JP5702293B2 - Ａｔｒキナーゼの阻害剤として有用な化合物 - Google Patents

Ａｔｒキナーゼの阻害剤として有用な化合物 Download PDF

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JP5702293B2
JP5702293B2 JP2011535772A JP2011535772A JP5702293B2 JP 5702293 B2 JP5702293 B2 JP 5702293B2 JP 2011535772 A JP2011535772 A JP 2011535772A JP 2011535772 A JP2011535772 A JP 2011535772A JP 5702293 B2 JP5702293 B2 JP 5702293B2
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alkyl
aliphatic
compound
pharmaceutically acceptable
acceptable salt
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JP2012508260A (ja
JP2012508260A5 (enExample
Inventor
ジャン−ダミアン シャリエ，
ジャン−ダミアン シャリエ，
スティーブン デュラント，
スティーブン デュラント，
ケイ，　デイビッド
デイビッド ケイ，
マイケル オドネル，
マイケル オドネル，
ネグテル，　ロナルド
ロナルド ネグテル，
サムヘアリー マコーミック，
サムヘアリー マコーミック，
ジョアン ピンダー，
ジョアン ピンダー，
アニサ ニザラリ ビラニ，
アニサ ニザラリ ビラニ，
スティーブン ヤング，
スティーブン ヤング，
ヘイリー マリー ビンチ，
ヘイリー マリー ビンチ，
トーマス クリーブランド，
トーマス クリーブランド，
レブ ティー．ディー． ファニング，
レブ ティー．ディー． ファニング，
デニス ジェイ． ハーレイ，
デニス ジェイ． ハーレイ，
プラモッド ジョシ，
プラモッド ジョシ，
ウルビー シェス，
ウルビー シェス，
アリナ シリナ，
アリナ シリナ，
フィリップ マイケル リーパー，
フィリップ マイケル リーパー，
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Vertex Pharmaceuticals Inc
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Vertex Pharmaceuticals Inc
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    • C—CHEMISTRY; METALLURGY
    • C07—ORGANIC CHEMISTRY
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    • C07D403/00—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00
    • C07D403/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing three or more hetero rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/495—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with two or more nitrogen atoms as the only ring heteroatoms, e.g. piperazine or tetrazines
    • A61K31/4965—Non-condensed pyrazines
    • A61K31/497—Non-condensed pyrazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
    • A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
    • A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
    • A61K31/00—Medicinal preparations containing organic active ingredients
    • A61K31/33—Heterocyclic compounds
    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/54—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one sulfur as the ring hetero atoms, e.g. sulthiame
    • A61K31/541—Non-condensed thiazines containing further heterocyclic rings
    • A—HUMAN NECESSITIES
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/55—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole
    • A61K31/551—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having seven-membered rings, e.g. azelastine, pentylenetetrazole having two nitrogen atoms, e.g. dilazep
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    • A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
    • A61P35/00—Antineoplastic agents
    • A—HUMAN NECESSITIES
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    • C07D241/10—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members
    • C07D241/14—Heterocyclic compounds containing 1,4-diazine or hydrogenated 1,4-diazine rings not condensed with other rings having three double bonds between ring members or between ring members and non-ring members with hetero atoms or with carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals, directly attached to ring carbon atoms
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    • C07D241/28—Carbon atoms having three bonds to hetero atoms with at the most one bond to halogen, e.g. ester or nitrile radicals with nitrogen atoms directly attached to ring carbon atoms in which said hetero-bound carbon atoms have double bonds to oxygen, sulfur or nitrogen atoms
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D401/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings
    • C07D401/12—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing two hetero rings linked by a chain containing hetero atoms as chain links
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    • C07D401/14—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, at least one ring being a six-membered ring with only one nitrogen atom containing three or more hetero rings
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    • C07D403/02—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings
    • C07D403/04—Heterocyclic compounds containing two or more hetero rings, having nitrogen atoms as the only ring hetero atoms, not provided for by group C07D401/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D405/04—Heterocyclic compounds containing both one or more hetero rings having oxygen atoms as the only ring hetero atoms, and one or more rings having nitrogen as the only ring hetero atom containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D417/04—Heterocyclic compounds containing two or more hetero rings, at least one ring having nitrogen and sulfur atoms as the only ring hetero atoms, not provided for by group C07D415/00 containing two hetero rings directly linked by a ring-member-to-ring-member bond
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    • C07D471/02—Heterocyclic compounds containing nitrogen atoms as the only ring hetero atoms in the condensed system, at least one ring being a six-membered ring with one nitrogen atom, not provided for by groups C07D451/00 - C07D463/00 in which the condensed system contains two hetero rings
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    • C07D491/02—Heterocyclic compounds containing in the condensed ring system both one or more rings having oxygen atoms as the only ring hetero atoms and one or more rings having nitrogen atoms as the only ring hetero atoms, not provided for by groups C07D451/00 - C07D459/00, C07D463/00, C07D477/00 or C07D489/00 in which the condensed system contains two hetero rings
    • C07D491/10—Spiro-condensed systems
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  • Tropical Medicine & Parasitology (AREA)
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  • AIDS & HIV (AREA)
  • Pharmaceuticals Containing Other Organic And Inorganic Compounds (AREA)
  • Nitrogen Condensed Heterocyclic Rings (AREA)
  • Plural Heterocyclic Compounds (AREA)
  • Nitrogen And Oxygen Or Sulfur-Condensed Heterocyclic Ring Systems (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)
  • Acyclic And Carbocyclic Compounds In Medicinal Compositions (AREA)
JP2011535772A 2008-11-10 2009-11-10 Ａｔｒキナーゼの阻害剤として有用な化合物 Expired - Fee Related JP5702293B2 (ja)

