JP2010539241A5 - - Google Patents
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- Publication number
- JP2010539241A5 JP2010539241A5 JP2010525943A JP2010525943A JP2010539241A5 JP 2010539241 A5 JP2010539241 A5 JP 2010539241A5 JP 2010525943 A JP2010525943 A JP 2010525943A JP 2010525943 A JP2010525943 A JP 2010525943A JP 2010539241 A5 JP2010539241 A5 JP 2010539241A5
- Authority
- JP
- Japan
- Prior art keywords
- group
- inhibitor
- clemizole
- compounds
- virus
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 239000003112 inhibitor Substances 0.000 claims 22
- 150000001875 compounds Chemical class 0.000 claims 21
- CJXAEXPPLWQRFR-UHFFFAOYSA-N clemizole Chemical group C1=CC(Cl)=CC=C1CN1C2=CC=CC=C2N=C1CN1CCCC1 CJXAEXPPLWQRFR-UHFFFAOYSA-N 0.000 claims 18
- 229950002020 clemizole Drugs 0.000 claims 9
- 239000003814 drug Substances 0.000 claims 8
- 150000003839 salts Chemical group 0.000 claims 7
- 241000700605 Viruses Species 0.000 claims 6
- 239000008194 pharmaceutical composition Substances 0.000 claims 5
- 238000004519 manufacturing process Methods 0.000 claims 4
- 229940124597 therapeutic agent Drugs 0.000 claims 4
- 241000710781 Flaviviridae Species 0.000 claims 2
- 229940124771 HCV-NS3 protease inhibitor Drugs 0.000 claims 2
- 241000711549 Hepacivirus C Species 0.000 claims 2
- VEXZGXHMUGYJMC-UHFFFAOYSA-N Hydrochloric acid Chemical compound Cl VEXZGXHMUGYJMC-UHFFFAOYSA-N 0.000 claims 2
- 102000006992 Interferon-alpha Human genes 0.000 claims 2
- 108010047761 Interferon-alpha Proteins 0.000 claims 2
- 241000710772 Yellow fever virus Species 0.000 claims 2
- 125000002015 acyclic group Chemical group 0.000 claims 2
- 125000000217 alkyl group Chemical group 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 125000004122 cyclic group Chemical group 0.000 claims 2
- 125000001495 ethyl group Chemical group [H]C([H])([H])C([H])([H])* 0.000 claims 2
- 108700008776 hepatitis C virus NS-5 Proteins 0.000 claims 2
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 2
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims 2
- 239000002777 nucleoside Substances 0.000 claims 2
- 150000003833 nucleoside derivatives Chemical class 0.000 claims 2
- 239000003730 rna directed rna polymerase inhibitor Substances 0.000 claims 2
- 238000013268 sustained release Methods 0.000 claims 2
- 239000012730 sustained-release form Substances 0.000 claims 2
- 125000002023 trifluoromethyl group Chemical group FC(F)(F)* 0.000 claims 2
- 229940051021 yellow-fever virus Drugs 0.000 claims 2
- 108091032973 (ribonucleotides)n+m Proteins 0.000 claims 1
- 108020005345 3' Untranslated Regions Proteins 0.000 claims 1
- 208000037404 Central European encephalitis Diseases 0.000 claims 1
- 241000725619 Dengue virus Species 0.000 claims 1
- 241000710831 Flavivirus Species 0.000 claims 1
- 241000710842 Japanese encephalitis virus Species 0.000 claims 1
- 241001466978 Kyasanur forest disease virus Species 0.000 claims 1
- 241000710908 Murray Valley encephalitis virus Species 0.000 claims 1
- 101800001019 Non-structural protein 4B Proteins 0.000 claims 1
- 241000725177 Omsk hemorrhagic fever virus Species 0.000 claims 1
- 241000710778 Pestivirus Species 0.000 claims 1
- 241000710884 Powassan virus Species 0.000 claims 1
- 241000907329 Russian Spring-Summer encephalitis virus Species 0.000 claims 1
- 241000710888 St. Louis encephalitis virus Species 0.000 claims 1
- 208000004006 Tick-borne encephalitis Diseases 0.000 claims 1
- 208000036142 Viral infection Diseases 0.000 claims 1
- 241000710886 West Nile virus Species 0.000 claims 1
- 208000019425 cirrhosis of liver Diseases 0.000 claims 1
- 125000001301 ethoxy group Chemical group [H]C([H])([H])C([H])([H])O* 0.000 claims 1
- 230000010807 negative regulation of binding Effects 0.000 claims 1
- 230000010076 replication Effects 0.000 claims 1
- 230000009385 viral infection Effects 0.000 claims 1
- 230000003612 virological effect Effects 0.000 claims 1
