JP2011524903A5 - - Google Patents
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- JP2011524903A5 JP2011524903A5 JP2011514598A JP2011514598A JP2011524903A5 JP 2011524903 A5 JP2011524903 A5 JP 2011524903A5 JP 2011514598 A JP2011514598 A JP 2011514598A JP 2011514598 A JP2011514598 A JP 2011514598A JP 2011524903 A5 JP2011524903 A5 JP 2011524903A5
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- KRKNYBCHXYNGOX-UHFFFAOYSA-N citric acid Chemical compound OC(=O)CC(O)(C(O)=O)CC(O)=O KRKNYBCHXYNGOX-UHFFFAOYSA-N 0.000 claims 33
- 150000001875 compounds Chemical class 0.000 claims 26
- 239000008194 pharmaceutical composition Substances 0.000 claims 21
- 239000000203 mixture Substances 0.000 claims 14
- 239000000945 filler Substances 0.000 claims 10
- DHMQDGOQFOQNFH-UHFFFAOYSA-N Glycine Natural products NCC(O)=O DHMQDGOQFOQNFH-UHFFFAOYSA-N 0.000 claims 8
- 239000000872 buffer Substances 0.000 claims 8
- 239000001509 sodium citrate Substances 0.000 claims 8
- NLJMYIDDQXHKNR-UHFFFAOYSA-K sodium citrate Chemical compound O.O.[Na+].[Na+].[Na+].[O-]C(=O)CC(O)(CC([O-])=O)C([O-])=O NLJMYIDDQXHKNR-UHFFFAOYSA-K 0.000 claims 8
- 239000000314 lubricant Substances 0.000 claims 7
- 239000004067 bulking agent Substances 0.000 claims 6
- 229910052739 hydrogen Inorganic materials 0.000 claims 6
- 239000001257 hydrogen Substances 0.000 claims 6
- 125000004435 hydrogen atom Chemical class [H]* 0.000 claims 6
- HQKMJHAJHXVSDF-UHFFFAOYSA-L magnesium stearate Chemical compound [Mg+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O HQKMJHAJHXVSDF-UHFFFAOYSA-L 0.000 claims 6
- 238000000034 method Methods 0.000 claims 6
- 239000004471 Glycine Substances 0.000 claims 5
- 125000003118 aryl group Chemical group 0.000 claims 5
- 229920000168 Microcrystalline cellulose Polymers 0.000 claims 4
- 206010028980 Neoplasm Diseases 0.000 claims 4
- FAPWRFPIFSIZLT-UHFFFAOYSA-M Sodium chloride Chemical compound [Na+].[Cl-] FAPWRFPIFSIZLT-UHFFFAOYSA-M 0.000 claims 4
- 239000006172 buffering agent Substances 0.000 claims 4
- 201000011510 cancer Diseases 0.000 claims 4
- 125000005842 heteroatom Chemical group 0.000 claims 4
- 239000008176 lyophilized powder Substances 0.000 claims 4
- 239000008108 microcrystalline cellulose Substances 0.000 claims 4
- 235000019813 microcrystalline cellulose Nutrition 0.000 claims 4
- 229940016286 microcrystalline cellulose Drugs 0.000 claims 4
- 229910052757 nitrogen Inorganic materials 0.000 claims 4
- 229910052760 oxygen Inorganic materials 0.000 claims 4
- 150000003839 salts Chemical class 0.000 claims 4
- 229910052717 sulfur Inorganic materials 0.000 claims 4
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims 3
- 125000001931 aliphatic group Chemical group 0.000 claims 3
- 229910052799 carbon Inorganic materials 0.000 claims 3
- 125000004432 carbon atom Chemical group C* 0.000 claims 3
- 239000007788 liquid Substances 0.000 claims 3
- 235000019359 magnesium stearate Nutrition 0.000 claims 3
- 238000004519 manufacturing process Methods 0.000 claims 3
- 125000006574 non-aromatic ring group Chemical group 0.000 claims 3
- 229920003109 sodium starch glycolate Polymers 0.000 claims 3
- 229940079832 sodium starch glycolate Drugs 0.000 claims 3
- 239000008109 sodium starch glycolate Substances 0.000 claims 3
- 239000000454 talc Substances 0.000 claims 3
- 229910052623 talc Inorganic materials 0.000 claims 3
- 239000008181 tonicity modifier Substances 0.000 claims 3
- -1 2,5-dichlorophenyl Chemical group 0.000 claims 2
- 239000002253 acid Substances 0.000 claims 2
- 125000002843 carboxylic acid group Chemical group 0.000 claims 2
- 239000002552 dosage form Substances 0.000 claims 2
- 239000003814 drug Substances 0.000 claims 2
- 238000004108 freeze drying Methods 0.000 claims 2
- 125000003630 glycyl group Chemical group [H]N([H])C([H])([H])C(*)=O 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000000623 heterocyclic group Chemical group 0.000 claims 2
- 125000000959 isobutyl group Chemical group [H]C([H])([H])C([H])(C([H])([H])[H])C([H])([H])* 0.000 claims 2
- 238000002360 preparation method Methods 0.000 claims 2
- 239000011780 sodium chloride Substances 0.000 claims 2
- 239000003021 water soluble solvent Substances 0.000 claims 2
