JP2010513478A5 - - Google Patents
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- Publication number
- JP2010513478A5 JP2010513478A5 JP2009542710A JP2009542710A JP2010513478A5 JP 2010513478 A5 JP2010513478 A5 JP 2010513478A5 JP 2009542710 A JP2009542710 A JP 2009542710A JP 2009542710 A JP2009542710 A JP 2009542710A JP 2010513478 A5 JP2010513478 A5 JP 2010513478A5
- Authority
- JP
- Japan
- Prior art keywords
- pharmaceutically acceptable
- acceptable salt
- compound
- indazol
- copd
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 150000001875 compounds Chemical class 0.000 claims 3
- 150000003839 salts Chemical class 0.000 claims 3
- DLFVBJFMPXGRIB-UHFFFAOYSA-N Acetamide Chemical group CC(N)=O DLFVBJFMPXGRIB-UHFFFAOYSA-N 0.000 claims 2
- 125000004207 3-methoxyphenyl group Chemical group [H]C1=C([H])C(*)=C([H])C(OC([H])([H])[H])=C1[H] 0.000 claims 1
- 125000001255 4-fluorophenyl group Chemical group [H]C1=C([H])C(*)=C([H])C([H])=C1F 0.000 claims 1
- 239000002671 adjuvant Substances 0.000 claims 1
- 208000006673 asthma Diseases 0.000 claims 1
- 239000003085 diluting agent Substances 0.000 claims 1
- 239000003814 drug Substances 0.000 claims 1
- 125000004537 indazol-5-yl group Chemical group N1N=CC2=CC(=CC=C12)* 0.000 claims 1
- 230000004968 inflammatory condition Effects 0.000 claims 1
- 125000001449 isopropyl group Chemical group [H]C([H])([H])C([H])(*)C([H])([H])[H] 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 239000008194 pharmaceutical composition Substances 0.000 claims 1
Applications Claiming Priority (7)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US87118406P | 2006-12-21 | 2006-12-21 | |
| US60/871,184 | 2006-12-21 | ||
| US94174507P | 2007-06-04 | 2007-06-04 | |
| US60/941,745 | 2007-06-04 | ||
| US97852607P | 2007-10-09 | 2007-10-09 | |
| US60/978,526 | 2007-10-09 | ||
| PCT/SE2007/001136 WO2008076048A1 (en) | 2006-12-21 | 2007-12-20 | Indazolyl ester and amide derivatives for the treatment of glucocorticoid receptor mediated disorders |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012184346A Division JP2012224647A (ja) | 2006-12-21 | 2012-08-23 | グルココルチコイド受容体介在障害の処置のためのインダゾリルエステルおよびアミド誘導体 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2010513478A JP2010513478A (ja) | 2010-04-30 |
| JP2010513478A5 true JP2010513478A5 (OSRAM) | 2012-10-11 |
| JP5119267B2 JP5119267B2 (ja) | 2013-01-16 |
Family
ID=39536557
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2009542710A Expired - Fee Related JP5119267B2 (ja) | 2006-12-21 | 2007-12-20 | グルココルチコイド受容体介在障害の処置のためのインダゾリルエステルおよびアミド誘導体 |
| JP2012184346A Pending JP2012224647A (ja) | 2006-12-21 | 2012-08-23 | グルココルチコイド受容体介在障害の処置のためのインダゾリルエステルおよびアミド誘導体 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2012184346A Pending JP2012224647A (ja) | 2006-12-21 | 2012-08-23 | グルココルチコイド受容体介在障害の処置のためのインダゾリルエステルおよびアミド誘導体 |
Country Status (36)
| Country | Link |
|---|---|
| US (4) | US7728030B2 (OSRAM) |
| EP (1) | EP2102169B1 (OSRAM) |
| JP (2) | JP5119267B2 (OSRAM) |
| KR (1) | KR20090091354A (OSRAM) |
| CN (1) | CN101611015B (OSRAM) |
| AR (1) | AR064505A1 (OSRAM) |
| AU (1) | AU2007334659B2 (OSRAM) |
| CA (1) | CA2673277A1 (OSRAM) |
| CL (1) | CL2007003804A1 (OSRAM) |
| CR (1) | CR10875A (OSRAM) |
| CY (1) | CY1113269T1 (OSRAM) |
| DK (1) | DK2102169T3 (OSRAM) |
| DO (1) | DOP2009000148A (OSRAM) |
