JP2010513539A5 - - Google Patents
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- Publication number
- JP2010513539A5 JP2010513539A5 JP2009542980A JP2009542980A JP2010513539A5 JP 2010513539 A5 JP2010513539 A5 JP 2010513539A5 JP 2009542980 A JP2009542980 A JP 2009542980A JP 2009542980 A JP2009542980 A JP 2009542980A JP 2010513539 A5 JP2010513539 A5 JP 2010513539A5
- Authority
- JP
- Japan
- Prior art keywords
- seq
- heavy chain
- light chain
- amino acid
- chain
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
- 125000003275 alpha amino acid group Chemical group 0.000 claims 21
- 239000000427 antigen Substances 0.000 claims 15
- 108091007433 antigens Proteins 0.000 claims 15
- 102000036639 antigens Human genes 0.000 claims 15
- 239000012634 fragment Substances 0.000 claims 13
- 108010047041 Complementarity Determining Regions Proteins 0.000 claims 12
- 150000001413 amino acids Chemical class 0.000 claims 9
- 108010021625 Immunoglobulin Fragments Proteins 0.000 claims 7
- 102000008394 Immunoglobulin Fragments Human genes 0.000 claims 7
- 108010067060 Immunoglobulin Variable Region Proteins 0.000 claims 5
- NFGXHKASABOEEW-UHFFFAOYSA-N 1-methylethyl 11-methoxy-3,7,11-trimethyl-2,4-dodecadienoate Chemical compound COC(C)(C)CCCC(C)CC=CC(C)=CC(=O)OC(C)C NFGXHKASABOEEW-UHFFFAOYSA-N 0.000 claims 4
- 108091035707 Consensus sequence Proteins 0.000 claims 4
- 108060003951 Immunoglobulin Proteins 0.000 claims 4
- 210000004602 germ cell Anatomy 0.000 claims 4
- 102000018358 immunoglobulin Human genes 0.000 claims 4
- 239000008194 pharmaceutical composition Substances 0.000 claims 4
- 102100022005 B-lymphocyte antigen CD20 Human genes 0.000 claims 2
- 101000897405 Homo sapiens B-lymphocyte antigen CD20 Proteins 0.000 claims 2
- 201000010099 disease Diseases 0.000 claims 2
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 claims 2
- 238000000034 method Methods 0.000 claims 2
- 150000007523 nucleic acids Chemical group 0.000 claims 2
- 208000003950 B-cell lymphoma Diseases 0.000 claims 1
- 108010054477 Immunoglobulin Fab Fragments Proteins 0.000 claims 1
- 102000001706 Immunoglobulin Fab Fragments Human genes 0.000 claims 1
- 102000017727 Immunoglobulin Variable Region Human genes 0.000 claims 1
- 108091028043 Nucleic acid sequence Proteins 0.000 claims 1
- 210000003719 b-lymphocyte Anatomy 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 238000009472 formulation Methods 0.000 claims 1
- 229940072221 immunoglobulins Drugs 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 230000001404 mediated effect Effects 0.000 claims 1
- 108020004707 nucleic acids Proteins 0.000 claims 1
- 102000039446 nucleic acids Human genes 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 239000000825 pharmaceutical preparation Substances 0.000 claims 1
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87106906P | 2006-12-20 | 2006-12-20 | |
| PCT/US2007/078568 WO2008079466A1 (en) | 2006-12-20 | 2007-09-14 | Antibodies and methods for making and using them |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013169145A Division JP2014028812A (ja) | 2006-12-20 | 2013-08-16 | 抗体とその製造法および使用法 |
