JP2008542278A5 - - Google Patents
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- JP2008542278A5 JP2008542278A5 JP2008513580A JP2008513580A JP2008542278A5 JP 2008542278 A5 JP2008542278 A5 JP 2008542278A5 JP 2008513580 A JP2008513580 A JP 2008513580A JP 2008513580 A JP2008513580 A JP 2008513580A JP 2008542278 A5 JP2008542278 A5 JP 2008542278A5
- Authority
- JP
- Japan
- Prior art keywords
- protein
- sequence
- variable domain
- chain variable
- light chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 108090000623 proteins and genes Proteins 0.000 claims 39
- 102000004169 proteins and genes Human genes 0.000 claims 39
- 239000008194 pharmaceutical composition Substances 0.000 claims 11
- 239000003814 drug Substances 0.000 claims 5
- 210000004602 germ cell Anatomy 0.000 claims 5
- 206010028980 Neoplasm Diseases 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 101000830598 Homo sapiens Tumor necrosis factor ligand superfamily member 12 Proteins 0.000 claims 3
- 102000058177 human TNFSF12 Human genes 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 150000007523 nucleic acids Chemical class 0.000 claims 3
- 208000023275 Autoimmune disease Diseases 0.000 claims 2
- 206010061902 Pancreatic neoplasm Diseases 0.000 claims 2
- 208000006011 Stroke Diseases 0.000 claims 2
- 125000003275 alpha amino acid group Chemical group 0.000 claims 2
- 210000004027 cell Anatomy 0.000 claims 2
- 239000003937 drug carrier Substances 0.000 claims 2
- 208000015486 malignant pancreatic neoplasm Diseases 0.000 claims 2
- 108020004707 nucleic acids Proteins 0.000 claims 2
- 102000039446 nucleic acids Human genes 0.000 claims 2
- 201000002528 pancreatic cancer Diseases 0.000 claims 2
- 208000008443 pancreatic carcinoma Diseases 0.000 claims 2
- 206010039073 rheumatoid arthritis Diseases 0.000 claims 2
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 208000034189 Sclerosis Diseases 0.000 claims 1
- 239000000427 antigen Substances 0.000 claims 1
- 102000036639 antigens Human genes 0.000 claims 1
- 108091007433 antigens Proteins 0.000 claims 1
- 230000003796 beauty Effects 0.000 claims 1
- 230000001684 chronic effect Effects 0.000 claims 1
- 230000000295 complement effect Effects 0.000 claims 1
- 201000006417 multiple sclerosis Diseases 0.000 claims 1
- 238000006467 substitution reaction Methods 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US68514905P | 2005-05-27 | 2005-05-27 | |
| US60/685,149 | 2005-05-27 | ||
| PCT/US2006/019706 WO2006130374A2 (en) | 2005-05-27 | 2006-05-25 | Tweak binding antibodies |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256386A Division JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2008542278A JP2008542278A (ja) | 2008-11-27 |
| JP2008542278A5 true JP2008542278A5 (enExample) | 2009-07-09 |
| JP5175181B2 JP5175181B2 (ja) | 2013-04-03 |
Family
ID=37482143
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008513580A Expired - Fee Related JP5175181B2 (ja) | 2005-05-27 | 2006-05-25 | Ｔｗｅａｋ結合抗体 |
| JP2012256386A Withdrawn JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