- 0 C*1CCCC1 Chemical compound C*1CCCC1 0.000 description 5
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US97330907P | 2007-09-18 | 2007-09-18 | |
| US60/973,309 | 2007-09-18 | ||
| US8875908P | 2008-08-14 | 2008-08-14 | |
| US61/088,759 | 2008-08-14 | ||
| US9253708P | 2008-08-28 | 2008-08-28 | |
| US61/092,537 | 2008-08-28 | ||
| PCT/US2008/076806 WO2009039248A2 (en) | 2007-09-18 | 2008-09-18 | Methods of treating a flaviviridae family viral infection and compositions for treating a flaviviridae family viral infection |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010539241A JP2010539241A (ja) | 2010-12-16 |
| JP2010539241A5 true JP2010539241A5 (cg-RX-API-DMAC7.html) | 2012-11-08 |
| JP5715820B2 JP5715820B2 (ja) | 2015-05-13 |
Family
ID=40468758
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2010525943A Expired - Fee Related JP5715820B2 (ja) | 2007-09-18 | 2008-09-18 | フラビウイルス科ファミリーのウイルスへの感染を治療する方法ならびに、フラビウイルス科ファミリーのウイルスへの感染を治療するための組成物 |
Country Status (8)
| Country | Link |
|---|---|
| US (3) | US9061010B2 (cg-RX-API-DMAC7.html) |
| EP (1) | EP2203168B1 (cg-RX-API-DMAC7.html) |
| JP (1) | JP5715820B2 (cg-RX-API-DMAC7.html) |
| CN (1) | CN101903026B (cg-RX-API-DMAC7.html) |
| AR (1) | AR066165A1 (cg-RX-API-DMAC7.html) |
| AU (1) | AU2008302295B2 (cg-RX-API-DMAC7.html) |
| TW (1) | TW200927102A (cg-RX-API-DMAC7.html) |
| WO (2) | WO2009039248A2 (cg-RX-API-DMAC7.html) |
Families Citing this family (42)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US9101628B2 (en) | 2007-09-18 | 2015-08-11 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and composition of treating a flaviviridae family viral infection |
| US9149463B2 (en) | 2007-09-18 | 2015-10-06 | The Board Of Trustees Of The Leland Standford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| TW200927102A (en) | 2007-09-18 | 2009-07-01 | Univ Stanford | Methods of treating a flaviviridae family viral infection, compositions for treating a flaviviridae family viral infection, and screening assays for identifying compositions for treating a flaviviridae family viral infection |
| US8940730B2 (en) | 2007-09-18 | 2015-01-27 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions of treating a Flaviviridae family viral infection |
| JP2012520884A (ja) * | 2009-03-18 | 2012-09-10 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | フラビウイルス科ウイルス感染症を治療する方法および組成物 |
| JP2012520885A (ja) * | 2009-03-18 | 2012-09-10 | ザ ボード オブ トラスティーズ オブ ザ リランド スタンフォード ジュニア ユニバーシティー | フラビウイルス科ウイルス感染症を治療する方法および組成物 |
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| RU2407738C1 (ru) * | 2009-07-03 | 2010-12-27 | Общество с ограниченной ответственностью "Интеллектуальный Диалог" | Противовирусный активный компонент, фармацевтическая композиция, лекарственное средство, способ лечения вирусных заболеваний |
| CN102666537A (zh) * | 2009-10-20 | 2012-09-12 | 艾格尔生物制药股份有限公司 | 治疗黄病毒科病毒感染的氮杂吲唑 |
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| RU2436786C1 (ru) * | 2010-07-23 | 2011-12-20 | Александр Васильевич Иващенко | Замещенные индолы, противовирусный активный компонент, способ получения и применения |
| CN107141309A (zh) | 2011-01-11 | 2017-09-08 | 桑诺维恩药品公司 | 杂芳基化合物及其使用方法 |
| JP6001049B2 (ja) | 2011-03-31 | 2016-10-05 | バイエル・インテレクチュアル・プロパティ・ゲゼルシャフト・ミット・ベシュレンクテル・ハフツングＢａｙｅｒ Ｉｎｔｅｌｌｅｃｔｕａｌ Ｐｒｏｐｅｒｔｙ ＧｍｂＨ | Ｍｐｓ−１キナーゼ阻害剤としての置換ベンズイミダゾール類 |
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| US8492386B2 (en) | 2011-10-21 | 2013-07-23 | Abbvie Inc. | Methods for treating HCV |
| US8466159B2 (en) | 2011-10-21 | 2013-06-18 | Abbvie Inc. | Methods for treating HCV |
| AU2013201406B2 (en) | 2011-10-21 | 2014-10-02 | Abbvie Ireland Unlimited Company | Methods for treating HCV |
| WO2013086133A1 (en) | 2011-12-06 | 2013-06-13 | The Board Of Trustees Of The Leland Stanford Junior University | Methods and compositions for treating viral diseases |
