JP2011521903A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2011521903A5 JP2011521903A5 JP2011506435A JP2011506435A JP2011521903A5 JP 2011521903 A5 JP2011521903 A5 JP 2011521903A5 JP 2011506435 A JP2011506435 A JP 2011506435A JP 2011506435 A JP2011506435 A JP 2011506435A JP 2011521903 A5 JP2011521903 A5 JP 2011521903A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- alkyl
- virus
- acceptable salt
- compound
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims description 49
- PXBRQCKWGAHEHS-UHFFFAOYSA-N dichlorodifluoromethane Chemical compound FC(F)(Cl)Cl PXBRQCKWGAHEHS-UHFFFAOYSA-N 0.000 claims description 40
- 150000003839 salts Chemical class 0.000 claims description 28
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 claims description 24
- 239000003112 inhibitor Substances 0.000 claims description 15
- 125000004648 C2-C8 alkenyl group Chemical group 0.000 claims description 14
- 229910052736 halogen Inorganic materials 0.000 claims description 14
- 150000002367 halogens Chemical class 0.000 claims description 14
- 239000003814 drug Substances 0.000 claims description 13
- 125000004649 C2-C8 alkynyl group Chemical group 0.000 claims description 12
- 241000700605 Viruses Species 0.000 claims description 10
- 229910052717 sulfur Inorganic materials 0.000 claims description 10
- 238000000034 method Methods 0.000 claims description 9
- 230000009385 viral infection Effects 0.000 claims description 9
- 208000036142 Viral infection Diseases 0.000 claims description 8
- 125000005884 carbocyclylalkyl group Chemical group 0.000 claims description 8
- 229910052799 carbon Inorganic materials 0.000 claims description 8
- 125000000623 heterocyclic group Chemical group 0.000 claims description 8
- 229910052760 oxygen Inorganic materials 0.000 claims description 8
- 229940124597 therapeutic agent Drugs 0.000 claims description 8
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- HSFWRNGVRCDJHI-UHFFFAOYSA-N alpha-acetylene Natural products C#C HSFWRNGVRCDJHI-UHFFFAOYSA-N 0.000 claims description 6
- 125000003118 aryl group Chemical group 0.000 claims description 6
- 150000001721 carbon Chemical group 0.000 claims description 6
- 125000004432 carbon atom Chemical group C* 0.000 claims description 6
- 125000001072 heteroaryl group Chemical group 0.000 claims description 6
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 6
- 125000000547 substituted alkyl group Chemical group 0.000 claims description 6
- 125000004426 substituted alkynyl group Chemical group 0.000 claims description 6
- 125000003107 substituted aryl group Chemical group 0.000 claims description 6
- 125000000391 vinyl group Chemical group [H]C([*])=C([H])[H] 0.000 claims description 6
- 125000002534 ethynyl group Chemical group [H]C#C* 0.000 claims description 5
- 101001023866 Arabidopsis thaliana Mannosyl-oligosaccharide glucosidase GCS1 Proteins 0.000 claims description 4
- 241000710780 Bovine viral diarrhea virus 1 Species 0.000 claims description 4
- 241000725619 Dengue virus Species 0.000 claims description 4
- 241000710781 Flaviviridae Species 0.000 claims description 4
- 241000711549 Hepacivirus C Species 0.000 claims description 4
- 102000014150 Interferons Human genes 0.000 claims description 4
- 108010050904 Interferons Proteins 0.000 claims description 4
- 241000710842 Japanese encephalitis virus Species 0.000 claims description 4
- 241000710912 Kunjin virus Species 0.000 claims description 4
- 241000124008 Mammalia Species 0.000 claims description 4
- 241000710908 Murray Valley encephalitis virus Species 0.000 claims description 4
- 241000725177 Omsk hemorrhagic fever virus Species 0.000 claims description 4
- IWUCXVSUMQZMFG-AFCXAGJDSA-N Ribavirin Chemical class N1=C(C(=O)N)N=CN1[C@H]1[C@H](O)[C@H](O)[C@@H](CO)O1 IWUCXVSUMQZMFG-AFCXAGJDSA-N 0.000 claims description 4
- 101800001838 Serine protease/helicase NS3 Proteins 0.000 claims description 4
- 241000710888 St. Louis encephalitis virus Species 0.000 claims description 4
- 241000710771 Tick-borne encephalitis virus Species 0.000 claims description 4
- 241000710886 West Nile virus Species 0.000 claims description 4
- 241000710772 Yellow fever virus Species 0.000 claims description 4
- 241000907316 Zika virus Species 0.000 claims description 4
- 125000000217 alkyl group Chemical group 0.000 claims description 4
- 125000003710 aryl alkyl group Chemical group 0.000 claims description 4
- 239000000134 cyclophilin inhibitor Substances 0.000 claims description 4
- 239000002777 nucleoside Substances 0.000 claims description 4
- 150000003833 nucleoside derivatives Chemical class 0.000 claims description 4
- 239000000137 peptide hydrolase inhibitor Substances 0.000 claims description 4
- 125000005017 substituted alkenyl group Chemical group 0.000 claims description 4
- 229940051021 yellow-fever virus Drugs 0.000 claims description 4
- 229940042399 direct acting antivirals protease inhibitors Drugs 0.000 claims description 3
- 229940079593 drug Drugs 0.000 claims description 3
- 229910052757 nitrogen Inorganic materials 0.000 claims description 3
- -1 —C (═O) OR 11 Chemical compound 0.000 claims description 3
- 125000003341 7 membered heterocyclic group Chemical group 0.000 claims description 2
- OKTJSMMVPCPJKN-UHFFFAOYSA-N Carbon Chemical compound [C] OKTJSMMVPCPJKN-UHFFFAOYSA-N 0.000 claims description 2
- 208000005176 Hepatitis C Diseases 0.000 claims description 2
- 125000003342 alkenyl group Chemical group 0.000 claims description 2
- 125000000304 alkynyl group Chemical group 0.000 claims description 2
- 229910052794 bromium Inorganic materials 0.000 claims description 2
- 125000002837 carbocyclic group Chemical group 0.000 claims description 2
- 229910052801 chlorine Inorganic materials 0.000 claims description 2
- 125000004122 cyclic group Chemical group 0.000 claims description 2
- 239000003937 drug carrier Substances 0.000 claims description 2
- 229910052731 fluorine Inorganic materials 0.000 claims description 2