| JP2014170135A Withdrawn JP2014221837A (ja) | 2005-05-27 | 2014-08-25 | Ｔｗｅａｋ結合抗体 |
| JP2016212746A Expired - Fee Related JP6234535B2 (ja) | 2005-05-27 | 2016-10-31 | Ｔｗｅａｋ結合抗体 |
Family Applications After (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012256386A Withdrawn JP2013040210A (ja) | 2005-05-27 | 2012-11-22 | Ｔｗｅａｋ結合抗体 |
| JP2014170135A Withdrawn JP2014221837A (ja) | 2005-05-27 | 2014-08-25 | Ｔｗｅａｋ結合抗体 |
| JP2016212746A Expired - Fee Related JP6234535B2 (ja) | 2005-05-27 | 2016-10-31 | Ｔｗｅａｋ結合抗体 |
Country Status (29)
| Country | Link |
|---|---|
| US (2) | US8048422B2 (enExample) |
| EP (3) | EP2460831B1 (enExample) |
| JP (4) | JP5175181B2 (enExample) |
| KR (2) | KR101679468B1 (enExample) |
| CN (3) | CN102441163A (enExample) |
| AU (1) | AU2006252830B2 (enExample) |
| BR (1) | BRPI0611414B8 (enExample) |
| CA (1) | CA2609600C (enExample) |
| CY (1) | CY1118343T1 (enExample) |
| DK (2) | DK1888113T3 (enExample) |
| EA (1) | EA018255B1 (enExample) |
| ES (2) | ES2605945T3 (enExample) |
| GE (1) | GEP20115324B (enExample) |
| HU (1) | HUE030701T2 (enExample) |
| IL (1) | IL187585A (enExample) |
| IS (1) | IS8693A (enExample) |
| LT (1) | LT2460831T (enExample) |
| ME (2) | ME00261B (enExample) |
| MX (1) | MX339015B (enExample) |
| NO (1) | NO20076607L (enExample) |
| NZ (2) | NZ564092A (enExample) |
| PL (3) | PL218791B1 (enExample) |
| PT (2) | PT1888113E (enExample) |
| RS (1) | RS55888B1 (enExample) |
| SG (1) | SG162728A1 (enExample) |
| SI (2) | SI1888113T1 (enExample) |
| UA (1) | UA96416C2 (enExample) |
| WO (1) | WO2006130374A2 (enExample) |
| ZA (1) | ZA200710765B (enExample) |
Families Citing this family (44)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US7129061B1 (en) * | 1996-08-07 | 2006-10-31 | Biogen Idec Ma Inc. | Tumor necrosis factor related ligand |
| EE200100372A (et) * | 1999-01-15 | 2002-10-15 | Biogen, Incorporated | TWEAK-valgu ja TWEAK-valgu retseptori antagonistid ja nende kasutamine immuunhaiguste raviks |
| CN103536916B (zh) * | 2002-04-09 | 2016-08-17 | 比奥根Ma公司 | 用于治疗tweak相关病症的方法 |
| WO2006052926A2 (en) * | 2004-11-08 | 2006-05-18 | University Of Maryland, Baltimore | Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and and cell death |
| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| WO2006088890A2 (en) * | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating stroke |
| US20090124993A1 (en) | 2005-02-17 | 2009-05-14 | Burkly Linda C | Treating neurological disorders |
| WO2006122187A2 (en) | 2005-05-10 | 2006-11-16 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) * | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| US20100284933A1 (en) * | 2006-10-16 | 2010-11-11 | Biogen Idec Ma Inc. | Biomarkers of Multiple Sclerosis |
| US8685741B1 (en) * | 2007-03-07 | 2014-04-01 | Nestec S.A. | Methods for diagnosing irritable bowel syndrome |
| JP5646457B2 (ja) | 2008-04-29 | 2014-12-24 | アッヴィ・インコーポレイテッド | 二重可変ドメイン免疫グロブリン及びその使用 |
| EP3002299A1 (en) | 2008-06-03 | 2016-04-06 | AbbVie Inc. | Dual variable domain immunoglobulins and uses thereof |
