JP2008542278A5 - - Google Patents
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- JP2008542278A5 JP2008542278A5 JP2008513580A JP2008513580A JP2008542278A5 JP 2008542278 A5 JP2008542278 A5 JP 2008542278A5 JP 2008513580 A JP2008513580 A JP 2008513580A JP 2008513580 A JP2008513580 A JP 2008513580A JP 2008542278 A5 JP2008542278 A5 JP 2008542278A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- sequence
- variable domain
- chain variable
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
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- 108090000623 proteins and genes Proteins 0.000 claims 39
- 102000004169 proteins and genes Human genes 0.000 claims 39
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 5
- 210000004602 germ cell Anatomy 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 101000830598 Homo sapiens Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 3
- 102000058177 human TNFSF12 Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68514905P | 2005-05-27 | 2005-05-27 | |
| US60/685,149 | 2005-05-27 | ||
| PCT/US2006/019706 WO2006130374A2 (en) | 2005-05-27 | 2006-05-25 | Tweak binding antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256386A Division JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542278A JP2008542278A (ja) | 2008-11-27 |
| JP2008542278A5 true JP2008542278A5 (enExample) | 2009-07-09 |
| JP5175181B2 JP5175181B2 (ja) | 2013-04-03 |
Family
ID=37482143
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513580A Expired - Fee Related JP5175181B2 (ja) | 2005-05-27 | 2006-05-25 | Ｔｗｅａｋ結合抗体 |
| JP2012256386A Withdrawn JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
| JP2014170135A Withdrawn JP2014221837A (ja) | 2005-05-27 | 2014-08-25 | Ｔｗｅａｋ結合抗体 |
| JP2016212746A Expired - Fee Related JP6234535B2 (ja) | 2005-05-27 | 2016-10-31 | Ｔｗｅａｋ結合抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256386A Withdrawn JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
| JP2014170135A Withdrawn JP2014221837A (ja) | 2005-05-27 | 2014-08-25 | Ｔｗｅａｋ結合抗体 |
| JP2016212746A Expired - Fee Related JP6234535B2 (ja) | 2005-05-27 | 2016-10-31 | Ｔｗｅａｋ結合抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8048422B2 (enExample) |
| EP (3) | EP2460831B1 (enExample) |
| JP (4) | JP5175181B2 (enExample) |
| KR (2) | KR20080023317A (enExample) |
| CN (3) | CN102441163A (enExample) |
| AU (1) | AU2006252830B2 (enExample) |
| BR (1) | BRPI0611414B8 (enExample) |
| CA (1) | CA2609600C (enExample) |
| CY (1) | CY1118343T1 (enExample) |
| DK (2) | DK1888113T3 (enExample) |
| EA (1) | EA018255B1 (enExample) |
| ES (2) | ES2605945T3 (enExample) |
| GE (1) | GEP20115324B (enExample) |
| HU (1) | HUE030701T2 (enExample) |
| IL (1) | IL187585A (enExample) |
| IS (1) | IS8693A (enExample) |
| LT (1) | LT2460831T (enExample) |
| ME (2) | ME00261B (enExample) |
| MX (1) | MX339015B (enExample) |
| NO (1) | NO20076607L (enExample) |
| NZ (2) | NZ564092A (enExample) |
| PL (3) | PL2460831T3 (enExample) |
| PT (2) | PT2460831T (enExample) |
| RS (1) | RS55888B1 (enExample) |
| SG (1) | SG162728A1 (enExample) |
| SI (2) | SI2460831T1 (enExample) |
| UA (1) | UA96416C2 (enExample) |
| WO (1) | WO2006130374A2 (enExample) |
| ZA (1) | ZA200710765B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
| EE200100372A (et) * | 1999-01-15 | 2002-10-15 | Biogen, Incorporated | TWEAK-valgu ja TWEAK-valgu retseptori antagonistid ja nende kasutamine immuunhaiguste raviks |
| CA2887716C (en) | 2002-04-09 | 2017-01-24 | Biogen Idec Ma Inc. | Methods for treating tweak-related conditions |
| WO2006052926A2 (en) * | 2004-11-08 | 2006-05-18 | University Of Maryland, Baltimore | Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and and cell death |
| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| US20090124993A1 (en) | 2005-02-17 | 2009-05-14 | Burkly Linda C | Treating neurological disorders |
| US20090068102A1 (en) * | 2005-02-17 | 2009-03-12 | Biogen Idec Ma Inc. | Treating stroke |
| CA2607697C (en) | 2005-05-10 | 2015-01-06 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| WO2008048924A2 (en) * | 2006-10-16 | 2008-04-24 | Biogen Idec Ma Inc. | Biomarkers of multiple sclerosis |
| US8685741B1 (en) * | 2007-03-07 | 2014-04-01 | Nestec S.A. | Methods for diagnosing irritable bowel syndrome |
| JP5646457B2 (ja) | 2008-04-29 | 2014-12-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリン及びその使用 |
| AR072000A1 (es) | 2008-06-03 | 2010-07-28 | Abbott Lab | Proteinas de union multivalentes con capacidad de unir dos o mas antigenos y usos de la misma |
| JP2011523853A (ja) | 2008-06-03 | 2011-08-25 | アボット・ラボラトリーズ | 二重可変ドメイン免疫グロブリン及びその使用 |
