JP2007504284A5 - - Google Patents
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- Publication number
- JP2007504284A5 JP2007504284A5 JP2006533807A JP2006533807A JP2007504284A5 JP 2007504284 A5 JP2007504284 A5 JP 2007504284A5 JP 2006533807 A JP2006533807 A JP 2006533807A JP 2006533807 A JP2006533807 A JP 2006533807A JP 2007504284 A5 JP2007504284 A5 JP 2007504284A5
- Authority
- JP
- Japan
- Prior art keywords
- halo
- compound according
- compound
- alkyl
- alkenyl
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 125000005843 halogen group Chemical group 0.000 claims 92
- 150000001875 compounds Chemical class 0.000 claims 45
- 125000001475 halogen functional group Chemical group 0.000 claims 37
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 claims 18
- 125000006370 trihalo methyl group Chemical group 0.000 claims 12
- 125000004076 pyridyl group Chemical group 0.000 claims 10
- 125000000999 tert-butyl group Chemical group [H]C([H])([H])C(*)(C([H])([H])[H])C([H])([H])[H] 0.000 claims 8
- 150000003839 salts Chemical class 0.000 claims 6
- 125000005842 heteroatom Chemical group 0.000 claims 5
- 125000000623 heterocyclic group Chemical group 0.000 claims 5
- 125000003342 alkenyl group Chemical group 0.000 claims 4
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 4
- 125000000008 (C1-C10) alkyl group Chemical group 0.000 claims 3
- 239000003814 drug Substances 0.000 claims 3
- 238000000034 method Methods 0.000 claims 3
- 125000006376 (C3-C10) cycloalkyl group Chemical group 0.000 claims 2
- -1 1,2,3,6-tetrahydro-pyridine-4-carboxamide compound Chemical class 0.000 claims 2
- 125000006374 C2-C10 alkenyl group Chemical group 0.000 claims 2
- 125000006375 C2-C10 alkynyl group Chemical group 0.000 claims 2
- 229940126062 Compound A Drugs 0.000 claims 2
- NLDMNSXOCDLTTB-UHFFFAOYSA-N Heterophylliin A Natural products O1C2COC(=O)C3=CC(O)=C(O)C(O)=C3C3=C(O)C(O)=C(O)C=C3C(=O)OC2C(OC(=O)C=2C=C(O)C(O)=C(O)C=2)C(O)C1OC(=O)C1=CC(O)=C(O)C(O)=C1 NLDMNSXOCDLTTB-UHFFFAOYSA-N 0.000 claims 2
- 125000003118 aryl group Chemical group 0.000 claims 2
- 150000001602 bicycloalkyls Chemical group 0.000 claims 2
- 125000000392 cycloalkenyl group Chemical group 0.000 claims 2
- 125000001072 heteroaryl group Chemical group 0.000 claims 2
- 125000004178 (C1-C4) alkyl group Chemical group 0.000 claims 1
- 208000022559 Inflammatory bowel disease Diseases 0.000 claims 1
- 208000025865 Ulcer Diseases 0.000 claims 1
- 206010046543 Urinary incontinence Diseases 0.000 claims 1
- 229940079593 drug Drugs 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 230000000694 effects Effects 0.000 claims 1
- 230000002401 inhibitory effect Effects 0.000 claims 1
- 208000002551 irritable bowel syndrome Diseases 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000000546 pharmaceutical excipient Substances 0.000 claims 1
- 231100000397 ulcer Toxicity 0.000 claims 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US47774403P | 2003-06-12 | 2003-06-12 | |
| US60/477,744 | 2003-06-12 | ||
| PCT/US2004/019189 WO2005004866A1 (en) | 2003-06-12 | 2004-06-14 | Therapeutic agents useful for treating pain |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011159464A Division JP2012021000A (ja) | 2003-06-12 | 2011-07-21 | 疼痛を治療するのに有用な治療薬 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2007504284A JP2007504284A (ja) | 2007-03-01 |