| PE20100054A1 (es) | 2008-06-03 | 2010-03-03 | Abbott Lab | Inmunoglobulina con dominio variable dual |
| MX2010014574A (es) | 2008-07-08 | 2011-04-27 | Abbott Lab | Inmunoglobulinas de dominio variable dual para prostaglandina e2 y usos de las mismas. |
| US8093006B2 (en) * | 2009-04-02 | 2012-01-10 | Hoffmann-La Roche Inc. | Antibodies against human tweak and uses thereof |
| EP3683317A3 (en) | 2009-05-13 | 2020-09-30 | Genzyme Corporation | Anti-human cd52 immunoglobulins |
| AR078254A1 (es) * | 2009-09-01 | 2011-10-26 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| MX2012004415A (es) * | 2009-10-15 | 2012-05-08 | Abbott Lab | Inmunoglobulinas de dominio variable doble y usos de las mismas. |
| UY32979A (es) | 2009-10-28 | 2011-02-28 | Abbott Lab | Inmunoglobulinas con dominio variable dual y usos de las mismas |
| US9096879B2 (en) | 2009-11-24 | 2015-08-04 | Biogen Ma Inc. | Method of supplementing culture media to prevent undesirable amino acid substitutions |
| US9068004B2 (en) | 2010-02-04 | 2015-06-30 | University Of Louisville Research Foundation, Inc. | TWEAK/Fn14 system regulates skeletal muscle atrophy and regeneration |
| KR20130043168A (ko) * | 2010-06-24 | 2013-04-29 | 아비에 인코포레이티드 | 이원 가변 도메인 면역글로불린 및 이의 용도 |
| US8735546B2 (en) | 2010-08-03 | 2014-05-27 | Abbvie Inc. | Dual variable domain immunoglobulins and uses thereof |
| PH12013500337A1 (en) | 2010-08-26 | 2017-08-23 | Abbvie Inc | Dual variable domain immunoglobulins and uses thereof |
| KR101584416B1 (ko) * | 2010-10-05 | 2016-01-13 | 에프. 호프만-라 로슈 아게 | 인간 tweak에 대한 항체 및 그의 용도 |
| US9120870B2 (en) | 2011-12-30 | 2015-09-01 | Abbvie Inc. | Dual specific binding proteins directed against IL-13 and IL-17 |
| CA2868404A1 (en) | 2012-04-05 | 2013-10-10 | F. Hoffmann-La Roche Ag | Bispecific antibodies against human tweak and human il17 and uses thereof |
| AU2013337775B2 (en) | 2012-11-01 | 2017-03-30 | Abbvie Inc. | Anti-VEGF/DLL4 dual variable domain immunoglobulins and uses thereof |
| AR095199A1 (es) * | 2013-03-15 | 2015-09-30 | Genzyme Corp | Anticuerpos anti-cd52 |
| EP2970459A2 (en) | 2013-03-15 | 2016-01-20 | AbbVie Inc. | Dual specific binding proteins directed against il-1beta and il-17 |
| JP2016000003A (ja) * | 2013-04-19 | 2016-01-07 | アステラス製薬株式会社 | 新規抗ヒトｔｗｅａｋ抗体 |
| WO2015051234A2 (en) | 2013-10-04 | 2015-04-09 | Biogen Idec Ma Inc. | Tweak antagonists for treating lupus nephritis and muscle atrophy |
| US10093733B2 (en) | 2014-12-11 | 2018-10-09 | Abbvie Inc. | LRP-8 binding dual variable domain immunoglobulin proteins |
| TW201710286A (zh) | 2015-06-15 | 2017-03-16 | 艾伯維有限公司 | 抗ｖｅｇｆ、ｐｄｇｆ及／或其受體之結合蛋白 |
| WO2018112362A1 (en) | 2016-12-16 | 2018-06-21 | Biogen Ma Inc. | Stabilized proteolytically activated growth differentiation factor 11 |
| CA3099547A1 (en) | 2018-05-07 | 2019-11-14 | Reshma Abdulla RANGWALA | Methods of treating cancer with a combination of an anti-pd-1 antibody and an anti-tissue factor antibody-drug conjugate |
| WO2020073047A1 (en) | 2018-10-05 | 2020-04-09 | Shifamed Holdings, Llc | Intravascular blood pumps and methods of use |