- 125000001475 halogen functional group Chemical group 0.000 claims description 2
- 229910052739 hydrogen Inorganic materials 0.000 claims description 2
- 125000004356 hydroxy functional group Chemical group O* 0.000 claims description 2
- 125000004029 hydroxymethyl group Chemical group [H]OC([H])([H])* 0.000 claims description 2
- 230000002401 inhibitory effect Effects 0.000 claims description 2
- 229940079322 interferon Drugs 0.000 claims description 2
- 229940047124 interferons Drugs 0.000 claims description 2
- 229910052740 iodine Inorganic materials 0.000 claims description 2
- 238000004519 manufacturing process Methods 0.000 claims description 2
- IJGRMHOSHXDMSA-UHFFFAOYSA-N nitrogen Substances N#N IJGRMHOSHXDMSA-UHFFFAOYSA-N 0.000 claims description 2
- QJGQUHMNIGDVPM-UHFFFAOYSA-N nitrogen group Chemical group [N] QJGQUHMNIGDVPM-UHFFFAOYSA-N 0.000 claims description 2
- 239000000203 mixture Substances 0.000 claims 9
- 108060004795 Methyltransferase Proteins 0.000 description 2
- 150000007523 nucleic acids Chemical class 0.000 description 2
- 102000039446 nucleic acids Human genes 0.000 description 2
- 108020004707 nucleic acids Proteins 0.000 description 2
- 229940122806 Cyclophilin inhibitor Drugs 0.000 description 1
- 208000004576 Flaviviridae Infections Diseases 0.000 description 1
- FWKQNCXZGNBPFD-UHFFFAOYSA-N Guaiazulene Chemical compound CC(C)C1=CC=C(C)C2=CC=C(C)C2=C1 FWKQNCXZGNBPFD-UHFFFAOYSA-N 0.000 description 1
- 241001465754 Metazoa Species 0.000 description 1
- 229940123066 Polymerase inhibitor Drugs 0.000 description 1
- 229940124158 Protease/peptidase inhibitor Drugs 0.000 description 1
- 230000001413 cellular effect Effects 0.000 description 1
- 230000003612 virological effect Effects 0.000 description 1
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US4726308P | 2008-04-23 | 2008-04-23 | |
| US61/047,263 | 2008-04-23 | ||
| US13944908P | 2008-12-19 | 2008-12-19 | |
| US61/139,449 | 2008-12-19 | ||
| PCT/US2009/041447 WO2009132135A1 (en) | 2008-04-23 | 2009-04-22 | 1' -substituted carba-nucleoside analogs for antiviral treatment |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013218129A Division JP2014040471A (ja) | 2008-04-23 | 2013-10-21 | 抗ウイルス処置のための１’−置換カルバ−ヌクレオシドアナログ |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2011521903A JP2011521903A (ja) | 2011-07-28 |
| JP2011521903A5 true JP2011521903A5 (cg-RX-API-DMAC7.html) | 2013-04-04 |
| JP5425187B2 JP5425187B2 (ja) | 2014-02-26 |
Family
ID=40887058
Family Applications (4)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506429A Active JP5425186B2 (ja) | 2008-04-23 | 2009-04-22 | 抗ウイルス処置のためのカルバ−ヌクレオシドアナログ |
| JP2011506435A Active JP5425187B2 (ja) | 2008-04-23 | 2009-04-22 | 抗ウイルス処置のための１’−置換カルバ−ヌクレオシドアナログ |
| JP2013218129A Withdrawn JP2014040471A (ja) | 2008-04-23 | 2013-10-21 | 抗ウイルス処置のための１’−置換カルバ−ヌクレオシドアナログ |
| JP2013218139A Withdrawn JP2014012739A (ja) | 2008-04-23 | 2013-10-21 | 抗ウイルス処置のためのカルバ−ヌクレオシドアナログ |
Family Applications Before (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011506429A Active JP5425186B2 (ja) | 2008-04-23 | 2009-04-22 | 抗ウイルス処置のためのカルバ−ヌクレオシドアナログ |
Family Applications After (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013218129A Withdrawn JP2014040471A (ja) | 2008-04-23 | 2013-10-21 | 抗ウイルス処置のための１’−置換カルバ−ヌクレオシドアナログ |
| JP2013218139A Withdrawn JP2014012739A (ja) | 2008-04-23 | 2013-10-21 | 抗ウイルス処置のためのカルバ−ヌクレオシドアナログ |
Country Status (32)
Families Citing this family (187)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
| AP3076A (en) * | 2008-04-23 | 2014-12-31 | Gilead Sciences Inc | Carba-nucleoside analogs for antiviral treatment |
| US8173621B2 (en) | 2008-06-11 | 2012-05-08 | Gilead Pharmasset Llc | Nucleoside cyclicphosphates |
| WO2010002877A2 (en) * | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| CN103497192B (zh) | 2008-12-09 | 2015-09-23 | 吉里德科学公司 | Toll样受体调节剂 |
| EP2376514A2 (en) | 2008-12-23 | 2011-10-19 | Pharmasset, Inc. | Nucleoside analogs |
| EA019341B1 (ru) | 2008-12-23 | 2014-02-28 | Джилид Фармассет, Ллс. | Фосфорамидаты нуклеозидов |
| BRPI0923815A2 (pt) | 2008-12-23 | 2015-07-14 | Pharmasset Inc | Síntese de nucleosídeos de purina |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8618076B2 (en) | 2009-05-20 | 2013-12-31 | Gilead Pharmasset Llc | Nucleoside phosphoramidates |
| US7973013B2 (en) | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| EA201200525A1 (ru) * | 2009-09-21 | 2012-09-28 | Гайлид Сайэнсиз, Инк. | 2'-фторзамещенные карба-нуклеозидные аналоги для противовирусного лечения |
| EP2480559B1 (en) | 2009-09-21 | 2013-07-03 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-cyano-carbanucleoside analogs |
| US8455451B2 (en) * | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| KR101774035B1 (ko) | 2009-10-30 | 2017-09-01 | 얀센 파마슈티카 엔.브이. | 이미다조［１，２―ｂ］피리다진 유도체 및 ＰＤＥ１０ 저해제로서의 그의 용도 |
| AR080754A1 (es) | 2010-03-09 | 2012-05-09 | Janssen Pharmaceutica Nv | Derivados de imidazo (1,2-a) pirazina y su uso como inhibidores de pde10 |
| LT2609923T (lt) * | 2010-03-31 | 2017-09-11 | Gilead Pharmasset Llc | (s)-izopropilo 2-(((s)-(perfluorfenoksi)(fenoksi)fosforil)amino)-propanoato kristalinimo būdas |
| TW201201815A (en) * | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| EP2596004B1 (en) * | 2010-07-19 | 2014-09-10 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| PT2595980E (pt) * | 2010-07-22 | 2014-11-27 | Gilead Sciences Inc | Métodos e compostos para tratar infeções pelo vírus da família paramyxoviridae |
| TW201305185A (zh) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之２’－氟取代之碳－核苷類似物 |
| CA2807496C (en) * | 2010-09-20 | 2019-01-22 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| EP2619215B1 (en) | 2010-09-22 | 2018-09-05 | Alios Biopharma, Inc. | Azido nucleosides and nucleotide analogs |
| US8841275B2 (en) | 2010-11-30 | 2014-09-23 | Gilead Pharmasset Llc | 2′-spiro-nucleosides and derivatives thereof useful for treating hepatitis C virus and dengue virus infections |
