|
US7763609B2
(en)
|
2003-12-15 |
2010-07-27 |
Schering Corporation |
Heterocyclic aspartyl protease inhibitors
|
|
US8173642B2
(en)
|
2005-10-25 |
2012-05-08 |
Shionogi & Co., Ltd. |
Aminodihydrothiazine derivatives
|
|
EP2151435A4
(en)
|
2007-04-24 |
2011-09-14 |
Shionogi & Co |
PHARMACEUTICAL COMPOSITION FOR THE TREATMENT OF ALZHEIMER'S DISEASE
|
|
MX2009011498A
(es)
|
2007-04-24 |
2009-11-10 |
Shionogi & Co |
Derivados de aminodihidrotiazina sustituida con un grupo ciclico.
|
|
US20100317850A1
(en)
*
|
2008-01-18 |
2010-12-16 |
Yuichi Suzuki |
Condensed aminodihydrothiazine derivative
|
|
KR101324426B1
(ko)
|
2008-06-13 |
2013-10-31 |
시오노기세야쿠 가부시키가이샤 |
β 세크레타제 저해 작용을 갖는 황 함유 복소환 유도체
|
|
KR20110048491A
(ko)
*
|
2008-07-28 |
2011-05-11 |
에자이 알앤드디 매니지먼트 가부시키가이샤 |
스피로아미노디하이드로티아진 유도체들
|
|
ES2539859T3
(es)
*
|
2008-09-30 |
2015-07-06 |
Eisai R&D Management Co., Ltd. |
Nuevo derivado de aminodihidrotiazina condensado
|
|
EP2360155A4
(en)
*
|
2008-10-22 |
2012-06-20 |
Shionogi & Co |
2-AMINOPYRIDIN-4-ON AND 2-AMINOPYRIDINE DERIVATIVE WITH BACE1-HEMDERING EFFECT
|
|
GB0912778D0
(en)
|
2009-07-22 |
2009-08-26 |
Eisai London Res Lab Ltd |
Fused aminodihydro-oxazine derivatives
|
|
GB0912777D0
(en)
|
2009-07-22 |
2009-08-26 |
Eisai London Res Lab Ltd |
Fused aminodihydropyrimidone derivatives
|
|
UA108363C2
(uk)
|
2009-10-08 |
2015-04-27 |
|
Похідні імінотіадіазиндіоксиду як інгібітори bace, композиція на їх основі і їх застосування
|
|
US8569310B2
(en)
|
2009-10-08 |
2013-10-29 |
Merck Sharp & Dohme Corp. |
Pentafluorosulfur imino heterocyclic compounds as BACE-1 inhibitors, compositions and their use
|
|
WO2011044184A1
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Pentafluorosulfur imino heterocyclic compounds as bace-1 inhibitors, compositions, and their use
|
|
WO2011044187A1
(en)
|
2009-10-08 |
2011-04-14 |
Schering Corporation |
Iminothiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
RU2012129168A
(ru)
|
2009-12-11 |
2014-01-20 |
Сионоги Энд Ко. Лтд. |
Производные оксазина
|
|
EP2511269A4
(en)
*
|
2009-12-11 |
2013-04-24 |
Shionogi & Co |
FUSED HETEROCYCLIC COMPOUND HAVING AN AMINO GROUP
|
|
AR081587A1
(es)
|
2010-06-09 |
2012-10-03 |
Janssen Pharmaceutica Nv |
DERIVADOS DE 5,6-DIHIDRO-2H-[1,4]OXAZIN-3-IL-AMINA UTILES COMO INHIBIDORES DE LA b-SECRETASA (BACE)
|
|
JP5766198B2
(ja)
|
2010-10-29 |
2015-08-19 |
塩野義製薬株式会社 |
縮合アミノジヒドロピリミジン誘導体
|
|
CN103261199A
(zh)
|
2010-10-29 |
2013-08-21 |
盐野义制药株式会社 |
萘啶衍生物
|
|
AU2011347377B2
(en)
|
2010-12-22 |
2016-03-03 |
Janssen Pharmaceutica Nv |
5,6-dihydro-imidazo[1,2-a]pyrazin-8-ylamine derivatives useful as inhibitors of beta-secretase (BACE)
|
|
GB201100181D0
(en)
*
|
2011-01-06 |
2011-02-23 |
Eisai Ltd |
Fused aminodihydrothiazine derivatives
|
|
GB201101140D0
(en)
|
2011-01-21 |
2011-03-09 |
Eisai Ltd |
Fused aminodihydrothiazine derivatives
|
|
GB201101139D0
(en)
|
