JP2006528643A5 - - Google Patents

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Publication number
JP2006528643A5
JP2006528643A5 JP2006521295A JP2006521295A JP2006528643A5 JP 2006528643 A5 JP2006528643 A5 JP 2006528643A5 JP 2006521295 A JP2006521295 A JP 2006521295A JP 2006521295 A JP2006521295 A JP 2006521295A JP 2006528643 A5 JP2006528643 A5 JP 2006528643A5
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halo
membered
alkyl
alkenyl
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JP2006521295A
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JP4521777B2 (ja
JP2006528643A (ja
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Priority claimed from PCT/US2004/023914 external-priority patent/WO2005009988A1/en
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Publication of JP2006528643A5 publication Critical patent/JP2006528643A5/ja
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Publication of JP4521777B2 publication Critical patent/JP4521777B2/ja
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JP2006521295A 2003-07-24 2004-07-23 疼痛治療または予防に有用な４−ヘテロアリール−テトラヒドロピペリジル化合物 Expired - Fee Related JP4521777B2 (ja)

Applications Claiming Priority (2)

Application Number Priority Date Filing Date Title
US48951603P 2003-07-24 2003-07-24
PCT/US2004/023914 WO2005009988A1 (en) 2003-07-24 2004-07-23 Heteroaryl-tetrahydropiperidyl compounds useful for treating or preventing pain

Publications (3)

Publication Number Publication Date
JP2006528643A JP2006528643A (ja) 2006-12-21
JP2006528643A5 true JP2006528643A5 (enExample) 2008-03-06
JP4521777B2 JP4521777B2 (ja) 2010-08-11

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JP2006521295A Expired - Fee Related JP4521777B2 (ja) 2003-07-24 2004-07-23 疼痛治療または予防に有用な４−ヘテロアリール−テトラヒドロピペリジル化合物

Country Status (28)

Country Link
US (4) US7776861B2 (enExample)
EP (2) EP1648879B1 (enExample)
JP (1) JP4521777B2 (enExample)
KR (2) KR100896499B1 (enExample)
CN (3) CN101935315A (enExample)
AT (2) ATE431822T1 (enExample)
AU (1) AU2004259358B2 (enExample)
BR (1) BRPI0412248B1 (enExample)
CA (1) CA2533515C (enExample)
CY (1) CY1109318T1 (enExample)
DE (2) DE602004021206D1 (enExample)
DK (2) DK1648879T3 (enExample)
EA (1) EA009480B1 (enExample)
EG (1) EG25185A (enExample)
ES (1) ES2327684T3 (enExample)
GE (1) GEP20094675B (enExample)
HR (1) HRP20090442T1 (enExample)
IL (2) IL173344A (enExample)
IS (1) IS2593B (enExample)
MA (1) MA27948A1 (enExample)
MX (1) MXPA06000940A (enExample)
NO (1) NO331675B1 (enExample)
NZ (1) NZ544009A (enExample)
PT (1) PT1867644E (enExample)
SI (1) SI1867644T1 (enExample)
UA (1) UA83855C2 (enExample)
WO (1) WO2005009988A1 (enExample)
ZA (1) ZA200509997B (enExample)

