JPS5724386A - Preparation of xanthine derivative - Google Patents
Preparation of xanthine derivativeInfo
- Publication number
- JPS5724386A JPS5724386A JP9681680A JP9681680A JPS5724386A JP S5724386 A JPS5724386 A JP S5724386A JP 9681680 A JP9681680 A JP 9681680A JP 9681680 A JP9681680 A JP 9681680A JP S5724386 A JPS5724386 A JP S5724386A
- Authority
- JP
- Japan
- Prior art keywords
- acid
- formula
- preparation
- xanthine derivative
- mineral acid
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Pending
Links
Abstract
PURPOSE: To prepare the titled compound useful as a drug having vasodilating activity, etc., using the most economical, simple and safe process comprising the heating in a mineral acid, without using an expensive reagent, by hydrolyzing a theobromine derivative in the presence of an acid.
CONSTITUTION: A theobromine derivative of formula I (R1 and R2 are H or group of formula II) is hydrolyzed in the presence of an acid (e.g. an aqueous solution of a mineral acid) at room temperature W200°C to obtain 1-(5'-oxohexyl)-3,7- dimethylxanthine of formula III.
EFFECT: The use of a highly toxic heavy metal salt is not necessary.
COPYRIGHT: (C)1982,JPO&Japio
Priority Applications (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9681680A JPS5724386A (en) | 1980-07-17 | 1980-07-17 | Preparation of xanthine derivative |
Applications Claiming Priority (1)
Application Number | Priority Date | Filing Date | Title |
---|---|---|---|
JP9681680A JPS5724386A (en) | 1980-07-17 | 1980-07-17 | Preparation of xanthine derivative |
Publications (1)
Publication Number | Publication Date |
---|---|
JPS5724386A true JPS5724386A (en) | 1982-02-08 |
Family
ID=14175105
Family Applications (1)
Application Number | Title | Priority Date | Filing Date |
---|---|---|---|
JP9681680A Pending JPS5724386A (en) | 1980-07-17 | 1980-07-17 | Preparation of xanthine derivative |
Country Status (1)
Country | Link |
---|---|
JP (1) | JPS5724386A (en) |
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
WO2013155465A1 (en) | 2012-04-13 | 2013-10-17 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
EP3199203A1 (en) | 2008-02-29 | 2017-08-02 | Concert Pharmaceuticals Inc. | Substitued xanthine derivatives |
-
1980
- 1980-07-17 JP JP9681680A patent/JPS5724386A/en active Pending
Cited By (3)
Publication number | Priority date | Publication date | Assignee | Title |
---|---|---|---|---|
EP3199203A1 (en) | 2008-02-29 | 2017-08-02 | Concert Pharmaceuticals Inc. | Substitued xanthine derivatives |
WO2011028835A1 (en) | 2009-09-02 | 2011-03-10 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
WO2013155465A1 (en) | 2012-04-13 | 2013-10-17 | Concert Pharmaceuticals, Inc. | Substituted xanthine derivatives |
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