| JP2022509372A (ja) | 2018-10-29 | 2022-01-20 | バイオジェン・エムエイ・インコーポレイテッド | 血液脳関門輸送の促進のためのヒト化され安定化されたｆｃ５バリアント |
| TWI844571B (zh) | 2018-10-30 | 2024-06-11 | 丹麥商珍美寶股份有限公司 | 使用抗血管內皮生長因子（ｖｅｇｆ）抗體與抗組織因子（ｔｆ）抗體－藥物共軛體之組合以治療癌症之方法 |
| MY204672A (en) * | 2018-10-31 | 2024-09-09 | Astellas Pharma Inc | Anti-human fn14 antibody |
| CN112778372B (zh) * | 2019-11-11 | 2025-09-23 | 苏州泽璟生物制药股份有限公司 | 咪唑并喹啉取代磷酸酯类激动剂及其制备方法和应用 |
| TW202302648A (zh) * | 2021-03-12 | 2023-01-16 | 美商健生生物科技公司 | Cd79b抗體於自體免疫治療應用之用途 |
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| US5179017A (en) | 1980-02-25 | 1993-01-12 | The Trustees Of Columbia University In The City Of New York | Processes for inserting DNA into eucaryotic cells and for producing proteinaceous materials |
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| WO2006052926A2 (en) | 2004-11-08 | 2006-05-18 | University Of Maryland, Baltimore | Tweak as a therapeutic target for treating central nervous system diseases associated with cerebral edema and and cell death |
| US7939490B2 (en) | 2004-12-13 | 2011-05-10 | University Of Maryland, Baltimore | TWEAK as a therapeutic target for treating central nervous system diseases associated with cerebral edema and cell death |
| US20090124993A1 (en) | 2005-02-17 | 2009-05-14 | Burkly Linda C | Treating neurological disorders |
| WO2006088890A2 (en) | 2005-02-17 | 2006-08-24 | Biogen Idec Ma Inc. | Treating stroke |
| AU2006220825A1 (en) | 2005-03-07 | 2006-09-14 | Genentech, Inc. | Methods and compositions for modulating TWEAK and FN14 activity |
| WO2006122187A2 (en) | 2005-05-10 | 2006-11-16 | Biogen Idec Ma Inc. | Treating and evaluating inflammatory disorders |
| WO2006130429A2 (en) | 2005-05-27 | 2006-12-07 | Biogen Idec Ma Inc. | Treatment of cancer |
| WO2006138219A2 (en) | 2005-06-13 | 2006-12-28 | Biogen Idec Ma Inc. | Methods of diagnosis / prognosis of inflammatory conditions |
| US20100284933A1 (en) | 2006-10-16 | 2010-11-11 | Biogen Idec Ma Inc. | Biomarkers of Multiple Sclerosis |
-
2006
- 2006-05-25 NZ NZ564092A patent/NZ564092A/en not_active IP Right Cessation
- 2006-05-25 PL PL384684A patent/PL218791B1/pl unknown
- 2006-05-25 KR KR1020137032481A patent/KR101679468B1/ko not_active Expired - Fee Related
- 2006-05-25 UA UAA200714838A patent/UA96416C2/uk unknown
- 2006-05-25 SI SI200631822T patent/SI1888113T1/sl unknown
- 2006-05-25 NZ NZ583636A patent/NZ583636A/en not_active IP Right Cessation
- 2006-05-25 PL PL11191771T patent/PL2460831T3/pl unknown
- 2006-05-25 BR BRPI0611414A patent/BRPI0611414B8/pt not_active IP Right Cessation
- 2006-05-25 CA CA2609600A patent/CA2609600C/en not_active Expired - Fee Related
- 2006-05-25 DK DK06760258.1T patent/DK1888113T3/da active
- 2006-05-25 AU AU2006252830A patent/AU2006252830B2/en not_active Ceased
- 2006-05-25 ME MEP-2008-354A patent/ME00261B/me unknown
- 2006-05-25 JP JP2008513580A patent/JP5175181B2/ja not_active Expired - Fee Related
- 2006-05-25 DK DK11191771.2T patent/DK2460831T3/en active
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