CN109982699A - 一种mor激动剂与kor激动剂的药物组合物及其用途 - Google Patents

一种mor激动剂与kor激动剂的药物组合物及其用途 Download PDF

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CN109982699A
CN109982699A CN201880004339.5A CN201880004339A CN109982699A CN 109982699 A CN109982699 A CN 109982699A CN 201880004339 A CN201880004339 A CN 201880004339A CN 109982699 A CN109982699 A CN 109982699A
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pain
alkyl
heterocycle
naphthenic base
heteroaryl
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牛卓璐
曹国庆
杨昌永
张连山
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Jiangsu Hengrui Medicine Co Ltd
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/444—Non condensed pyridines; Hydrogenated derivatives thereof containing further heterocyclic ring systems containing a six-membered ring with nitrogen as a ring heteroatom, e.g. amrinone
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Abstract

一种μ阿片受体(MOR)激动剂与κ阿片受体(KOR)激动剂联合在制备缓解和/或治疗疼痛的药物中的用途。所述MOR激动剂选自如通式(I)所示化合物，或其互变异构体、内消旋体、外消旋体、对映异构体、非对映异构体或其混合物形式，或其可药用的盐。一种含有所述MOR激动剂与KOR激动剂的药物组合物。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN201880004339.5A 2017-04-14 2018-04-13 一种mor激动剂与kor激动剂的药物组合物及其用途 Pending CN109982699A (zh)

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CN201710242435 2017-04-14
CN2017102424350 2017-04-14
PCT/CN2018/082912 WO2018188641A1 (zh) 2017-04-14 2018-04-13 一种mor激动剂与kor激动剂的药物组合物及其用途

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US (1) US20200054594A1 (zh)
EP (1) EP3610874A4 (zh)
JP (1) JP2020516591A (zh)
KR (1) KR20190133047A (zh)
CN (1) CN109982699A (zh)
AU (1) AU2018251118A1 (zh)
BR (1) BR112019020691A2 (zh)
CA (1) CA3058272A1 (zh)
MX (1) MX2019011904A (zh)
TW (1) TW201836606A (zh)
WO (1) WO2018188641A1 (zh)

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US11471503B2 (en) * 2017-12-06 2022-10-18 Jiangsu Hengrui Medicine Co., Ltd. Use of KOR agonist in combination with MOR agonist in preparing drug for treating pain
WO2019205983A1 (zh) * 2018-04-28 2019-10-31 四川科伦博泰生物医药股份有限公司 氧杂螺环类化合物及其制备方法和用途
WO2020147848A1 (zh) * 2019-01-17 2020-07-23 上海海雁医药科技有限公司 三环取代的氧杂螺环衍生物、其制法与医药上的用途
CN111662284B (zh) * 2019-03-06 2021-08-10 上海海雁医药科技有限公司 双杂环取代的氧杂螺环衍生物、其制法与医药上的用途
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CN112789276A (zh) * 2019-08-14 2021-05-11 上海海雁医药科技有限公司 镇痛化合物、其制法与医药上的用途
CN112552374A (zh) * 2019-09-10 2021-03-26 四川海思科制药有限公司 一种肽酰胺类化合物及其中间体的制备方法
AU2021208113B2 (en) * 2020-01-17 2023-11-30 Shanghai Haiyan Pharmaceutical Technology Co., Ltd. Azabicyclic substituted oxaspiro derivative, preparation method therefor and medical use thereof
WO2021143803A1 (zh) * 2020-01-17 2021-07-22 上海海雁医药科技有限公司 光学纯的氧杂螺环取代的吡咯并吡唑衍生物、其制法与医药上的用途
CN113214264B (zh) * 2020-01-21 2022-08-09 上海海雁医药科技有限公司 二氢吡咯并五元杂芳基取代的氧杂螺环衍生物、其制法与医药上的用途
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CN116615242A (zh) * 2021-03-04 2023-08-18 寿协株式会社 癌症治疗药

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TW201836606A (zh) 2018-10-16
EP3610874A1 (en) 2020-02-19
US20200054594A1 (en) 2020-02-20
CA3058272A1 (en) 2018-10-18
AU2018251118A8 (en) 2019-10-31
KR20190133047A (ko) 2019-11-29
WO2018188641A1 (zh) 2018-10-18
BR112019020691A2 (pt) 2020-05-12
EP3610874A4 (en) 2021-01-06
MX2019011904A (es) 2019-11-25
AU2018251118A1 (en) 2019-10-17
JP2020516591A (ja) 2020-06-11

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