Families Citing this family (38)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
DE60234812D1 (de) 2001-01-29 2010-02-04 Shionogi & Co Arzneipräparat, das als wirkstoff 5-methyl-1-phenyl-2-(1h)-pyridon enthält
US7157462B2 (en) * 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
MY142655A (en) * 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
SI1867644T1 (sl) 2003-07-24 2009-10-31 Euro Celtique Sa Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine
PL1867644T3 (pl) 2003-07-24 2009-10-30 Euro Celtique Sa Związki heteroarylo-tetrahydropiperydylowe przydatne w leczeniu lub zapobieganiu bólu
GB0510141D0 (en) * 2005-05-18 2005-06-22 Addex Pharmaceuticals Sa Novel compounds B3
US8315162B2 (en) 2006-08-24 2012-11-20 Research In Motion Limited System and method for determining that a maximum number of IP sessions have been established
US20080051380A1 (en) 2006-08-25 2008-02-28 Auerbach Alan H Methods and compositions for treating cancer
CA2685121A1 (en) * 2007-04-27 2008-11-06 Purdue Pharma L.P. Therapeutic agents useful for treating pain
DK2142529T3 (da) 2007-04-27 2014-02-10 Purdue Pharma Lp Trpv1-antagonister og anvendelser deraf
AU2011226773C1 (en) * 2007-04-27 2012-07-26 Purdue Pharma L.P. TRPV1 antagonists and uses thereof
US8759362B2 (en) * 2008-10-24 2014-06-24 Purdue Pharma L.P. Bicycloheteroaryl compounds and their use as TRPV1 ligands
US8703962B2 (en) * 2008-10-24 2014-04-22 Purdue Pharma L.P. Monocyclic compounds and their use as TRPV1 ligands
JP5876423B2 (ja) * 2010-06-22 2016-03-02 塩野義製薬株式会社 Ｔｒｐｖ１阻害活性を有する化合物とその使用
EP2606033A1 (de) * 2010-08-20 2013-06-26 Grünenthal GmbH Substituierte cyclische carboxamid- und harnstoff-derivate als liganden des vanilloid-rezeptors
AR084457A1 (es) 2010-12-22 2013-05-15 Lundbeck & Co As H Derivados de biciclo[3,2,1]octilamida
EP2709609B1 (en) * 2011-05-17 2017-10-04 Shionogi & Co., Ltd. Heterocyclic compounds
SG10201605163PA (en) 2011-06-22 2016-08-30 Purdue Pharma Lp Trpv1 antagonists including dihydroxy substituent and uses thereof
WO2013021276A1 (en) 2011-08-10 2013-02-14 Purdue Pharma L.P. Trpv1 antagonists including dihydroxy substituent and uses thereof
US8924211B2 (en) * 2012-07-09 2014-12-30 Nuance Communications, Inc. Detecting potential significant errors in speech recognition results
US9064492B2 (en) 2012-07-09 2015-06-23 Nuance Communications, Inc. Detecting potential significant errors in speech recognition results
US20160213659A1 (en) 2013-09-24 2016-07-28 George Sylvestre Treatment of burn pain by trpv1 modulators
WO2015148271A1 (en) * 2014-03-26 2015-10-01 Vivid Pharma, Inc. Compositions for treating or preventing alcohol-induced symptoms
US10668041B2 (en) 2014-12-08 2020-06-02 Societe Des Produits Nestle Sa Compositions and methods comprising medium chain triglycerides for treatment of epilepsy
RU2712942C2 (ru) * 2014-12-08 2020-02-03 Сосьете Де Продюи Нестле С.А. Композиции и способы, включающие триглицериды со средней длиной цепи, для лечения эпилепсии
WO2017007755A1 (en) 2015-07-06 2017-01-12 Rodin Therapeutics, Inc. Heterobicyclic n-aminophenyl-amides as inhibitors of histone deacetylase
LT3319959T (lt) 2015-07-06 2021-12-27 Alkermes, Inc. Histono deacetilazės hetero-halogeno inhibitoriai
US9943513B1 (en) 2015-10-07 2018-04-17 Banner Life Sciences Llc Opioid abuse deterrent dosage forms
CA2937365C (en) 2016-03-29 2018-09-18 F. Hoffmann-La Roche Ag Granulate formulation of 5-methyl-1-phenyl-2-(1h)-pyridone and method of making the same
US10335405B1 (en) 2016-05-04 2019-07-02 Patheon Softgels, Inc. Non-burst releasing pharmaceutical composition
WO2017202376A1 (zh) * 2016-05-26 2017-11-30 南京明德新药研发股份有限公司 磺酰胺衍生物
MX2019001224A (es) 2016-07-29 2019-06-03 Janssen Pharmaceutica Nv Metodos para tratar el cancer de prostata.
US10793567B2 (en) 2017-01-11 2020-10-06 Rodin Therapeutics, Inc. Bicyclic inhibitors of histone deacetylase
US10335375B2 (en) 2017-05-30 2019-07-02 Patheon Softgels, Inc. Anti-overingestion abuse deterrent compositions
GB201709459D0 (en) * 2017-06-14 2017-07-26 Intrabio Ltd Treatment for migraine
EA039417B1 (ru) 2017-08-07 2022-01-25 Родин Терапеутикс, Инк. Бициклические ингибиторы гистондеацетилазы
DE102022104759A1 (de) 2022-02-28 2023-08-31 SCi Kontor GmbH Co-Kristall-Screening Verfahren, insbesondere zur Herstellung von Co-Kristallen
WO2024095962A1 (ja) 2022-10-31 2024-05-10 塩野義製薬株式会社 Ｔｒｐｖ１アンタゴニストであるピリジン誘導体の使用