| TW201701876A (zh) | 2010-12-20 | 2017-01-16 | 吉李德科學股份有限公司 | 治療ｃ型肝炎病毒（ｈｃｖ）之方法 |
| US9243025B2 (en) | 2011-03-31 | 2016-01-26 | Idenix Pharmaceuticals, Llc | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US8877744B2 (en) * | 2011-04-04 | 2014-11-04 | Hoffmann-La Roche Inc. | 1,4-Oxazepines as BACE1 and/or BACE2 inhibitors |
| EP2697242B1 (en) * | 2011-04-13 | 2018-10-03 | Merck Sharp & Dohme Corp. | 2'-azido substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| PE20140522A1 (es) | 2011-04-13 | 2014-05-03 | Merck Sharp & Dohme | Derivados de nucleosidos 2'- sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
| US9150603B2 (en) | 2011-04-13 | 2015-10-06 | Merck Sharp & Dohme Corp. | 2′-cyano substituted nucleoside derivatives and methods of use thereof useful for the treatment of viral diseases |
| EA027418B1 (ru) | 2011-06-27 | 2017-07-31 | Янссен Фармацевтика Нв | ПРОИЗВОДНЫЕ 1-АРИЛ-4-МЕТИЛ[1,2,4]ТРИАЗОЛО[4,3-a]ХИНОКСАЛИНА, ФАРМАЦЕВТИЧЕСКАЯ КОМПОЗИЦИЯ НА ИХ ОСНОВЕ, СПОСОБЫ ПОЛУЧЕНИЯ И ПРИМЕНЕНИЯ ИХ, ПРОМЕЖУТОЧНЫЕ СОЕДИНЕНИЯ |
| WO2013009737A1 (en) | 2011-07-13 | 2013-01-17 | Merck Sharp & Dohme Corp. | 5'-substituted nucleoside analogs and methods of use thereof for the treatment of viral diseases |
| EP2731434A4 (en) | 2011-07-13 | 2014-12-31 | Merck Sharp & Dohme | 5'-SUBSTITUTED NUCLEOSIDE DERIVATIVES AND METHOD FOR THEIR USE FOR THE TREATMENT OF VIRUS DISEASES |
| WO2013030750A1 (en) | 2011-09-01 | 2013-03-07 | Lupin Limited | Antiviral compounds |
| EP2755983B1 (en) | 2011-09-12 | 2017-03-15 | Idenix Pharmaceuticals LLC. | Substituted carbonyloxymethylphosphoramidate compounds and pharmaceutical compositions for the treatment of viral infections |
| CA2840242C (en) | 2011-09-16 | 2019-03-26 | Gilead Sciences, Inc. | Methods for treating hcv |
| AU2012315988A1 (en) * | 2011-09-30 | 2014-04-10 | Kineta, Inc. | Anti-viral compounds |
| US8507460B2 (en) | 2011-10-14 | 2013-08-13 | Idenix Pharmaceuticals, Inc. | Substituted 3′,5′-cyclic phosphates of purine nucleotide compounds and pharmaceutical compositions for the treatment of viral infections |
| AR088408A1 (es) * | 2011-10-21 | 2014-05-28 | Abbvie Inc | Metodos para el tratamiento de hcv |
| US8889159B2 (en) | 2011-11-29 | 2014-11-18 | Gilead Pharmasset Llc | Compositions and methods for treating hepatitis C virus |
| NZ628515A (en) | 2012-02-10 | 2016-06-24 | Lupin Ltd | Antiviral compounds with a dibenzooxaheterocycle moiety |
| SI2834258T1 (sl) * | 2012-03-13 | 2017-04-26 | Gilead Sciences, Inc. | 2'-substituirani karba-nukleozidni analogi za protivirusno zdravljenje |
| WO2013177195A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphate prodrugs for hcv infection |
| WO2013177188A1 (en) | 2012-05-22 | 2013-11-28 | Idenix Pharmaceuticals, Inc. | 3',5'-cyclic phosphoramidate prodrugs for hcv infection |
| JP6165848B2 (ja) | 2012-05-22 | 2017-07-19 | イデニク ファーマシューティカルズ エルエルシー | 肝疾患のためのｄ−アミノ酸化合物 |
| EA027929B1 (ru) | 2012-05-25 | 2017-09-29 | Янссен Сайенсиз Айрлэнд Юси | Нуклеозиды на основе урацила и спирооксетана |
| ES2855575T3 (es) | 2012-06-26 | 2021-09-23 | Janssen Pharmaceutica Nv | Combinaciones que comprenden compuestos de 4-metil-[1,2,4]triazolo[4,3-a]quinoxalina como inhibidores de PDE2 e inhibidores de PDE10 para su uso en el tratamiento de trastornos neurológicos o metabólicos |
| KR102171706B1 (ko) | 2012-07-09 | 2020-10-30 | 얀센 파마슈티카 엔.브이. | 포스포디에스테라아제 10 효소의 억제제 |
| WO2014035140A2 (en) * | 2012-08-30 | 2014-03-06 | Kainos Medicine, Inc. | Compounds and compositions for modulating histone methyltransferase activity |
| WO2014042433A2 (en) * | 2012-09-14 | 2014-03-20 | Kainos Medicine, Inc. | Compounds and compositions for modulating adenosine a3 receptor activity |
| US9192621B2 (en) | 2012-09-27 | 2015-11-24 | Idenix Pharmaceuticals Llc | Esters and malonates of SATE prodrugs |
| HK1207647A1 (en) | 2012-10-08 | 2016-02-05 | Idenix Pharmaceuticals Llc | 2'-chloro nucleoside analogs for hcv infection |
| US9457039B2 (en) | 2012-10-17 | 2016-10-04 | Merck Sharp & Dohme Corp. | 2′-disubstituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| AR092959A1 (es) | 2012-10-17 | 2015-05-06 | Merck Sharp & Dohme | Derivados de nucleosidos 2-metil sustituidos y metodos de uso de los mismos para el tratamiento de enfermedades virales |
| WO2014059901A1 (en) | 2012-10-17 | 2014-04-24 | Merck Sharp & Dohme Corp. | 2'-cyano substituted nucleoside derivatives and methods of use thereof for treatment of viral diseases |
| WO2014066239A1 (en) | 2012-10-22 | 2014-05-01 | Idenix Pharmaceuticals, Inc. | 2',4'-bridged nucleosides for hcv infection |
| WO2014078463A1 (en) | 2012-11-19 | 2014-05-22 | Merck Sharp & Dohme Corp. | 2 -alkynyl substituted nucleoside derivatives for treating viral diseases |
| WO2014099941A1 (en) | 2012-12-19 | 2014-06-26 | Idenix Pharmaceuticals, Inc. | 4'-fluoro nucleosides for the treatment of hcv |
| EP3650013A1 (en) | 2013-01-31 | 2020-05-13 | Gilead Pharmasset LLC | Combination formulation of two antiviral compounds |
| US10034893B2 (en) | 2013-02-01 | 2018-07-31 | Enanta Pharmaceuticals, Inc. | 5, 6-D2 uridine nucleoside/tide derivatives |
| US9339541B2 (en) | 2013-03-04 | 2016-05-17 | Merck Sharp & Dohme Corp. | Thiophosphate nucleosides for the treatment of HCV |
| WO2014137926A1 (en) | 2013-03-04 | 2014-09-12 | Idenix Pharmaceuticals, Inc. | 3'-deoxy nucleosides for the treatment of hcv |
| WO2014160484A1 (en) | 2013-03-13 | 2014-10-02 | Idenix Pharmaceuticals, Inc. | Amino acid phosphoramidate pronucleotides of 2'-cyano, azido and amino nucleosides for the treatment of hcv |
| WO2014165542A1 (en) | 2013-04-01 | 2014-10-09 | Idenix Pharmaceuticals, Inc. | 2',4'-fluoro nucleosides for the treatment of hcv |
| EP3004130B1 (en) | 2013-06-05 | 2019-08-07 | Idenix Pharmaceuticals LLC. | 1',4'-thio nucleosides for the treatment of hcv |
| EP3010512B1 (en) | 2013-06-18 | 2017-12-27 | Merck Sharp & Dohme Corp. | Cyclic phosphonate substituted nucleoside derivatives and methods of use thereof for the treatment of viral diseases |
