JP2003503387A5 - - Google Patents
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- Publication number
- JP2003503387A5 JP2003503387A5 JP2001506989A JP2001506989A JP2003503387A5 JP 2003503387 A5 JP2003503387 A5 JP 2003503387A5 JP 2001506989 A JP2001506989 A JP 2001506989A JP 2001506989 A JP2001506989 A JP 2001506989A JP 2003503387 A5 JP2003503387 A5 JP 2003503387A5
- Authority
- JP
- Japan
- Prior art keywords
- alkyl
- halogen
- group
- aryl
- compound according
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 description 44
- 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 43
- 229910052736 halogen Inorganic materials 0.000 description 34
- 150000002367 halogens Chemical class 0.000 description 34
- 0 C*c1cc(*)c(**)cc1* Chemical compound C*c1cc(*)c(**)cc1* 0.000 description 28
- 125000004404 heteroalkyl group Chemical group 0.000 description 21
- 125000003118 aryl group Chemical group 0.000 description 16
- 125000004435 hydrogen atom Chemical group [H]* 0.000 description 15
- 125000003545 alkoxy group Chemical group 0.000 description 14
- 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 14
- 125000001424 substituent group Chemical group 0.000 description 10
- 125000004093 cyano group Chemical group *C#N 0.000 description 8
- 125000000217 alkyl group Chemical group 0.000 description 7
- 229910052739 hydrogen Inorganic materials 0.000 description 7
- -1 -CF 3 Chemical group 0.000 description 6
- 125000000956 methoxy group Chemical group [H]C([H])([H])O* 0.000 description 6
- 239000000126 substance Substances 0.000 description 6
- 125000000876 trifluoromethoxy group Chemical group FC(F)(F)O* 0.000 description 6
- UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 5
- 239000001257 hydrogen Substances 0.000 description 5
- 125000003161 (C1-C6) alkylene group Chemical group 0.000 description 4
- 239000003814 drug Substances 0.000 description 4
- 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 4
- 229910052757 nitrogen Inorganic materials 0.000 description 4
- 125000004433 nitrogen atom Chemical group N* 0.000 description 4
- 201000010099 disease Diseases 0.000 description 3
- 208000016097 disease of metabolism Diseases 0.000 description 3
- 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 3
- 208000027866 inflammatory disease Diseases 0.000 description 3
- 230000001404 mediated effect Effects 0.000 description 3
- 208000030159 metabolic disease Diseases 0.000 description 3
- 239000008194 pharmaceutical composition Substances 0.000 description 3
- 239000000546 pharmaceutical excipient Substances 0.000 description 3
- 150000003839 salts Chemical class 0.000 description 3
- 239000012453 solvate Substances 0.000 description 3
- 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
- OHDLZTDSTWANIC-UHFFFAOYSA-N C[I]1CCCC1 Chemical compound C[I]1CCCC1 OHDLZTDSTWANIC-UHFFFAOYSA-N 0.000 description 2
- CHOJVEYZTDHFDD-UHFFFAOYSA-N Cc(cc(c(Cl)c1)S(Nc(cc2Cl)cc(Cl)c2Oc2cnc(cccc3)c3c2)(=O)=O)c1Cl Chemical compound Cc(cc(c(Cl)c1)S(Nc(cc2Cl)cc(Cl)c2Oc2cnc(cccc3)c3c2)(=O)=O)c1Cl CHOJVEYZTDHFDD-UHFFFAOYSA-N 0.000 description 2
