JP2011527902A5 - - Google Patents
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- JP2011527902A5 JP2011527902A5 JP2011518030A JP2011518030A JP2011527902A5 JP 2011527902 A5 JP2011527902 A5 JP 2011527902A5 JP 2011518030 A JP2011518030 A JP 2011518030A JP 2011518030 A JP2011518030 A JP 2011518030A JP 2011527902 A5 JP2011527902 A5 JP 2011527902A5
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- Prior art keywords
- seq
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- antibody
- chain variable
- variable region
- Prior art date
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- 239000012634 fragment Substances 0.000 claims 19
- 101100112922 Candida albicans CDR3 gene Proteins 0.000 claims 16
- 108090000623 proteins and genes Proteins 0.000 claims 13
- 102000004169 proteins and genes Human genes 0.000 claims 13
- 239000000427 antigen Substances 0.000 claims 6
- 102000036639 antigens Human genes 0.000 claims 6
- 108091007433 antigens Proteins 0.000 claims 6
- 108020004707 nucleic acids Proteins 0.000 claims 5
- 102000039446 nucleic acids Human genes 0.000 claims 5
- 150000007523 nucleic acids Chemical class 0.000 claims 5
- 206010011831 Cytomegalovirus infection Diseases 0.000 claims 4
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 238000004519 manufacturing process Methods 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 210000002798 bone marrow cell Anatomy 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 210000002889 endothelial cell Anatomy 0.000 claims 1
- 210000002919 epithelial cell Anatomy 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 208000015181 infectious disease Diseases 0.000 claims 1
- 230000003472 neutralizing effect Effects 0.000 claims 1
- 239000002773 nucleotide Substances 0.000 claims 1
- 125000003729 nucleotide group Chemical group 0.000 claims 1
- 230000002207 retinal effect Effects 0.000 claims 1
- 210000002536 stromal cell Anatomy 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US8133408P | 2008-07-16 | 2008-07-16 | |
| US61/081,334 | 2008-07-16 | ||
| PCT/IB2009/006641 WO2010007533A2 (en) | 2008-07-16 | 2009-07-15 | Human cytomegalovirus neutralizing antibodies and use thereof |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013218791A Division JP5807050B2 (ja) | 2008-07-16 | 2013-10-22 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011527902A JP2011527902A (ja) | 2011-11-10 |
| JP2011527902A5 true JP2011527902A5 (enExample) | 2012-05-17 |
| JP5422649B2 JP5422649B2 (ja) | 2014-02-19 |
Family
ID=41550776
Family Applications (5)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011518030A Expired - Fee Related JP5422649B2 (ja) | 2008-07-16 | 2009-07-15 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2013218791A Expired - Fee Related JP5807050B2 (ja) | 2008-07-16 | 2013-10-22 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2015082325A Expired - Fee Related JP6062477B2 (ja) | 2008-07-16 | 2015-04-14 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2016241815A Expired - Fee Related JP6345753B2 (ja) | 2008-07-16 | 2016-12-14 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2018098457A Expired - Fee Related JP6703037B2 (ja) | 2008-07-16 | 2018-05-23 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Family Applications After (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013218791A Expired - Fee Related JP5807050B2 (ja) | 2008-07-16 | 2013-10-22 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2015082325A Expired - Fee Related JP6062477B2 (ja) | 2008-07-16 | 2015-04-14 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2016241815A Expired - Fee Related JP6345753B2 (ja) | 2008-07-16 | 2016-12-14 | ヒトサイトメガロウイルス中和抗体およびその使用 |