| EA (1) | EA016895B1 (OSRAM) |
| EC (1) | ECSP099452A (OSRAM) |
| ES (1) | ES2387584T3 (OSRAM) |
| GT (1) | GT200900175A (OSRAM) |
| HR (1) | HRP20120656T1 (OSRAM) |
| IL (1) | IL198880A (OSRAM) |
| JO (1) | JO2754B1 (OSRAM) |
| MA (1) | MA31087B1 (OSRAM) |
| MX (1) | MX2009006540A (OSRAM) |
| MY (1) | MY153270A (OSRAM) |
| NO (1) | NO20092723L (OSRAM) |
| NZ (1) | NZ577186A (OSRAM) |
| PE (1) | PE20081838A1 (OSRAM) |
| PL (1) | PL2102169T3 (OSRAM) |
| PT (1) | PT2102169E (OSRAM) |
| RS (1) | RS52411B (OSRAM) |
| SA (1) | SA07280740B1 (OSRAM) |
| SV (1) | SV2009003305A (OSRAM) |
| TN (1) | TN2009000250A1 (OSRAM) |
| TW (1) | TWI417094B (OSRAM) |
| UY (1) | UY30824A1 (OSRAM) |
| WO (1) | WO2008076048A1 (OSRAM) |
| ZA (1) | ZA200903654B (OSRAM) |
Families Citing this family (43)
| Publication number | Priority date | Publication date | Assignee | Title |
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| JPH081035Y2 (ja) | 1993-06-30 | 1996-01-17 | 伸夫 高橋 | 家庭用雑排水の処理装置 |
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| TW200829578A (en) | 2006-11-23 | 2008-07-16 | Astrazeneca Ab | Chemical compounds 537 |
| JO2754B1 (en) * | 2006-12-21 | 2014-03-15 | استرازينكا ايه بي | Amylendazoleil derivatives for the treatment of glucocorticoid-mediated disorders |
| WO2009142568A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Combination of (a) glucocorticoid receptor modulator and (b) a b2-agonist |
| TW200951114A (en) * | 2008-05-20 | 2009-12-16 | Astrazeneca Ab | Phenyl or pyridinyl substituted indazoles derivatives |
| WO2009142588A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Combination of (a) a chemokine receptor 1 (ccr1) antagonist and (b) glucocorticoid receptor modulator |
| WO2009142589A1 (en) * | 2008-05-20 | 2009-11-26 | Astrazeneca Ab | Combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
| WO2010008341A1 (en) * | 2008-07-16 | 2010-01-21 | Astrazeneca Ab | A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
| WO2010138421A1 (en) * | 2009-05-27 | 2010-12-02 | Merck Sharp & Dohme Corp. | HEXAHYDROCYCLOPENTYL[f]INDAZOLE REVERSED AMIDES AND DERIVATIVES AS SELECTIVE GLUCOCORTICOID RECEPTOR MODULATORS |
| EP2549875B1 (en) | 2010-03-25 | 2015-05-13 | Merck Sharp & Dohme Corp. | Soluble guanylate cyclase activators |
| GB201016912D0 (en) | 2010-10-07 | 2010-11-24 | Astrazeneca Ab | Novel combination |
| GB201021979D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | New compound |
| GB201021992D0 (en) | 2010-12-23 | 2011-02-02 | Astrazeneca Ab | Compound |
| RU2013153466A (ru) | 2011-06-29 | 2015-08-10 | Астразенека Аб | Кристаллическая форма производных индазолиламида для лечения опосредованных глюкокортикоидными рецепторами расстройств |
| WO2015058028A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| WO2015058024A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| KR20160075565A (ko) | 2013-10-17 | 2016-06-29 | 다우 아그로사이언시즈 엘엘씨 | 살충성 화합물의 제조 방법 |
| CA2925873A1 (en) | 2013-10-17 | 2015-04-23 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| JP2016536296A (ja) | 2013-10-17 | 2016-11-24 | ダウ アグロサイエンシィズ エルエルシー | 有害生物防除性化合物の製造方法 |
| EP3057431A4 (en) | 2013-10-17 | 2017-04-05 | Dow AgroSciences LLC | Processes for the preparation of pesticidal compounds |
| MX2016004946A (es) | 2013-10-17 | 2016-06-28 | Dow Agrosciences Llc | Procesos para la preparacion de compuestos plaguicidas. |