Publications (2)
| Publication Number | Publication Date |
|---|---|
| JP2010513539A JP2010513539A (ja) | 2010-04-30 |
| JP2010513539A5 true JP2010513539A5 (enExample) | 2010-09-30 |
Family
ID=39536929
Family Applications (3)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542980A Pending JP2010513539A (ja) | 2006-12-20 | 2007-09-14 | 抗体とその製造法および使用法 |
| JP2013169145A Pending JP2014028812A (ja) | 2006-12-20 | 2013-08-16 | 抗体とその製造法および使用法 |
| JP2015056137A Pending JP2015145394A (ja) | 2006-12-20 | 2015-03-19 | 抗体とその製造法および使用法 |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013169145A Pending JP2014028812A (ja) | 2006-12-20 | 2013-08-16 | 抗体とその製造法および使用法 |
| JP2015056137A Pending JP2015145394A (ja) | 2006-12-20 | 2015-03-19 | 抗体とその製造法および使用法 |
Country Status (10)
| Country | Link |
|---|---|
| US (3) | US8465741B2 (enExample) |
| EP (3) | EP2716658A3 (enExample) |
| JP (3) | JP2010513539A (enExample) |
| KR (2) | KR101378302B1 (enExample) |
| CN (2) | CN101675074B (enExample) |
| AU (1) | AU2007338607B2 (enExample) |
| BR (1) | BRPI0720565A2 (enExample) |
| CA (2) | CA2832111A1 (enExample) |
| MX (1) | MX2009006659A (enExample) |
| WO (2) | WO2008076487A2 (enExample) |
Families Citing this family (24)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| CA2832111A1 (en) * | 2006-12-20 | 2008-07-03 | Mmrglobal, Inc. | Antibodies and methods for making and using them |
| MX2011007049A (es) | 2009-02-24 | 2011-08-03 | Esbatech Alcon Biomed Res Unit | Metodos para identificar inmunoligadores de los antegenos de la superficie celular. |
| SG10201501342UA (en) * | 2010-02-24 | 2015-04-29 | Immunogen Inc | Folate receptor 1 antibodies and immunoconjugates and uses thereof |
| SG185487A1 (en) | 2010-05-11 | 2012-12-28 | Aveo Pharmaceuticals Inc | Anti-fgfr2 antibodies |
| CN103620032B (zh) | 2010-12-31 | 2016-02-24 | 生物蛋白有限公司 | 抗体的快速人源化 |
| US10670608B2 (en) * | 2010-12-31 | 2020-06-02 | Bioatla, Llc | Comprehensive monoclonal antibody generation |
| JP2014511174A (ja) * | 2011-02-07 | 2014-05-15 | ネオトープ バイオサイエンシーズ リミテッド | Ａｐｏｅ免疫療法 |
| SI2694106T1 (en) | 2011-04-01 | 2018-04-30 | Immunogen, Inc. | Methods for increasing the effectiveness of treatment with FOLR1 receptor cancer |
| US9790280B2 (en) | 2011-10-26 | 2017-10-17 | Elanco Tiergesundheit Ag | Monoclonal canine CD20 antibodies and methods of use |
| US12384848B2 (en) | 2011-12-19 | 2025-08-12 | The Rockefeller University | Anti-inflammatory polypeptides |
| CN104010659A (zh) | 2011-12-19 | 2014-08-27 | 洛克菲勒大学 | 非唾液酸化的抗炎多肽 |
| US9200073B2 (en) | 2012-08-31 | 2015-12-01 | Immunogen, Inc. | Diagnostic assays and kits for detection of folate receptor 1 |
| JP2016501877A (ja) | 2012-11-28 | 2016-01-21 | シーエヌジェー ホールディングス，インコーポレイテッド | クロストリジウム・ディフィシルに対する抗体 |
| CA3222465A1 (en) | 2013-08-30 | 2015-03-05 | Immunogen, Inc. | Antibodies and assays for detection of folate receptor 1 |
| EA202191471A1 (ru) | 2015-03-04 | 2022-01-31 | Зе Рокфеллер Юниверсити | Противовоспалительные полипептиды |
