JP2009521929A5 - - Google Patents
Download PDFInfo
- Publication number
- JP2009521929A5 JP2009521929A5 JP2008548745A JP2008548745A JP2009521929A5 JP 2009521929 A5 JP2009521929 A5 JP 2009521929A5 JP 2008548745 A JP2008548745 A JP 2008548745A JP 2008548745 A JP2008548745 A JP 2008548745A JP 2009521929 A5 JP2009521929 A5 JP 2009521929A5
- Authority
- JP
- Japan
- Prior art keywords
- population
- stem cells
- placental stem
- gene
- cells
- Prior art date
- Legal status (The legal status is an assumption and is not a legal conclusion. Google has not performed a legal analysis and makes no representation as to the accuracy of the status listed.)
- Granted
Links
- 210000000130 stem cell Anatomy 0.000 claims description 61
- 230000003169 placental Effects 0.000 claims description 49
- 210000002901 Mesenchymal Stem Cells Anatomy 0.000 claims description 7
- 239000002609 media Substances 0.000 claims description 7
- 239000008194 pharmaceutical composition Substances 0.000 claims description 7
- 210000001185 Bone Marrow Anatomy 0.000 claims description 6
- 210000002826 Placenta Anatomy 0.000 claims description 6
- 210000002966 Serum Anatomy 0.000 claims description 6
- UREBDLICKHMUKA-CXSFZGCWSA-N Dexamethasone Chemical compound C1CC2=CC(=O)C=C[C@]2(C)[C@]2(F)[C@@H]1[C@@H]1C[C@@H](C)[C@@](C(=O)CO)(O)[C@@]1(C)C[C@@H]2O UREBDLICKHMUKA-CXSFZGCWSA-N 0.000 claims description 5
- 229960003957 Dexamethasone Drugs 0.000 claims description 5
- 230000002188 osteogenic Effects 0.000 claims description 5
- 238000010186 staining Methods 0.000 claims description 5
- MIJPAVRNWPDMOR-ZAFYKAAXSA-K [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-oxido-5-oxo-2H-furan-4-yl] phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP([O-])([O-])=O)=C1[O-] MIJPAVRNWPDMOR-ZAFYKAAXSA-K 0.000 claims description 4
- 230000014509 gene expression Effects 0.000 claims description 4
- 239000000203 mixture Substances 0.000 claims description 4
- 210000003954 Umbilical Cord Anatomy 0.000 claims description 3
- DHCLVCXQIBBOPH-UHFFFAOYSA-N β-glycerophosphoric acid Chemical compound OCC(CO)OP(O)(O)=O DHCLVCXQIBBOPH-UHFFFAOYSA-N 0.000 claims description 3
- 102000002260 Alkaline Phosphatase Human genes 0.000 claims description 2
- 108020004774 Alkaline Phosphatase Proteins 0.000 claims description 2
- WQZGKKKJIJFFOK-GASJEMHNSA-N D-Glucose Natural products OC[C@H]1OC(O)[C@H](O)[C@@H](O)[C@@H]1O WQZGKKKJIJFFOK-GASJEMHNSA-N 0.000 claims description 2
- 229920002307 Dextran Polymers 0.000 claims description 2
- 210000003958 Hematopoietic Stem Cells Anatomy 0.000 claims description 2
- 102000004887 Transforming Growth Factor beta Human genes 0.000 claims description 2
- 108090001012 Transforming Growth Factor beta Proteins 0.000 claims description 2
- 239000008103 glucose Substances 0.000 claims description 2
- 238000002347 injection Methods 0.000 claims description 2