| JP2018098457A Expired - Fee Related JP6703037B2 (ja) | 2008-07-16 | 2018-05-23 | ヒトサイトメガロウイルス中和抗体およびその使用 |
Country Status (30)
| Country | Link |
|---|---|
| US (21) | US8603480B2 (enExample) |
| EP (3) | EP3009449B1 (enExample) |
| JP (5) | JP5422649B2 (enExample) |
| KR (1) | KR101356350B1 (enExample) |
| CN (3) | CN102203133B (enExample) |
| AU (1) | AU2009272284C1 (enExample) |
| BR (1) | BRPI0916443A2 (enExample) |
| CA (2) | CA3022196A1 (enExample) |
| CL (3) | CL2011000084A1 (enExample) |
| CO (1) | CO6351801A2 (enExample) |
| CR (2) | CR20160355A (enExample) |
| CU (1) | CU23953B1 (enExample) |
| DK (2) | DK2352759T3 (enExample) |
| EA (1) | EA031177B1 (enExample) |
| EC (2) | ECSP11010827A (enExample) |
| ES (2) | ES2654543T3 (enExample) |
| GT (4) | GT201100011DA (enExample) |
| HN (1) | HN2011000161A (enExample) |
| IL (7) | IL210356A (enExample) |
| MA (1) | MA32561B1 (enExample) |
| MX (5) | MX338067B (enExample) |
| NZ (5) | NZ619953A (enExample) |
| PE (7) | PE20141434A1 (enExample) |
| PH (1) | PH12015500782A1 (enExample) |
| PL (2) | PL2352759T3 (enExample) |
| PT (2) | PT3009449T (enExample) |
| SG (3) | SG10201608381SA (enExample) |
| UA (1) | UA106354C2 (enExample) |
| WO (1) | WO2010007533A2 (enExample) |
| ZA (1) | ZA201600335B (enExample) |
Families Citing this family (50)
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| US7947274B2 (en) | 2007-01-04 | 2011-05-24 | Humabs, LLC. | Human cytomegalovirus neutralising antibodies and use thereof |
| GB0700133D0 (en) | 2007-01-04 | 2007-02-14 | Humabs Llc | Human cytomegalovirus neutralising antibodies and use thereof |
| CN102203133B (zh) | 2008-07-16 | 2015-01-07 | 生物医学研究学会 | 人巨细胞病毒中和抗体及其应用 |
| KR20120105543A (ko) | 2009-12-23 | 2012-09-25 | 4-안티바디 아게 | 인간 사이토메갈로바이러스에 대한 결합 멤버 |
| BR112012032182A2 (pt) | 2010-06-16 | 2016-10-25 | Trellis Bioscience Inc | anticorpos humanos de alta afinidade para proteína gb de citomegalovírus (cmv) humano. |
| EP2591114B1 (en) | 2010-07-06 | 2016-06-08 | GlaxoSmithKline Biologicals SA | Immunisation of large mammals with low doses of rna |
| HUE047796T2 (hu) | 2010-07-06 | 2020-05-28 | Glaxosmithkline Biologicals Sa | RNS bevitele több immunútvonal bekapcsolására |
| PT2590626E (pt) | 2010-07-06 | 2016-01-26 | Glaxosmithkline Biolog Sa | Lipossomas com lípidos que têm um valor de pka vantajoso para administração de arn |
| HUE058361T2 (hu) | 2010-08-31 | 2022-07-28 | Glaxosmithkline Biologicals Sa | Pegilált liposzómák immunogént kódoló RNA bejuttatására |
| EP2621533A4 (en) * | 2010-09-29 | 2015-06-17 | Hoffmann La Roche | ANTIBODY COMPOSITIONS AND METHOD FOR THEIR USE |
| ES2945135T3 (es) | 2010-10-11 | 2023-06-28 | Glaxosmithkline Biologicals Sa | Plataformas de suministro de antígenos |
| EP3854413A1 (en) | 2011-07-06 | 2021-07-28 | GlaxoSmithKline Biologicals SA | Immunogenic combination compositions and uses thereof |
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| US10413620B2 (en) | 2012-08-17 | 2019-09-17 | The Regents Of The University Of Colorado, A Body Corporate | Light-emitting versions of the monoclonal antibody to C3D (MAB 3D29) for imaging |
| JP2015535212A (ja) | 2012-08-17 | 2015-12-10 | ザ・リージエンツ・オブ・ザ・ユニバーシテイ・オブ・コロラド、ア・ボデイー・コーポレイト | 補体活性化を検出するための組成物および方法 |
| CN109369808B (zh) | 2012-08-24 | 2023-11-07 | 加利福尼亚大学董事会 | 用于治疗ror1癌症并抑制转移的抗体和疫苗 |
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| EP3347045A4 (en) | 2015-09-10 | 2019-08-28 | City of Hope | MVA-GH / GL-PC VACCINATED ANTIBODIES FOR NEUTRALIZING THE INFECTIOSITY OF HUMAN CYTOMEGALOVIRUS AND METHOD THEREFOR |