2011-01-21 |
2011-03-09 |
Eisai Ltd |
Fused aminodihydrothiazine derivatives
|
|
SG191710A1
(en)
*
|
2011-01-21 |
2013-08-30 |
Eisai R&D Man Co Ltd |
Methods and compounds useful in the synthesis of fused aminodihydrothiazine derivatives
|
|
CA2825620C
(en)
|
2011-03-09 |
2019-04-23 |
Janssen Pharmaceutica Nv |
3,4-dihydro-pyrrolo[1,2-a]pyrazin-1-ylamine derivatives useful as inhibitors of beta-secretase (bace)
|
|
EP2694521B1
(en)
|
2011-04-07 |
2015-11-25 |
Merck Sharp & Dohme Corp. |
Pyrrolidine-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
WO2012138734A1
(en)
|
2011-04-07 |
2012-10-11 |
Merck Sharp & Dohme Corp. |
C5-c6 oxacyclic-fused thiadiazine dioxide compounds as bace inhibitors, compositions, and their use
|
|
JPWO2012147763A1
(ja)
|
2011-04-26 |
2014-07-28 |
塩野義製薬株式会社 |
オキサジン誘導体およびそれを含有するｂａｃｅ１阻害剤
|
|
US8604024B2
(en)
|
2011-05-24 |
2013-12-10 |
Bristol-Myers Squibb Company |
Compounds for the reduction of beta-amyloid production
|
|
US8598161B2
(en)
|
2011-05-24 |
2013-12-03 |
Bristol-Myers Squibb Company |
Compounds for the reduction of beta-amyloid production
|
|
US8927535B2
(en)
*
|
2011-07-06 |
2015-01-06 |
Hoffman-La Roche Inc. |
Cyclopropyl-fused-1,3-thiazepines as BACE1 and/or BACE2 inhibitors
|
|
WO2013028670A1
(en)
|
2011-08-22 |
2013-02-28 |
Merck Sharp & Dohme Corp. |
2-spiro-substituted iminothiazines and their mono-and dioxides as bace inhibitors, compositions and their use
|
|
EP2751116B1
(en)
|
2011-08-31 |
2016-10-12 |
Pfizer Inc |
Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds
|
|
JO3143B1
(ar)
|
2012-04-03 |
2017-09-20 |
Lilly Co Eli |
مركبات تتراهيدرو بيرولو ثيازين
|
|
US9227942B2
(en)
|
2012-04-27 |
2016-01-05 |
Eisai R&D Management Co., Ltd. |
Method for producing 5-(difluoromethyl)pyrazine-2-carboxylic acid and production intermediate thereof
|
|
JP6110937B2
(ja)
|
2012-05-04 |
2017-04-05 |
ファイザー・インク |
ＡＰＰ、ＢＡＣＥ１、およびＢＡＣＥ２の阻害剤としての複素環式置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
|
|
GB201212871D0
(en)
|
2012-07-20 |
2012-09-05 |
Eisai Ltd |
Novel compounds
|
|
US9260455B2
(en)
|
2012-09-20 |
2016-02-16 |
Pfizer Inc. |
Alkyl-substituted hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
|
|
JP2016501827A
(ja)
|
2012-10-24 |
2016-01-21 |
塩野義製薬株式会社 |
Ｂａｃｅ１阻害作用を有するジヒドロオキサジンまたはオキサゼピン誘導体
|
|
SI2912041T1
(sl)
|
2012-10-26 |
2017-02-28 |
Eli Lilly And Company |
Derivati tetrahidropirolotiazina kot inhibitorji beta sekretaze (bace)
|
|
WO2014091352A1
(en)
|
2012-12-11 |
2014-06-19 |
Pfizer Inc. |
Hexahydropyrano [3,4-d][1,3]thiazin-2-amine compounds as inhibitors of bace1
|
|
JP6162820B2
(ja)
|
2012-12-19 |
2017-07-12 |
ファイザー・インク |
炭素環式および複素環式置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
|
|
EP2935256B1
(en)
|
2012-12-19 |
2018-01-24 |
Bristol-Myers Squibb Company |
4,6-diarylaminothiazines as bace1 inhibitors and their use for the reduction of beta-amyloid production