- YZCKVEUIGOORGS-UHFFFAOYSA-N Hydrogen atom Chemical compound [H] YZCKVEUIGOORGS-UHFFFAOYSA-N 0.000 description 2
- NMRWDFUZLLQSBN-UHFFFAOYSA-N O=S(c(c(Cl)c1)ccc1Cl)(Nc(cc1Cl)cc(Cl)c1Oc1cnc(cccc2)c2c1)=O Chemical compound O=S(c(c(Cl)c1)ccc1Cl)(Nc(cc1Cl)cc(Cl)c1Oc1cnc(cccc2)c2c1)=O NMRWDFUZLLQSBN-UHFFFAOYSA-N 0.000 description 2
- 102000000536 PPAR gamma Human genes 0.000 description 2
- 108010016731 PPAR gamma Proteins 0.000 description 2
- 238000000034 method Methods 0.000 description 2
- 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
- 206010003210 Arteriosclerosis Diseases 0.000 description 1
- 241000282693 Cercopithecidae Species 0.000 description 1
- 208000035150 Hypercholesterolemia Diseases 0.000 description 1
- 241000124008 Mammalia Species 0.000 description 1
- URNHKABEDJIWRH-UHFFFAOYSA-N Nc(cc1Cl)cc(Cl)c1Sc1cc(cccc2)c2nc1 Chemical compound Nc(cc1Cl)cc(Cl)c1Sc1cc(cccc2)c2nc1 URNHKABEDJIWRH-UHFFFAOYSA-N 0.000 description 1
- QWRAHLJXUPOZRK-UHFFFAOYSA-N O=S(c1ccccc1Cl)(Nc(cc1Cl)cc(Cl)c1Sc1cc(cccc2)c2nc1)=O Chemical compound O=S(c1ccccc1Cl)(Nc(cc1Cl)cc(Cl)c1Sc1cc(cccc2)c2nc1)=O QWRAHLJXUPOZRK-UHFFFAOYSA-N 0.000 description 1
- XSPOHQBAMUMLLS-UHFFFAOYSA-N O=Sc(ccc(C(F)(F)F)c1)c1Cl Chemical compound O=Sc(ccc(C(F)(F)F)c1)c1Cl XSPOHQBAMUMLLS-UHFFFAOYSA-N 0.000 description 1
- 208000008589 Obesity Diseases 0.000 description 1
- 125000005237 alkyleneamino group Chemical group 0.000 description 1
- 125000005529 alkyleneoxy group Chemical group 0.000 description 1
- 208000011775 arteriosclerosis disease Diseases 0.000 description 1
- 125000005842 heteroatom Chemical group 0.000 description 1
- 150000002632 lipids Chemical class 0.000 description 1
- 238000004519 manufacturing process Methods 0.000 description 1
- 230000002503 metabolic effect Effects 0.000 description 1
- 125000000896 monocarboxylic acid group Chemical group 0.000 description 1
- 235000020824 obesity Nutrition 0.000 description 1
- 238000007911 parenteral administration Methods 0.000 description 1
- 125000002943 quinolinyl group Chemical group N1=C(C=CC2=CC=CC=C12)* 0.000 description 1
- 206010039073 rheumatoid arthritis Diseases 0.000 description 1
- 238000011200 topical administration Methods 0.000 description 1
Applications Claiming Priority (3)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US14167299P | 1999-06-30 | 1999-06-30 | |
| US60/141,672 | 1999-06-30 | ||
| PCT/US2000/018178 WO2001000579A1 (en) | 1999-06-30 | 2000-06-28 | COMPOUNDS FOR THE MODULATION OF PPARη ACTIVITY |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2003503387A JP2003503387A (ja) | 2003-01-28 |
| JP2003503387A5 true JP2003503387A5 (enExample) | 2006-01-05 |
| JP4295458B2 JP4295458B2 (ja) | 2009-07-15 |
Family
ID=22496697
Family Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2001506989A Expired - Lifetime JP4295458B2 (ja) | 1999-06-30 | 2000-06-28 | Ｐｐａｒ−ガンマ活性調節用化合物 |
Country Status (14)
| Country | Link |
|---|---|
| EP (1) | EP1192137B1 (enExample) |
| JP (1) | JP4295458B2 (enExample) |
| CN (1) | CN1171872C (enExample) |
| CA (1) | CA2377309C (enExample) |
| DK (1) | DK1192137T3 (enExample) |