- OKMWKBLSFKFYGZ-UHFFFAOYSA-N 1-behenoylglycerol Chemical compound CCCCCCCCCCCCCCCCCCCCCC(=O)OCC(O)CO OKMWKBLSFKFYGZ-UHFFFAOYSA-N 0.000 claims 1
- GUBGYTABKSRVRQ-UHFFFAOYSA-N 2-(hydroxymethyl)-6-[4,5,6-trihydroxy-2-(hydroxymethyl)oxan-3-yl]oxyoxane-3,4,5-triol Chemical compound OCC1OC(OC2C(O)C(O)C(O)OC2CO)C(O)C(O)C1O GUBGYTABKSRVRQ-UHFFFAOYSA-N 0.000 claims 1
- ZOXJGFHDIHLPTG-UHFFFAOYSA-N Boron Chemical group [B] ZOXJGFHDIHLPTG-UHFFFAOYSA-N 0.000 claims 1
- 229920000881 Modified starch Polymers 0.000 claims 1
- 229920002472 Starch Polymers 0.000 claims 1
- SZYSLWCAWVWFLT-UTGHZIEOSA-N [(2s,3s,4s,5r)-3,4-dihydroxy-5-(hydroxymethyl)-2-[(2r,3r,4s,5s,6r)-3,4,5-trihydroxy-6-(hydroxymethyl)oxan-2-yl]oxyoxolan-2-yl]methyl octadecanoate Chemical compound O([C@@H]1[C@@H]([C@@H](O)[C@H](O)[C@@H](CO)O1)O)[C@]1(COC(=O)CCCCCCCCCCCCCCCCC)O[C@H](CO)[C@@H](O)[C@@H]1O SZYSLWCAWVWFLT-UTGHZIEOSA-N 0.000 claims 1
- 125000004429 atom Chemical group 0.000 claims 1
- 229910052796 boron Inorganic materials 0.000 claims 1
- CJZGTCYPCWQAJB-UHFFFAOYSA-L calcium stearate Chemical compound [Ca+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O CJZGTCYPCWQAJB-UHFFFAOYSA-L 0.000 claims 1
- 239000008116 calcium stearate Substances 0.000 claims 1
- 235000013539 calcium stearate Nutrition 0.000 claims 1
- 239000002775 capsule Substances 0.000 claims 1
- 239000001913 cellulose Substances 0.000 claims 1
- 229940049654 glyceryl behenate Drugs 0.000 claims 1
- 239000008172 hydrogenated vegetable oil Substances 0.000 claims 1
- 125000002887 hydroxy group Chemical group [H]O* 0.000 claims 1
- 239000000178 monomer Substances 0.000 claims 1
- 125000004430 oxygen atom Chemical group O* 0.000 claims 1
- 235000019814 powdered cellulose Nutrition 0.000 claims 1
- 229920003124 powdered cellulose Polymers 0.000 claims 1
- 229920003133 pregelled starch Polymers 0.000 claims 1
- RYYKJJJTJZKILX-UHFFFAOYSA-M sodium octadecanoate Chemical compound [Na+].CCCCCCCCCCCCCCCCCC([O-])=O RYYKJJJTJZKILX-UHFFFAOYSA-M 0.000 claims 1
- 239000008107 starch Substances 0.000 claims 1
- 229940032147 starch Drugs 0.000 claims 1
- 235000019698 starch Nutrition 0.000 claims 1
- XLYOFNOQVPJJNP-UHFFFAOYSA-N water Chemical compound O XLYOFNOQVPJJNP-UHFFFAOYSA-N 0.000 claims 1
- 239000008215 water for injection Substances 0.000 claims 1
- XOOUIPVCVHRTMJ-UHFFFAOYSA-L zinc stearate Chemical compound [Zn+2].CCCCCCCCCCCCCCCCCC([O-])=O.CCCCCCCCCCCCCCCCCC([O-])=O XOOUIPVCVHRTMJ-UHFFFAOYSA-L 0.000 claims 1
- 0 CC(C)(C(C(*)NC(C)(C)P)=O)NC(*)C(NCBOC(CC(O)=O)(CC(O)=O)C(O)=O)=O Chemical compound CC(C)(C(C(*)NC(C)(C)P)=O)NC(*)C(NCBOC(CC(O)=O)(CC(O)=O)C(O)=O)=O 0.000 description 2
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US13224408P | 2008-06-17 | 2008-06-17 | |
| US61/132,244 | 2008-06-17 | ||
| US21149909P | 2009-03-31 | 2009-03-31 | |
| US61/211,499 | 2009-03-31 | ||
| PCT/US2009/003602 WO2009154737A1 (en) | 2008-06-17 | 2009-06-16 | Boronate ester compounds and pharmaceutical compositions thereof |
Related Child Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014103396A Division JP6110813B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103398A Division JP2014169317A (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103397A Division JP5926319B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103395A Division JP6010066B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011524903A JP2011524903A (ja) | 2011-09-08 |
| JP2011524903A5 true JP2011524903A5 (cg-RX-API-DMAC7.html) | 2012-08-02 |
| JP5566380B2 JP5566380B2 (ja) | 2014-08-06 |
Family
ID=41061278
Family Applications (10)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011514598A Active JP5566380B2 (ja) | 2008-06-17 | 2009-06-16 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103397A Active JP5926319B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103395A Active JP6010066B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103398A Withdrawn JP2014169317A (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103396A Active JP6110813B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2017128843A Withdrawn JP2017214396A (ja) | 2008-06-17 | 2017-06-30 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2019216272A Withdrawn JP2020055829A (ja) | 2008-06-17 | 2019-11-29 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2021109909A Withdrawn JP2021165288A (ja) | 2008-06-17 | 2021-07-01 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2023145377A Withdrawn JP2023158150A (ja) | 2008-06-17 | 2023-09-07 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2025141388A Pending JP2025172854A (ja) | 2008-06-17 | 2025-08-27 | ボロン酸エステル化合物およびその医薬組成物 |
