CN111065390A - Kor激动剂与mor激动剂联合在制备治疗疼痛的药物中的用途 - Google Patents

Kor激动剂与mor激动剂联合在制备治疗疼痛的药物中的用途 Download PDF

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CN111065390A
CN111065390A CN201880059072.XA CN201880059072A CN111065390A CN 111065390 A CN111065390 A CN 111065390A CN 201880059072 A CN201880059072 A CN 201880059072A CN 111065390 A CN111065390 A CN 111065390A
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cycloalkyl
heteroaryl
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CN111065390B (zh
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黄晓星
曹国庆
杨昌永
张连山
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Jiangsu Hengrui Medicine Co Ltd
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    • A61K31/00—Medicinal preparations containing organic active ingredients
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    • A61K31/395—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins
    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
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    • A61K31/44—Non condensed pyridines; Hydrogenated derivatives thereof
    • A61K31/445—Non condensed piperidines, e.g. piperocaine
    • A61K31/4468—Non condensed piperidines, e.g. piperocaine having a nitrogen directly attached in position 4, e.g. clebopride, fentanyl
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    • A61K31/435—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with one nitrogen as the only ring hetero atom
    • A61K31/47—Quinolines; Isoquinolines
    • A61K31/4709—Non-condensed quinolines and containing further heterocyclic rings
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    • A61K31/535—Heterocyclic compounds having nitrogen as a ring hetero atom, e.g. guanethidine or rifamycins having six-membered rings with at least one nitrogen and one oxygen as the ring hetero atoms, e.g. 1,2-oxazines
    • A61K31/5375—1,4-Oxazines, e.g. morpholine
    • A—HUMAN NECESSITIES
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    • C—CHEMISTRY; METALLURGY
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Abstract

KOR激动剂与MOR激动剂联合在制备治疗疼痛的药物中的用途。所述KOR激动剂选自如通式(I)所示化合物，所述MOR激动剂选自如通式(II)所示化合物，其中通式(I)、(II)的各取代基与说明书中的定义相同。

Description

PCT国内申请，说明书已公开。

Claims (14)

  1. PCT国内申请，权利要求书已公开。
CN201880059072.XA 2017-12-06 2018-12-05 Kor激动剂与mor激动剂联合在制备治疗疼痛的药物中的用途 Active CN111065390B (zh)

Applications Claiming Priority (3)

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CN201711272869 2017-12-06
CN2017112728691 2017-12-06
PCT/CN2018/119313 WO2019109937A1 (zh) 2017-12-06 2018-12-05 Kor激动剂与mor激动剂联合在制备治疗疼痛的药物中的用途

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CN111065390A true CN111065390A (zh) 2020-04-24
CN111065390B CN111065390B (zh) 2023-01-24

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US (1) US11471503B2 (zh)
EP (1) EP3714882A4 (zh)
JP (1) JP2021505547A (zh)
KR (1) KR20200096787A (zh)
CN (1) CN111065390B (zh)
AU (1) AU2018380173A1 (zh)
BR (1) BR112020010429A2 (zh)
CA (1) CA3083028A1 (zh)
MX (1) MX2020005660A (zh)
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Cited By (3)

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CN109982699A (zh) * 2017-04-14 2019-07-05 江苏恒瑞医药股份有限公司 一种mor激动剂与kor激动剂的药物组合物及其用途
CN112694485A (zh) * 2020-09-10 2021-04-23 四川海品信医药科技有限公司 一种阿片受体激动剂噻吩类化合物及其制备方法
CN114269738A (zh) * 2020-08-10 2022-04-01 成都苑东生物制药股份有限公司 一种mor受体激动剂化合物、制备方法及其用途

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WO2020147848A1 (zh) * 2019-01-17 2020-07-23 上海海雁医药科技有限公司 三环取代的氧杂螺环衍生物、其制法与医药上的用途
CN113493490B (zh) * 2020-04-03 2024-03-12 成都诺和晟泰生物科技有限公司 一种合成肽酰胺类化合物及其在医药领域的用途
JP2023536221A (ja) 2020-06-25 2023-08-24 ヒューマンウェル ファーマシューティカル ユーエス 医学的障害の治療のためのペプチド
CN113995733B (zh) * 2021-09-18 2023-08-22 中国人民解放军军事科学院军事医学研究院 一种噻吩诺啡缓释药物组合物及其制备方法和其用途
CN115317453A (zh) * 2022-09-01 2022-11-11 广东嘉博制药有限公司 一种缓释微球制剂及其制备方法与用途

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WO2017063509A1 (zh) * 2015-10-15 2017-04-20 江苏恒瑞医药股份有限公司 氧杂螺环类衍生物、其制备方法及其在医药上的应用

Cited By (5)

* Cited by examiner, † Cited by third party
Publication number Priority date Publication date Assignee Title
CN109982699A (zh) * 2017-04-14 2019-07-05 江苏恒瑞医药股份有限公司 一种mor激动剂与kor激动剂的药物组合物及其用途
CN114269738A (zh) * 2020-08-10 2022-04-01 成都苑东生物制药股份有限公司 一种mor受体激动剂化合物、制备方法及其用途
CN114269738B (zh) * 2020-08-10 2023-09-29 成都苑东生物制药股份有限公司 一种mor受体激动剂化合物、制备方法及其用途
CN112694485A (zh) * 2020-09-10 2021-04-23 四川海品信医药科技有限公司 一种阿片受体激动剂噻吩类化合物及其制备方法
CN112694485B (zh) * 2020-09-10 2023-04-07 四川海品信医药科技有限公司 一种阿片受体激动剂噻吩类化合物及其制备方法

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JP2021505547A (ja) 2021-02-18
EP3714882A1 (en) 2020-09-30
US20200368309A1 (en) 2020-11-26
RU2020115687A (ru) 2022-01-11
US11471503B2 (en) 2022-10-18
MX2020005660A (es) 2020-08-20
EP3714882A4 (en) 2021-09-01
BR112020010429A2 (pt) 2020-11-24
KR20200096787A (ko) 2020-08-13
AU2018380173A1 (en) 2020-05-21
WO2019109937A1 (zh) 2019-06-13
RU2020115687A3 (zh) 2022-01-31
CN111065390B (zh) 2023-01-24
TW201924681A (zh) 2019-07-01
CA3083028A1 (en) 2019-06-13

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