|
|
US9309263B2
(en)
|
2013-01-29 |
2016-04-12 |
Amgen Inc. |
Fused multi-cyclic sulfone compounds as inhibitors of beta-secretase and methods of use thereof
|
|
CN104995176B
(zh)
|
2013-02-12 |
2019-02-22 |
巴克老龄化研究所 |
调节bace所介导的app加工的乙内酰脲
|
|
JP2016507551A
(ja)
|
2013-02-13 |
2016-03-10 |
ファイザー・インク |
ヘテロアリール置換ヘキサヒドロピラノ［３，４−ｄ］［１，３］チアジン−２−アミン化合物
|
|
US9233981B1
(en)
|
2013-02-15 |
2016-01-12 |
Pfizer Inc. |
Substituted phenyl hexahydropyrano[3,4-d][1,3]thiazin-2-amine compounds
|
|
AU2014223334C1
(en)
|
2013-03-01 |
2018-10-18 |
Amgen Inc. |
Perfluorinated 5,6-dihydro-4H-1,3-oxazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
|
EA201591614A1
(ru)
|
2013-03-08 |
2015-12-30 |
Эмджен Инк. |
Соединения 1,3-оксазин-2-амина, конденсированные с перфторированным циклопропилом, в качестве ингибиторов бета-секретазы и способы их применения
|
|
TWI593692B
(zh)
|
2013-03-12 |
2017-08-01 |
美國禮來大藥廠 |
四氫吡咯并噻嗪化合物
|
|
EA032662B1
(ru)
|
2013-06-12 |
2019-06-28 |
Янссен Фармацевтика Нв |
ПРОИЗВОДНЫЕ 4-АМИНО-6-ФЕНИЛ-5,6-ДИГИДРОИМИДАЗО[1,5-а]ПИРАЗИН-3(2H)-ОНА В КАЧЕСТВЕ ИНГИБИТОРОВ БЕТА-СЕКРЕТАЗЫ (BACE)
|
|
EA028775B1
(ru)
|
2013-06-12 |
2017-12-29 |
Янссен Фармацевтика Нв |
Производные 4-амино-6-фенил-6,7-дигидро[1,2,3]триазоло[1,5-a]пиразина в качестве ингибиторов бета-секретазы (bace)
|
|
TWI639607B
(zh)
|
2013-06-18 |
2018-11-01 |
美國禮來大藥廠 |
Ｂａｃｅ抑制劑
|
|
WO2015017407A1
(en)
|
2013-07-30 |
2015-02-05 |
Amgen Inc. |
Bridged bicyclic amino thiazine dioxide compounds as inhibitors of beta- secretase
|
|
SG11201607896YA
(en)
|
2014-04-10 |
2016-10-28 |
Pfizer |
2-AMINO-6-METHYL-4,4a,5,6-TETRAHYDROPYRANO[3,4-d][1,3]THIAZIN-8a(8H)-YL-1,3-THIAZOL-4-YL AMIDES
|
|
CN106795147B
(zh)
|
2014-08-08 |
2020-09-22 |
美国安进公司 |
作为β-分泌酶抑制剂的环丙基稠合噻嗪-2-胺化合物和使用方法
|
|
JO3458B1
(ar)
|
2014-11-10 |
2020-07-05 |
H Lundbeck As |
2- أمينو-6- (دايفلوروميثيل) – 5، 5- ديفلورو-6-فينيل-3،4، 5، 6-تيتراهيدروبيريدين كمثبطات bace1
|
|
CR20170187A
(es)
|
2014-11-10 |
2018-02-01 |
H Lundbeck As |
2-Amino-3,5-difluoro-6-metil-6-fenil-3,4,5,6-tetrahidropiridinas en calidad de inhibidores de BACE1 para el tratamiento de la enfermedad de Alzheimer
|
|
MA40941A
(fr)
|
2014-11-10 |
2017-09-19 |
H Lundbeck As |
2-amino-5,5-difluoro-6-(fluorométhyl)-6-phényl-3,4,5,6-tétrahydropyridines comme inhibiteurs de bace1
|
|
EA031041B1
(ru)
|
2014-12-18 |
2018-11-30 |
Янссен Фармацевтика Нв |
Соединения 2,3,4,5-тетрагидропиридин-6-амин и 3,4-дигидро-2h-пиррол-5-амин - ингибиторы бета-секретазы
|
|
AR103680A1
(es)
|
2015-02-23 |
2017-05-24 |
Lilly Co Eli |
Inhibidores selectivos de bace1
|
|
EP3271356B1
(en)
|
2015-03-19 |
2019-10-16 |
Eli Lilly and Company |
Selective bace1 inhibitors
|
|
AR104241A1
(es)
|
2015-04-29 |
2017-07-05 |
Lilly Co Eli |
Derivados de tetrahidrofuro tiazina como inhibidores de bace1 selectivos
|
|
US10246429B2
(en)
|
2015-08-06 |
2019-04-02 |
Amgen Inc. |