Family Applications After (9)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2014103397A Active JP5926319B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103395A Active JP6010066B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103398A Withdrawn JP2014169317A (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2014103396A Active JP6110813B2 (ja) | 2008-06-17 | 2014-05-19 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2017128843A Withdrawn JP2017214396A (ja) | 2008-06-17 | 2017-06-30 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2019216272A Withdrawn JP2020055829A (ja) | 2008-06-17 | 2019-11-29 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2021109909A Withdrawn JP2021165288A (ja) | 2008-06-17 | 2021-07-01 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2023145377A Withdrawn JP2023158150A (ja) | 2008-06-17 | 2023-09-07 | ボロン酸エステル化合物およびその医薬組成物 |
| JP2025141388A Pending JP2025172854A (ja) | 2008-06-17 | 2025-08-27 | ボロン酸エステル化合物およびその医薬組成物 |
Country Status (39)
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| UA101303C2 (uk) | 2006-06-19 | 2013-03-25 | Протеолікс, Інк. | Сполуки для інгібування ферменту протеасоми |
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- 2015-05-27 PH PH12015501193A patent/PH12015501193A1/en unknown
- 2015-05-27 PH PH12015501191A patent/PH12015501191B1/en unknown
- 2015-06-08 ZA ZA2015/04133A patent/ZA201504133B/en unknown
- 2015-06-16 CY CY20151100519T patent/CY1116435T1/el unknown
- 2015-10-12 US US14/880,776 patent/US20160031913A1/en not_active Abandoned
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2016
- 2016-01-08 CR CR20160015A patent/CR20160015A/es unknown
- 2016-01-08 CR CR20160014A patent/CR20160014A/es unknown
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2017
- 2017-05-04 NO NO2017016C patent/NO2017016I1/no unknown
- 2017-06-30 JP JP2017128843A patent/JP2017214396A/ja not_active Withdrawn
- 2017-09-12 US US15/701,791 patent/US20180002350A1/en not_active Abandoned
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2018
- 2018-03-22 US US15/928,139 patent/US20180208609A1/en not_active Abandoned
- 2018-03-27 HK HK18104204.4A patent/HK1244811A1/zh unknown
- 2018-03-27 HK HK18104201.7A patent/HK1244809A1/zh unknown
- 2018-03-27 HK HK18104203.5A patent/HK1244810A1/zh unknown
- 2018-03-27 HK HK18104202.6A patent/HK1244827A1/zh unknown
- 2018-10-18 US US16/163,694 patent/US20190048028A1/en not_active Abandoned
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2019
- 2019-01-29 US US16/260,596 patent/US10526351B2/en active Active
- 2019-05-08 US US16/406,159 patent/US20190263839A1/en not_active Abandoned
- 2019-09-13 US US16/570,065 patent/US10604538B2/en active Active
- 2019-11-29 JP JP2019216272A patent/JP2020055829A/ja not_active Withdrawn
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2020
- 2020-02-12 US US16/788,824 patent/US20200181176A1/en not_active Abandoned
- 2020-04-24 US US16/857,227 patent/US11485746B2/en active Active
- 2020-09-01 US US17/009,199 patent/US20200392164A1/en not_active Abandoned
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2021
- 2021-03-11 US US17/198,442 patent/US20210198289A1/en not_active Abandoned
- 2021-07-01 JP JP2021109909A patent/JP2021165288A/ja not_active Withdrawn
- 2021-09-23 US US17/483,724 patent/US20220009948A1/en not_active Abandoned
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2023
- 2023-05-03 US US18/311,290 patent/US20230265111A1/en not_active Abandoned
- 2023-09-07 JP JP2023145377A patent/JP2023158150A/ja not_active Withdrawn
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2025
- 2025-08-27 JP JP2025141388A patent/JP2025172854A/ja active Pending
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