MX358997B - Metodo para evaluar la reaccion de coagulacion sanguinea. - Google Patents

Metodo para evaluar la reaccion de coagulacion sanguinea.

Info

Publication number
MX358997B
MX358997B MX2015003740A MX2015003740A MX358997B MX 358997 B MX358997 B MX 358997B MX 2015003740 A MX2015003740 A MX 2015003740A MX 2015003740 A MX2015003740 A MX 2015003740A MX 358997 B MX358997 B MX 358997B
Authority
MX
Mexico
Prior art keywords
blood coagulation
activity
coagulation
coagulation reaction
blood
Prior art date
Application number
MX2015003740A
Other languages
English (en)
Other versions
MX2015003740A (es
Inventor
Soeda Tetsuhiro
Kitazawa Takehisa
Shima Midori
Original Assignee
Chugai Pharmaceutical Co Ltd
Priority date (The priority date is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the date listed.)
Filing date
Publication date
Application filed by Chugai Pharmaceutical Co Ltd filed Critical Chugai Pharmaceutical Co Ltd
Publication of MX2015003740A publication Critical patent/MX2015003740A/es
Publication of MX358997B publication Critical patent/MX358997B/es

Links

Classifications

    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N33/00—Investigating or analysing materials by specific methods not covered by groups G01N1/00 - G01N31/00
    • G01N33/48—Biological material, e.g. blood, urine; Haemocytometers
    • G01N33/50—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing
    • G01N33/86—Chemical analysis of biological material, e.g. blood, urine; Testing involving biospecific ligand binding methods; Immunological testing involving blood coagulating time or factors, or their receptors
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12N—MICROORGANISMS OR ENZYMES; COMPOSITIONS THEREOF; PROPAGATING, PRESERVING, OR MAINTAINING MICROORGANISMS; MUTATION OR GENETIC ENGINEERING; CULTURE MEDIA
    • C12N9/00—Enzymes; Proenzymes; Compositions thereof; Processes for preparing, activating, inhibiting, separating or purifying enzymes
    • C12N9/14—Hydrolases (3)
    • C12N9/48—Hydrolases (3) acting on peptide bonds (3.4)
    • C12N9/50—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25)
    • C12N9/64—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue
    • C12N9/6421—Proteinases, e.g. Endopeptidases (3.4.21-3.4.25) derived from animal tissue from mammals
    • C12N9/6424—Serine endopeptidases (3.4.21)
    • C12N9/6443—Coagulation factor XIa (3.4.21.27)
    • C—CHEMISTRY; METALLURGY
    • C12—BIOCHEMISTRY; BEER; SPIRITS; WINE; VINEGAR; MICROBIOLOGY; ENZYMOLOGY; MUTATION OR GENETIC ENGINEERING
    • C12Q—MEASURING OR TESTING PROCESSES INVOLVING ENZYMES, NUCLEIC ACIDS OR MICROORGANISMS; COMPOSITIONS OR TEST PAPERS THEREFOR; PROCESSES OF PREPARING SUCH COMPOSITIONS; CONDITION-RESPONSIVE CONTROL IN MICROBIOLOGICAL OR ENZYMOLOGICAL PROCESSES
    • C12Q1/00—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions
    • C12Q1/56—Measuring or testing processes involving enzymes, nucleic acids or microorganisms; Compositions therefor; Processes of preparing such compositions involving blood clotting factors, e.g. involving thrombin, thromboplastin, fibrinogen
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/435—Assays involving biological materials from specific organisms or of a specific nature from animals; from humans
    • G01N2333/745—Assays involving non-enzymic blood coagulation factors
    • G01N2333/755—Factors VIII, e.g. factor VIII C [AHF], factor VIII Ag [VWF]
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2333/00—Assays involving biological materials from specific organisms or of a specific nature
    • G01N2333/90—Enzymes; Proenzymes
    • G01N2333/914—Hydrolases (3)
    • G01N2333/948—Hydrolases (3) acting on peptide bonds (3.4)
    • G01N2333/95—Proteinases, i.e. endopeptidases (3.4.21-3.4.99)
    • G01N2333/964—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue
    • G01N2333/96425—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals
    • G01N2333/96427—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general
    • G01N2333/9643—Proteinases, i.e. endopeptidases (3.4.21-3.4.99) derived from animal tissue from mammals in general with EC number
    • G01N2333/96433—Serine endopeptidases (3.4.21)
    • G01N2333/96441—Serine endopeptidases (3.4.21) with definite EC number
    • G01N2333/96452—Factor XI (3.4.21.27)
    • G—PHYSICS
    • G01—MEASURING; TESTING
    • G01N—INVESTIGATING OR ANALYSING MATERIALS BY DETERMINING THEIR CHEMICAL OR PHYSICAL PROPERTIES
    • G01N2800/00—Detection or diagnosis of diseases
    • G01N2800/22—Haematology
    • G01N2800/224—Haemostasis or coagulation

Landscapes

  • Health & Medical Sciences (AREA)
  • Life Sciences & Earth Sciences (AREA)
  • Chemical & Material Sciences (AREA)
  • Engineering & Computer Science (AREA)
  • Hematology (AREA)
  • Molecular Biology (AREA)
  • Organic Chemistry (AREA)
  • Immunology (AREA)
  • Biomedical Technology (AREA)
  • Zoology (AREA)
  • Wood Science & Technology (AREA)
  • Microbiology (AREA)
  • Biotechnology (AREA)
  • Biochemistry (AREA)
  • General Health & Medical Sciences (AREA)
  • Urology & Nephrology (AREA)
  • Physics & Mathematics (AREA)
  • Analytical Chemistry (AREA)
  • Proteomics, Peptides & Aminoacids (AREA)
  • Bioinformatics & Cheminformatics (AREA)
  • Genetics & Genomics (AREA)
  • Medicinal Chemistry (AREA)
  • General Engineering & Computer Science (AREA)
  • Food Science & Technology (AREA)
  • General Physics & Mathematics (AREA)
  • Cell Biology (AREA)
  • Pathology (AREA)
  • Biophysics (AREA)
  • Neurosurgery (AREA)
  • Medicines That Contain Protein Lipid Enzymes And Other Medicines (AREA)
  • Investigating Or Analysing Biological Materials (AREA)
  • Measuring Or Testing Involving Enzymes Or Micro-Organisms (AREA)
  • Peptides Or Proteins (AREA)
  • Medicines Containing Material From Animals Or Micro-Organisms (AREA)