Vinyl fluoride cyclopropyl fused thiazin-2-amine compounds as beta-secretase inhibitors and methods of use
|
|
TW201717948A
(zh)
|
2015-08-10 |
2017-06-01 |
Ｈ 朗德貝克公司 |
包括給予２－胺基－３，５，５－三氟－３，４，５，６－四氫吡啶的聯合治療
|
|
PE20181015A1
(es)
|
2015-08-12 |
2018-06-26 |
H Lundbeck As |
2-amino-3-fluoro-3-(fluorometil)-6-meti-6-fenil-3,4,5,6-tetrahidropiridinas como inhibidores de bace1
|
|
MA42604A
(fr)
*
|
2015-08-12 |
2018-06-20 |
H Lundbeck As |
2-amino-7a-phényl-3,4,4a,5,7,7a-hexahydrofuro[3,4-b]pyridines comme inhibiteurs de bace1
|
|
BR112018003489A2
(pt)
|
2015-09-24 |
2018-09-25 |
Pfizer |
n-[2-(2-amino-6,6-dissubstituído-4,4a,5,6-tetra-hidropirano[3,4-d][1,3]tiazin-8a(8h)-il)-1,3-tiazol-4-il]amidas
|
|
EP3353182A1
(en)
|
2015-09-24 |
2018-08-01 |
Pfizer Inc |
Tetrahydropyrano[3,4-d][1,3]oxazin derivatives and their use as bace inhibitors
|
|
WO2017051294A1
(en)
|
2015-09-24 |
2017-03-30 |
Pfizer Inc. |
N-[2-(3-amino-2,5-dimethyl-1,1-dioxido-5,6-dihydro-2h-1,2,4-thiadiazin-5-yl)-1,3-thiazol-4-yl] amides useful as bace inhibitors
|
|
TWI675034B
(zh)
*
|
2016-05-20 |
2019-10-21 |
美商美國禮來大藥廠 |
四氫呋喃并<img align="absmiddle" height="18px" width="27px" file="d10999.TIF" alt="其他非圖式 ed10999.png" img-content="tif" orientation="portrait" inline="yes" giffile="ed10999.png"></img>化合物及其作為選擇性ＢＡＣＥ１抑制劑之用途
|
|
MA46698A
(fr)
|
2016-11-04 |
2021-04-07 |
Janssen Pharmaceutica Nv |
Composés de 4,4 a, 5,7-têtrahydro -3 h-furo [3,4-b]pyridinyl
|
|
US10947223B2
(en)
|
2016-12-15 |
2021-03-16 |
Amgen Inc. |
Substituted oxazines as beta-secretase inhibitors
|
|
CA3047288A1
(en)
|
2016-12-15 |
2018-06-21 |
Amgen Inc. |
Thiazine derivatives as beta-secretase inhibitors and methods of use
|
|
MA50007A
(fr)
|
2016-12-15 |
2021-04-07 |
Amgen Inc |
Dérivés de dioxyde de 1,4-thiazine et de dioxyde de 1,2,4-thiadiazine en tant qu'inhibiteurs de bêta-sécrétase et procédés d'utilisation
|
|
WO2018112086A1
(en)
|
2016-12-15 |
2018-06-21 |
Amgen Inc. |
Cyclopropyl fused thiazine derivatives as beta-secretase inhibitors and methods of use
|
|
US11548903B2
(en)
|
2016-12-15 |
2023-01-10 |
Amgen Inc. |
Bicyclic thiazine and oxazine derivatives as beta-secretase inhibitors and methods of use
|
|
CN110418793A
(zh)
*
|
2017-03-07 |
2019-11-05 |
詹森药业有限公司 |
β-分泌酶的抑制剂
|
|
WO2018162445A1
(en)
*
|
2017-03-07 |
2018-09-13 |
Janssen Pharmaceutica Nv |
Inhibitors of beta secretase
|
|
WO2018162444A1
(en)
*
|
2017-03-07 |
2018-09-13 |
Janssen Pharmaceutica Nv |
Inhibitors of beta secretase
|
|
EP3592752A1
(en)
*
|
2017-03-07 |
2020-01-15 |
Janssen Pharmaceutica NV |
Inhibitors of beta secretase
|
|
WO2018162443A1
(en)
*
|
2017-03-07 |
2018-09-13 |
Janssen Pharmaceutica Nv |
Inhibitors of beta secretase
|
|
AU2018229722A1
(en)
*
|
2017-03-07 |
2019-08-08 |
Janssen Pharmaceutica Nv |
Inhibitors of beta secretase
|
|
CN110590517A
(zh)
*
|
2019-09-24 |
2019-12-20 |
武汉嘉诺康医药技术有限公司 |
一种3，4-二羟基-2′-氯苯乙酮的制备方法
|