| US9029555B1 (en) | 2014-07-31 | 2015-05-12 | Dow Agrosciences Llc | Process for the preparation of 3-(3-chloro-1H-pyrazol-1-yl)pyridine |
| CN106470976A (zh) | 2014-07-31 | 2017-03-01 | 美国陶氏益农公司 | 制备3‑(3‑氯‑1h‑吡唑‑1‑基)吡啶的方法 |
| AR098110A1 (es) | 2014-07-31 | 2016-05-04 | Dow Agrosciences Llc | Proceso para la preparación de 3-(3-cloro-1h-pirazol-1-il)piridina |
| BR112017002735A2 (pt) | 2014-08-19 | 2017-12-19 | Dow Agrosciences Llc | processo para a preparação de 3-(3-cloro-1h-pirazol-1-il)piridina |
| KR20170058388A (ko) | 2014-09-12 | 2017-05-26 | 다우 아그로사이언시즈 엘엘씨 | 3-(3-클로로-1h-피라졸-1-일)피리딘의 제조 방법 |
| FR3026105B1 (fr) * | 2014-09-24 | 2019-04-19 | Greenpharma | Composition contenant au moins un inhibiteur de certaines chimiokines, son procede d'obtention et son utilisation dermocosmetique ou pharmaceutique |
| EA031945B1 (ru) * | 2014-09-26 | 2019-03-29 | Астразенека Аб | Соединения 1-алкил-6-оксо-1,6-дигидропиридин-3-ила и применение в качестве модуляторов sgrm |
| HRP20200130T1 (hr) | 2015-09-15 | 2020-05-15 | Leo Pharma A/S | Ne-steroidni modulatori glukokortikoidnog receptora za lokalni unos lijeka |
| WO2017161518A1 (en) * | 2016-03-23 | 2017-09-28 | Astrazeneca Ab | New physical form |
| CN110139853B (zh) | 2016-12-29 | 2023-06-16 | 美国陶氏益农公司 | 用于制备杀有害生物化合物的方法 |
| WO2018125817A1 (en) | 2016-12-29 | 2018-07-05 | Dow Agrosciences Llc | Processes for the preparation of pesticidal compounds |
| TW201927769A (zh) | 2017-12-18 | 2019-07-16 | 德商歌林達有限公司 | 經取代之吡咯啶醯胺ｉｉ |
| EA202091429A1 (ru) | 2017-12-18 | 2020-10-27 | Грюненталь Гмбх | Замещенные амиды i пирролидина |
| WO2020144375A1 (en) | 2019-01-11 | 2020-07-16 | Grünenthal GmbH | Substituted pyrrolidine amides iii |
| ES2980934T3 (es) | 2019-01-22 | 2024-10-03 | Akribes Biomedical Gmbh | Modificadores selectivos del receptor de glucocorticoides para tratar la cicatrización alterada de heridas en la piel |
| EP3986886A2 (en) | 2019-06-19 | 2022-04-27 | Grünenthal GmbH | Substituted pyrrolidine amides v |
| EP3986885B1 (en) | 2019-06-19 | 2023-05-03 | Grünenthal GmbH | Substituted pyrrolidine amides iv |
| CN114929684B (zh) * | 2019-12-31 | 2023-08-18 | 南京明德新药研发有限公司 | 苯并吡唑类化合物 |
| EP4178954B1 (en) | 2020-07-09 | 2025-11-19 | Grünenthal GmbH | Substituted pyrrolidine amines and amides as mediator of the glucocortoid receptor |
| EP4365171A4 (en) * | 2021-06-28 | 2025-07-09 | Medshine Discovery Inc | CRYSTALLINE FORM OF A TRIAZOLOPYRIDINE-SUBSTITUTED INDAZOLE COMPOUND AND PROCESS FOR ITS PREPARATION |
| KR102571432B1 (ko) * | 2023-02-08 | 2023-08-29 | 주식회사 에스씨엘테라퓨틱스 | 인다졸릴에스테르 및 아미드 유도체를 포함하는 암 치료용 조성물 |
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| GB0720557D0 (en) | 2007-10-19 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
| GB0720546D0 (en) | 2007-10-19 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
| GB0720544D0 (en) | 2007-10-19 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
| GB0720556D0 (en) | 2007-10-19 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
| GB0720549D0 (en) | 2007-10-19 | 2007-11-28 | Glaxo Group Ltd | Novel compounds |
| GB0722211D0 (en) | 2007-11-12 | 2007-12-27 | Glaxo Group Ltd | Novel compounds |
| GB0724254D0 (en) | 2007-12-12 | 2008-01-23 | Glaxo Group Ltd | Novel compounds |