| EA (1) | EA004887B1 (enExample) |
| ES (1) | ES2437103T3 (enExample) |
| HK (1) | HK1043369B (enExample) |
| IL (2) | IL147308A0 (enExample) |
| MX (2) | MXPA01013199A (enExample) |
| NZ (2) | NZ530833A (enExample) |
| SG (1) | SG148834A1 (enExample) |
| WO (1) | WO2001000579A1 (enExample) |
| ZA (1) | ZA200200057B (enExample) |
Families Citing this family (68)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US6583157B2 (en) | 1998-01-29 | 2003-06-24 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US7041691B1 (en) | 1999-06-30 | 2006-05-09 | Amgen Inc. | Compounds for the modulation of PPARγ activity |
| WO2001082916A2 (en) * | 2000-05-03 | 2001-11-08 | Tularik Inc. | Combination therapeutic compositions and methods of use |
| BRPI0112115B8 (pt) * | 2000-06-28 | 2021-05-25 | Japan Tobacco Inc | compostos moduladores ppar-gamma de quinolinil e benzotiazolil |
| US20030171399A1 (en) | 2000-06-28 | 2003-09-11 | Tularik Inc. | Quinolinyl and benzothiazolyl modulators |
| US6982251B2 (en) | 2000-12-20 | 2006-01-03 | Schering Corporation | Substituted 2-azetidinones useful as hypocholesterolemic agents |
| US7071181B2 (en) | 2001-01-26 | 2006-07-04 | Schering Corporation | Methods and therapeutic combinations for the treatment of diabetes using sterol absorption inhibitors |
| EP1911462A3 (en) | 2001-01-26 | 2011-11-30 | Schering Corporation | Compositions comprising a sterol absorption inhibitor |
| RU2756946C2 (ru) | 2001-01-26 | 2021-10-07 | Мерк Шарп И Доум Корп. | Применение замещенных азетидинонов для лечения ситостеролемии |
| AU2002247019C1 (en) | 2001-01-26 | 2017-05-11 | Organon Llc | Combinations of peroxisome proliferator-activated receptor (PPAR) activator(s) and sterol absorption inhibitor(s) and treatments for vascular indications |
| WO2003004458A1 (en) * | 2001-07-03 | 2003-01-16 | Biovitrum Ab | New compounds |
| SE0102764D0 (sv) | 2001-08-17 | 2001-08-17 | Astrazeneca Ab | Compounds |
| BR0212512A (pt) | 2001-09-14 | 2004-10-26 | Tularik Inc | Composto, composição farmacêutica e métodos para tratar um distúrbio, condição ou doença, elevar os nìveis do colesterol hdl, reduzir os nìveis de triglicerìdeo, tratar diabete, diminuir a resistência à insulina ou diminuir a pressão arterial e modular a ppardelta |
| US7056906B2 (en) | 2001-09-21 | 2006-06-06 | Schering Corporation | Combinations of hormone replacement therapy composition(s) and sterol absorption inhibitor(s) and treatments for vascular conditions in post-menopausal women |
| US7053080B2 (en) | 2001-09-21 | 2006-05-30 | Schering Corporation | Methods and therapeutic combinations for the treatment of obesity using sterol absorption inhibitors |
| DE60216300T2 (de) | 2001-09-21 | 2007-06-28 | Schering Corp. | Behandlung von xanthom mittels azetidinon-derivate als hemmer der sterol absorption |
| EP2402310A1 (en) | 2002-05-24 | 2012-01-04 | Millennium Pharmaceuticals, Inc. | CCR9 inhibitors and methods of use thereof |
| CA2504878A1 (en) | 2002-11-06 | 2004-05-27 | Schering Corporation | Cholesterol absorption inhibitors for the treatment of demyelination |