| JP2007504284A5 true JP2007504284A5 (enExample) | 2011-09-08 |
| JP5269315B2 JP5269315B2 (ja) | 2013-08-21 |
Family
ID=34061917
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2006533807A Expired - Fee Related JP5269315B2 (ja) | 2003-06-12 | 2004-06-14 | 疼痛を治療するのに有用な治療薬 |
| JP2011159464A Withdrawn JP2012021000A (ja) | 2003-06-12 | 2011-07-21 | 疼痛を治療するのに有用な治療薬 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2011159464A Withdrawn JP2012021000A (ja) | 2003-06-12 | 2011-07-21 | 疼痛を治療するのに有用な治療薬 |
Country Status (28)
| Country | Link |
|---|---|
| US (3) | US7683063B2 (enExample) |
| EP (3) | EP1862458B1 (enExample) |
| JP (2) | JP5269315B2 (enExample) |
| KR (2) | KR20090008439A (enExample) |
| CN (2) | CN1835751B (enExample) |
| AR (1) | AR044688A1 (enExample) |
| AT (2) | ATE369133T1 (enExample) |
| AU (1) | AU2004255169B2 (enExample) |
| BR (1) | BRPI0411241A (enExample) |
| CA (1) | CA2528920C (enExample) |
| CY (1) | CY1108738T1 (enExample) |
| DE (2) | DE602004017658D1 (enExample) |
| DK (1) | DK1862458T3 (enExample) |
| EA (1) | EA009593B1 (enExample) |
| ES (1) | ES2317623T3 (enExample) |
| GE (1) | GEP20084488B (enExample) |
| IL (1) | IL172418A (enExample) |
| IS (1) | IS8142A (enExample) |
| MA (1) | MA27908A1 (enExample) |
| MX (1) | MXPA05013587A (enExample) |
| MY (1) | MY142655A (enExample) |
| NO (1) | NO20060192L (enExample) |
| PL (1) | PL1862458T3 (enExample) |
| PT (1) | PT1862458E (enExample) |
| SI (1) | SI1862458T1 (enExample) |
| TW (1) | TWI287010B (enExample) |
| WO (1) | WO2005004866A1 (enExample) |
| ZA (1) | ZA200508744B (enExample) |
Families Citing this family (40)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| KR100777169B1 (ko) | 2001-01-29 | 2007-11-16 | 시오노기세이야쿠가부시키가이샤 | 5-메틸-1-페닐-2-(1ｈ)-피리돈을 활성 성분으로서함유하는 의약 제제 |
| ATE556067T1 (de) | 2003-05-20 | 2012-05-15 | Ajinomoto Kk | Modulatoren des vanilloid rezeptors |
| AR044688A1 (es) * | 2003-06-12 | 2005-09-21 | Euro Celtique Sa | Agentes terapeuticos utiles para el tratamiento del dolor |
| US20050009841A1 (en) * | 2003-07-11 | 2005-01-13 | Zheng Guo Zhu | Novel amides useful for treating pain |
| DE602004021206D1 (de) * | 2003-07-24 | 2009-07-02 | Euro Celtique Sa | Zur Behandlung oder Vorbeugung von Schmerzen geeignete Heteroaryl-Tetrahydropiperidyl-Verbindungen |
| DE602004020994D1 (de) * | 2003-07-24 | 2009-06-18 | Euro Celtique Sa | Piperidinverbindungen und pharmazeutische zusammensetzungen, die diese enthalten |
| TW200738232A (en) * | 2006-01-31 | 2007-10-16 | Alcon Mfg Ltd | Use of vanilloid receptor-1 antagonists for the prevention and treatment of glaucoma |
| US20080051380A1 (en) | 2006-08-25 | 2008-02-28 | Auerbach Alan H | Methods and compositions for treating cancer |
| KR100801278B1 (ko) * | 2006-08-29 | 2008-02-04 | 삼성전기주식회사 | 하이브리드형 광도파로 센서 |
| US7645767B2 (en) * | 2006-08-31 | 2010-01-12 | Trinity Laboratories, Inc. | Pharmaceutical compositions for treating chronic pain and pain associated with neuropathy |
| US20080153845A1 (en) * | 2006-10-27 | 2008-06-26 | Redpoint Bio Corporation | Trpv1 antagonists and uses thereof |
| CA2685266C (en) | 2007-04-27 | 2014-01-28 | Purdue Pharma L.P. | Trpv1 antagonists and uses thereof for the treatment of prevention of pain, ui and ulcer, ibd, or ibs in an animal |
