JP2007504812A5 - - Google Patents
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- Publication number
- JP2007504812A5 JP2007504812A5 JP2006525744A JP2006525744A JP2007504812A5 JP 2007504812 A5 JP2007504812 A5 JP 2007504812A5 JP 2006525744 A JP2006525744 A JP 2006525744A JP 2006525744 A JP2006525744 A JP 2006525744A JP 2007504812 A5 JP2007504812 A5 JP 2007504812A5
- Authority
- JP
- Japan
- Prior art keywords
- antibody
- seq
- nos
- amino acid
- acid sequence
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 15
- 125000003275 alpha amino acid group Chemical group 0.000 claims 12
- 102100022641 Coagulation factor IX Human genes 0.000 claims 4
- 108010076282 Factor IX Proteins 0.000 claims 4
- 229960004222 factor ix Drugs 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 108010048049 Factor IXa Proteins 0.000 claims 3
- 239000000203 mixture Substances 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 102000039446 nucleic acids Human genes 0.000 claims 3
- 108020004707 nucleic acids Proteins 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 2
- 102100026735 Coagulation factor VIII Human genes 0.000 claims 1
- 206010053567 Coagulopathies Diseases 0.000 claims 1
- 201000003542 Factor VIII deficiency Diseases 0.000 claims 1
- 208000009292 Hemophilia A Diseases 0.000 claims 1
- 101000911390 Homo sapiens Coagulation factor VIII Proteins 0.000 claims 1
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 1
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 1
- 230000023555 blood coagulation Effects 0.000 claims 1
- 208000015294 blood coagulation disease Diseases 0.000 claims 1
- 238000012258 culturing Methods 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000002008 hemorrhagic effect Effects 0.000 claims 1
- 230000002947 procoagulating effect Effects 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/661,366 US7297336B2 (en) | 2003-09-12 | 2003-09-12 | Factor IXa specific antibodies displaying factor VIIIa like activity |
| US10/661,366 | 2003-09-12 | ||
| PCT/EP2004/009975 WO2005025615A2 (en) | 2003-09-12 | 2004-09-07 | FACTOR IXa SPECIFIC ANTIBODIES DISPLAYING FACTOR VIIIa LIKE ACTIVITY |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007504812A JP2007504812A (ja) | 2007-03-08 |
| JP2007504812A5 true JP2007504812A5 (enExample) | 2007-08-16 |
| JP4887148B2 JP4887148B2 (ja) | 2012-02-29 |
Family
ID=34273861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006525744A Expired - Fee Related JP4887148B2 (ja) | 2003-09-12 | 2004-09-07 | 第ＶＩＩＩａ因子様活性を示す第ＩＸａ因子特異抗体 |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7297336B2 (enExample) |
| EP (1) | EP1660536B1 (enExample) |
| JP (1) | JP4887148B2 (enExample) |
| AT (1) | ATE419277T1 (enExample) |
| AU (1) | AU2004271706B2 (enExample) |
| CA (1) | CA2538895A1 (enExample) |
| DE (1) | DE602004018788D1 (enExample) |
| ES (1) | ES2320665T3 (enExample) |
| WO (1) | WO2005025615A2 (enExample) |
Families Citing this family (32)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT411997B (de) * | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
| CN101198698B (zh) | 2005-03-31 | 2014-03-19 | 中外制药株式会社 | 通过调节多肽缔合制备多肽的方法 |
| CA2603264C (en) * | 2005-04-08 | 2017-03-21 | Chugai Seiyaku Kabushiki Kaisha | Antibody substituting for function of blood coagulation factor viii |
| EP1760092A1 (en) * | 2005-08-26 | 2007-03-07 | Applied Research Systems ARS Holding N.V. | System for screening cells for high expression of a protein of interest |
| CN104761637B (zh) | 2006-03-31 | 2021-10-15 | 中外制药株式会社 | 调控抗体血液动力学的方法 |
| EP2009101B1 (en) | 2006-03-31 | 2017-10-25 | Chugai Seiyaku Kabushiki Kaisha | Antibody modification method for purifying bispecific antibody |
| CN101874042B9 (zh) | 2007-09-26 | 2019-01-01 | 中外制药株式会社 | 利用cdr的氨基酸取代来改变抗体等电点的方法 |
| KR101962483B1 (ko) | 2010-11-17 | 2019-03-29 | 추가이 세이야쿠 가부시키가이샤 | 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자 |
| CA2886326C (en) * | 2012-09-28 | 2021-11-02 | Chugai Seiyaku Kabushiki Kaisha | Method for evaluating blood coagulation reaction |
| CN105764922B (zh) | 2013-09-27 | 2020-07-17 | 中外制药株式会社 | 多肽异源多聚体的制备方法 |