| US7227035B2 (en) | 2002-11-18 | 2007-06-05 | Chemocentryx | Bis-aryl sulfonamides |
| US7420055B2 (en) | 2002-11-18 | 2008-09-02 | Chemocentryx, Inc. | Aryl sulfonamides |
| US7741519B2 (en) | 2007-04-23 | 2010-06-22 | Chemocentryx, Inc. | Bis-aryl sulfonamides |
| CA2500492C (en) | 2002-11-18 | 2010-03-16 | Solomon Ungashe | Aryl sulfonamides |
| EP1601668B1 (en) | 2003-03-07 | 2008-08-27 | Schering Corporation | Substituted azetidinone compounds, formulations and uses thereof for the treatment of hypercholesterolemia |
| US7459442B2 (en) | 2003-03-07 | 2008-12-02 | Schering Corporation | Substituted azetidinone compounds, processes for preparing the same, formulations and uses thereof |
| MXPA05009502A (es) | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| MXPA05009501A (es) | 2003-03-07 | 2005-10-18 | Schering Corp | Compuestos de azetidinona sustituidos, formulaciones y usos de los mismos para el tratamiento de hipercolesterolemia. |
| CN100447139C (zh) * | 2003-07-08 | 2008-12-31 | 诺瓦提斯公司 | 苯磺酰氨基化合物和含有这些化合物的药物组合物 |
| DE10344223A1 (de) * | 2003-09-24 | 2005-04-21 | Merck Patent Gmbh | 1,3-Benzoxazolylderivate als Kinase-Inhibitoren |
| US7223761B2 (en) | 2003-10-03 | 2007-05-29 | Amgen Inc. | Salts and polymorphs of a potent antidiabetic compound |
| GB0401334D0 (en) | 2004-01-21 | 2004-02-25 | Novartis Ag | Organic compounds |
| EP2305352A1 (en) | 2004-04-02 | 2011-04-06 | Merck Sharp & Dohme Corp. | 5-alpha-reductase inhibitors for use in the treatment of men with metabolic and anthropometric disorders |
| US7544702B2 (en) | 2004-08-12 | 2009-06-09 | Amgen Inc. | Bisaryl-sulfonamides |
| NZ564608A (en) | 2005-07-09 | 2009-09-25 | Astrazeneca Ab | Heteroaryl benzamide derivatives for use as GLK activators in the treatment of diabetes |
| ES2360763T3 (es) * | 2006-09-21 | 2011-06-08 | Piramal Life Sciences Limited | Derivados de piridina para el tratamiento de desórdenes metabólicos relacionados con la resistencia a la insulina o hiperglucemia. |
| NZ576197A (en) | 2006-09-21 | 2011-12-22 | Piramal Life Sciences Ltd | 3 -amino- pyridine derivatives for the treatment of metabolic disorders |
| DK2170930T3 (da) | 2007-06-04 | 2012-11-05 | Synergy Pharmaceuticals Inc | Agonister af guanylatcyclase, anvendelige til behandlingen af gastrointestinale sygdomme, inflammation, cancer og andre sygdomme |
| US8969514B2 (en) | 2007-06-04 | 2015-03-03 | Synergy Pharmaceuticals, Inc. | Agonists of guanylate cyclase useful for the treatment of hypercholesterolemia, atherosclerosis, coronary heart disease, gallstone, obesity and other cardiovascular diseases |
| US8304441B2 (en) | 2007-09-14 | 2012-11-06 | Metabolic Solutions Development Company, Llc | Thiazolidinedione analogues for the treatment of metabolic diseases |
| WO2009038681A1 (en) | 2007-09-14 | 2009-03-26 | Metabolic Solutions Development Company | Thiazolidinedione analogues for the treatment of hypertension |
| EP2328910B1 (en) | 2008-06-04 | 2014-08-06 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase useful for the treatment of gastrointestinal disorders, inflammation, cancer and other disorders |