| ES2675583T3 (es) * | 2012-06-11 | 2018-07-11 | Ucb Biopharma Sprl | Bencimidazoles moduladores de TNF-alfa |
| CN103585616B (zh) * | 2013-08-14 | 2015-05-27 | 南京工业大学 | 二肽类似物的用途 |
| WO2015026849A1 (en) | 2013-08-19 | 2015-02-26 | The Regents Of The University Of California | Compounds and methods for treating an epileptic disorder |
| EP3052219B1 (en) | 2013-10-01 | 2020-04-22 | The Broad Institute, Inc. | Sieve valves, microfluidic circuits, microfluidic devices, kits, and methods for isolating an analyte |
| EP3632434A1 (en) * | 2015-02-25 | 2020-04-08 | The Regents of the University of California | The 5ht agonist clemizole for use in treating disorders |
| AU2016288699B2 (en) * | 2015-06-30 | 2020-11-26 | Eiger Group International, Inc. | Use of chloroquine and clemizole compounds for treatment of inflammatory and cancerous conditions |
| CN109069482B (zh) * | 2016-04-01 | 2022-04-05 | 杨森制药公司 | 作为登革热病毒复制抑制剂的经取代的吲哚化合物衍生物 |
| US10653678B2 (en) | 2016-04-11 | 2020-05-19 | Genfit | Methods of treatment for cholestatic and fibrotic diseases |
| MY195437A (en) | 2016-04-11 | 2023-01-20 | Genfit | Methods of Treatment for Cholestatic and Fibrotic Diseases |
| EA201892448A1 (ru) | 2016-04-28 | 2019-06-28 | Эмори Юниверсити | Алкинсодержащие нуклеотидные и нуклеозидные терапевтические композиции и связанные с ними способы применения |
| WO2018129702A1 (zh) * | 2017-01-13 | 2018-07-19 | 史仅 | 蚊虫叮咬瘙痒寨卡等病毒预防医疗器具 |
| CN108096562B (zh) * | 2017-12-25 | 2021-05-11 | 武汉百药联科科技有限公司 | 20s蛋白酶体抑制剂在制备治疗日本乙型脑炎病毒感染的药物中的用途 |
| WO2019126860A1 (pt) * | 2017-12-29 | 2019-07-04 | Instituto Butantan | Composição farmacêutica para o tratamento de infecção causada por vírus da família flaviviridae, e, uso da composição |
| CN108660253B (zh) * | 2018-04-17 | 2022-05-31 | 广东省妇幼保健院（广东省妇产医院、广东省儿童医院） | 一种基于悬浮微珠阵列系统检测虫媒介病毒的探针、引物、检测试剂盒及检测方法 |
| CN109020895B (zh) * | 2018-08-07 | 2020-04-24 | 枣庄学院 | 一种金属催化的1-苄胺基取代苯并咪唑的合成方法 |
| HUE066335T2 (hu) | 2018-10-05 | 2024-07-28 | Annapurna Bio Inc | Vegyületek és készítmények APJ receptor aktivitáshoz kapcsolódó állapotok kezelésére |
| WO2020210341A1 (en) * | 2019-04-09 | 2020-10-15 | Tremeau Pharmaceuticals, Inc. | Treatment of viral hemorrhagic fevers with cox-2 selective non-steroidal antiinflammatory drugs |
| EP4010481A4 (en) | 2019-08-09 | 2023-09-20 | Nutcracker Therapeutics, Inc. | MICROFLUIDIC DEVICE AND METHODS OF USE |
| US20230241037A1 (en) * | 2020-03-09 | 2023-08-03 | 1Globe Health Institute, Nanjing | Cross-linked medication for treatment of coronaviral infection and method of treatment |
| CN111393372B (zh) * | 2020-05-12 | 2022-08-26 | 中国药科大学 | 一种苯并咪唑衍生物及其制备方法和用途 |
| US12274700B1 (en) | 2020-10-30 | 2025-04-15 | Accencio LLC | Methods of treating symptoms of coronavirus infection with RNA polymerase inhibitors |
| CA3251843A1 (en) * | 2022-05-20 | 2023-11-23 | The Board Of Trustees Of The Leland Stanford Junior University | METHODS AND COMPOSITIONS FOR THE TREATMENT OF HEPATIC STEATOSE AND VIRAL INFECTIONS |
| CN119707828B (zh) * | 2024-12-18 | 2025-12-05 | 江苏天和制药股份有限公司 | 一种盐酸克立咪唑的合成方法 |
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-
2008
- 2008-09-18 TW TW097135844A patent/TW200927102A/zh unknown
- 2008-09-18 CN CN200880116387XA patent/CN101903026B/zh not_active Expired - Fee Related
- 2008-09-18 EP EP08832123.7A patent/EP2203168B1/en not_active Not-in-force
- 2008-09-18 US US12/677,989 patent/US9061010B2/en not_active Expired - Fee Related
- 2008-09-18 AU AU2008302295A patent/AU2008302295B2/en not_active Ceased
- 2008-09-18 WO PCT/US2008/076806 patent/WO2009039248A2/en not_active Ceased
- 2008-09-18 WO PCT/US2008/076804 patent/WO2009039246A2/en not_active Ceased
- 2008-09-18 US US12/678,014 patent/US8895598B2/en not_active Expired - Fee Related
- 2008-09-18 JP JP2010525943A patent/JP5715820B2/ja not_active Expired - Fee Related
- 2008-09-18 AR ARP080104066A patent/AR066165A1/es unknown
-
2014
- 2014-09-23 US US14/493,529 patent/US20150044169A1/en not_active Abandoned