ES8801303A1 - Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido. - Google Patents

Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.

Info

Publication number
ES8801303A1
ES8801303A1 ES554967A ES554967A ES8801303A1 ES 8801303 A1 ES8801303 A1 ES 8801303A1 ES 554967 A ES554967 A ES 554967A ES 554967 A ES554967 A ES 554967A ES 8801303 A1 ES8801303 A1 ES 8801303A1
Authority
ES
Spain
Prior art keywords
preparation
therapeutic nucleosides
nucleosides
therapeutic
dideoxynucleosides
Prior art date
Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
Expired
Application number
ES554967A
Other languages
English (en)
Other versions
ES554967A0 (es
Current Assignee (The listed assignees may be inaccurate. Google has not performed a legal analysis and makes no representation or warranty as to the accuracy of the list.)
Wellcome Foundation Ltd
Original Assignee
Wellcome Foundation Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Priority claimed from GB858512330A external-priority patent/GB8512330D0/en
Priority claimed from GB868604239A external-priority patent/GB8604239D0/en
Application filed by Wellcome Foundation Ltd filed Critical Wellcome Foundation Ltd
Publication of ES554967A0 publication Critical patent/ES554967A0/es
Publication of ES8801303A1 publication Critical patent/ES8801303A1/es
Expired legal-status Critical Current

Links

Classifications

    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P31/00—Antiinfectives, i.e. antibiotics, antiseptics, chemotherapeutics
    • A61P31/12—Antivirals
    • A61P31/14—Antivirals for RNA viruses
    • A61P31/18—Antivirals for RNA viruses for HIV
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D405/00—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom
    • C07D405/02—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings
    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/02—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6
    • C07D473/04—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms
    • C07D473/06—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3
    • C07D473/10—Heterocyclic compounds containing purine ring systems with oxygen, sulphur, or nitrogen atoms directly attached in positions 2 and 6 two oxygen atoms with radicals containing only hydrogen and carbon atoms, attached in position 1 or 3 with methyl radicals in positions 3 and 7, e.g. theobromine
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/32—Nitrogen atom
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07D—HETEROCYCLIC COMPOUNDS
    • C07D473/00—Heterocyclic compounds containing purine ring systems
    • C07D473/26—Heterocyclic compounds containing purine ring systems with an oxygen, sulphur, or nitrogen atom directly attached in position 2 or 6, but not in both
    • C07D473/36—Sulfur atom
    • C07D473/38—Sulfur atom attached in position 6
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/06—Pyrimidine radicals
    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
    • C07H—SUGARS; DERIVATIVES THEREOF; NUCLEOSIDES; NUCLEOTIDES; NUCLEIC ACIDS
    • C07H19/00—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof
    • C07H19/02—Compounds containing a hetero ring sharing one ring hetero atom with a saccharide radical; Nucleosides; Mononucleotides; Anhydro-derivatives thereof sharing nitrogen
    • C07H19/04—Heterocyclic radicals containing only nitrogen atoms as ring hetero atom
    • C07H19/16—Purine radicals

Landscapes

  • Chemical & Material Sciences (AREA)
  • Organic Chemistry (AREA)
  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • General Health & Medical Sciences (AREA)
  • Molecular Biology (AREA)
  • Virology (AREA)
  • Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
  • Biochemistry (AREA)
  • Chemical Kinetics & Catalysis (AREA)
  • General Chemical & Material Sciences (AREA)
  • Medicinal Chemistry (AREA)
  • Communicable Diseases (AREA)
  • Genetics & Genomics (AREA)
  • Pharmacology & Pharmacy (AREA)
  • Animal Behavior & Ethology (AREA)
  • Biotechnology (AREA)
  • Public Health (AREA)
  • Veterinary Medicine (AREA)
  • Engineering & Computer Science (AREA)
  • Oncology (AREA)
  • AIDS & HIV (AREA)
  • Tropical Medicine & Parasitology (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Saccharide Compounds (AREA)
  • Plural Heterocyclic Compounds (AREA)