| ES2624828T3 (es) | 2008-07-16 | 2017-07-17 | Synergy Pharmaceuticals Inc. | Agonistas de la guanilato ciclasa útiles para el tratamiento de trastornos gastrointestinales, inflamación, cáncer y otros |
| US8394969B2 (en) * | 2008-09-26 | 2013-03-12 | Merck Sharp & Dohme Corp. | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| US8410284B2 (en) | 2008-10-22 | 2013-04-02 | Merck Sharp & Dohme Corp | Cyclic benzimidazole derivatives useful as anti-diabetic agents |
| EP2362731B1 (en) | 2008-10-31 | 2016-04-06 | Merck Sharp & Dohme Corp. | Novel cyclic benzimidazole derivatives useful anti-diabetic agents |
| AU2010243353B2 (en) | 2009-04-30 | 2014-09-11 | Astex Therapeutics Limited | Imidazole derivatives and their use as modulators of Cyclin dependent Kinases |
| US20120316138A1 (en) * | 2009-12-15 | 2012-12-13 | Metabolic Solutions Development Company, Llc | Ppar-sparing thiazolidinediones and combinations for the treatment of obesity and other metabolic diseases |
| NZ600390A (en) | 2009-12-15 | 2013-08-30 | Metabolic Solutions Dev Co Llc | Ppar-sparing thiazolidinedione salts for the treatment of metabolic diseases |
| JP2013520502A (ja) | 2010-02-25 | 2013-06-06 | メルク・シャープ・エンド・ドーム・コーポレイション | 有用な抗糖尿病薬である新規な環状ベンズイミダゾール誘導体 |
| US20130156720A1 (en) | 2010-08-27 | 2013-06-20 | Ironwood Pharmaceuticals, Inc. | Compositions and methods for treating or preventing metabolic syndrome and related diseases and disorders |
| US9616097B2 (en) | 2010-09-15 | 2017-04-11 | Synergy Pharmaceuticals, Inc. | Formulations of guanylate cyclase C agonists and methods of use |
| WO2012040082A2 (en) | 2010-09-21 | 2012-03-29 | Intekrin Therapeutics, Inc. | Antidiabetic solid pharmaceutical compositions |
| SG192941A1 (en) | 2011-02-25 | 2013-09-30 | Merck Sharp & Dohme | Novel cyclic azabenzimidazole derivatives useful as anti-diabetic agents |
| WO2013082106A1 (en) | 2011-12-02 | 2013-06-06 | The General Hospital Corporation | Differentiation into brown adipocytes |
| US20130158077A1 (en) | 2011-12-19 | 2013-06-20 | Ares Trading S.A. | Pharmaceutical compositions |
| EP3338776A1 (en) | 2012-05-01 | 2018-06-27 | Translatum Medicus Inc. | Methods for treating and diagnosing blinding eye diseases |
| WO2014022528A1 (en) | 2012-08-02 | 2014-02-06 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| JP2016516004A (ja) | 2013-02-22 | 2016-06-02 | メルク・シャープ・アンド・ドーム・コーポレーションＭｅｒｃｋ Ｓｈａｒｐ ＆ Ｄｏｈｍｅ Ｃｏｒｐ． | 抗糖尿病二環式化合物 |
| EP2970119B1 (en) | 2013-03-14 | 2021-11-03 | Merck Sharp & Dohme Corp. | Novel indole derivatives useful as anti-diabetic agents |
| CA2905438A1 (en) | 2013-03-15 | 2014-09-25 | Synergy Pharmaceuticals Inc. | Agonists of guanylate cyclase and their uses |
| US9486494B2 (en) | 2013-03-15 | 2016-11-08 | Synergy Pharmaceuticals, Inc. | Compositions useful for the treatment of gastrointestinal disorders |
| JP6606491B2 (ja) | 2013-06-05 | 2019-11-13 | シナジー ファーマシューティカルズ インコーポレイテッド | グアニル酸シクラーゼｃの超高純度アゴニスト、その作成および使用方法 |
| WO2015051496A1 (en) | 2013-10-08 | 2015-04-16 | Merck Sharp & Dohme Corp. | Antidiabetic tricyclic compounds |