| EP3027636B1 (en) | 2013-08-01 | 2022-01-05 | Idenix Pharmaceuticals LLC | D-amino acid phosphoramidate pronucleotides of halogeno pyrimidine compounds for liver disease |
| UA119050C2 (uk) * | 2013-11-11 | 2019-04-25 | Ґілеад Саєнсиз, Інк. | ПІРОЛО[1.2-f][1.2.4]ТРИАЗИНИ, ЯКІ ВИКОРИСТОВУЮТЬСЯ ДЛЯ ЛІКУВАННЯ РЕСПІРАТОРНО-СИНЦИТІАЛЬНИХ ВІРУСНИХ ІНФЕКЦІЙ |
| EP3074399A1 (en) * | 2013-11-27 | 2016-10-05 | Idenix Pharmaceuticals LLC | 2'-dichloro and 2'-fluoro-2'-chloro nucleoside analogues for hcv infection |
| WO2015143712A1 (en) | 2014-03-28 | 2015-10-01 | Merck Sharp & Dohme Corp. | 4'-substituted nucleoside reverse transcriptase inhibitors |
| WO2015161137A1 (en) | 2014-04-16 | 2015-10-22 | Idenix Pharmaceuticals, Inc. | 3'-substituted methyl or alkynyl nucleosides for the treatment of hcv |
| US9856263B2 (en) | 2014-04-28 | 2018-01-02 | Pfizer Inc. | Heteroaromatic compounds and their use as dopamine D1 ligands |
| JP6522732B2 (ja) | 2014-07-11 | 2019-05-29 | ギリアード サイエンシーズ， インコーポレイテッド | Ｈｉｖを治療するためのトール様受容体の調節因子 |
| TWI678369B (zh) * | 2014-07-28 | 2019-12-01 | 美商基利科學股份有限公司 | 用於治療呼吸道合胞病毒感染之噻吩並［３,２-ｄ］嘧啶、呋喃並［３,２-ｄ］嘧啶及吡咯並［３,２-ｄ］嘧啶化合物類 |
| US10526363B2 (en) | 2014-08-15 | 2020-01-07 | Merck Sharp & Dohme Corp. | Substituted phosphoramidate compounds and uses thereof |
| TWI673283B (zh) | 2014-08-21 | 2019-10-01 | 美商基利科學股份有限公司 | ２’－氯胺基嘧啶酮及嘧啶二酮核苷類 |
| WO2016033164A1 (en) | 2014-08-26 | 2016-03-03 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
| KR20190125537A (ko) | 2014-09-16 | 2019-11-06 | 길리애드 사이언시즈, 인코포레이티드 | 톨-유사 수용체 조정제의 고체 형태 |
| TWI740546B (zh) * | 2014-10-29 | 2021-09-21 | 美商基利科學股份有限公司 | 製備核糖苷的方法 |
| EP3212658A4 (en) * | 2014-10-31 | 2018-07-25 | Cocrystal Pharma, Inc. | 2',2'-dihalo nucleoside analogs for treatment of the flaviviridae family of viruses and cancer |
| US9718851B2 (en) | 2014-11-06 | 2017-08-01 | Enanta Pharmaceuticals, Inc. | Deuterated nucleoside/tide derivatives |
| US9732110B2 (en) | 2014-12-05 | 2017-08-15 | Enanta Pharmaceuticals, Inc. | Nucleoside and nucleotide derivatives |
| IL280459B2 (en) * | 2014-12-15 | 2023-03-01 | Univ Emory | Phosphoramidates for the treatment of hepatitis b virus |
| CN107427529A (zh) | 2014-12-26 | 2017-12-01 | 埃莫里大学 | N4‑羟基胞苷和衍生物及与其相关的抗病毒用途 |
| EA039561B1 (ru) * | 2015-01-20 | 2022-02-10 | Джилид Сайэнс, Инк. | Соединения для лечения вирусных инфекций filoviridae |
| KR102363946B1 (ko) | 2015-03-06 | 2022-02-17 | 아테아 파마슈티컬즈, 인크. | HCV 치료를 위한 β-D-2'-데옥시-2'-α-플루오로-2'-β-C-치환된-2-변형된-N6-치환된 퓨린 뉴클레오티드 |
| WO2016160646A1 (en) | 2015-04-02 | 2016-10-06 | Merck Sharp & Dohme Corp. | Process for making phosphoramidate protected nucleoside compounds |
| MX382566B (es) | 2015-05-01 | 2025-03-13 | Univ Emory | Analogos de nucleosidos para el tratamiento de la familia de virus flaviviridae y cancer |
| EP3294746B1 (en) * | 2015-05-12 | 2021-10-06 | F. Hoffmann-La Roche AG | Substituted aminothiazolopyrimidinedione derivatives for the treatment and prophylaxis of virus infection |
| KR102354784B1 (ko) | 2015-08-05 | 2022-01-25 | 메트로 인터내셔널 바이오테크 엘엘씨 | 니코틴아미드 모노뉴클레오티드 유도체 및 그 용도 |
| PL3349758T3 (pl) | 2015-09-16 | 2022-09-12 | Gilead Sciences, Inc. | Sposoby leczenia zakażeń wirusami arenaviridae |
| RU2720811C2 (ru) | 2015-09-23 | 2020-05-13 | Мерк Шарп И Доум Лимитед | 4'-замещенные нуклеозидные ингибиторы обратной транскриптазы и их получение |
| US10745427B2 (en) | 2016-03-09 | 2020-08-18 | Janssen Biopharma, Inc. | Acyclic antivirals |
| KR102744951B1 (ko) | 2016-03-28 | 2024-12-23 | 인사이트 코포레이션 | Tam 억제제로서 피롤로트리아진 화합물 |
| WO2017184668A1 (en) * | 2016-04-20 | 2017-10-26 | Gilead Sciences, Inc. | Methods for treating flaviviridae virus infections |
| WO2017184670A2 (en) | 2016-04-22 | 2017-10-26 | Gilead Sciences, Inc. | Methods for treating zika virus infections |
| CN109689065A (zh) | 2016-06-24 | 2019-04-26 | 埃默里大学 | 用于治疗乙型肝炎病毒的磷酰胺化物 |
| US10202412B2 (en) | 2016-07-08 | 2019-02-12 | Atea Pharmaceuticals, Inc. | β-D-2′-deoxy-2′-substituted-4′-substituted-2-substituted-N6-substituted-6-aminopurinenucleotides for the treatment of paramyxovirus and orthomyxovirus infections |
| US10711029B2 (en) | 2016-07-14 | 2020-07-14 | Atea Pharmaceuticals, Inc. | Beta-d-2′-deoxy-2′-alpha-fluoro-2′-beta-c-substituted-4′fluoro-n6-substituted-6-amino-2-substituted purine nucleotides for the treatment of hepatitis c virus infection |
| TW201811339A (zh) * | 2016-08-12 | 2018-04-01 | 美商艾洛斯生物製藥公司 | 經取代之核苷、核苷酸及其類似物 |
| HRP20220278T1 (hr) | 2016-09-07 | 2022-05-13 | Atea Pharmaceuticals, Inc. | 2'-supstituirani-n6-supstituirani purinski nukleotidi za liječenje bolesti izazvanih rnk virusima |
| US20190350960A1 (en) | 2017-01-04 | 2019-11-21 | President And Fellows Of Harvard College | Modulating nudix homology domain (nhd) with nicotinamide mononucleotide analogs and derivatives of same |
| IL295609B2 (en) | 2017-02-01 | 2023-11-01 | Atea Pharmaceuticals Inc | Nucleotide hemisulfate salt for the treatment of hepatitis C virus |
| KR102460968B1 (ko) | 2017-03-14 | 2022-11-01 | 길리애드 사이언시즈, 인코포레이티드 | 고양이 코로나바이러스 감염의 치료 방법 |
| JP2020518578A (ja) | 2017-05-01 | 2020-06-25 | ギリアード サイエンシーズ， インコーポレイテッド | （Ｓ）−２−エチルブチル２−（（（Ｓ）−（（（２Ｒ，３Ｓ，４Ｒ，５Ｒ）−５−（４−アミノピロロ［２，１−ｆ］［１，２，４］トリアジン−７−イル）−５−シアノ−３，４−ジヒドロキシテトラヒドロフラン−２−イル）メトキシ）（フェノキシ）ホスホリル）アミノ）プロパノエートの結晶形態 |
| CA3077489A1 (en) | 2017-07-11 | 2019-01-17 | Gilead Sciences, Inc. | Compositions comprising an rna polymerase inhibitor and cyclodextrin for treating viral infections |
| TWI624264B (zh) * | 2017-08-11 | 2018-05-21 | 景鑫生物科技股份有限公司 | 南洋山蘇水萃物的用途 |
| CR20200126A (es) | 2017-09-18 | 2020-07-11 | Janssen Biopharma Inc | Nucleósidos sustituidos, nucleótidos y análogos de estos |
| ES2995458T3 (en) | 2017-12-07 | 2025-02-10 | Univ Emory | N4-hydroxycytidine derivative and anti-viral uses related thereto |
| US11040975B2 (en) | 2017-12-08 | 2021-06-22 | Merck Sharp & Dohme Corp. | Carbocyclic nucleoside reverse transcriptase inhibitors |
| EP3732180A4 (en) * | 2017-12-27 | 2022-05-11 | Emory University | COMBINED MODALITIES FOR NUCLEOSIDES AND/OR NADPH OXIDASE (NOX) INHIBITORS AS MYELOID-SPECIFIC ANTIVIRALS |
