DE602004018788D1 - Faktor-ixa-spezifische antikörper, die faktor-viiia-ähnliche wirkung zeigen - Google Patents
Faktor-ixa-spezifische antikörper, die faktor-viiia-ähnliche wirkung zeigenInfo
- Publication number
- DE602004018788D1 DE602004018788D1 DE602004018788T DE602004018788T DE602004018788D1 DE 602004018788 D1 DE602004018788 D1 DE 602004018788D1 DE 602004018788 T DE602004018788 T DE 602004018788T DE 602004018788 T DE602004018788 T DE 602004018788T DE 602004018788 D1 DE602004018788 D1 DE 602004018788D1
- Authority
- DE
- Germany
- Prior art keywords
- factor
- specific antibodies
- similar effect
- ligands
- show
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Active
Links
- 239000003446 ligand Substances 0.000 abstract 4
- 108010048049 Factor IXa Proteins 0.000 abstract 3
- 102100022641 Coagulation factor IX Human genes 0.000 abstract 1
- 108010076282 Factor IX Proteins 0.000 abstract 1
- 230000023555 blood coagulation Effects 0.000 abstract 1
- 229960004222 factor ix Drugs 0.000 abstract 1
- 238000000034 method Methods 0.000 abstract 1
- 150000007523 nucleic acids Chemical class 0.000 abstract 1
- 102000039446 nucleic acids Human genes 0.000 abstract 1
- 108020004707 nucleic acids Proteins 0.000 abstract 1
- 239000008194 pharmaceutical composition Substances 0.000 abstract 1
- 230000002947 procoagulating effect Effects 0.000 abstract 1
Classifications
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/18—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans
- C07K16/36—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against material from animals or humans against blood coagulation factors
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61P—SPECIFIC THERAPEUTIC ACTIVITY OF CHEMICAL COMPOUNDS OR MEDICINAL PREPARATIONS
- A61P7/00—Drugs for disorders of the blood or the extracellular fluid
- A61P7/04—Antihaemorrhagics; Procoagulants; Haemostatic agents; Antifibrinolytic agents
-
- C—CHEMISTRY; METALLURGY
- C07—ORGANIC CHEMISTRY
- C07K—PEPTIDES
- C07K16/00—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies
- C07K16/40—Immunoglobulins [IGs], e.g. monoclonal or polyclonal antibodies against enzymes
-
- A—HUMAN NECESSITIES
- A61—MEDICAL OR VETERINARY SCIENCE; HYGIENE
- A61K—PREPARATIONS FOR MEDICAL, DENTAL OR TOILETRY PURPOSES
- A61K39/00—Medicinal preparations containing antigens or antibodies
- A61K2039/505—Medicinal preparations containing antigens or antibodies comprising antibodies
Landscapes
- Health & Medical Sciences (AREA)
- Chemical & Material Sciences (AREA)
- Organic Chemistry (AREA)
- Medicinal Chemistry (AREA)
- General Health & Medical Sciences (AREA)
- Life Sciences & Earth Sciences (AREA)
- Molecular Biology (AREA)
- Proteomics, Peptides & Aminoacids (AREA)
- Genetics & Genomics (AREA)
- Biophysics (AREA)
- Biochemistry (AREA)
- Immunology (AREA)
- Hematology (AREA)
- Chemical Kinetics & Catalysis (AREA)
- Engineering & Computer Science (AREA)
- Public Health (AREA)
- Veterinary Medicine (AREA)
- Pharmacology & Pharmacy (AREA)
- Animal Behavior & Ethology (AREA)
- Bioinformatics & Cheminformatics (AREA)
- Diabetes (AREA)
- Nuclear Medicine, Radiotherapy & Molecular Imaging (AREA)
- General Chemical & Material Sciences (AREA)
- Peptides Or Proteins (AREA)
- Medicines Containing Antibodies Or Antigens For Use As Internal Diagnostic Agents (AREA)
- Preparation Of Compounds By Using Micro-Organisms (AREA)
- Micro-Organisms Or Cultivation Processes Thereof (AREA)
- Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
Applications Claiming Priority (2)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US10/661,366 US7297336B2 (en) | 2003-09-12 | 2003-09-12 | Factor IXa specific antibodies displaying factor VIIIa like activity |