Family Cites Families (85)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
US3536809A (en) * 1969-02-17 1970-10-27 Alza Corp Medication method
US3598123A (en) * 1969-04-01 1971-08-10 Alza Corp Bandage for administering drugs
BE757436A (fr) * 1969-10-27 1971-03-16 Robins Co Inc A H 1-carbamoyl-4-phenyl-piperidines et -tetrahydropyridines, leur procede de preparation et leurs applications comme anticonvulsivants et relaxants musculaires
US3845770A (en) * 1972-06-05 1974-11-05 Alza Corp Osmatic dispensing device for releasing beneficial agent
US3916899A (en) * 1973-04-25 1975-11-04 Alza Corp Osmotic dispensing device with maximum and minimum sizes for the passageway
US4008719A (en) * 1976-02-02 1977-02-22 Alza Corporation Osmotic system having laminar arrangement for programming delivery of active agent
IE58110B1 (en) * 1984-10-30 1993-07-14 Elan Corp Plc Controlled release powder and process for its preparation
DE3440141A1 (de) 1984-11-02 1986-05-07 Heiner Dipl.-Chem. Dr. 8000 München Eckert Verwendung von kohlensaeure-bis-trichlormethylester als proreagens fuer phosgen
JPH0680054B2 (ja) 1985-06-19 1994-10-12 吉富製薬株式会社 ピペリジン誘導体
US5316759A (en) * 1986-03-17 1994-05-31 Robert J. Schaap Agonist-antagonist combination to reduce the use of nicotine and other drugs
US4797419A (en) * 1986-11-03 1989-01-10 Warner-Lambert Company Method of treating the symptoms of senile cognitive decline employing di- or trisubstituted urea cholinergic agents
DE3822792C2 (de) * 1987-07-11 1997-11-27 Sandoz Ag Neue Verwendung von 5HT¶3¶-Antagonisten
US5198459A (en) * 1987-07-11 1993-03-30 Sandoz Ltd. Use of 5HT-3 antagonists in preventing or reducing dependency on dependency-inducing agents
US5506191A (en) * 1987-11-02 1996-04-09 Sandoz Ltd. Heterocyclic hydrazines and hydrazones
US5073543A (en) * 1988-07-21 1991-12-17 G. D. Searle & Co. Controlled release formulations of trophic factors in ganglioside-lipsome vehicle
IT1229203B (it) * 1989-03-22 1991-07-25 Bioresearch Spa Impiego di acido 5 metiltetraidrofolico, di acido 5 formiltetraidrofolico e dei loro sali farmaceuticamente accettabili per la preparazione di composizioni farmaceutiche in forma a rilascio controllato attive nella terapia dei disturbi mentali organici e composizioni farmaceutiche relative.
US5120548A (en) * 1989-11-07 1992-06-09 Merck & Co., Inc. Swelling modulated polymeric drug delivery device
US5075341A (en) * 1989-12-01 1991-12-24 The Mclean Hospital Corporation Treatment for cocaine abuse
US5733566A (en) * 1990-05-15 1998-03-31 Alkermes Controlled Therapeutics Inc. Ii Controlled release of antiparasitic agents in animals
US5698155A (en) * 1991-05-31 1997-12-16 Gs Technologies, Inc. Method for the manufacture of pharmaceutical cellulose capsules
US6204284B1 (en) * 1991-12-20 2001-03-20 American Cyanamid Company Use of 1-(substitutedphenyl)-3-azabicyclo[3.1.0]hexanes for the treatment of chemical dependencies
US5580578A (en) * 1992-01-27 1996-12-03 Euro-Celtique, S.A. Controlled release formulations coated with aqueous dispersions of acrylic polymers
US5232934A (en) * 1992-07-17 1993-08-03 Warner-Lambert Co. Method for the treatment of psychomotor stimulant addiction
DE4234295A1 (de) * 1992-10-12 1994-04-14 Thomae Gmbh Dr K Carbonsäurederivate, diese Verbindungen enthaltende Arzneimittel und Verfahren zu ihrer Herstellung
US5591767A (en) * 1993-01-25 1997-01-07 Pharmetrix Corporation Liquid reservoir transdermal patch for the administration of ketorolac
US5321012A (en) * 1993-01-28 1994-06-14 Virginia Commonwealth University Medical College Inhibiting the development of tolerance to and/or dependence on a narcotic addictive substance