Abstract

PROCEDIMIENTO PARA LA PREPARACION DE COMPOSICIONES FARMACEUTICAS QUE CONTIENEN 2'',3''-DIDESOXI-NUCLEOXIDO, DE FORMULA (I), Y DE SUS DERIVADOS FISIOLOGICAMENTE COMPATIBLES. COMPRENDE LA REACCION DE UNA BASE DE PURINA O CITOSINA, DE FORMULA B-H, O UN DERIVADO FUNCIONAL DE LA MISMA CON UN COMPUESTO QUE PERMITE INTRODUCIR EL ANILLO DE RIBOFURANOSILO EN LA POSICION 9 O 1 DE LA BASE, PARA OBTENER UN COMPUESTO DE FORMULA (I), EN LA QUE B ES UNA BASE DE PURINA O CITOSINA. LA REACCION SE EFECTUA EN PRESENCIA DE ENZIMAS, A UN PH DE 6 A 9, Y A TEMPERATURA AMBIENTE. ESTAS COMPOSICIONES TIENEN APLICACIONES FARMACOLOGICAS PARA EL TRATAMIENTO Y PROFILAXIS DE INFECCIONES VIRICAS.
ES554967A 1985-05-15 1986-05-14 Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido. Expired ES8801303A1 (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
GB858512330A GB8512330D0 (en) 1985-05-15 1985-05-15 Antiviral compounds
GB868604239A GB8604239D0 (en) 1986-02-20 1986-02-20 Antiviral compounds

Publications (2)

Publication Number Publication Date
ES554967A0 ES554967A0 (es) 1987-12-16
ES8801303A1 true ES8801303A1 (es) 1987-12-16

Family

ID=26289262

Family Applications (1)

Application Number Title Priority Date Filing Date
ES554967A Expired ES8801303A1 (es) 1985-05-15 1986-05-14 Un procedimiento para preparar una formulacion farmaceutica que contiene un 2'3'-didesoxi-nucleosido.

Country Status (13)

Country Link
EP (1) EP0206497B1 (es)
JP (1) JPH07116042B2 (es)
AT (1) ATE108794T1 (es)
AU (2) AU591125B2 (es)
CA (1) CA1314875C (es)
DE (1) DE3689976T2 (es)
DK (1) DK224286A (es)
ES (1) ES8801303A1 (es)
FI (1) FI87783C (es)
GR (1) GR861255B (es)
HU (1) HU196607B (es)
NZ (1) NZ216172A (es)
PT (1) PT82580B (es)

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US4879277A (en) * 1985-08-26 1989-11-07 The United States Of America As Represented By The Department Of Health And Human Services Antiviral compositions and methods
WO1987001284A1 (en) * 1985-08-26 1987-03-12 United States Of America, Represented By The Unite Inhibition of in vitro infectivity and cytopathic effect of htlv-iii/lav by 2',3'-dideoxynosine, 2',3'-dideoxyguanosine, or 2',3'-dideoxyadenosine
GB8602346D0 (en) * 1986-01-30 1986-03-05 Wellcome Found Antiviral combinations
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WO1988002629A1 (en) * 1986-10-16 1988-04-21 American Health Products Corporation 2',3'-didesoxyadenosine composition
NZ223910A (en) * 1987-03-20 1991-02-26 Bristol Myers Co 2',3'-dideoxynucleosides, process for their production and intermediates therefor
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DE3850571T2 (de) * 1987-03-24 1994-10-27 Nycomed Imaging As 2',3'-dideoxyribofuranoxid-derivate.
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Also Published As

Publication number Publication date
AU622950B2 (en) 1992-04-30
PT82580A (en) 1986-06-01
EP0206497A2 (en) 1986-12-30
FI87783B (fi) 1992-11-13
PT82580B (pt) 1989-01-17
FI87783C (fi) 1993-02-25
JPH07116042B2 (ja) 1995-12-13
DK224286D0 (da) 1986-05-14
FI862011A0 (fi) 1986-05-14
ES554967A0 (es) 1987-12-16
ATE108794T1 (de) 1994-08-15
HU196607B (en) 1988-12-28
EP0206497A3 (en) 1988-06-08
NZ216172A (en) 1989-08-29
AU591125B2 (en) 1989-11-30
FI862011A (fi) 1986-11-16
JPS61280500A (ja) 1986-12-11
DE3689976T2 (de) 1995-03-16
AU4544389A (en) 1990-05-17
DK224286A (da) 1986-11-16
AU5744086A (en) 1986-11-20
EP0206497B1 (en) 1994-07-20
GR861255B (en) 1986-09-16
CA1314875C (en) 1993-03-23
DE3689976D1 (de) 1994-08-25
HUT41809A (en) 1987-05-28

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