| CN116440279A (zh) | 2015-09-17 | 2023-07-18 | 伊缪诺金公司 | 包含抗folr1免疫缀合物的治疗组合 |
| CA3029977A1 (en) | 2016-07-06 | 2018-01-11 | Celgene Corporation | Antibodies with low immunogenicity and uses thereof |
| PE20200486A1 (es) * | 2017-08-03 | 2020-03-03 | Alector Llc | Anticuerpos anti-cd33 y metodos para utilizarlos |
| WO2020041896A1 (en) * | 2018-08-31 | 2020-03-05 | Immune Biosolutions Inc | Antibodies specific for ntsr1 and uses thereof |
| CN111662382A (zh) * | 2019-03-06 | 2020-09-15 | 瑞阳(苏州)生物科技有限公司 | 特异结合cd3的抗体、抗原结合片段和单链抗体可变区片段及其应用 |
| JP7370569B2 (ja) * | 2019-08-07 | 2023-10-30 | 国立大学法人 大分大学 | アミロイドβタンパク質オリゴマーと結合するヒト化抗体 |
| CN115803340A (zh) * | 2020-04-24 | 2023-03-14 | 纪念斯隆凯特琳癌症中心 | 抗cd3抗体及其用途 |
| CN116635948A (zh) * | 2020-12-07 | 2023-08-22 | Absci公司 | 用于产生疾病相关蛋白质组合物的系统和方法 |
| WO2025024323A1 (en) * | 2023-07-21 | 2025-01-30 | Bighat Biosciences, Inc. | P- and e-selectin-binding compositions and methods of use thereof |
Family Cites Families (30)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0590058B1 (en) * | 1991-06-14 | 2003-11-26 | Genentech, Inc. | HUMANIZED Heregulin ANTIBODy |
| ATE188708T1 (de) * | 1991-08-21 | 2000-01-15 | Novartis Ag | Antikörperderivate |
| US5565332A (en) | 1991-09-23 | 1996-10-15 | Medical Research Council | Production of chimeric antibodies - a combinatorial approach |
| US5840299A (en) | 1994-01-25 | 1998-11-24 | Athena Neurosciences, Inc. | Humanized antibodies against leukocyte adhesion molecule VLA-4 |
| US5721121A (en) | 1995-06-06 | 1998-02-24 | Genentech, Inc. | Mammalian cell culture process for producing a tumor necrosis factor receptor immunoglobulin chimeric protein |
| US6562594B1 (en) | 1999-09-29 | 2003-05-13 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US6764835B2 (en) | 1995-12-07 | 2004-07-20 | Diversa Corporation | Saturation mutageneis in directed evolution |
| US6537776B1 (en) | 1999-06-14 | 2003-03-25 | Diversa Corporation | Synthetic ligation reassembly in directed evolution |
| US6171820B1 (en) | 1995-12-07 | 2001-01-09 | Diversa Corporation | Saturation mutagenesis in directed evolution |
| US5834597A (en) * | 1996-05-20 | 1998-11-10 | Protein Design Labs, Inc. | Mutated nonactivating IgG2 domains and anti CD3 antibodies incorporating the same |
| JP2000169393A (ja) * | 1998-09-30 | 2000-06-20 | Sankyo Co Ltd | 抗Ｆａｓ抗体を含有する医薬 |
| EP3029062A1 (en) | 2000-05-26 | 2016-06-08 | Bristol-Myers Squibb Company | Soluble ctla4 mutant molecules and uses thereof |
| US20030026806A1 (en) * | 2000-10-27 | 2003-02-06 | Amgen Inc. | Antibodies and other selective IL-1 binding agents that allow binding to IL-1 receptor but not activation thereof |
| US7321026B2 (en) * | 2001-06-27 | 2008-01-22 | Skytech Technology Limited | Framework-patched immunoglobulins |
| WO2004006955A1 (en) | 2001-07-12 | 2004-01-22 | Jefferson Foote | Super humanized antibodies |
| CN100522999C (zh) * | 2002-02-14 | 2009-08-05 | 免疫医疗公司 | 抗cd20抗体及其融合蛋白和使用方法 |
| AR044388A1 (es) * | 2003-05-20 | 2005-09-07 | Applied Molecular Evolution | Moleculas de union a cd20 |