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| US20170145475A1 (en) | 2015-11-20 | 2017-05-25 | Streck, Inc. | Single spin process for blood plasma separation and plasma composition including preservative |
| EP3426676A1 (en) | 2016-03-11 | 2019-01-16 | Pfizer Inc | Human cytomegalovirus gb polypeptide |
| US10611800B2 (en) | 2016-03-11 | 2020-04-07 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| WO2017184619A2 (en) | 2016-04-18 | 2017-10-26 | Celldex Therapeutics, Inc. | Agonistic antibodies that bind human cd40 and uses thereof |
| CA3019588A1 (en) | 2016-04-20 | 2017-10-26 | Merck Sharp & Dohme Corp. | Cmv neutralizing antigen binding proteins |
| WO2017196819A2 (en) * | 2016-05-09 | 2017-11-16 | Icahn School Of Medicine At Mount Sinai | Broadly neutralizing anti-human cytomegalovirus (hcmv) antibodies and methods of use thereof |
| WO2018005519A2 (en) | 2016-06-27 | 2018-01-04 | The Regents Of The University Of California | Cancer treatment combinations |
| US20190177774A1 (en) | 2016-08-12 | 2019-06-13 | Streck, Inc. | Molecular reference controls |
| CN106519027B (zh) * | 2016-11-11 | 2019-09-17 | 深圳先进技术研究院 | 抗h7n9全人源单克隆抗体5j13及其制法与应用 |
| US11484570B2 (en) | 2017-04-14 | 2022-11-01 | University Of Massachusetts | Targeting cell tropism receptors to inhibit cytomegalovirus infection |
| CA3060019A1 (en) | 2017-04-19 | 2018-10-25 | Glaxosmithkline Biologicals Sa | Modified cytomegalovirus proteins and stabilized complexes |
| CN107325178A (zh) * | 2017-06-29 | 2017-11-07 | 佛山市南海区普罗圣塔生物科技有限公司 | 一种抗人巨细胞病毒卵黄抗体及其制备方法和应用 |
| EP4427588A3 (en) | 2017-10-19 | 2024-10-16 | Streck LLC | Compositions for hemolysis and coagulation regulation and stabilization of extracellular vesicles |
| WO2019183375A1 (en) * | 2018-03-22 | 2019-09-26 | Eureka Therapeutics, Inc. | Antibody agents specifically recognizing monocarboxylate transporter 4 and uses thereof |
| MX2020010913A (es) | 2018-04-17 | 2021-01-08 | Celldex Therapeutics Inc | Anticuerpos anti-cd27 y anti-pd-l1 y constructos biespecíficos. |
| IL270214B2 (en) | 2018-07-13 | 2024-07-01 | Alector Llc | Anti-sortilin antibodies and methods of using them |
| WO2020079586A1 (en) | 2018-10-17 | 2020-04-23 | Glaxosmithkline Biologicals Sa | Modified cytomegalovirus proteins and stabilized complexes |
| CN109580944A (zh) * | 2018-12-07 | 2019-04-05 | 潍坊医学院 | 一种人巨细胞病毒检测试纸及其制造方法 |
| US11629172B2 (en) | 2018-12-21 | 2023-04-18 | Pfizer Inc. | Human cytomegalovirus gB polypeptide |
| CN109738631A (zh) * | 2019-01-21 | 2019-05-10 | 潍坊医学院 | 一种人巨细胞病毒IgM抗体检测试纸的制备方法 |
| WO2020176871A1 (en) * | 2019-02-28 | 2020-09-03 | Ann And Robert H. Lurie Children's Hospital Of Chicago | Kawasaki disease antibodies identify hepacivirus peptides |
| WO2020208082A1 (en) * | 2019-04-09 | 2020-10-15 | INSERM (Institut National de la Santé et de la Recherche Médicale) | Method for treating cmv related diseases |
| CN112898414B (zh) * | 2019-12-04 | 2024-05-10 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
| EP4126931A1 (en) * | 2020-03-27 | 2023-02-08 | GlaxoSmithKline Biologicals S.A. | Hcvm pentamer binding antibodies |
| US11857622B2 (en) | 2020-06-21 | 2024-01-02 | Pfizer Inc. | Human cytomegalovirus GB polypeptide |
| WO2023034950A2 (en) * | 2021-09-03 | 2023-03-09 | Icahn School Of Medicine At Mount Sinai | Anti-hcmv antibodies and antigen-binding fragments thereof |
| CN116162154B (zh) * | 2022-10-21 | 2024-06-11 | 珠海泰诺麦博制药股份有限公司 | 抗人巨细胞病毒抗体及其用途 |
| CN115947869B (zh) * | 2022-11-28 | 2023-12-12 | 广州佰芮慷生物科技有限公司 | 一种靶向人巨细胞病毒的嵌合抗原受体、car-nk细胞及用途 |
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