| AU2009217493B2 (en) | 2008-02-26 | 2013-06-13 | Merck Sharp & Dohme Corp. | Hexahydrocyclopentyl[f]indazole carboxamides and derivatives thereof as selective glucocorticoid receptor modulators |
| AU2009220458A1 (en) | 2008-03-06 | 2009-09-11 | Merck Sharp & Dohme Corp. | Hexahydrocyclopentyl[f]findazole sulfonamides and derivates thereof as selective glucocorticoid receptor modulators |
| TW200951114A (en) | 2008-05-20 | 2009-12-16 | Astrazeneca Ab | Phenyl or pyridinyl substituted indazoles derivatives |
| WO2010008341A1 (en) * | 2008-07-16 | 2010-01-21 | Astrazeneca Ab | A combination of (a) glucocorticoid receptor modulator and (b) a muscarinic antagonist |
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2007
- 2007-12-17 JO JO2007553A patent/JO2754B1/en active
- 2007-12-20 HR HRP20120656TT patent/HRP20120656T1/hr unknown
- 2007-12-20 NZ NZ577186A patent/NZ577186A/en not_active IP Right Cessation
- 2007-12-20 TW TW096148902A patent/TWI417094B/zh not_active IP Right Cessation
- 2007-12-20 DK DK07852132.5T patent/DK2102169T3/da active
- 2007-12-20 ES ES07852132T patent/ES2387584T3/es active Active
- 2007-12-20 WO PCT/SE2007/001136 patent/WO2008076048A1/en not_active Ceased
- 2007-12-20 CA CA002673277A patent/CA2673277A1/en not_active Abandoned
- 2007-12-20 PT PT07852132T patent/PT2102169E/pt unknown
- 2007-12-20 CN CN200780051662XA patent/CN101611015B/zh not_active Expired - Fee Related
- 2007-12-20 MX MX2009006540A patent/MX2009006540A/es active IP Right Grant
- 2007-12-20 US US12/005,066 patent/US7728030B2/en not_active Expired - Fee Related
- 2007-12-20 KR KR1020097015234A patent/KR20090091354A/ko not_active Ceased
- 2007-12-20 JP JP2009542710A patent/JP5119267B2/ja not_active Expired - Fee Related
- 2007-12-20 EP EP07852132A patent/EP2102169B1/en active Active
- 2007-12-20 UY UY30824A patent/UY30824A1/es not_active Application Discontinuation
- 2007-12-20 EA EA200900658A patent/EA016895B1/ru not_active IP Right Cessation
- 2007-12-20 MY MYPI20092610A patent/MY153270A/en unknown
- 2007-12-20 AU AU2007334659A patent/AU2007334659B2/en not_active Ceased
- 2007-12-20 PL PL07852132T patent/PL2102169T3/pl unknown
- 2007-12-20 RS RS20120358A patent/RS52411B/sr unknown
- 2007-12-21 AR ARP070105870A patent/AR064505A1/es not_active Application Discontinuation
- 2007-12-21 CL CL200703804A patent/CL2007003804A1/es unknown
- 2007-12-29 SA SA7280740A patent/SA07280740B1/ar unknown
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2009
- 2009-05-21 IL IL198880A patent/IL198880A/en not_active IP Right Cessation
- 2009-05-26 ZA ZA2009/03654A patent/ZA200903654B/en unknown
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- 2009-06-19 SV SV2009003305A patent/SV2009003305A/es active IP Right Grant
- 2009-06-19 TN TNP2009000250A patent/TN2009000250A1/fr unknown
- 2009-06-19 GT GT200900175A patent/GT200900175A/es unknown
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- 2009-06-23 EC EC2009009452A patent/ECSP099452A/es unknown
- 2009-07-09 MA MA32078A patent/MA31087B1/fr unknown
- 2009-07-17 NO NO20092723A patent/NO20092723L/no not_active Application Discontinuation
- 2009-12-21 US US12/643,504 patent/US20100197644A1/en not_active Abandoned
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2010
- 2010-12-02 US US12/959,027 patent/US8143290B2/en not_active Expired - Fee Related
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