| WO2016144862A1 (en) | 2015-03-09 | 2016-09-15 | Intekrin Therapeutics, Inc. | Methods for the treatment of nonalcoholic fatty liver disease and/or lipodystrophy |
| JP6902748B2 (ja) * | 2016-09-29 | 2021-07-14 | 雪印種苗株式会社 | 植物成長調整剤 |
| WO2018106518A1 (en) | 2016-12-06 | 2018-06-14 | Merck Sharp & Dohme Corp. | Antidiabetic heterocyclic compounds |
| WO2018118670A1 (en) | 2016-12-20 | 2018-06-28 | Merck Sharp & Dohme Corp. | Antidiabetic spirochroman compounds |
| KR20200036808A (ko) | 2017-04-03 | 2020-04-07 | 코히러스 바이오사이언시스, 인크. | 진행성 핵상 마비 치료를 위한 PPARγ 작용제 |
| CN116693433B (zh) * | 2023-06-02 | 2024-04-16 | 济南悟通生物科技有限公司 | 一种烷基取代苯硫酚的合成方法 |
Family Cites Families (10)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| EP0069585B1 (en) * | 1981-07-06 | 1985-07-03 | EASTMAN KODAK COMPANY (a New Jersey corporation) | Color-forming sulfonamidodiphenylamines, photographic elements containing them and corresponding sulfonimide dyes |
| DE3632329A1 (de) * | 1986-09-24 | 1988-03-31 | Bayer Ag | Substituierte phenylsulfonamide |
| JP3894949B2 (ja) * | 1993-06-30 | 2007-03-22 | ザ、ウェルカム、ファンデーション、リミテッド | 抗アテローム性動脈硬化症ジアリール化合物 |
| TW321649B (enExample) * | 1994-11-12 | 1997-12-01 | Zeneca Ltd | |
| TW438587B (en) * | 1995-06-20 | 2001-06-07 | Takeda Chemical Industries Ltd | A pharmaceutical composition for prophylaxis and treatment of diabetes |
| GB9604242D0 (en) * | 1996-02-28 | 1996-05-01 | Glaxo Wellcome Inc | Chemical compounds |
| JP3243733B2 (ja) * | 1996-08-07 | 2002-01-07 | 雪印乳業株式会社 | 新規イソキノリン誘導体 |
| ZA986732B (en) * | 1997-07-29 | 1999-02-02 | Warner Lambert Co | Irreversible inhibitiors of tyrosine kinases |
| US6284923B1 (en) * | 1997-08-22 | 2001-09-04 | Tularik Inc | Substituted benzene compounds as antiproliferative and cholesterol lowering action |
| US6200995B1 (en) * | 1998-01-29 | 2001-03-13 | Tularik Inc. | PPAR-γ modulators |
-
2000
- 2000-06-28 JP JP2001506989A patent/JP4295458B2/ja not_active Expired - Lifetime
- 2000-06-28 ES ES00946961.0T patent/ES2437103T3/es not_active Expired - Lifetime
- 2000-06-28 CA CA2377309A patent/CA2377309C/en not_active Expired - Lifetime
- 2000-06-28 NZ NZ530833A patent/NZ530833A/en not_active IP Right Cessation
- 2000-06-28 MX MXPA01013199A patent/MXPA01013199A/es active IP Right Grant
- 2000-06-28 IL IL14730800A patent/IL147308A0/xx unknown
- 2000-06-28 HK HK02105143.3A patent/HK1043369B/en unknown
- 2000-06-28 SG SG200403480-7A patent/SG148834A1/en unknown
- 2000-06-28 WO PCT/US2000/018178 patent/WO2001000579A1/en not_active Ceased
- 2000-06-28 EP EP00946961.0A patent/EP1192137B1/en not_active Expired - Lifetime
- 2000-06-28 EA EA200200105A patent/EA004887B1/ru not_active IP Right Cessation
- 2000-06-28 NZ NZ516455A patent/NZ516455A/xx not_active IP Right Cessation
- 2000-06-28 CN CNB008113076A patent/CN1171872C/zh not_active Expired - Lifetime
- 2000-06-28 DK DK00946961.0T patent/DK1192137T3/da active
-
2001
- 2001-12-18 MX MX2011005852A patent/MX339420B/es unknown
- 2001-12-25 IL IL147308A patent/IL147308A/en active IP Right Grant
-
2002
- 2002-01-03 ZA ZA200200057A patent/ZA200200057B/en unknown
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