| WO2019200005A1 (en) | 2018-04-10 | 2019-10-17 | Atea Pharmaceuticals, Inc. | Treatment of hcv infected patients with cirrhosis |
| CR20210486A (es) | 2019-03-22 | 2021-12-07 | Gilead Sciences Inc | Compuestos de carbamoyl piridona tricíclicos con puente y su uso farmacéutico |
| CA3137119A1 (en) | 2019-05-09 | 2020-11-12 | Aligos Therapeutics, Inc. | Modified cyclic dinucleoside compounds as sting modulators |
| JP7595643B2 (ja) * | 2019-08-02 | 2024-12-06 | ベイジーン リミテッド | Ｔｌｒ８アゴニストとしてのイミダゾ［２，１－ｆ］［１，２，４］トリアジン－４－アミン誘導体 |
| CN110724174B (zh) * | 2019-09-10 | 2021-02-05 | 广州六顺生物科技股份有限公司 | 吡咯并三嗪类化合物、组合物及其应用 |
| CN118766947A (zh) | 2020-01-27 | 2024-10-15 | 吉利德科学公司 | 用于治疗SARS CoV-2感染的方法 |
| CN113214262B (zh) * | 2020-02-05 | 2023-07-07 | 华创合成制药股份有限公司 | 一种含有胍基的化合物及其制备方法和用途 |
| CN113214334A (zh) * | 2020-02-05 | 2021-08-06 | 华创合成制药股份有限公司 | 用于治疗病毒感染的化合物及其制备方法和用途 |
| EP4644394A2 (en) | 2020-02-18 | 2025-11-05 | Gilead Sciences, Inc. | Antiviral compounds |
| TWI874791B (zh) | 2020-02-18 | 2025-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI794742B (zh) | 2020-02-18 | 2023-03-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| TWI791193B (zh) | 2020-02-18 | 2023-02-01 | 美商基利科學股份有限公司 | 抗病毒化合物 |
| CN113292565B (zh) * | 2020-02-24 | 2023-01-31 | 浙江森科建设有限公司 | 核苷类化合物及其制备方法和应用 |
| US10874687B1 (en) | 2020-02-27 | 2020-12-29 | Atea Pharmaceuticals, Inc. | Highly active compounds against COVID-19 |
| CN111269248A (zh) * | 2020-03-05 | 2020-06-12 | 江苏福瑞康泰药业有限公司 | 一种核苷氨基磷酸酯类药物母液回收的新方法 |
| TWI890963B (zh) | 2020-03-12 | 2025-07-21 | 美商基利科學股份有限公司 | 1'-氰基核苷之製備方法 |
| AU2021237718B2 (en) | 2020-03-20 | 2023-09-21 | Gilead Sciences, Inc. | Prodrugs of 4'-C-substituted-2-halo-2'-deoxyadenosine nucleosides and methods of making and using the same |
| CN115315252A (zh) * | 2020-03-22 | 2022-11-08 | 盈擘医药股份有限公司 | 用于预防或暴露后治疗感染或呼吸疾病的抗病毒组合物 |
| WO2021202669A2 (en) | 2020-04-01 | 2021-10-07 | Reyoung Corporation | Nucleoside and nucleotide conjugate compounds and uses thereof |
| CN115362004A (zh) | 2020-04-06 | 2022-11-18 | 吉利德科学公司 | 1’-氰基取代的碳核苷类似物的吸入制剂 |
| CN112778310B (zh) * | 2020-04-20 | 2025-05-30 | 中国科学院上海药物研究所 | 核苷类似物或含有核苷类似物的组合制剂在抗病毒中的应用 |
| CN115605492B (zh) * | 2020-04-21 | 2025-09-16 | 配体制药股份有限公司 | 核苷酸前药化合物 |
| ES3041698T3 (en) | 2020-05-29 | 2025-11-13 | Gilead Sciences Inc | Remdesivir for the treatment of viral infections |
| JP2023531524A (ja) | 2020-06-24 | 2023-07-24 | ギリアード サイエンシーズ， インコーポレイテッド | １’－シアノヌクレオシド類似体及びその使用 |
| AU2021311814A1 (en) * | 2020-07-23 | 2023-03-02 | Arjil Biotech Holding Company Limited | Method and composition for inhibiting virus infection |
| CA3185450A1 (en) | 2020-08-06 | 2022-02-10 | Istvan Borza | Remdesivir intermediates |
| CN111956630A (zh) * | 2020-08-20 | 2020-11-20 | 大连理工大学 | 一种瑞德西韦供雾化器用的液体制剂、制备方法及其应用 |
| JP7559223B2 (ja) | 2020-08-24 | 2024-10-01 | ギリアード サイエンシーズ， インコーポレイテッド | リン脂質化合物及びその使用 |
| IL300453A (en) * | 2020-08-27 | 2023-04-01 | Gilead Sciences Inc | COMPOSITIONS AND METHODS FOR THE TREATMENT OF VIRAL INFECTIONS |
| CN114149434A (zh) * | 2020-09-08 | 2022-03-08 | 安徽诺全药业有限公司 | 一种杂环化合物及其制备方法、应用 |
| TW202344257A (zh) * | 2020-10-16 | 2023-11-16 | 美商基利科學股份有限公司 | 磷脂化合物及其用途 |
| TWI815194B (zh) | 2020-10-22 | 2023-09-11 | 美商基利科學股份有限公司 | 介白素2-Fc融合蛋白及使用方法 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| WO2022098371A1 (en) * | 2020-11-09 | 2022-05-12 | Yan Matthew | Prodrugs of 1'-substituted carba-nucleoside analogues for antiviral treatment |
| EP4244396B1 (en) | 2020-11-11 | 2025-08-13 | Gilead Sciences, Inc. | Methods of identifying hiv patients sensitive to therapy with gp120 cd4 binding site-directed antibodies |
| CN112494500B (zh) * | 2020-11-26 | 2022-01-11 | 北京箭牧科技有限公司 | 瑞德西韦在制备治疗抗肿瘤药物心脏毒性药物中的应用 |
| CN114621229B (zh) * | 2020-12-11 | 2024-07-02 | 嘉兴金派特生物科技有限公司 | 治疗或预防猫传染性腹膜炎的化合物或组合物 |
| CN112592348B (zh) * | 2020-12-21 | 2022-03-08 | 南京法恩化学有限公司 | 一种4-氨基吡咯并[2,1-f][1,2,4]三嗪的制备方法 |
| WO2022142477A1 (en) * | 2020-12-30 | 2022-07-07 | Southern University Of Science And Technology | Methods and modified nucleosides for treating coronavirus infections |
| KR20230170745A (ko) | 2021-04-16 | 2023-12-19 | 길리애드 사이언시즈, 인코포레이티드 | 아미드를 사용한 카르바뉴클레오시드를 제조하는 방법 |
| MX2023014898A (es) | 2021-06-17 | 2024-04-29 | Atea Pharmaceuticals Inc | Terapia combinada anti-vhc ventajosa. |
| KR20230001208A (ko) | 2021-06-28 | 2023-01-04 | 동아대학교 산학협력단 | 오각고리 염기를 포함하는 비고리형 핵산 모방체 |
| CN115703796A (zh) * | 2021-08-09 | 2023-02-17 | 苏州恩泰新材料科技有限公司 | 一种瑞德西韦重要中间体制备方法 |
| WO2023023527A1 (en) | 2021-08-18 | 2023-02-23 | Gilead Sciences, Inc. | Phospholipid compounds and methods of making and using the same |
| CN118355020A (zh) | 2021-12-03 | 2024-07-16 | 吉利德科学公司 | Hiv病毒感染的治疗性化合物 |
| PL4445900T3 (pl) | 2021-12-03 | 2025-09-22 | Gilead Sciences, Inc. | Związki terapeutyczne przeciwko zakażeniu wirusem hiv |
| KR20240113832A (ko) | 2021-12-03 | 2024-07-23 | 길리애드 사이언시즈, 인코포레이티드 | Hiv 바이러스 감염 치료용 화합물 |
| TW202525810A (zh) | 2022-03-02 | 2025-07-01 | 美商基利科學股份有限公司 | 用於治療病毒感染的化合物及方法 |
| TWI843506B (zh) | 2022-04-06 | 2024-05-21 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| CN114437159B (zh) * | 2022-04-11 | 2022-06-28 | 佛山市晨康生物科技有限公司 | 一种环状碳酸酯核苷类化合物及其应用 |
| JP2025514335A (ja) * | 2022-04-25 | 2025-05-02 | 北京沐華生物科技有限責任公司 | コロナウイルス感染症を治療又は予防するためのヌクレオシド系薬物及びその使用 |
| US20240043466A1 (en) * | 2022-06-30 | 2024-02-08 | Gilead Sciences, Inc. | Solid forms of a nucleoside analogue and uses thereof |
| US20240034724A1 (en) | 2022-07-01 | 2024-02-01 | Gilead Sciences, Inc. | Therapeutic compounds useful for the prophylactic or therapeutic treatment of an hiv virus infection |
| JP2025527677A (ja) | 2022-08-26 | 2025-08-22 | ギリアード サイエンシーズ， インコーポレイテッド | 広域中和抗体のための投与及びスケジューリングレジメン |
| EP4598934A1 (en) | 2022-10-04 | 2025-08-13 | Gilead Sciences, Inc. | 4'-thionucleoside analogues and their pharmaceutical use |
| WO2024088183A1 (en) * | 2022-10-23 | 2024-05-02 | Shanghai Curegene Pharmaceutical Co., Ltd. | Anticoronviral compounds and compositions and uses thereof |