Abstract

La presente invención se refiere a varios métodos para evaluar el efecto hemostático y varios reactivos de inicio de coagulación sanguínea para construir un método para evaluar la reacción de coagulación sanguínea mediada por una sustancia que tiene la actividad de sustituir el factor VIII de coagulación (FVIII). Como resultado, se descubrió que al usar un reactivo de inicio de coagulación que contiene el factor IX de coagulación, activado (FXIa9 y fosfolípidos, se puede evaluar el efecto de una sustancia que tiene la actividad de sustituir el factor VIII de coagulación (FVIII) en la reacción de coagulación sanguínea, usando la cantidad de trombina generada en la muestra de sangre como un indicador.
MX2015003740A 2012-09-28 2013-09-26 Metodo para evaluar la reaccion de coagulacion sanguinea. MX358997B (es)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
JP2012217925 2012-09-28
PCT/JP2013/075978 WO2014050926A1 (ja) 2012-09-28 2013-09-26 血液凝固反応の評価方法

Publications (2)

Publication Number Publication Date
MX2015003740A MX2015003740A (es) 2015-09-23
MX358997B true MX358997B (es) 2018-09-12

Family

ID=50388321

Family Applications (1)

Application Number Title Priority Date Filing Date
MX2015003740A MX358997B (es) 2012-09-28 2013-09-26 Metodo para evaluar la reaccion de coagulacion sanguinea.

Country Status (14)

Country Link
US (1) US11078518B2 (es)
EP (1) EP2902787B1 (es)
JP (1) JP6284481B2 (es)
KR (1) KR102134305B1 (es)
CN (1) CN104937423B (es)
BR (1) BR112015006634B1 (es)
CA (1) CA2886326C (es)
ES (1) ES2668455T3 (es)
HK (1) HK1212443A1 (es)
MX (1) MX358997B (es)
PL (1) PL2902787T3 (es)
RU (1) RU2683933C2 (es)
TW (1) TWI609083B (es)
WO (1) WO2014050926A1 (es)

Families Citing this family (8)

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Publication number Priority date Publication date Assignee Title
KR101398363B1 (ko) 2010-11-17 2014-05-22 추가이 세이야쿠 가부시키가이샤 혈액응고 제viii 인자의 기능을 대체하는 기능을 갖는 다중특이성 항원 결합 분자
TWI700300B (zh) * 2014-09-26 2020-08-01 日商中外製藥股份有限公司 中和具有第ｖｉｉｉ凝血因子（ｆｖｉｉｉ）機能替代活性的物質之抗體
TWI701435B (zh) * 2014-09-26 2020-08-11 日商中外製藥股份有限公司 測定ｆｖｉｉｉ的反應性之方法
JP6147945B2 (ja) * 2015-04-24 2017-06-14 公立大学法人奈良県立医科大学 血液検体の凝固能の評価方法、並びにその方法に用いるための試薬、試薬キット及び装置
JP7101351B2 (ja) 2016-04-28 2022-07-15 シスメックス株式会社 血液検体の分析方法、血液検体分析用試薬及び試薬キット、並びに血液検体分析装置
RU2699798C1 (ru) * 2019-05-22 2019-09-11 Федеральное государственное бюджетное учреждение "Национальный медицинский исследовательский центр гематологии" Министерства здравоохранения Российской Федерации (ФГБУ "НМИЦ гематологии" Минздрава России) Способ выявления дефицитов факторов свертывания крови методом тромбоэластометрии
JP6883899B1 (ja) * 2020-12-07 2021-06-09 株式会社血栓トランスレーショナルリサーチラボ 血液凝固検査試薬、および血液凝固検査方法
WO2024143525A1 (ja) * 2022-12-28 2024-07-04 積水メディカル株式会社 血液検体の血液凝固能の分析方法

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Also Published As

Publication number Publication date
EP2902787A1 (en) 2015-08-05
US20150240287A1 (en) 2015-08-27
TWI609083B (zh) 2017-12-21
CN104937423A (zh) 2015-09-23
JP6284481B2 (ja) 2018-02-28
ES2668455T3 (es) 2018-05-18
EP2902787B1 (en) 2018-03-28
WO2014050926A1 (ja) 2014-04-03
TW201418470A (zh) 2014-05-16
BR112015006634A2 (es) 2017-09-05
BR112015006634B1 (pt) 2022-06-14
US11078518B2 (en) 2021-08-03
HK1212443A1 (en) 2016-06-10
KR20150068406A (ko) 2015-06-19
CA2886326A1 (en) 2014-04-03
CN104937423B (zh) 2017-05-24
JPWO2014050926A1 (ja) 2016-08-22
RU2015115277A (ru) 2016-11-20
MX2015003740A (es) 2015-09-23
EP2902787A4 (en) 2016-03-23
PL2902787T3 (pl) 2018-08-31
RU2683933C2 (ru) 2019-04-03
KR102134305B1 (ko) 2020-07-15
CA2886326C (en) 2021-11-02

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