IT1270594B (it) * 1994-07-07 1997-05-07 Recordati Chem Pharm Composizione farmaceutica a rilascio controllato di moguisteina in sospensione liquida
US5556837A (en) * 1994-08-01 1996-09-17 Regeneron Pharmaceuticals Inc. Methods for treating addictive disorders
US5762925A (en) * 1994-11-03 1998-06-09 Sagen; Jacqueline Preventing opiate tolerance by cellular implantation
ATE301457T1 (de) * 1995-06-12 2005-08-15 Searle & Co Mittel, enthaltend einen cyclooxygenase-2 inhibitor und einen 5-lipoxygenase inhibitor
TR199800409T1 (xx) * 1995-09-07 1998-05-21 F.Hoffmann-La Roche Ag Kalp ve b�brek yetersizli�inin tedavii�in yeni 4-(oksialkoksifenil)-3-oksi-piperidinler
FR2740134B1 (fr) 1995-10-18 1998-01-09 Pf Medicament Derives d'amines cycliques d'aryl-piperazines, leur preparation et les compositions pharmaceutiques les contenant
FR2744448B1 (fr) * 1996-02-02 1998-04-24 Pf Medicament Nouvelles piperidines derivees d'aryl piperazine, ainsi que leur procede de preparation, les compositions pharmaceutiques et leur utilisation comme medicaments
CA2274593A1 (en) * 1996-12-13 1998-06-18 Banyu Pharmaceutical Co., Ltd. Novel aminopyrazole derivatives
FR2758328B1 (fr) * 1997-01-15 1999-04-02 Pf Medicament Nouvelles amines aromatiques derivees d'amines cycliques utiles comme medicaments
EP1009804B1 (en) * 1997-08-20 2003-10-29 The Regents of the University of California Nucleic acid sequences encoding capsaicin receptor and capsaicin receptor-related polypeptides and uses thereof
EP0943683A1 (en) * 1998-03-10 1999-09-22 Smithkline Beecham Plc Human vanilloid receptor homologue Vanilrep1
JP2002518386A (ja) 1998-06-19 2002-06-25 イーライ・リリー・アンド・カンパニー ヘテロアリール化合物の製造
ES2151828B1 (es) * 1998-07-10 2001-08-16 Esteve Labor Dr Empleo de derivados de tetrahidropiridinas (ohidroxi-piperidinas)-b utilazoles en la elaboracion de un medicamento para el tratamiento del dolor.
US6673799B1 (en) 1998-09-22 2004-01-06 Yamanouchi Pharmaceutical Co. Ltd. Cyanophenyl derivative
SE9803773D0 (sv) 1998-11-05 1998-11-05 Astra Pharma Prod Compounds
DE69907963T2 (de) 1998-12-23 2004-05-19 Eli Lilly And Co., Indianapolis Heteroaromatische amide als inhibitoren von faktor xa
JP2002535256A (ja) 1999-01-25 2002-10-22 スミスクライン・ビーチャム・コーポレイション 化合物および方法
GB9907097D0 (en) * 1999-03-26 1999-05-19 Novartis Ag Organic compounds
EP1183238A1 (en) * 1999-05-17 2002-03-06 Eli Lilly And Company Metabotropic glutamate receptor antagonists
AU7514700A (en) * 1999-09-07 2001-04-10 Syngenta Participations Ag Cyanopiperidines
EP1272187B1 (de) * 2000-03-27 2008-07-30 Abbott GmbH & Co. KG Dopamin-d3-rezeptor-liganden zur behandlung von sucht
CA2407149C (en) * 2000-04-28 2010-10-12 Takeda Chemical Industries, Ltd. Melanin-concentrating hormone antagonist
AU5741301A (en) 2000-05-22 2001-12-03 Aventis Pharm Prod Inc Arylmethylamine derivatives for use as tryptase inhibitors
CZ2003182A3 (cs) * 2000-06-21 2003-06-18 F. Hoffmann-La Roche Ag Deriváty benzothiazolu
AU2001280599A1 (en) 2000-07-15 2002-01-30 Smith Kline Beecham Corporation Compounds and methods
AU8066701A (en) 2000-07-20 2002-02-05 Neurogen Corp Capsaicin receptor ligands
US20040259912A1 (en) * 2001-09-28 2004-12-23 Takahiro Matsumoto Benzine derivatives, process for preparing the same and use thereof
EP1458385A4 (en) * 2001-12-19 2005-12-21 Merck & Co Inc METABOTROPIC GLUTAMATE RECEPTOR 5-HETEROARYL-SUBSTITUTED IMIDAZOLE MODULATORS
US7390813B1 (en) * 2001-12-21 2008-06-24 Xenon Pharmaceuticals Inc. Pyridylpiperazines and aminonicotinamides and their use as therapeutic agents