| WO2024088184A1 (en) * | 2022-10-23 | 2024-05-02 | Shanghai Curegene Pharmaceutical Co., Ltd. | Anti-feline-coronavirus compounds and uses thereof |
| CN115819423B (zh) * | 2022-11-29 | 2024-11-22 | 武汉大学 | 一种瑞德西韦或其中间体的protac化合物及其制备方法与抗ev71的应用 |
| US20240390349A1 (en) | 2023-04-19 | 2024-11-28 | Gilead Sciences, Inc. | Dosing regimen of capsid inhibitor |
| CN118852168B (zh) * | 2023-04-26 | 2025-09-19 | 深圳科兴药业有限公司 | 一种制备苄基碳核苷类似物的新方法及其应用 |
| CN116217621B (zh) * | 2023-04-26 | 2023-08-11 | 北京沐华生物科技有限责任公司 | 一种核苷类双前药、合成方法及应用 |
| CN121219281A (zh) | 2023-05-31 | 2025-12-26 | 吉利德科学公司 | 用于治疗hiv的化合物的固体形式 |
| US20250042926A1 (en) | 2023-05-31 | 2025-02-06 | Gilead Sciences, Inc. | Therapeutic compounds for hiv |
| WO2025029247A1 (en) | 2023-07-28 | 2025-02-06 | Gilead Sciences, Inc. | Weekly regimen of lenacapavir for the treatment and prevention of hiv |
| WO2025042394A1 (en) | 2023-08-23 | 2025-02-27 | Gilead Sciences, Inc. | Dosing regimen of hiv capsid inhibitor |
| US20250122219A1 (en) | 2023-10-11 | 2025-04-17 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| TW202515549A (zh) | 2023-10-11 | 2025-04-16 | 美商基利科學股份有限公司 | 橋聯三環胺甲醯基吡啶酮化合物及其用途 |
| US20250127801A1 (en) | 2023-10-11 | 2025-04-24 | Gilead Sciences, Inc. | Bridged tricyclic carbamoylpyridone compounds and uses thereof |
| US20250230163A1 (en) | 2023-12-22 | 2025-07-17 | Gilead Sciences, Inc. | Solid forms of hiv integrase inhibitors |
| US12357577B1 (en) | 2024-02-02 | 2025-07-15 | Gilead Sciences, Inc. | Pharmaceutical formulations and uses thereof |
| US20250296932A1 (en) | 2024-03-01 | 2025-09-25 | Gilead Sciences, Inc. | Pharmaceutical compositions comprising hiv integrase inhibitors |
| US20250289822A1 (en) | 2024-03-01 | 2025-09-18 | Gilead Sciences, Inc. | Solid forms of hiv integrase inhibitors |
| WO2025184609A1 (en) | 2024-03-01 | 2025-09-04 | Gilead Sciences, Inc. | Antiviral compounds |
| WO2025260028A1 (en) | 2024-06-14 | 2025-12-18 | Gilead Sciences, Inc. | Pharmaceutical compositions comprising hiv integrase inhibitors |
Family Cites Families (77)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US4816570A (en) | 1982-11-30 | 1989-03-28 | The Board Of Regents Of The University Of Texas System | Biologically reversible phosphate and phosphonate protective groups |
| JPS59141856A (ja) | 1983-02-02 | 1984-08-14 | Fuji Electric Co Ltd | Ｆｓ変復調方式 |
| US4968788A (en) | 1986-04-04 | 1990-11-06 | Board Of Regents, The University Of Texas System | Biologically reversible phosphate and phosphonate protective gruops |
| DE69115694T2 (de) | 1990-06-13 | 1996-10-17 | Arnold Newton Mass. Glazier | Phosphorylierte prodrugs |
| DE10399025I2 (de) | 1990-09-14 | 2007-11-08 | Acad Of Science Czech Republic | Wirkstoffvorläufer von Phosphonaten |
| US6887707B2 (en) | 1996-10-28 | 2005-05-03 | University Of Washington | Induction of viral mutation by incorporation of miscoding ribonucleoside analogs into viral RNA |
| US6312662B1 (en) | 1998-03-06 | 2001-11-06 | Metabasis Therapeutics, Inc. | Prodrugs phosphorus-containing compounds |
| EP1121361B1 (en) | 1998-10-16 | 2007-08-29 | Merck Sharp & Dohme Limited | Pyrazolo-triazine derivatives as ligands for gaba receptors |
| DE19912636A1 (de) | 1999-03-20 | 2000-09-21 | Aventis Cropscience Gmbh | Bicyclische Heterocyclen, Verfahren zu ihrer Herstellung und ihre Verwendung als Herbizide und pharmazeutische Mittel |
| WO2001019375A1 (en) | 1999-09-15 | 2001-03-22 | Biocryst Pharmaceuticals, Inc. | Inhibiting t-cell proliferation |
| US6566365B1 (en) | 1999-11-04 | 2003-05-20 | Biochem Pharma Inc. | Method for the treatment of Flaviviridea viral infection using nucleoside analogues |
| PL364995A1 (en) | 2000-02-18 | 2004-12-27 | Shire Biochem Inc. | Method for the treatment or prevention of flavivirus |
| MY164523A (en) | 2000-05-23 | 2017-12-29 | Univ Degli Studi Cagliari | Methods and compositions for treating hepatitis c virus |
| KR20080021797A (ko) | 2000-05-26 | 2008-03-07 | 이데닉스(케이만)리미티드 | 플라비바이러스 및 페스티바이러스의 치료방법 및 조성물 |
| US20030008841A1 (en) | 2000-08-30 | 2003-01-09 | Rene Devos | Anti-HCV nucleoside derivatives |
| PT2251015E (pt) | 2000-10-18 | 2013-04-15 | Gilead Pharmasset Llc | Nucleosídeos modificados para o tratamento de infeções virais e de proliferação celular anormal |
| BR0206614A (pt) * | 2001-01-22 | 2004-02-17 | Merck & Co Inc | Composto, composição farmacêutica, método para inibir a polimerase viral de rna dependente de rna e/ou inibir a replicação viral de rna dependente de rna, método para tratar uma infecção viral de rna dependente de rna, e, uso de um composto |
| US20040006002A1 (en) | 2001-09-28 | 2004-01-08 | Jean-Pierre Sommadossi | Methods and compositions for treating flaviviruses and pestiviruses using 4'-modified nucleoside |
| AT410792B (de) | 2001-12-28 | 2003-07-25 | Dsm Fine Chem Austria Gmbh | Verfahren zur herstellung von geschützten, enantiomeren-angereicherten cyanhydrinen durch in-situ-derivatisierung |
| AU2003217863B9 (en) | 2002-02-28 | 2009-10-29 | Biota Scientific Management Pty Ltd | Nucleotide mimics and their prodrugs |
| CA2477795A1 (en) | 2002-02-28 | 2003-09-12 | Kandasamy Sakthivel | Nucleoside 5'-monophosphate mimics and their prodrugs |
| US20040138170A1 (en) | 2002-03-06 | 2004-07-15 | Montgomery John A. | Nucleosides, preparation thereof and use as inhibitors of rna viral polymerases |
| GB0210127D0 (en) | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| GB0210124D0 (en) | 2002-05-02 | 2002-06-12 | Merck Sharp & Dohme | Therapeutic agents |
| MXPA04010983A (es) | 2002-05-06 | 2005-02-14 | Genelabs Tech Inc | Derivados de nucleosidos para tratar infecciones por el virus de la hepatitis c. |
| WO2003100009A2 (en) | 2002-05-23 | 2003-12-04 | Biocryst Pharmaceuticals, Inc. | Enhancing the efficacy of reverse transcriptase and dna polymerase inhibitors (nucleoside analogs) using pnp inhibitors and/or 2'-deoxyguanosine and/or prodrug thereof |
