JP2012519181A - ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用 - Google Patents

ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用 Download PDF

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Publication number
JP2012519181A
JP2012519181A JP2011552194A JP2011552194A JP2012519181A JP 2012519181 A JP2012519181 A JP 2012519181A JP 2011552194 A JP2011552194 A JP 2011552194A JP 2011552194 A JP2011552194 A JP 2011552194A JP 2012519181 A JP2012519181 A JP 2012519181A
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compound
prodrug
pharmaceutically acceptable
acceptable salt
composition
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JP2012519181A5 (https=
Inventor
ポーター，スティーブン，ビー．
ブラッドフォード，ウィリアムスン，ジーグラー
スミス，パトリック，エフ．
イェッツァー，エレン，エス．
ラ ロサ，アベル デ
ロジャース，マイケル，ディー．
サイモンズ，ウィリアム，ティー．
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Roche Palo Alto LLC
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Roche Palo Alto LLC
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Application filed by Roche Palo Alto LLC filed Critical Roche Palo Alto LLC
Publication of JP2012519181A publication Critical patent/JP2012519181A/ja
Publication of JP2012519181A5 publication Critical patent/JP2012519181A5/ja
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    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/70—Carbohydrates; Sugars; Derivatives thereof
    • A61K31/7042—Compounds having saccharide radicals and heterocyclic rings
    • A61K31/7052—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides
    • A61K31/706—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom
    • A61K31/7064—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines
    • A61K31/7068—Compounds having saccharide radicals and heterocyclic rings having nitrogen as a ring hetero atom, e.g. nucleosides, nucleotides containing six-membered rings with nitrogen as a ring hetero atom containing condensed or non-condensed pyrimidines having oxo groups directly attached to the pyrimidine ring, e.g. cytidine, cytidylic acid
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P1/00—Drugs for disorders of the alimentary tract or the digestive system
    • A61P1/16—Drugs for disorders of the alimentary tract or the digestive system for liver or gallbladder disorders, e.g. hepatoprotective agents, cholagogues, litholytics
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P37/00—Drugs for immunological or allergic disorders
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P43/00—Drugs for specific purposes, not provided for in groups A61P1/00-A61P41/00
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K2121/00—Preparations for use in therapy

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  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Veterinary Medicine (AREA)
  • Public Health (AREA)
  • Chemical & Material Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Animal Behavior & Ethology (AREA)
  • Epidemiology (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • General Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Engineering & Computer Science (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Oncology (AREA)
  • Communicable Diseases (AREA)
  • Immunology (AREA)
  • Gastroenterology & Hepatology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
JP2011552194A 2009-02-27 2010-02-26 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用 Pending JP2012519181A (ja)

Applications Claiming Priority (5)

Application Number Priority Date Filing Date Title
US15641409P 2009-02-27 2009-02-27
US61/156,414 2009-02-27
US25736709P 2009-11-02 2009-11-02
US61/257,367 2009-11-02
PCT/US2010/025611 WO2010099458A1 (en) 2009-02-27 2010-02-26 Combination of a nucleoside polymerase inhibitor with a macrocyclic protease inhibitor and use thereof in the treatment of hepatitis c, liver fibrosis and impaired liver function

Related Child Applications (1)

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JP2015041648A Division JP2015098501A (ja) 2009-02-27 2015-03-03 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用

Publications (2)

Publication Number Publication Date
JP2012519181A true JP2012519181A (ja) 2012-08-23
JP2012519181A5 JP2012519181A5 (https=) 2013-03-28

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JP2011552194A Pending JP2012519181A (ja) 2009-02-27 2010-02-26 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用
JP2015041648A Withdrawn JP2015098501A (ja) 2009-02-27 2015-03-03 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用

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JP2015041648A Withdrawn JP2015098501A (ja) 2009-02-27 2015-03-03 ヌクレオシドポリメラーゼインヒビターと大環状プロテアーゼインヒビターの併用ならびにｃ型肝炎、肝臓線維症および肝臓機能障害の治療におけるその使用

Country Status (22)

Country Link
US (2) US20120128628A1 (https=)
EP (1) EP2400966A1 (https=)
JP (2) JP2012519181A (https=)
KR (1) KR20110135941A (https=)
CN (1) CN102361641A (https=)
AR (1) AR075584A1 (https=)
AU (1) AU2010217818A1 (https=)
BR (1) BRPI1009338A2 (https=)
CA (1) CA2751220A1 (https=)
CL (1) CL2011002082A1 (https=)
CO (1) CO6410304A2 (https=)
CR (1) CR20110453A (https=)
EC (1) ECSP11011292A (https=)
IL (1) IL214760A0 (https=)
MA (1) MA33236B1 (https=)
MX (1) MX2011008980A (https=)
NZ (1) NZ594524A (https=)
PE (1) PE20120777A1 (https=)
RU (1) RU2011139180A (https=)
SG (1) SG173774A1 (https=)
TW (1) TWI473810B (https=)
WO (1) WO2010099458A1 (https=)

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