MX2010009300A - Derivados de xantina substituidos. - Google Patents
Derivados de xantina substituidos.Info
- Publication number
- MX2010009300A MX2010009300A MX2010009300A MX2010009300A MX2010009300A MX 2010009300 A MX2010009300 A MX 2010009300A MX 2010009300 A MX2010009300 A MX 2010009300A MX 2010009300 A MX2010009300 A MX 2010009300A MX 2010009300 A MX2010009300 A MX 2010009300A
- Authority
- MX
- Mexico
- Prior art keywords
- compound
- deuterium
- taken together
- taken
- hydrogen
- Prior art date
Links
- LRFVTYWOQMYALW-UHFFFAOYSA-N 9H-xanthine Chemical class O=C1NC(=O)NC2=C1NC=N2 LRFVTYWOQMYALW-UHFFFAOYSA-N 0.000 title abstract 4
- 229940083747 low-ceiling diuretics xanthine derivative Drugs 0.000 title abstract 2
- 150000001875 compounds Chemical class 0.000 claims abstract description 311
- 238000000034 method Methods 0.000 claims abstract description 80
- 239000000203 mixture Substances 0.000 claims abstract description 60
- 150000003839 salts Chemical class 0.000 claims abstract description 23
- 229910052805 deuterium Chemical group 0.000 claims description 165
- YZCKVEUIGOORGS-OUBTZVSYSA-N Deuterium Chemical group [2H] YZCKVEUIGOORGS-OUBTZVSYSA-N 0.000 claims description 157
- 125000002496 methyl group Chemical group [H]C([H])([H])* 0.000 claims description 103
- 229910052739 hydrogen Inorganic materials 0.000 claims description 51
- 239000001257 hydrogen Substances 0.000 claims description 51
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 claims description 35
- 125000004435 hydrogen atom Chemical group [H]* 0.000 claims description 27
- 229910052799 carbon Inorganic materials 0.000 claims description 20
- 125000004432 carbon atom Chemical group C* 0.000 claims description 13
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- WQZGKKKJIJFFOK-GASJEMHNSA-N Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 6
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- 101100313176 Saccharomyces cerevisiae (strain ATCC 204508 / S288c) TCD2 gene Proteins 0.000 claims 1
- BYPFEZZEUUWMEJ-UHFFFAOYSA-N Pentoxifylline Chemical class O=C1N(CCCCC(=O)C)C(=O)N(C)C2=C1N(C)C=N2 BYPFEZZEUUWMEJ-UHFFFAOYSA-N 0.000 abstract description 60
- 229960001476 pentoxifylline Drugs 0.000 abstract description 50
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 abstract description 43
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- 230000009286 beneficial effect Effects 0.000 abstract description 4
- 229940075420 xanthine Drugs 0.000 abstract 1
- WEVYAHXRMPXWCK-UHFFFAOYSA-N Acetonitrile Chemical compound CC#N WEVYAHXRMPXWCK-UHFFFAOYSA-N 0.000 description 63
- 239000002207 metabolite Substances 0.000 description 43
- BDAGIHXWWSANSR-UHFFFAOYSA-N methanoic acid Natural products OC=O BDAGIHXWWSANSR-UHFFFAOYSA-N 0.000 description 33
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- OSWFIVFLDKOXQC-UHFFFAOYSA-N 4-(3-methoxyphenyl)aniline Chemical compound COC1=CC=CC(C=2C=CC(N)=CC=2)=C1 OSWFIVFLDKOXQC-UHFFFAOYSA-N 0.000 description 16
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- OKKJLVBELUTLKV-UHFFFAOYSA-N Methanol Chemical compound OC OKKJLVBELUTLKV-UHFFFAOYSA-N 0.000 description 15
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- 229940125396 insulin Drugs 0.000 description 12
- BWHMMNNQKKPAPP-UHFFFAOYSA-L potassium carbonate Chemical compound [K+].[K+].[O-]C([O-])=O BWHMMNNQKKPAPP-UHFFFAOYSA-L 0.000 description 12
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- KDCGOANMDULRCW-UHFFFAOYSA-N 7H-purine Chemical group N1=CNC2=NC=NC2=C1 KDCGOANMDULRCW-UHFFFAOYSA-N 0.000 description 10
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N Dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 description 10
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- QTBSBXVTEAMEQO-UHFFFAOYSA-N Acetic acid Chemical compound CC(O)=O QTBSBXVTEAMEQO-UHFFFAOYSA-N 0.000 description 9
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- HBAQYPYDRFILMT-UHFFFAOYSA-N 8-[3-(1-cyclopropylpyrazol-4-yl)-1H-pyrazolo[4,3-d]pyrimidin-5-yl]-3-methyl-3,8-diazabicyclo[3.2.1]octan-2-one Chemical class C1(CC1)N1N=CC(=C1)C1=NNC2=C1N=C(N=C2)N1C2C(N(CC1CC2)C)=O HBAQYPYDRFILMT-UHFFFAOYSA-N 0.000 description 6
