691971B2
(en)
|
2008-09-23 |
2014-04-08 |
Scott G. Petersen |
Self delivering bio-labile phosphate protected pro-oligos for oligonucleotide based therapeutics and mediating RNA interference
|
|
ES2740129T3
(es)
*
|
2008-09-25 |
2020-02-05 |
Alnylam Pharmaceuticals Inc |
Composiciones formuladas en lípidos y métodos de inhibición de la expresión del gen de suero amiloide A
|
|
WO2010059226A2
(en)
|
2008-11-19 |
2010-05-27 |
Rxi Pharmaceuticals Corporation |
Inhibition of map4k4 through rnai
|
|
US9493774B2
(en)
|
2009-01-05 |
2016-11-15 |
Rxi Pharmaceuticals Corporation |
Inhibition of PCSK9 through RNAi
|
|
WO2010090762A1
(en)
|
2009-02-04 |
2010-08-12 |
Rxi Pharmaceuticals Corporation |
Rna duplexes with single stranded phosphorothioate nucleotide regions for additional functionality
|
|
US8486909B2
(en)
|
2009-06-24 |
2013-07-16 |
Board Of Regents Of The University Of Nebraska |
Compositions and methods for the diagnosis and treatment of inflammatory disorders and fibrotic disease
|
|
JP2013506697A
(ja)
|
2009-10-06 |
2013-02-28 |
アンジオケム インコーポレーテッド |
治療薬を輸送するための組成物と方法
|
|
WO2011109248A1
(en)
|
2010-03-02 |
2011-09-09 |
Hapten Pharmaceuticals, Llc |
Effective sensitizing dose of a gelled immunomodulating topical composition
|
|
WO2011109698A1
(en)
|
2010-03-04 |
2011-09-09 |
Rxi Pharmaceuticals Corporation |
Formulations and methods for targeted delivery to phagocyte cells
|
|
CN106074591B
(zh)
|
2010-03-24 |
2020-01-14 |
菲奥医药公司 |
眼部症候中的rna干扰
|
|
EP2550000A4
(en)
|
2010-03-24 |
2014-03-26 |
Advirna Inc |
RNAI COMPOUNDS OF REDUCED SIZE ADMINISTERING
|
|
EP2550002B1
(en)
|
2010-03-24 |
2019-05-08 |
Phio Pharmaceuticals Corp. |
Rna interference in dermal and fibrotic indications
|
|
ES2729956T3
(es)
|
2011-02-02 |
2019-11-07 |
Excaliard Pharmaceuticals Inc |
Compuestos antisentido dirigidos al factor de crecimiento de tejido conectivo (ctgf) para su uso en un procedimiento de tratamiento de queloides o cicatrices hipertróficas
|
|
US20140072613A1
(en)
|
2012-09-10 |
2014-03-13 |
Cynthia Lander |
Compositions and Methods for Treating Cutaneous Scarring
|
|
JP6772062B2
(ja)
|
2013-12-02 |
2020-10-21 |
フィオ ファーマシューティカルズ コーポレーションPhio Pharmaceuticals Corp. |
癌の免疫療法
|
|
US20160304875A1
(en)
|
2013-12-04 |
2016-10-20 |
Rxi Pharmaceuticals Corporation |
Methods for treatment of wound healing utilizing chemically modified oligonucleotides
|
|
US11279934B2
(en)
|
2014-04-28 |
2022-03-22 |
Phio Pharmaceuticals Corp. |
Methods for treating cancer using nucleic acids targeting MDM2 or MYCN
|
|
US20170051290A1
(en)
|
2014-05-01 |
2017-02-23 |
Rxi Pharmaceuticals Corporation |
Methods for treatment of disorders in the front of the eye utilizing nucleic acid molecules
|
|
US10900039B2
(en)
|
2014-09-05 |
2021-01-26 |
Phio Pharmaceuticals Corp. |
Methods for treating aging and skin disorders using nucleic acids targeting Tyr or MMP1
|
|
CA2969590A1
(en)
|
2014-12-03 |
2016-06-09 |
Rxi Pharmaceuticals Corporation |
Methods for the treatment of alopecia areata utilizing gene modulation approaches
|
|
US9809817B2
(en)
|
2015-04-03 |
2017-11-07 |
University Of Massachusetts |
Oligonucleotide compounds for targeting huntingtin mRNA
|
|
RS62672B1
(sr)
|
2015-04-03 |
2021-12-31 |
Univ Massachusetts |
Oligonukleotidna jedinjenja za tretman preeklampsije i drugih angiogenskih poremećaja
|
|
JP6892433B2
(ja)
|
2015-04-03 |
2021-06-23 |
ユニバーシティ・オブ・マサチューセッツUniversity Of Massachusetts |
十分に安定化された非対称sirna
|
|
US11001845B2
(en)
|
2015-07-06 |
2021-05-11 |
Phio Pharmaceuticals Corp. |
Nucleic acid molecules targeting superoxide dismutase 1 (SOD1)
|
|
WO2017007825A1
(en)
|
2015-07-06 |
2017-01-12 |
Rxi Pharmaceuticals Corporation |
Methods for treating neurological disorders using a synergistic small molecule and nucleic acids therapeutic approach
|
|
EP3347000A4
(en)
|
2015-09-11 |
2019-03-27 |
Phio Pharmaceuticals Corp. |
METHODS OF TREATING DISORDERS AND SKIN DISORDERS USING HAPTENES
|
|
AU2016322934A1
(en)
|
2015-09-14 |
2018-04-12 |
Compass Therapeutics Llc |
Compositions and methods for treating cancer via antagonism of the CD155/TIGIT pathway and TGF-beta
|
|
US11021707B2
(en)
|
2015-10-19 |
2021-06-01 |
Phio Pharmaceuticals Corp. |
Reduced size self-delivering nucleic acid compounds targeting long non-coding RNA
|
|
US20200085764A1
(en)
|
2017-04-19 |
2020-03-19 |
Phio Pharmaceuticals Corp. |
Topical delivery of nucleic acid compounds
|