| PCT/EP2004/009975 WO2005025615A2 (en) | 2003-09-12 | 2004-09-07 | FACTOR IXa SPECIFIC ANTIBODIES DISPLAYING FACTOR VIIIa LIKE ACTIVITY |
Publications (1)
| Publication Number | Publication Date |
|---|---|
| DE602004018788D1 true DE602004018788D1 (de) | 2009-02-12 |
Family
ID=34273861
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| DE602004018788T Active DE602004018788D1 (de) | 2003-09-12 | 2004-09-07 | Faktor-ixa-spezifische antikörper, die faktor-viiia-ähnliche wirkung zeigen |
Country Status (9)
| Country | Link |
|---|---|
| US (1) | US7297336B2 (de) |
| EP (1) | EP1660536B1 (de) |
| JP (1) | JP4887148B2 (de) |
| AT (1) | ATE419277T1 (de) |
| AU (1) | AU2004271706B2 (de) |
| CA (1) | CA2538895A1 (de) |
| DE (1) | DE602004018788D1 (de) |
| ES (1) | ES2320665T3 (de) |
| WO (1) | WO2005025615A2 (de) |
Families Citing this family (25)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT411997B (de) * | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
| WO2006106905A1 (ja) | 2005-03-31 | 2006-10-12 | Chugai Seiyaku Kabushiki Kaisha | 会合制御によるポリペプチド製造方法 |
| EP1760092A1 (de) * | 2005-08-26 | 2007-03-07 | Applied Research Systems ARS Holding N.V. | System für Screening von Zellen mit hoher Expression von einem interessierenden Protein |
| US9670269B2 (en) | 2006-03-31 | 2017-06-06 | Chugai Seiyaku Kabushiki Kaisha | Methods of modifying antibodies for purification of bispecific antibodies |
| ES2568436T3 (es) | 2006-03-31 | 2016-04-29 | Chugai Seiyaku Kabushiki Kaisha | Procedimiento para controlar la farmacocinética en sangre de anticuerpos |
| EP3689912A1 (de) | 2007-09-26 | 2020-08-05 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur modifizierung eines isoelektrischen punkts eines antikörpers über aminosäuresubstitution in cdr |
| MY166429A (en) | 2010-11-17 | 2018-06-26 | Chugai Pharmaceutical Co Ltd | Multi-specific antigen-binding molecule having alternative function to function of blood coagulation factor viii |
| MX358997B (es) * | 2012-09-28 | 2018-09-12 | Chugai Pharmaceutical Co Ltd | Metodo para evaluar la reaccion de coagulacion sanguinea. |
| KR102441231B1 (ko) | 2013-09-27 | 2022-09-06 | 추가이 세이야쿠 가부시키가이샤 | 폴리펩티드 이종 다량체의 제조방법 |
| SG11201607143UA (en) | 2014-03-11 | 2016-09-29 | Univ Leland Stanford Junior | Anti sirp-alpha antibodies and bi-specific macrophage enhancing antibodies |
| TWI701435B (zh) | 2014-09-26 | 2020-08-11 | 日商中外製藥股份有限公司 | 測定ｆｖｉｉｉ的反應性之方法 |
| TWI700300B (zh) | 2014-09-26 | 2020-08-01 | 日商中外製藥股份有限公司 | 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體 |
| MA40764A (fr) | 2014-09-26 | 2017-08-01 | Chugai Pharmaceutical Co Ltd | Agent thérapeutique induisant une cytotoxicité |
| EP3279216A4 (de) | 2015-04-01 | 2019-06-19 | Chugai Seiyaku Kabushiki Kaisha | Verfahren zur herstellung von polypeptid-hetero-oligomer |
| AU2016381992B2 (en) | 2015-12-28 | 2024-01-04 | Chugai Seiyaku Kabushiki Kaisha | Method for promoting efficiency of purification of Fc region-containing polypeptide |
| RU2770006C2 (ru) * | 2016-05-16 | 2022-04-14 | Такеда Фармасьютикал Компани Лимитед | Антитела к фактору ix padua |
| SG11201901961SA (en) | 2016-09-06 | 2019-04-29 | Chugai Pharmaceutical Co Ltd | Methods of using a bispecific antibody that recognizes coagulation factor ix and/or activated coagulation factor ix and coagulation factor x and/or activated coagulation factor x |
| CN110023339A (zh) * | 2016-09-23 | 2019-07-16 | Csl有限公司 | 凝血因子结合蛋白及其应用 |
| BR112019015611A2 (pt) | 2017-02-01 | 2020-03-17 | Novo Nordisk A/S | Anticorpos pró-coagulantes |
| GB201709970D0 (en) | 2017-06-22 | 2017-08-09 | Kymab Ltd | Bispecific antigen-binding molecules |