Applications Claiming Priority (9)

Application Number Priority Date Filing Date Title
US11290608P 2008-11-10 2008-11-10
US61/112,906 2008-11-10
US11420408P 2008-11-13 2008-11-13
US61/114,204 2008-11-13
US14646309P 2009-01-22 2009-01-22
US61/146,463 2009-01-22
US16365509P 2009-03-26 2009-03-26
US61/163,655 2009-03-26
PCT/US2009/063922 WO2010054398A1 (en) 2008-11-10 2009-11-10 Compounds useful as inhibitors of atr kinase

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JP2012508260A JP2012508260A (ja) 2012-04-05
JP2012508260A5 JP2012508260A5 (enExample) 2012-12-27
JP5702293B2 true JP5702293B2 (ja) 2015-04-15

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JP2014165380A Expired - Fee Related JP5972942B2 (ja) 2008-11-10 2014-08-15 Ａｔｒキナーゼの阻害剤として有用な化合物
JP2016141092A Pending JP2016216495A (ja) 2008-11-10 2016-07-19 Ａｔｒキナーゼの阻害剤として有用な化合物

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JP2016141092A Pending JP2016216495A (ja) 2008-11-10 2016-07-19 Ａｔｒキナーゼの阻害剤として有用な化合物

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US (2) US8410112B2 (enExample)
EP (1) EP2370424A1 (enExample)
JP (3) JP5702293B2 (enExample)
KR (2) KR101712576B1 (enExample)
CN (1) CN102264721B (enExample)
AU (2) AU2009313198B2 (enExample)
CA (1) CA2743134A1 (enExample)
IL (1) IL212817A (enExample)
MX (1) MX2011004953A (enExample)
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RU (1) RU2011123647A (enExample)
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Cited By (1)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
JP2014240410A (ja) * 2008-11-10 2014-12-25 バーテックス ファーマシューティカルズ インコーポレイテッドＶｅｒｔｅｘ Ｐｈａｒｍａｃｅｕｔｉｃａｌｓ Ｉｎｃｏｒｐｏｒａｔｅｄ Ａｔｒキナーゼの阻害剤として有用な化合物

Families Citing this family (82)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
PL3354650T3 (pl) 2008-12-19 2022-06-13 Vertex Pharmaceuticals Incorporated Związki przydatne jako inhibitory kinazy atr
US8198285B2 (en) 2010-01-19 2012-06-12 Astrazeneca Ab Pyrazine derivatives
JP2013526540A (ja) 2010-05-12 2013-06-24 バーテックス ファーマシューティカルズ インコーポレイテッド Ａｔｒキナーゼ阻害剤として有用な化合物
US8962631B2 (en) 2010-05-12 2015-02-24 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
US9096584B2 (en) 2010-05-12 2015-08-04 Vertex Pharmaceuticals Incorporated Compounds useful as inhibitors of ATR kinase
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JP2012508260A (ja) 2012-04-05
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IL212817A (en) 2015-05-31
AU2009313198B2 (en) 2016-03-24
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US20140113005A1 (en) 2014-04-24
JP2016216495A (ja) 2016-12-22
CN102264721A (zh) 2011-11-30
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IL212817A0 (en) 2011-07-31
EP2370424A1 (en) 2011-10-05
AU2016203414A1 (en) 2016-06-23
CA2743134A1 (en) 2010-05-14
WO2010054398A1 (en) 2010-05-14
US20120040020A1 (en) 2012-02-16
RU2011123647A (ru) 2012-12-20
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