| JP5372913B2 (ja) * | 2007-04-27 | 2013-12-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | 疼痛治療に有効な治療薬 |
| AP2516A (en) | 2007-05-03 | 2012-11-26 | Pfizer Ltd | 2-Pyridine carboxamide derivatives as sodium channel modulators |
| CA2708320A1 (en) * | 2007-08-09 | 2009-02-19 | Abbott Laboratories | Amide derivatives as trpv1 antagonists |
| US8084616B2 (en) | 2007-10-24 | 2011-12-27 | Abbott Laboratories | TRPV1 antagonists |
| AU2009265760B2 (en) | 2008-06-30 | 2013-07-18 | Novartis Ag | Combinations comprising mGluR modulators for the treatment of parkinson's disease |
| WO2011162409A1 (en) | 2010-06-22 | 2011-12-29 | Shionogi & Co., Ltd. | Compounds having trpv1 antagonistic activity and uses thereof |
| US9156830B2 (en) | 2011-05-17 | 2015-10-13 | Shionogi & Co., Ltd. | Heterocyclic compounds |
| PE20141531A1 (es) | 2011-06-22 | 2014-10-23 | Purdue Pharma Lp | Antagonistas de trpv1 que incluyen sustituyentes dihidroxi y sus usos |
| DK2773779T3 (da) * | 2011-11-04 | 2020-11-23 | Population Bio Inc | Fremgangsmåder og sammensætninger til diagnosticering, prognose og forebyggelse af neurologiske tilstande |
| WO2013146970A1 (ja) * | 2012-03-29 | 2013-10-03 | 第一三共株式会社 | 新規キノリン誘導体 |
| TW201730188A (zh) * | 2015-11-30 | 2017-09-01 | 阿斯特捷利康公司 | 1,3,4-噻二唑化合物及其在治療癌症中之用途 |
| CA2937365C (en) | 2016-03-29 | 2018-09-18 | F. Hoffmann-La Roche Ag | Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same |
| TWI808055B (zh) | 2016-05-11 | 2023-07-11 | 美商滬亞生物國際有限公司 | Hdac 抑制劑與 pd-1 抑制劑之組合治療 |
| TWI794171B (zh) | 2016-05-11 | 2023-03-01 | 美商滬亞生物國際有限公司 | Ｈｄａｃ抑制劑與ｐｄ-ｌ１抑制劑之組合治療 |
| MX383697B (es) | 2016-06-23 | 2025-03-14 | St Jude Childrens Res Hospital Inc | Moduladores de moleculas peque?as de pantotenato cinasas |
| IL322013A (en) | 2016-07-29 | 2025-09-01 | Janssen Pharmaceutica Nv | Niraparib or its salts for use in the treatment of prostate cancer |
| GB201709459D0 (en) * | 2017-06-14 | 2017-07-26 | Intrabio Ltd | Treatment for migraine |
| JP6964506B2 (ja) * | 2017-12-19 | 2021-11-10 | ライオン株式会社 | 錠剤及び錠剤の製造方法 |
| CA3086711A1 (en) | 2017-12-27 | 2019-07-04 | St. Jude Children's Research Hospital, Inc. | Use of arylpiperazine-1-carboxamide derivatives in the treatment of coenzyme a-mediated disorders |
| KR102728619B1 (ko) | 2017-12-27 | 2024-11-08 | 세인트 쥬드 칠드런즈 리써치 호스피탈, 인코포레이티드 | 판토테네이트 키나제의 소분자 조절제 |
| US12460178B2 (en) | 2018-04-12 | 2025-11-04 | Cellresearch Corporation Pte. Ltd. | Method of inducing or improving wound healing properties of mesenchymal stem cells |
| TWI882956B (zh) * | 2018-04-12 | 2025-05-11 | 新加坡商細胞研究私人有限公司 | 一種誘導或改善間質幹細胞傷口癒合特性的方法 |
| RU2744162C1 (ru) * | 2020-03-18 | 2021-03-03 | Федеральное государственное бюджетное образовательное учреждение высшего образования "Пермская государственная фармацевтическая академия" Министерства здравоохранения Российской Федерации (ФГБОУ ВО ПГФА Минздрава России) | Анальгетическое средство на основе 5-(2-аминопропил)-6-оксо-3,4-дифенилпирроло[3,4-c]пиразола |
| KR102885259B1 (ko) | 2020-07-31 | 2025-11-14 | 삼성전자주식회사 | 차폐 및 방열 구조를 포함하는 전자 장치 |
| CN115536648B (zh) * | 2021-06-29 | 2024-09-17 | 深圳开悦生命科技有限公司 | 一类抑制rna解旋酶dhx33的多环化合物及其应用 |
| CN113061593B (zh) * | 2021-04-02 | 2023-11-10 | 洛阳华荣生物技术有限公司 | 一种l-苹果酸脱氢酶突变体及其应用 |
| DE102022104759A1 (de) | 2022-02-28 | 2023-08-31 | SCi Kontor GmbH | Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen |