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| PCT/US2009/001294 WO2009108375A1 (en) | 2008-02-29 | 2009-02-27 | Substituted xanthine derivatives |
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| US8263601B2 (en) | 2009-02-27 | 2012-09-11 | Concert Pharmaceuticals, Inc. | Deuterium substituted xanthine derivatives |
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| US9085788B2 (en) * | 2010-09-01 | 2015-07-21 | Concert Pharmaceuticals, Inc. | Process for preparing an enantiomerically enriched, deuterated secondary alcohol from a corresponding ketone without reducing deuterium incorporation |
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| JO2630B1 (en) | 2006-04-13 | 2012-06-17 | نوفارتيس ايه جي | Organic compounds |
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| EP2265334A2 (en) | 2008-02-29 | 2010-12-29 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
| US20110053961A1 (en) | 2009-02-27 | 2011-03-03 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
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| US8485557B2 (en) | 2009-08-27 | 2013-07-16 | Kermit Zarley Enterprises | Self-supporting book |
| EP2473052A4 (en) | 2009-09-02 | 2013-03-20 | Concert Pharmaceuticals Inc | SUBSTITUTED XANTHINE DERIVATIVES |
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2009
- 2009-02-27 EP EP09714926A patent/EP2265334A2/en not_active Withdrawn
- 2009-02-27 EP EP09715566.7A patent/EP2265612B1/en active Active
- 2009-02-27 WO PCT/US2009/001294 patent/WO2009108375A1/en not_active Ceased
- 2009-02-27 BR BRPI0908107A patent/BRPI0908107A2/pt not_active IP Right Cessation
- 2009-02-27 EA EA201001391A patent/EA019088B1/ru not_active IP Right Cessation
- 2009-02-27 JP JP2010548747A patent/JP5567503B2/ja not_active Expired - Fee Related
- 2009-02-27 CA CA2716788A patent/CA2716788C/en active Active
- 2009-02-27 US US12/380,579 patent/US20090239886A1/en not_active Abandoned
- 2009-02-27 MX MX2010009300A patent/MX2010009300A/es active IP Right Grant
- 2009-02-27 CN CN2009801114859A patent/CN101998957B/zh active Active
- 2009-02-27 JP JP2010548745A patent/JP5292413B2/ja active Active
- 2009-02-27 EP EP17160882.1A patent/EP3199203B1/en active Active
- 2009-02-27 WO PCT/US2009/001305 patent/WO2009108383A2/en not_active Ceased
- 2009-02-27 KR KR1020107021407A patent/KR20100121527A/ko not_active Abandoned
- 2009-02-27 AU AU2009217680A patent/AU2009217680B2/en active Active
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2010
- 2010-08-26 ZA ZA2010/06104A patent/ZA201006104B/en unknown
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2013
- 2013-07-24 US US13/949,888 patent/US9035050B2/en active Active
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2015
- 2015-05-15 US US14/713,423 patent/US9493463B2/en active Active
Also Published As
| Publication number | Publication date |
|---|---|
| WO2009108383A2 (en) | 2009-09-03 |
| EA019088B1 (ru) | 2014-01-30 |
| CA2716788C (en) | 2016-08-16 |
| EP2265334A2 (en) | 2010-12-29 |
| JP2011513307A (ja) | 2011-04-28 |
| AU2009217680B2 (en) | 2013-09-05 |
| EP2265612A1 (en) | 2010-12-29 |
| CN101998957B (zh) | 2013-06-05 |
| CN101998957A (zh) | 2011-03-30 |
| US9035050B2 (en) | 2015-05-19 |
| JP2011513309A (ja) | 2011-04-28 |
| AU2009217680A1 (en) | 2009-09-03 |
| CA2716788A1 (en) | 2009-09-03 |
| EA201001391A1 (ru) | 2011-08-30 |
| EP3199203B1 (en) | 2020-02-05 |
| US20140121226A1 (en) | 2014-05-01 |
| EP2265612B1 (en) | 2017-04-05 |
| ZA201006104B (en) | 2012-01-25 |
| US9493463B2 (en) | 2016-11-15 |
| EP3199203A1 (en) | 2017-08-02 |
| JP5292413B2 (ja) | 2013-09-18 |
| KR20100121527A (ko) | 2010-11-17 |
| WO2009108383A3 (en) | 2009-10-22 |
| BRPI0908107A2 (pt) | 2019-09-24 |
| US20090239886A1 (en) | 2009-09-24 |
| WO2009108375A1 (en) | 2009-09-03 |
| JP5567503B2 (ja) | 2014-08-06 |
| US20150322068A1 (en) | 2015-11-12 |
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