| CA2523716C (en) | 2003-05-31 | 2014-11-25 | Micromet Ag | Human anti-human cd3 binding molecules |
| US20060228350A1 (en) | 2003-08-18 | 2006-10-12 | Medimmune, Inc. | Framework-shuffling of antibodies |
| KR101229731B1 (ko) * | 2003-10-16 | 2013-03-07 | 암젠 리서치 (뮌헨) 게엠베하 | 다중특이적 탈면역화된 ｃｄ3-바인더 |
| ME01775B (me) * | 2003-11-05 | 2011-02-28 | Glycart Biotechnology Ag | Cd20 antitijela sa povećanim afinitetom vezivanja za fc receptor i efektornom funkcijom |
| JP2007532681A (ja) * | 2004-04-16 | 2007-11-15 | ジェネンテック・インコーポレーテッド | Ｂ細胞の枯渇を増大させる方法 |
| BRPI0510224A (pt) * | 2004-05-05 | 2007-10-23 | Genentech Inc | métodos de prevenção de doença autoimunológica e artigo industrializado |
| BRPI0514068B8 (pt) * | 2004-08-04 | 2021-05-25 | Applied Molecular Evolution Inc | anticorpo anti-cd20, e, composição farmacêutica |
| JO3000B1 (ar) * | 2004-10-20 | 2016-09-05 | Genentech Inc | مركبات أجسام مضادة . |
| WO2006102095A2 (en) * | 2005-03-18 | 2006-09-28 | Medimmune, Inc. | Framework-shuffling of antibodies |
| US20110129412A1 (en) * | 2005-06-02 | 2011-06-02 | Astrazeneca Ab | Antibodies Directed to CD20 and Uses Thereof |
| MY149159A (en) * | 2005-11-15 | 2013-07-31 | Hoffmann La Roche | Method for treating joint damage |
| US10155816B2 (en) | 2005-11-28 | 2018-12-18 | Genmab A/S | Recombinant monovalent antibodies and methods for production thereof |
| CA2832111A1 (en) * | 2006-12-20 | 2008-07-03 | Mmrglobal, Inc. | Antibodies and methods for making and using them |
-
2007
- 2007-09-14 CA CA2832111A patent/CA2832111A1/en not_active Abandoned
- 2007-09-14 EP EP13198631.7A patent/EP2716658A3/en not_active Withdrawn
- 2007-09-14 JP JP2009542980A patent/JP2010513539A/ja active Pending
- 2007-09-14 MX MX2009006659A patent/MX2009006659A/es active IP Right Grant
- 2007-09-14 KR KR1020097015196A patent/KR101378302B1/ko not_active Expired - Fee Related
- 2007-09-14 CA CA2673725A patent/CA2673725C/en not_active Expired - Fee Related
- 2007-09-14 KR KR1020137022383A patent/KR101546441B1/ko not_active Expired - Fee Related
- 2007-09-14 CN CN200780051557.6A patent/CN101675074B/zh not_active Expired - Fee Related
- 2007-09-14 US US11/855,943 patent/US8465741B2/en not_active Expired - Fee Related
- 2007-09-14 BR BRPI0720565-1A2A patent/BRPI0720565A2/pt not_active IP Right Cessation
- 2007-09-14 WO PCT/US2007/078566 patent/WO2008076487A2/en not_active Ceased
- 2007-09-14 WO PCT/US2007/078568 patent/WO2008079466A1/en not_active Ceased
- 2007-09-14 AU AU2007338607A patent/AU2007338607B2/en not_active Ceased
- 2007-09-14 CN CN201310355119.6A patent/CN103709249B/zh not_active Expired - Fee Related
- 2007-09-14 EP EP13198591.3A patent/EP2716657A3/en not_active Withdrawn
- 2007-09-14 EP EP07842553A patent/EP2121756A4/en not_active Withdrawn
-
2009
- 2009-06-18 US US12/487,422 patent/US8945550B2/en not_active Expired - Fee Related
-
2013
- 2013-04-19 US US13/866,120 patent/US20130287766A1/en not_active Abandoned
- 2013-08-16 JP JP2013169145A patent/JP2014028812A/ja active Pending
-
2015
- 2015-03-19 JP JP2015056137A patent/JP2015145394A/ja active Pending