| WO2015138600A2 (en) * | 2014-03-11 | 2015-09-17 | The Board Of Trustees Of The Leland Stanford Junior University | Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
| TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定ｆｖｉｉｉ的反應性之方法 |
| US11142587B2 (en) | 2015-04-01 | 2021-10-12 | Chugai Seiyaku Kabushiki Kaisha | Method for producing polypeptide hetero-oligomer |
| WO2017110980A1 (ja) | 2015-12-25 | 2017-06-29 | 中外製薬株式会社 | 増強された活性を有する抗体及びその改変方法 |
| SG11201803989WA (en) | 2015-12-28 | 2018-06-28 | Chugai Pharmaceutical Co Ltd | Method for promoting efficiency of purification of fc region-containing polypeptide |
| ES3055961T3 (en) | 2016-04-28 | 2026-02-17 | Chugai Pharmaceutical Co Ltd | Antibody-containing preparation |
| IL262813B2 (en) * | 2016-05-16 | 2025-12-01 | Baxalta GmbH | Anti-factor ix padua antibodies |
| CN109415444B (zh) | 2016-07-29 | 2024-03-01 | 中外制药株式会社 | 显示增加的备选fviii辅因子功能活性的双特异性抗体 |
| EP3509637B1 (en) | 2016-09-06 | 2024-11-27 | Chugai Seiyaku Kabushiki Kaisha | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
| AU2017331739A1 (en) * | 2016-09-23 | 2019-03-07 | Csl Limited | Coagulation factor binding proteins and uses thereof |
| CN110662770A (zh) * | 2016-11-23 | 2020-01-07 | 比奥维拉迪维治疗股份有限公司 | 结合凝血因子ix和凝血因子x的双特异性抗体 |
| KR20190112747A (ko) | 2017-02-01 | 2019-10-07 | 노보 노르디스크 에이/에스 | 응고촉진 항체 |
| EP3603670A4 (en) | 2017-03-31 | 2021-03-10 | Public University Corporation Nara Medical University | MEDICAL COMPOSITION FOR THE PREVENTION AND / OR TREATMENT OF BLOOD CLOG FACTOR IX ANOMALY WITH A MULTI-SPECIFIC ANTIGIBINDING MOLECULAR FUNCTION OF BLOOD CLOTHING FACTOR VIII |
| GB201709970D0 (en) | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| JP6496095B1 (ja) | 2017-09-29 | 2019-04-03 | 中外製薬株式会社 | 血液凝固第ｖｉｉｉ因子（ｆｖｉｉｉ）補因子機能代替活性を有する多重特異性抗原結合分子および当該分子を有効成分として含有する薬学的製剤 |
| TW202600611A (zh) | 2017-11-01 | 2026-01-01 | 日商中外製藥股份有限公司 | 生物活性降低之抗體變異體與同功型 |
| CN112513096B (zh) | 2018-08-01 | 2023-08-25 | 诺和诺德股份有限公司 | 改进的促凝血抗体 |
| US11220554B2 (en) | 2018-09-07 | 2022-01-11 | Novo Nordisk A/S | Procoagulant antibodies |
| US20220064327A1 (en) | 2018-12-21 | 2022-03-03 | Kymab Limited | Fixaxfx bispecific antibody with common light chain |
| CN115052898B (zh) | 2020-01-30 | 2025-09-16 | 诺和诺德股份有限公司 | 双特异性因子viii模拟抗体 |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT368883B (de) | 1980-07-22 | 1982-11-25 | Immuno Ag | Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| DK0658168T3 (da) | 1992-08-27 | 2001-01-22 | Sanquin Bloedvoorziening | Antistoffer, som er specifikke for et hæmostatisk protein, anvendelse heraf til isolering af intakt protein, hæmostatiske p |
| DK128093D0 (da) | 1993-11-12 | 1993-11-12 | Novo Nordisk As | Hidtil ukendte forbindelser |
| MA24512A1 (fr) | 1996-01-17 | 1998-12-31 | Univ Vermont And State Agrienl | Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose |
| US6013256A (en) * | 1996-09-24 | 2000-01-11 | Protein Design Labs, Inc. | Method of preventing acute rejection following solid organ transplantation |
| EP1001991A4 (en) | 1997-07-03 | 2005-01-26 | Smithkline Beecham Corp | CRYSTALLINE STRUCTURES OF FAB ANTI-FACTOR IX FRAGMENTS AND METHODS OF USE FOR PEPTIDOMIMETIC DESIGN |
| AT411997B (de) * | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
| CU23007A1 (es) * | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
| KR100900166B1 (ko) * | 2001-05-03 | 2009-06-02 | 메르크 파텐트 게엠베하 | 재조합 종양 특이적 항체 및 이들의 용도 |
-
2003
- 2003-09-12 US US10/661,366 patent/US7297336B2/en not_active Expired - Lifetime
-
2004
- 2004-09-07 CA CA002538895A patent/CA2538895A1/en not_active Abandoned
- 2004-09-07 DE DE602004018788T patent/DE602004018788D1/de not_active Expired - Lifetime
- 2004-09-07 AU AU2004271706A patent/AU2004271706B2/en not_active Expired
- 2004-09-07 EP EP04764918A patent/EP1660536B1/en not_active Expired - Lifetime
- 2004-09-07 ES ES04764918T patent/ES2320665T3/es not_active Expired - Lifetime
- 2004-09-07 JP JP2006525744A patent/JP4887148B2/ja not_active Expired - Fee Related
- 2004-09-07 WO PCT/EP2004/009975 patent/WO2005025615A2/en not_active Ceased
- 2004-09-07 AT AT04764918T patent/ATE419277T1/de active
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