| CN114957214A (zh) * | 2022-06-22 | 2022-08-30 | 九江善水科技股份有限公司 | 一种氯虫苯甲酰胺中间体的制备方法 |
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| DE602004021206D1 (de) * | 2003-07-24 | 2009-07-02 | Euro Celtique Sa | Zur Behandlung oder Vorbeugung von Schmerzen geeignete Heteroaryl-Tetrahydropiperidyl-Verbindungen |
| DE602004020994D1 (de) * | 2003-07-24 | 2009-06-18 | Euro Celtique Sa | Piperidinverbindungen und pharmazeutische zusammensetzungen, die diese enthalten |
| JP5372913B2 (ja) * | 2007-04-27 | 2013-12-18 | パーデュー、ファーマ、リミテッド、パートナーシップ | 疼痛治療に有効な治療薬 |
-
2004
- 2004-06-11 AR ARP040102043A patent/AR044688A1/es unknown
- 2004-06-11 TW TW093116961A patent/TWI287010B/zh not_active IP Right Cessation
- 2004-06-11 MY MYPI20042274A patent/MY142655A/en unknown
- 2004-06-14 AT AT04776652T patent/ATE369133T1/de active
- 2004-06-14 CA CA2528920A patent/CA2528920C/en not_active Expired - Fee Related
- 2004-06-14 GE GEAP20049166A patent/GEP20084488B/en unknown
- 2004-06-14 WO PCT/US2004/019189 patent/WO2005004866A1/en not_active Ceased
- 2004-06-14 AT AT07113391T patent/ATE413385T1/de active
- 2004-06-14 EA EA200501820A patent/EA009593B1/ru not_active IP Right Cessation
- 2004-06-14 ES ES07113391T patent/ES2317623T3/es not_active Expired - Lifetime
- 2004-06-14 DE DE602004017658T patent/DE602004017658D1/de not_active Expired - Lifetime
- 2004-06-14 MX MXPA05013587A patent/MXPA05013587A/es active IP Right Grant
- 2004-06-14 PL PL07113391T patent/PL1862458T3/pl unknown
- 2004-06-14 PT PT07113391T patent/PT1862458E/pt unknown
- 2004-06-14 CN CN200480023060XA patent/CN1835751B/zh not_active Expired - Fee Related
- 2004-06-14 SI SI200431012T patent/SI1862458T1/sl unknown
- 2004-06-14 JP JP2006533807A patent/JP5269315B2/ja not_active Expired - Fee Related
- 2004-06-14 AU AU2004255169A patent/AU2004255169B2/en not_active Ceased
- 2004-06-14 KR KR1020087029450A patent/KR20090008439A/ko not_active Withdrawn
- 2004-06-14 EP EP07113391A patent/EP1862458B1/en not_active Expired - Lifetime
- 2004-06-14 US US10/867,546 patent/US7683063B2/en active Active
- 2004-06-14 BR BRPI0411241-5A patent/BRPI0411241A/pt not_active IP Right Cessation
- 2004-06-14 DE DE602004008069T patent/DE602004008069D1/de not_active Expired - Lifetime
- 2004-06-14 CN CN201010168011A patent/CN101863877A/zh active Pending
- 2004-06-14 KR KR1020057023740A patent/KR100896497B1/ko not_active Expired - Fee Related
- 2004-06-14 EP EP04776652A patent/EP1631285B1/en not_active Expired - Lifetime
- 2004-06-14 DK DK07113391T patent/DK1862458T3/da active
- 2004-06-14 EP EP08168291A patent/EP2060260A1/en not_active Withdrawn
-
2005
- 2005-10-28 ZA ZA200508744A patent/ZA200508744B/xx unknown
- 2005-11-23 IS IS8142A patent/IS8142A/is unknown
- 2005-12-06 IL IL172418A patent/IL172418A/en not_active IP Right Cessation
-
2006
- 2006-01-09 MA MA28715A patent/MA27908A1/fr unknown
- 2006-01-12 NO NO20060192A patent/NO20060192L/no not_active Application Discontinuation
-
2009
- 2009-01-30 CY CY20091100110T patent/CY1108738T1/el unknown
-
2010
- 2010-02-16 US US12/706,571 patent/US8227467B2/en not_active Expired - Lifetime
-
2011
- 2011-07-21 JP JP2011159464A patent/JP2012021000A/ja not_active Withdrawn
-
2012
- 2012-06-18 US US13/525,950 patent/US8680118B2/en not_active Expired - Lifetime
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