JP2004501905A5 - - Google Patents

Info

Publication number

JP2004501905A5

JP2004501905A5 JP2002505381A JP2002505381A JP2004501905A5 JP 2004501905 A5 JP2004501905 A5 JP 2004501905A5 JP 2002505381 A JP2002505381 A JP 2002505381A JP 2002505381 A JP2002505381 A JP 2002505381A JP 2004501905 A5 JP2004501905 A5 JP 2004501905A5

Authority

JP

Japan

Prior art keywords

alkyl

group

aryl

halogen

use according

Prior art date

2001-06-27

Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)

Granted

Links

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• 125000004209 (C1-C8) alkyl group Chemical group 0.000 description 13
• 150000001875 compounds Chemical class 0.000 description 13
• 229910052736 halogen Inorganic materials 0.000 description 10
• 150000002367 halogens Chemical class 0.000 description 10
• 125000004093 cyano group Chemical group *C#N 0.000 description 8
• 125000003545 alkoxy group Chemical group 0.000 description 7
• 125000000217 alkyl group Chemical group 0.000 description 7
• 125000003118 aryl group Chemical group 0.000 description 7
• 125000004435 hydrogen atom Chemical group [H]* 0.000 description 7
• 125000004404 heteroalkyl group Chemical group 0.000 description 5
• 239000000126 substance Substances 0.000 description 5
• 208000016097 disease of metabolism Diseases 0.000 description 4
• 208000030159 metabolic disease Diseases 0.000 description 4
• 229910052757 nitrogen Inorganic materials 0.000 description 4
• 125000004433 nitrogen atom Chemical group N* 0.000 description 4
• UFHFLCQGNIYNRP-UHFFFAOYSA-N Hydrogen Chemical compound [H][H] UFHFLCQGNIYNRP-UHFFFAOYSA-N 0.000 description 3
• 229910052739 hydrogen Inorganic materials 0.000 description 3
• 239000001257 hydrogen Substances 0.000 description 3
• 208000027866 inflammatory disease Diseases 0.000 description 3
• 125000004169 (C1-C6) alkyl group Chemical group 0.000 description 2
• -1 2-benzothiazolyl Chemical group 0.000 description 2
• 102000000536 PPAR gamma Human genes 0.000 description 2
• 108010016731 PPAR gamma Proteins 0.000 description 2
• NOESYZHRGYRDHS-UHFFFAOYSA-N insulin Chemical compound N1C(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(NC(=O)CN)C(C)CC)CSSCC(C(NC(CO)C(=O)NC(CC(C)C)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CCC(N)=O)C(=O)NC(CC(C)C)C(=O)NC(CCC(O)=O)C(=O)NC(CC(N)=O)C(=O)NC(CC=2C=CC(O)=CC=2)C(=O)NC(CSSCC(NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2C=CC(O)=CC=2)NC(=O)C(CC(C)C)NC(=O)C(C)NC(=O)C(CCC(O)=O)NC(=O)C(C(C)C)NC(=O)C(CC(C)C)NC(=O)C(CC=2NC=NC=2)NC(=O)C(CO)NC(=O)CNC2=O)C(=O)NCC(=O)NC(CCC(O)=O)C(=O)NC(CCCNC(N)=N)C(=O)NCC(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC=CC=3)C(=O)NC(CC=3C=CC(O)=CC=3)C(=O)NC(C(C)O)C(=O)N3C(CCC3)C(=O)NC(CCCCN)C(=O)NC(C)C(O)=O)C(=O)NC(CC(N)=O)C(O)=O)=O)NC(=O)C(C(C)CC)NC(=O)C(CO)NC(=O)C(C(C)O)NC(=O)C1CSSCC2NC(=O)C(CC(C)C)NC(=O)C(NC(=O)C(CCC(N)=O)NC(=O)C(CC(N)=O)NC(=O)C(NC(=O)C(N)CC=1C=CC=CC=1)C(C)C)CC1=CN=CN1 NOESYZHRGYRDHS-UHFFFAOYSA-N 0.000 description 2
• 230000001404 mediated effect Effects 0.000 description 2
• 125000000449 nitro group Chemical group [O-][N+](*)=O 0.000 description 2
• 125000001997 phenyl group Chemical group [H]C1=C([H])C([H])=C(*)C([H])=C1[H] 0.000 description 2
• 208000001072 type 2 diabetes mellitus Diseases 0.000 description 2
• 125000004178 (C1-C4) alkyl group Chemical group 0.000 description 1
• 125000000229 (C1-C4)alkoxy group Chemical group 0.000 description 1
• 0 **c1cc(*)c(*[Al]I)c(*)c1 Chemical compound **c1cc(*)c(*[Al]I)c(*)c1 0.000 description 1
• 201000001320 Atherosclerosis Diseases 0.000 description 1
• 241000282472 Canis lupus familiaris Species 0.000 description 1
• 208000032928 Dyslipidaemia Diseases 0.000 description 1
• 241000283086 Equidae Species 0.000 description 1
• 241000282326 Felis catus Species 0.000 description 1
• 241000282412 Homo Species 0.000 description 1
• 208000035150 Hypercholesterolemia Diseases 0.000 description 1
• 206010060378 Hyperinsulinaemia Diseases 0.000 description 1
• 208000031226 Hyperlipidaemia Diseases 0.000 description 1
• 102000004877 Insulin Human genes 0.000 description 1
• 108090001061 Insulin Proteins 0.000 description 1
• 206010022489 Insulin Resistance Diseases 0.000 description 1
• 208000017170 Lipid metabolism disease Diseases 0.000 description 1
• 241000699670 Mus sp. Species 0.000 description 1
• 208000008589 Obesity Diseases 0.000 description 1
• 241000288906 Primates Species 0.000 description 1
• 241000700159 Rattus Species 0.000 description 1
• 206010012601 diabetes mellitus Diseases 0.000 description 1
• 201000010099 disease Diseases 0.000 description 1
• 208000037265 diseases, disorders, signs and symptoms Diseases 0.000 description 1
• 239000003814 drug Substances 0.000 description 1
• 201000001421 hyperglycemia Diseases 0.000 description 1
• 230000003451 hyperinsulinaemic effect Effects 0.000 description 1
• 201000008980 hyperinsulinism Diseases 0.000 description 1
• 208000006575 hypertriglyceridemia Diseases 0.000 description 1
• 229940125396 insulin Drugs 0.000 description 1
• 238000004519 manufacturing process Methods 0.000 description 1
• 230000002503 metabolic effect Effects 0.000 description 1
• 235000020824 obesity Nutrition 0.000 description 1
• 238000007911 parenteral administration Methods 0.000 description 1
• 239000008194 pharmaceutical composition Substances 0.000 description 1
• 239000000546 pharmaceutical excipient Substances 0.000 description 1
• 206010039073 rheumatoid arthritis Diseases 0.000 description 1
• 150000003839 salts Chemical class 0.000 description 1
• 239000012453 solvate Substances 0.000 description 1
• 125000001424 substituent group Chemical group 0.000 description 1
• 238000011200 topical administration Methods 0.000 description 1