| BRPI0915448A2 (pt) | 2008-07-08 | 2015-11-10 | Abbott Lab | imunoglobulinas de domínio variável duplo para prostaglandina e2 e usos das mesmas |
| US8093006B2 (en) | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
| MY160126A (en) | 2009-05-13 | 2017-02-28 | Genzyme Corp | Anti-human cd52 immunoglobulins |
| KR20120060877A (ko) * | 2009-09-01 | 2012-06-12 | 아보트 러보러터리즈 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| TW201119676A (en) * | 2009-10-15 | 2011-06-16 | Abbott Lab | Dual variable domain immunoglobulins and uses thereof |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| US9096879B2 (en) | 2009-11-24 | 2015-08-04 | Biogen Ma Inc. | Method of supplementing culture media to prevent undesirable amino acid substitutions |
| US9068004B2 (en) | 2010-02-04 | 2015-06-30 | University Of Louisville Research Foundation, Inc. | TWEAK/Fn14 system regulates skeletal muscle atrophy and regeneration |
| JP2013539353A (ja) * | 2010-06-24 | 2013-10-24 | アボット・ラボラトリーズ | 二重可変ドメイン免疫グロブリンおよびその使用 |
| EP3252072A3 (en) | 2010-08-03 | 2018-03-14 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| SG187938A1 (en) | 2010-08-26 | 2013-04-30 | Abbvie Inc | Dual variable domain immunoglobulins and uses thereof |
| PE20131411A1 (es) | 2010-10-05 | 2013-12-16 | Hoffmann La Roche | Anticuerpos contra la tweak humana y usos de los mismos |
| CN104159920A (zh) | 2011-12-30 | 2014-11-19 | 艾伯维公司 | 针对il-13和/或il-17的双重可变结构域免疫球蛋白 |
| EP2834273B1 (en) | 2012-04-05 | 2018-08-22 | F.Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
| MY171664A (en) | 2012-11-01 | 2019-10-22 | Abbvie Inc | Anti-dll4/vegf dual variable domain immunoglobulins and uses thereof |
| JP2016522793A (ja) | 2013-03-15 | 2016-08-04 | アッヴィ・インコーポレイテッド | ＩＬ−１βおよび／またはＩＬ−１７に対して指向された二重特異的結合タンパク質 |
| AR095199A1 (es) * | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| JP2016000003A (ja) * | 2013-04-19 | 2016-01-07 | アステラス製薬株式会社 | 新規抗ヒトｔｗｅａｋ抗体 |
| WO2015051234A2 (en) | 2013-10-04 | 2015-04-09 | Biogen Idec Ma Inc. | Tweak antagonists for treating lupus nephritis and muscle atrophy |
| WO2016094881A2 (en) | 2014-12-11 | 2016-06-16 | Abbvie Inc. | Lrp-8 binding proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| US20200031895A1 (en) | 2016-12-16 | 2020-01-30 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| CA3099547A1 (en) | 2018-05-07 | 2019-11-14 | Reshma Abdulla RANGWALA | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| WO2020073047A1 (en) | 2018-10-05 | 2020-04-09 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| KR20210111242A (ko) | 2018-10-29 | 2021-09-10 | 바이오젠 엠에이 인코포레이티드 | 혈액 뇌 장벽 수송을 향상시키기 위한 인간화 및 안정화된 fc5 변이체 |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| IL282650B2 (en) * | 2018-10-31 | 2024-09-01 | Astellas Pharma Inc | Anti-human fn14 antibody |
| CN112778372B (zh) * | 2019-11-11 | 2025-09-23 | 苏州泽璟生物制药股份有限公司 | 咪唑并喹啉取代磷酸酯类激动剂及其制备方法和应用 |
| TW202302648A (zh) * | 2021-03-12 | 2023-01-16 | 美商健生生物科技公司 | Cd79b抗體於自體免疫治療應用之用途 |
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| CA2887716C (en) * | 2002-04-09 | 2017-01-24 | Biogen Idec Ma Inc. | Methods for treating tweak-related conditions |
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| EP1566636A1 (en) | 2004-02-23 | 2005-08-24 | AXARON Bioscience AG | Use of Tweak modulators and inhibitors for the treatment of neurological conditions |
| WO2006052926A2 (en) | 2004-11-08 | 2006-05-18 | University Of Maryland, Baltimore | Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and and cell death |
| US7939490B2 (en) * | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| US20090124993A1 (en) * | 2005-02-17 | 2009-05-14 | Burkly Linda C | Treating neurological disorders |
| US20090068102A1 (en) * | 2005-02-17 | 2009-03-12 | Biogen Idec Ma Inc. | Treating stroke |
| BRPI0608012A2 (pt) * | 2005-03-07 | 2009-11-03 | Genentech Inc | método de tratamento de cáncer, método de aumento de atividade de célula nk, método de aumento de resposta ou atividade th1 inata, método de tratamento de uma disfunção mediada por th2, método de tratamento de uma doença imune, usos de uma molécula antagonista e uso de uma molécula agonista |
| CA2607697C (en) | 2005-05-10 | 2015-01-06 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| WO2006138219A2 (en) * | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| WO2008048924A2 (en) | 2006-10-16 | 2008-04-24 | Biogen Idec Ma Inc. | Biomarkers of multiple sclerosis |
-
2006
- 2006-05-25 DK DK06760258.1T patent/DK1888113T3/da active
- 2006-05-25 ES ES11191771.2T patent/ES2605945T3/es active Active
- 2006-05-25 SG SG201003724-0A patent/SG162728A1/en unknown
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