EP2033951A3 (en) * 2002-02-01 2009-12-23 Euro-Celtique S.A. 2-Piperazine-pyridines useful for treating pain
WO2003068749A1 (en) 2002-02-15 2003-08-21 Glaxo Group Limited Vanilloid receptor modulators
US6974818B2 (en) 2002-03-01 2005-12-13 Euro-Celtique S.A. 1,2,5-thiadiazol-3-YL-piperazine therapeutic agents useful for treating pain
GB0209715D0 (en) * 2002-04-27 2002-06-05 Astrazeneca Ab Chemical compounds
US20030232836A1 (en) * 2002-05-23 2003-12-18 Stewart Andrew O. Acetamides and benzamides that are useful in treating sexual dysfunction
WO2003099266A2 (en) * 2002-05-23 2003-12-04 Abbott Laboratories Acetamides and benzamides that are useful in treating sexual dysfunction
EP2508204B1 (en) 2002-06-26 2014-09-24 Ono Pharmaceutical Co., Ltd. Remedies for diseases caused by vascular contraction or dilation
IL165862A0 (en) * 2002-06-28 2006-01-15 Euro Celtique Sa Therapeutic piperazine derivatives useful for tre ating pain
US7262194B2 (en) 2002-07-26 2007-08-28 Euro-Celtique S.A. Therapeutic agents useful for treating pain
US7157462B2 (en) 2002-09-24 2007-01-02 Euro-Celtique S.A. Therapeutic agents useful for treating pain
DE10252666A1 (de) * 2002-11-11 2004-08-05 Grünenthal GmbH N-Piperidyl-cyclohexan-Derivate
US7582635B2 (en) * 2002-12-24 2009-09-01 Purdue Pharma, L.P. Therapeutic agents useful for treating pain
US7223788B2 (en) * 2003-02-14 2007-05-29 Sanofi-Aventis Deutschland Gmbh Substituted N-aryl heterocycles, process for their preparation and their use as medicaments
DE10306250A1 (de) * 2003-02-14 2004-09-09 Aventis Pharma Deutschland Gmbh Substituierte N-Arylheterozyklen, Verfahren zu ihrer Herstellung und ihre Verwendung als Arzneimittel
WO2004080411A2 (en) * 2003-03-07 2004-09-23 Neurocrine Biosciences, Inc. Melanin-concentrating hormone receptor antagonists and compositions and methods related thereto
DE10311065A1 (de) * 2003-03-13 2004-09-23 Abbott Gmbh & Co. Kg Pyrimidin-2-on-Verbindungen und ihre therapeutische Verwendung
CN1780836A (zh) 2003-04-28 2006-05-31 埃科特莱茵药品有限公司 作为血管紧张肽原酶抑制剂的新型二氮杂双环壬烯和四氢吡啶衍生物
ATE556067T1 (de) * 2003-05-20 2012-05-15 Ajinomoto Kk Modulatoren des vanilloid rezeptors
MY142655A (en) 2003-06-12 2010-12-15 Euro Celtique Sa Therapeutic agents useful for treating pain
US7129235B2 (en) * 2003-07-11 2006-10-31 Abbott Laboratories Amides useful for treating pain
US20050009841A1 (en) * 2003-07-11 2005-01-13 Zheng Guo Zhu Novel amides useful for treating pain
SI1867644T1 (sl) * 2003-07-24 2009-10-31 Euro Celtique Sa Heteroaril-tetrahidropiperidilne spojine, koristne za zdravljenje ali preprečevanje bolečine
UA84710C2 (ru) 2003-07-24 2008-11-25 Евро-Селтик С.А. Пиперидиновые производные, фармацевтическая композиция, которая их содержит, и способ лечения
SG145695A1 (en) * 2003-07-29 2008-09-29 Xenon Pharmaceuticals Inc Pyridyl derivatives and their use as therapeutic agents
KR20060037409A (ko) * 2003-07-30 2006-05-03 제논 파마슈티칼스 인크. 피페라진 유도체 및 그의 치료제로서의 용도
BRPI0412343A (pt) * 2003-07-30 2006-09-05 Xenon Pharmaceuticals Inc derivados de piridazina e seu uso como agentes terapêuticos
WO2005012287A1 (en) 2003-08-01 2005-02-10 Euro-Celtique S.A. Therapeutic agents useful for treating pain
EP2017276B1 (en) * 2003-09-22 2011-01-19 Euro-Celtique S.A. Phenyl-carboxamide compounds useful for treating pain
US20050130974A1 (en) * 2003-10-17 2005-06-16 Rigel Pharmaceuticals, Inc. Benzothiazole compositions and their use as ubiquitin ligase inhibitors
EP1684694A2 (en) * 2003-11-21 2006-08-02 Array Biopharma, Inc. Akt protein kinase inhibitors

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