| US7824851B2 (en) | 2002-11-15 | 2010-11-02 | Idenix Pharmaceuticals, Inc. | 2′-branched nucleosides and Flaviviridae mutation |
| PT1628685E (pt) | 2003-04-25 | 2011-03-16 | Gilead Sciences Inc | Análogos de fosfonatos antivirais |
| WO2005020885A2 (en) * | 2003-05-21 | 2005-03-10 | Isis Pharmaceuticals, Inc. | Compositions and methods for the treatment of severe acute respiratory syndrome (sars) |
| RU2006105640A (ru) | 2003-07-25 | 2007-09-10 | Айденикс (Кайман) Лимитед (Ky) | Аналоги пуриновых нуклеозидов для лечения flaviviridae, включая гепатит с |
| WO2005021568A2 (en) | 2003-08-27 | 2005-03-10 | Biota, Inc. | Novel tricyclic nucleosides or nucleotides as therapeutic agents |
| EP1758453B1 (en) * | 2004-06-15 | 2014-07-16 | Merck Sharp & Dohme Corp. | C-purine nucleoside analogs as inhibitors of rna-dependent rna viral polymerase |
| US7560434B2 (en) | 2004-06-22 | 2009-07-14 | Biocryst Pharmaceuticals, Inc. | AZA nucleosides, preparation thereof and use as inhibitors of RNA viral polymerases |
| WO2006031725A2 (en) | 2004-09-14 | 2006-03-23 | Pharmasset, Inc. | Preparation of 2'fluoro-2'- alkyl- substituted or other optionally substituted ribofuranosyl pyrimidines and purines and their derivatives |
| AU2005317081A1 (en) | 2004-10-21 | 2006-06-22 | Merck & Co., Inc. | Fluorinated pyrrolo[2,3-d]pyrimidine nucleosides for the treatment of RNA-dependent RNA viral infection |
| CN101043893A (zh) | 2004-10-21 | 2007-09-26 | 默克公司 | 治疗RNA－依赖性RNA病毒感染的氟化吡咯并[2,3－d]嘧啶核苷 |
| US8133870B2 (en) | 2004-10-29 | 2012-03-13 | Biocryst Pharmaceuticals, Inc. | Therapeutic furopyrimidines and thienopyrimidines |
| WO2006094347A1 (en) | 2005-03-08 | 2006-09-14 | Biota Scientific Management Pty Ltd. | Bicyclic nucleosides and nucleotides as therapeutic agents |
| CA2602533A1 (en) | 2005-03-29 | 2006-10-05 | Biocryst Pharmaceuticals, Inc. | Use of c-nucleoside analogs for treatment of hepatitis c related viral infections |
| WO2006121820A1 (en) | 2005-05-05 | 2006-11-16 | Valeant Research & Development | Phosphoramidate prodrugs for treatment of viral infection |
| WO2007027248A2 (en) | 2005-05-16 | 2007-03-08 | Valeant Research & Development | 3', 5' - cyclic nucleoside analogues for treatment of hcv |
| WO2007038860A2 (en) | 2005-10-03 | 2007-04-12 | University Health Network | Odcase inhibitors as anti-virals and antibiotics |
| EP1945222B1 (en) | 2005-11-02 | 2012-12-26 | Bayer Pharma Aktiengesellschaft | Pyrrolo[2,1-f] [1,2,4]-triazin-4-ylamines as igf-1r kinase inhibitors for the treatment of cancer and other hyperproliferative diseases |
| PE20070855A1 (es) | 2005-12-02 | 2007-10-14 | Bayer Pharmaceuticals Corp | Derivados de 4-amino-pirrolotriazina sustituida como inhibidores de quinasas |
| CN101466710B (zh) | 2005-12-02 | 2013-05-29 | 拜尔健康护理有限责任公司 | 用于治疗与血管生成有关的过度增殖性病症和疾病的取代的4-氨基-吡咯并三嗪衍生物 |
| WO2007097991A2 (en) | 2006-02-16 | 2007-08-30 | Pharmasset, Inc. | Methods and kits for dosing of antiviral agents |
| AR061024A1 (es) | 2006-05-22 | 2008-07-30 | Novartis Ag | Maleato de 5-amino-3- (2'3'-di-o-acetil-beta-d-ribofuranosil)-3h-tiazolo[4,5-d] pirimidin-2-ona. |
| WO2008005542A2 (en) | 2006-07-07 | 2008-01-10 | Gilead Sciences, Inc., | Antiviral phosphinate compounds |
| US20080161324A1 (en) | 2006-09-14 | 2008-07-03 | Johansen Lisa M | Compositions and methods for treatment of viral diseases |
| ITBO20060683A1 (it) | 2006-10-03 | 2008-04-04 | Sympak Corazza S P A | Dispositivo per il raggruppamento di confezioni. |
| WO2008079206A1 (en) | 2006-12-20 | 2008-07-03 | Merck & Co., Inc. | Nucleoside cyclic phosphoramidates for the treatment of rna-dependent rna viral infection |
| US7951789B2 (en) | 2006-12-28 | 2011-05-31 | Idenix Pharmaceuticals, Inc. | Compounds and pharmaceutical compositions for the treatment of viral infections |
| US8071568B2 (en) | 2007-01-05 | 2011-12-06 | Merck Sharp & Dohme Corp. | Nucleoside aryl phosphoramidates for the treatment of RNA-dependent RNA viral infection |
| SI2114980T1 (sl) | 2007-01-12 | 2012-11-30 | Biocryst Pharm Inc | Protivirusni nukleozidni analogi |
| US8188272B2 (en) | 2007-03-21 | 2012-05-29 | Bristol-Myers Squibb Company | Fused heterocyclic compounds useful as kinase modulators |
| US7964580B2 (en) | 2007-03-30 | 2011-06-21 | Pharmasset, Inc. | Nucleoside phosphoramidate prodrugs |
| JP2011513195A (ja) | 2007-05-10 | 2011-04-28 | バイオクライスト ファーマシューティカルズ， インコーポレイテッド | ウイルス感染およびがんの処置に使用するためのテトラヒドロフロ［３，４−ｄ］ジオキソラン化合物 |
| CN100532388C (zh) | 2007-07-16 | 2009-08-26 | 郑州大学 | 2’-氟-4’-取代-核苷类似物、其制备方法及应用 |
| TW200942243A (en) | 2008-03-05 | 2009-10-16 | Biocryst Pharm Inc | Antiviral therapeutic agents |
| US7863291B2 (en) | 2008-04-23 | 2011-01-04 | Bristol-Myers Squibb Company | Quinuclidine compounds as alpha-7 nicotinic acetylcholine receptor ligands |
| AP3076A (en) | 2008-04-23 | 2014-12-31 | Gilead Sciences Inc | Carba-nucleoside analogs for antiviral treatment |
| WO2010036407A2 (en) * | 2008-05-15 | 2010-04-01 | Biocryst Pharmaceuticals, Inc. | Antiviral nucleoside analogs |
| WO2010002877A2 (en) | 2008-07-03 | 2010-01-07 | Biota Scientific Management | Bycyclic nucleosides and nucleotides as therapeutic agents |
| CN102348713B (zh) | 2009-02-10 | 2015-12-02 | 吉里德科学公司 | 用于抗病毒治疗的carba-核苷类似物 |
| US8501753B2 (en) | 2009-03-24 | 2013-08-06 | Biocryst Pharmaceuticals, Inc. | Useful pharmaceutical salts of 7-[(3R, 4R)-3-Hydroxy-4-hydroxymethyl-pyrrolidin-1-ylmethyl]-3, 5-dihydro-pyrrolo [3, 2-D] pyrimidin-4-one |
| TWI598358B (zh) | 2009-05-20 | 2017-09-11 | 基利法瑪席特有限責任公司 | 核苷磷醯胺 |
| US8455451B2 (en) | 2009-09-21 | 2013-06-04 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| US7973013B2 (en) | 2009-09-21 | 2011-07-05 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| EA201200525A1 (ru) | 2009-09-21 | 2012-09-28 | Гайлид Сайэнсиз, Инк. | 2'-фторзамещенные карба-нуклеозидные аналоги для противовирусного лечения |
| EP2480559B1 (en) | 2009-09-21 | 2013-07-03 | Gilead Sciences, Inc. | Processes and intermediates for the preparation of 1'-cyano-carbanucleoside analogs |
