JP2012508260A5 - - Google Patents
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- JP2012508260A5 JP2012508260A5 JP2011535772A JP2011535772A JP2012508260A5 JP 2012508260 A5 JP2012508260 A5 JP 2012508260A5 JP 2011535772 A JP2011535772 A JP 2011535772A JP 2011535772 A JP2011535772 A JP 2011535772A JP 2012508260 A5 JP2012508260 A5 JP 2012508260A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- aliphatic
- compound
- acceptable salt
- pharmaceutically acceptable
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
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- 125000001931 aliphatic group Chemical group 0.000 claims description 181
- 150000001875 compounds Chemical class 0.000 claims description 145
- 125000000217 alkyl group Chemical group 0.000 claims description 130
- 229910052760 oxygen Inorganic materials 0.000 claims description 90
- 229910052757 nitrogen Inorganic materials 0.000 claims description 89
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 86
- 125000005842 heteroatom Chemical group 0.000 claims description 62
- 229910052717 sulfur Chemical group 0.000 claims description 62
- 150000003839 salts Chemical class 0.000 claims description 60
- 229910052799 carbon Inorganic materials 0.000 claims description 57
- 125000005843 halogen group Chemical group 0.000 claims description 56
- QVGXLLKOCUKJST-UHFFFAOYSA-N atomic oxygen Chemical group [O] QVGXLLKOCUKJST-UHFFFAOYSA-N 0.000 claims description 50
- 239000001301 oxygen Chemical group 0.000 claims description 50
- NINIDFKCEFEMDL-UHFFFAOYSA-N Sulfur Chemical group [S] NINIDFKCEFEMDL-UHFFFAOYSA-N 0.000 claims description 49
- 239000011593 sulfur Chemical group 0.000 claims description 49
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 claims description 44
- 125000006273 (C1-C3) alkyl group Chemical group 0.000 claims description 41
- -1 benzimidazolinyl Chemical group 0.000 claims description 34
- 125000002950 monocyclic group Chemical group 0.000 claims description 34
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 30
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- 229920006395 saturated elastomer Polymers 0.000 claims description 28
- 125000002619 bicyclic group Chemical group 0.000 claims description 27
- 229910052739 hydrogen Inorganic materials 0.000 claims description 25
- 125000004076 pyridyl group Chemical group 0.000 claims description 24
- 125000001797 benzyl group Chemical group [H]C1=C([H])C([H])=C(C([H])=C1[H])C([H])([H])* 0.000 claims description 16
- 229910002091 carbon monoxide Inorganic materials 0.000 claims description 15
- 125000000719 pyrrolidinyl group Chemical group 0.000 claims description 15
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- 125000004568 thiomorpholinyl group Chemical group 0.000 claims description 8
- 125000002777 acetyl group Chemical group [H]C([H])([H])C(*)=O 0.000 claims description 7
- 125000002883 imidazolyl group Chemical group 0.000 claims description 6
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- 125000003118 aryl group Chemical group 0.000 claims description 5
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- GLUUGHFHXGJENI-UHFFFAOYSA-N Piperazine Chemical compound C1CNCCN1 GLUUGHFHXGJENI-UHFFFAOYSA-N 0.000 claims description 4
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- 125000003354 benzotriazolyl group Chemical group N1N=NC2=C1C=CC=C2* 0.000 claims description 2
- 125000004541 benzoxazolyl group Chemical group O1C(=NC2=C1C=CC=C2)* 0.000 claims description 2
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- 125000006085 pyrrolopyridyl group Chemical group 0.000 claims description 2
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-
2009
- 2009-11-10 WO PCT/US2009/063922 patent/WO2010054398A1/en not_active Ceased
- 2009-11-10 AU AU2009313198A patent/AU2009313198B2/en not_active Ceased
- 2009-11-10 NZ NZ593316A patent/NZ593316A/xx not_active IP Right Cessation
- 2009-11-10 MX MX2011004953A patent/MX2011004953A/es active IP Right Grant
- 2009-11-10 CA CA2743134A patent/CA2743134A1/en not_active Abandoned
- 2009-11-10 CN CN200980152891.XA patent/CN102264721B/zh not_active Expired - Fee Related
- 2009-11-10 JP JP2011535772A patent/JP5702293B2/ja not_active Expired - Fee Related
- 2009-11-10 EP EP09756203A patent/EP2370424A1/en not_active Withdrawn
- 2009-11-10 KR KR1020117013234A patent/KR101712576B1/ko not_active Expired - Fee Related
- 2009-11-10 RU RU2011123647/04A patent/RU2011123647A/ru not_active Application Discontinuation
- 2009-11-10 KR KR1020177002740A patent/KR20170015566A/ko not_active Ceased
-
2011
- 2011-05-10 ZA ZA2011/03411A patent/ZA201103411B/en unknown
- 2011-05-11 IL IL212817A patent/IL212817A/en active IP Right Grant
- 2011-10-27 US US13/104,291 patent/US8410112B2/en not_active Expired - Fee Related
-
2013
- 2013-01-16 US US13/742,948 patent/US20140113005A1/en not_active Abandoned
-
2014
- 2014-08-15 JP JP2014165380A patent/JP5972942B2/ja not_active Expired - Fee Related
-
2016
- 2016-05-25 AU AU2016203414A patent/AU2016203414A1/en not_active Abandoned
- 2016-07-19 JP JP2016141092A patent/JP2016216495A/ja active Pending
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