| BR112020005834A2 (pt) | 2017-09-29 | 2020-09-24 | Chugai Seiyaku Kabushiki Kaisha | molécula multiespecífica de ligação ao antígeno tendo atividade de substituição de função de cofator do fator viii de coagulação sanguínea (fviii), e formulação farmacêutica contendo a referida molécula como ingrediente ativo |
| US11220554B2 (en) | 2018-09-07 | 2022-01-11 | Novo Nordisk A/S | Procoagulant antibodies |
| CN117343188A (zh) | 2018-08-01 | 2024-01-05 | 诺和诺德股份有限公司 | 改进的促凝血抗体 |
| CA3123177A1 (en) * | 2018-12-21 | 2020-06-25 | Kymab Limited | Fixaxfx bispecific antibody with common light chain |
| WO2021152066A1 (en) | 2020-01-30 | 2021-08-05 | Novo Nordisk A/S | Bispecific factor viii mimetic antibodies |
Family Cites Families (11)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| AT368883B (de) | 1980-07-22 | 1982-11-25 | Immuno Ag | Verfahren zur herstellung einer neuen blutgerinnungsfoerdernden praeparation auf basis von humanproteinen |
| US4873316A (en) | 1987-06-23 | 1989-10-10 | Biogen, Inc. | Isolation of exogenous recombinant proteins from the milk of transgenic mammals |
| US5859205A (en) | 1989-12-21 | 1999-01-12 | Celltech Limited | Humanised antibodies |
| CA2143125C (en) | 1992-08-27 | 2008-09-23 | Koenraad Mertens | Antibodies specific for a haemostatic protein, their use for isolating intact protein, haemostatic compositions devoid of proteolytic cleavage products of the protein |
| DK128093D0 (da) | 1993-11-12 | 1993-11-12 | Novo Nordisk As | Hidtil ukendte forbindelser |
| MA24512A1 (fr) | 1996-01-17 | 1998-12-31 | Univ Vermont And State Agrienl | Procede pour la preparation d'agents anticoagulants utiles dans le traitement de la thrombose |
| US6013256A (en) * | 1996-09-24 | 2000-01-11 | Protein Design Labs, Inc. | Method of preventing acute rejection following solid organ transplantation |
| WO1999001476A1 (en) | 1997-07-03 | 1999-01-14 | Smithkline Beecham Corporation | CRYSTAL STRUCTURES OF ANTI-FACTOR IX Fab FRAGMENTS AND METHODS OF USE FOR PEPTIDOMIMETIC DESIGN |
| AT411997B (de) * | 1999-09-14 | 2004-08-26 | Baxter Ag | Faktor ix/faktor ixa aktivierende antikörper und antikörper-derivate |
| CU23007A1 (es) * | 2001-04-06 | 2004-12-17 | Ct De Inmunologia Molecular Ct De Inmunologia Mole | Combinaciones inmunoterapéuticas para el tratamiencombinaciones inmunoterapéuticas para el tratamiento de tumores que sobre-expresan gangliósidos to de tumores que sobre-expresan gangliósidos |
| BR0209177A (pt) * | 2001-05-03 | 2004-10-05 | Merck Patent Gmbh | Anticorpo especìfico a tumor recombinante e uso do mesmo |
-
2003
- 2003-09-12 US US10/661,366 patent/US7297336B2/en active Active
-
2004
- 2004-09-07 DE DE602004018788T patent/DE602004018788D1/de active Active
- 2004-09-07 JP JP2006525744A patent/JP4887148B2/ja not_active Expired - Fee Related
- 2004-09-07 EP EP04764918A patent/EP1660536B1/de active Active
- 2004-09-07 ES ES04764918T patent/ES2320665T3/es active Active
- 2004-09-07 CA CA002538895A patent/CA2538895A1/en not_active Abandoned
- 2004-09-07 AU AU2004271706A patent/AU2004271706B2/en active Active
- 2004-09-07 AT AT04764918T patent/ATE419277T1/de active
- 2004-09-07 WO PCT/EP2004/009975 patent/WO2005025615A2/en active Application Filing
Also Published As
| Publication number | Publication date |
|---|---|
| US7297336B2 (en) | 2007-11-20 |
| ATE419277T1 (de) | 2009-01-15 |
| ES2320665T3 (es) | 2009-05-27 |
| US20050058640A1 (en) | 2005-03-17 |
| CA2538895A1 (en) | 2005-03-24 |
| JP4887148B2 (ja) | 2012-02-29 |
| AU2004271706A1 (en) | 2005-03-24 |
| AU2004271706B2 (en) | 2010-09-02 |
| WO2005025615A2 (en) | 2005-03-24 |
| JP2007504812A (ja) | 2007-03-08 |
| WO2005025615A3 (en) | 2005-06-02 |
| EP1660536B1 (de) | 2008-12-31 |
| EP1660536A2 (de) | 2006-05-31 |
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Legal Events
| Date | Code | Title | Description |
|---|---|---|---|
| 8363 | Opposition against the patent |