JP2011513309A5 - - Google Patents

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Publication number
JP2011513309A5
JP2011513309A5 JP2010548747A JP2010548747A JP2011513309A5 JP 2011513309 A5 JP2011513309 A5 JP 2011513309A5 JP 2010548747 A JP2010548747 A JP 2010548747A JP 2010548747 A JP2010548747 A JP 2010548747A JP 2011513309 A5 JP2011513309 A5 JP 2011513309A5
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JP
Japan
Prior art keywords
disease
patient
deuterium
compound
pharmaceutically acceptable
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JP2010548747A
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English (en)
Japanese (ja)
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JP2011513309A (ja
JP5567503B2 (ja
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Priority claimed from PCT/US2009/001305 external-priority patent/WO2009108383A2/en
Publication of JP2011513309A publication Critical patent/JP2011513309A/ja
Publication of JP2011513309A5 publication Critical patent/JP2011513309A5/ja
Application granted granted Critical
Publication of JP5567503B2 publication Critical patent/JP5567503B2/ja
Expired - Fee Related legal-status Critical Current
Anticipated expiration legal-status Critical

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JP2010548747A 2008-02-29 2009-02-27 置換キサンチン誘導体 Expired - Fee Related JP5567503B2 (ja)

Applications Claiming Priority (7)

Application Number Priority Date Filing Date Title
US6773608P 2008-02-29 2008-02-29
US61/067,736 2008-02-29
US13456808P 2008-07-11 2008-07-11
US61/134,568 2008-07-11
US19871508P 2008-11-07 2008-11-07
US61/198,715 2008-11-07
PCT/US2009/001305 WO2009108383A2 (en) 2008-02-29 2009-02-27 Substituted xanthine derivatives

Publications (3)

Publication Number Publication Date
JP2011513309A JP2011513309A (ja) 2011-04-28
JP2011513309A5 true JP2011513309A5 (enExample) 2012-04-12
JP5567503B2 JP5567503B2 (ja) 2014-08-06

Family

ID=40600003

Family Applications (2)

Application Number Title Priority Date Filing Date
JP2010548747A Expired - Fee Related JP5567503B2 (ja) 2008-02-29 2009-02-27 置換キサンチン誘導体
JP2010548745A Active JP5292413B2 (ja) 2008-02-29 2009-02-27 置換キサンチン誘導体

Family Applications After (1)

Application Number Title Priority Date Filing Date
JP2010548745A Active JP5292413B2 (ja) 2008-02-29 2009-02-27 置換キサンチン誘導体

Country Status (12)

Country Link
US (3) US20090239886A1 (enExample)
EP (3) EP2265334A2 (enExample)
JP (2) JP5567503B2 (enExample)
KR (1) KR20100121527A (enExample)
CN (1) CN101998957B (enExample)
AU (1) AU2009217680B2 (enExample)
BR (1) BRPI0908107A2 (enExample)
CA (1) CA2716788C (enExample)
EA (1) EA019088B1 (enExample)
MX (1) MX2010009300A (enExample)
WO (2) WO2009108375A1 (enExample)
ZA (1) ZA201006104B (enExample)

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EP2265334A2 (en) 2008-02-29 2010-12-29 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
EP2331140B1 (en) 2008-08-11 2018-07-04 Nektar Therapeutics Multi-arm polymeric alkanoate conjugates
US20100087455A1 (en) * 2008-10-06 2010-04-08 Auspex Pharmaceuticals, Inc. Substituted xanthine compounds
WO2010075086A2 (en) * 2008-12-15 2010-07-01 Auspex Pharmaceuticals, Inc. Pyrrolidinone inhibitors of pde-4
US20110053961A1 (en) * 2009-02-27 2011-03-03 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
US8263601B2 (en) 2009-02-27 2012-09-11 Concert Pharmaceuticals, Inc. Deuterium substituted xanthine derivatives
WO2011028820A1 (en) 2009-09-02 2011-03-10 Concert Pharmaceuticals, Inc. Substituted derivatives of bicyclic [4.3.0] heteroaryl compounds
EP2473052A4 (en) * 2009-09-02 2013-03-20 Concert Pharmaceuticals Inc SUBSTITUTED XANTHINE DERIVATIVES
US9085788B2 (en) * 2010-09-01 2015-07-21 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
WO2012031073A1 (en) * 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation
WO2012031068A1 (en) * 2010-09-01 2012-03-08 Concert Pharmaceuticals, Inc. Method of utilizing recycled deuterium oxide in the synthesis of deuterated compounds
US20130324564A1 (en) * 2010-09-01 2013-12-05 Concert Pharmaceuticals, Inc. Polymorphs of (s)-1-(4,4,6,6,6-pentadeutero-5-hydroxyhexyl)-3-7-dimethyl-1h-purine-2,6(3h,7h)-dione
US20130331443A1 (en) 2010-12-22 2013-12-12 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of taxane-based compounds
US10894087B2 (en) 2010-12-22 2021-01-19 Nektar Therapeutics Multi-arm polymeric prodrug conjugates of cabazitaxel-based compounds
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WO2013013052A1 (en) * 2011-07-19 2013-01-24 Concert Pharmaceuticals, Inc. Substituted xanthine derivatives
CN104364255A (zh) * 2012-04-13 2015-02-18 康塞特医药品有限公司 取代的黄嘌呤衍生物
US20150087660A1 (en) * 2012-05-10 2015-03-26 Mahesh Kandula Compositions and methods for the treatment of chronic diseases and inflammatory disorders
EA201691582A1 (ru) 2014-02-07 2017-01-30 Оспекс Фармасьютикалз, Инк. Новые фармацевтические препараты
CA2981791A1 (en) 2014-04-18 2015-10-22 Concert Pharmaceuticals, Inc. Methods of treating hyperglycemia
WO2015175008A1 (en) * 2014-05-14 2015-11-19 Concert Pharmaceuticals, Inc. Methods of treating chronic kidney disease characterized by macroalbuminuria
US10954300B2 (en) 2015-09-28 2021-03-23 The Trustees Of Columbia University In The City Of New York Use of pentoxifylline with immune checkpoint-blockade therapies for the treatment of melanoma
WO2017071606A1 (zh) * 2015-10-29 2017-05-04 南京明德新药研发股份有限公司 羟基嘌呤类化合物的医药用途

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