| TW201136945A (en) | 2010-03-31 | 2011-11-01 | Pharmasset Inc | Purine nucleoside phosphoramidate |
| TW201201815A (en) | 2010-05-28 | 2012-01-16 | Gilead Sciences Inc | 1'-substituted-carba-nucleoside prodrugs for antiviral treatment |
| EP2596004B1 (en) | 2010-07-19 | 2014-09-10 | Gilead Sciences, Inc. | Methods for the preparation of diasteromerically pure phosphoramidate prodrugs |
| PT2595980E (pt) | 2010-07-22 | 2014-11-27 | Gilead Sciences Inc | Métodos e compostos para tratar infeções pelo vírus da família paramyxoviridae |
| TW201305185A (zh) | 2010-09-13 | 2013-02-01 | Gilead Sciences Inc | 用於抗病毒治療之２’－氟取代之碳－核苷類似物 |
| CA2807496C (en) | 2010-09-20 | 2019-01-22 | Gilead Sciences, Inc. | 2'-fluoro substituted carba-nucleoside analogs for antiviral treatment |
| PL2898885T3 (pl) | 2010-10-15 | 2018-04-30 | Biocryst Pharmaceuticals, Inc. | Pochodne pirolopirymidynowe do zastosowania w leczeniu zakażeń wirusowych |
-
2009
- 2009-04-22 AP AP2010005439A patent/AP3076A/xx active
- 2009-04-22 KR KR1020107026178A patent/KR101681559B1/ko active Active
- 2009-04-22 CN CN2009801202188A patent/CN102046626A/zh active Pending
- 2009-04-22 PL PL09735162T patent/PL2280973T3/pl unknown
- 2009-04-22 AR ARP090101420A patent/AR071395A1/es active IP Right Grant
- 2009-04-22 HU HUE09734175A patent/HUE025528T2/en unknown
- 2009-04-22 NZ NZ588670A patent/NZ588670A/xx not_active IP Right Cessation
- 2009-04-22 AU AU2009240630A patent/AU2009240630B2/en active Active
- 2009-04-22 TW TW102115415A patent/TW201334784A/zh unknown
- 2009-04-22 SI SI200931153T patent/SI2268642T1/sl unknown
- 2009-04-22 BR BRPI0910455A patent/BRPI0910455B8/pt active IP Right Grant
- 2009-04-22 CN CN201410408008.1A patent/CN104262345B/zh active Active
- 2009-04-22 MX MX2010011661A patent/MX2010011661A/es active IP Right Grant
- 2009-04-22 EP EP09735162A patent/EP2280973B1/en active Active
- 2009-04-22 US US12/428,234 patent/US8012941B2/en active Active
- 2009-04-22 KR KR1020107026265A patent/KR101645742B1/ko active Active
- 2009-04-22 EP EP09734175.4A patent/EP2268642B1/en active Active
- 2009-04-22 EP EP15155479.7A patent/EP2937350B9/en active Active
- 2009-04-22 CA CA2722177A patent/CA2722177C/en active Active
- 2009-04-22 HR HRP20150359TT patent/HRP20150359T1/hr unknown
- 2009-04-22 DK DK09735162.1T patent/DK2280973T3/da active
- 2009-04-22 ES ES15155479.7T patent/ES2665272T3/es active Active
- 2009-04-22 PT PT97341754T patent/PT2268642E/pt unknown
- 2009-04-22 EA EA201071170A patent/EA020659B1/ru unknown
- 2009-04-22 SI SI200930503T patent/SI2280973T1/sl unknown
- 2009-04-22 SI SI200931823T patent/SI2937350T1/en unknown
- 2009-04-22 PT PT97351621T patent/PT2280973E/pt unknown
- 2009-04-22 HU HUE15155479A patent/HUE038946T2/hu unknown
- 2009-04-22 HR HRP20130048AT patent/HRP20130048T1/hr unknown
- 2009-04-22 TW TW098113324A patent/TWI401084B/zh active
- 2009-04-22 ES ES09734175.4T patent/ES2536193T3/es active Active
- 2009-04-22 US US12/428,176 patent/US8008264B2/en active Active
- 2009-04-22 NZ NZ588400A patent/NZ588400A/xx unknown
- 2009-04-22 ES ES09735162T patent/ES2398684T3/es active Active
- 2009-04-22 JP JP2011506429A patent/JP5425186B2/ja active Active
- 2009-04-22 WO PCT/US2009/041447 patent/WO2009132135A1/en not_active Ceased
- 2009-04-22 CA CA2722084A patent/CA2722084C/en active Active
- 2009-04-22 RS RS20180408A patent/RS57092B1/sr unknown
- 2009-04-22 PT PT151554797T patent/PT2937350T/pt unknown
- 2009-04-22 KR KR1020167033059A patent/KR101856404B1/ko active Active
- 2009-04-22 MX MX2010011659A patent/MX2010011659A/es active IP Right Grant
- 2009-04-22 NO NO15155479A patent/NO2937350T3/no unknown
- 2009-04-22 DK DK15155479.7T patent/DK2937350T3/en active
- 2009-04-22 LT LTEP15155479.7T patent/LT2937350T/lt unknown
- 2009-04-22 ME MEP-2018-95A patent/ME03089B/me unknown
- 2009-04-22 RS RS20150348A patent/RS54008B1/sr unknown
- 2009-04-22 AU AU2009240642A patent/AU2009240642B2/en active Active
- 2009-04-22 EA EA201071128A patent/EA019883B1/ru not_active IP Right Cessation
- 2009-04-22 JP JP2011506435A patent/JP5425187B2/ja active Active
- 2009-04-22 AP AP2010005414A patent/AP3237A/xx active
- 2009-04-22 PL PL15155479T patent/PL2937350T3/pl unknown
- 2009-04-22 BR BRPI0911410A patent/BRPI0911410A2/pt not_active Application Discontinuation
- 2009-04-22 CN CN200980114224.2A patent/CN102015714B/zh active Active
- 2009-04-22 DK DK09734175.4T patent/DK2268642T3/en active
- 2009-04-22 PL PL09734175T patent/PL2268642T3/pl unknown
- 2009-04-22 WO PCT/US2009/041432 patent/WO2009132123A1/en not_active Ceased
-
2010
- 2010-09-30 CO CO10121513A patent/CO6321235A2/es not_active Application Discontinuation
- 2010-10-06 IL IL208515A patent/IL208515A/en active IP Right Grant
- 2010-10-14 IL IL208701A patent/IL208701A/en active IP Right Grant
- 2010-10-22 CO CO10131479A patent/CO6300958A2/es not_active Application Discontinuation
- 2010-10-28 ZA ZA2010/07713A patent/ZA201007713B/en unknown
- 2010-11-09 ZA ZA2010/08008A patent/ZA201008008B/en unknown
- 2010-11-15 EC EC2010010609A patent/ECSP10010609A/es unknown
- 2010-11-19 EC EC2010010618A patent/ECSP10010618A/es unknown
-
2011
- 2011-08-02 US US13/196,117 patent/US8318682B2/en active Active
-
2012
- 2012-10-11 US US13/649,511 patent/US8853171B2/en not_active Ceased
-
2013
- 2013-02-08 CY CY20131100119T patent/CY1113647T1/el unknown
- 2013-10-21 JP JP2013218129A patent/JP2014040471A/ja not_active Withdrawn
- 2013-10-21 JP JP2013218139A patent/JP2014012739A/ja not_active Withdrawn
-
2015
- 2015-05-11 CY CY20151100412T patent/CY1116425T1/el unknown
-
2016
- 2016-10-07 US US15/288,271 patent/USRE46762E1/en active Active
-
2018
- 2018-04-04 CY CY20181100377T patent/CY1120366T1/el unknown
- 2018-04-10 HR HRP20180572TT patent/HRP20180572T1/hr unknown
-
2020
- 2020-12-17 LU LU00193C patent/LUC00193I2/en unknown
- 2020-12-18 LT LTPA2020539C patent/LTC2937350I2/lt unknown
- 2020-12-18 CY CY2020044C patent/CY2020044I2/el unknown
- 2020-12-18 HU HUS2000055C patent/HUS2000055I1/hu unknown