- 239000007924 injection Substances 0.000 claims description 2
- 210000004027 cells Anatomy 0.000 claims 13
- 230000001809 detectable Effects 0.000 claims 7
- 102100015659 B4GALT6 Human genes 0.000 claims 3
- 101710025561 B4GALT6 Proteins 0.000 claims 3
- 102100003123 CPA4 Human genes 0.000 claims 3
- 101710003556 CPA4 Proteins 0.000 claims 3
- 108060002519 ELOVL2 Proteins 0.000 claims 3
- 102100001576 ELOVL5 Human genes 0.000 claims 3
- 108060002522 ELOVL5 Proteins 0.000 claims 3
- 102100001862 NUAK1 Human genes 0.000 claims 3
- 101700045229 NUAK1 Proteins 0.000 claims 3
- 102100003785 PNMA8A Human genes 0.000 claims 3
- 101710003312 PNMA8A Proteins 0.000 claims 3
- 102100002138 SLC12A8 Human genes 0.000 claims 3
- 108091006543 SLC12A8 Proteins 0.000 claims 3
- 102100018004 ST3GAL6 Human genes 0.000 claims 3
- 101710029039 ST3GAL6 Proteins 0.000 claims 3
- 102100009032 ST6GALNAC5 Human genes 0.000 claims 3
- 108010069296 ST6GalNAc V brain-specific GD1alpha synthase Proteins 0.000 claims 3
- 102100007982 TCF21 Human genes 0.000 claims 3
- 101700013703 TCF21 Proteins 0.000 claims 3
- 210000001519 tissues Anatomy 0.000 claims 3
- 108091003117 Bovine Serum Albumin Proteins 0.000 claims 2
- 229940098773 Bovine Serum Albumin Drugs 0.000 claims 2
- 101700033006 EGF Proteins 0.000 claims 2
- 102100010813 EGF Human genes 0.000 claims 2
- 229940116977 Epidermal Growth Factor Drugs 0.000 claims 2
- 108091006822 Human Serum Albumin Proteins 0.000 claims 2
- 102000008100 Human Serum Albumin Human genes 0.000 claims 2
- 102000010780 Platelet-Derived Growth Factor Human genes 0.000 claims 2
- 108010038512 Platelet-Derived Growth Factor Proteins 0.000 claims 2
- 102000004142 Trypsin Human genes 0.000 claims 2
- 108090000631 Trypsin Proteins 0.000 claims 2
- 102100009661 VTN Human genes 0.000 claims 2
- 101710004211 VTN Proteins 0.000 claims 2
- 230000001464 adherent Effects 0.000 claims 2
- 230000002648 chondrogenic Effects 0.000 claims 2
- 230000029087 digestion Effects 0.000 claims 2
- IAZDPXIOMUYVGZ-UHFFFAOYSA-N dimethylsulphoxide Chemical compound CS(C)=O IAZDPXIOMUYVGZ-UHFFFAOYSA-N 0.000 claims 2
- 230000001605 fetal Effects 0.000 claims 2
- 229910052711 selenium Inorganic materials 0.000 claims 2
- 239000011669 selenium Substances 0.000 claims 2
- 229960001322 trypsin Drugs 0.000 claims 2
- 239000012588 trypsin Substances 0.000 claims 2
- KDXHLJMVLXJXCW-UHFFFAOYSA-J Alcian blue stain Chemical compound [Cl-].[Cl-].[Cl-].[Cl-].[Cu+2].[N-]1C(N=C2C3=CC(CSC(N(C)C)=[N+](C)C)=CC=C3C(N=C3C4=CC=C(CSC(N(C)C)=[N+](C)C)C=C4C(=N4)[N-]3)=N2)=C(C=C(CSC(N(C)C)=[N+](C)C)C=C2)C2=C1N=C1C2=CC(CSC(N(C)C)=[N+](C)C)=CC=C2C4=N1 KDXHLJMVLXJXCW-UHFFFAOYSA-J 0.000 claims 1
- 102100016201 ERAP1 Human genes 0.000 claims 1
- 101700030458 ERAP1 Proteins 0.000 claims 1
- 102100016202 ERAP2 Human genes 0.000 claims 1
- 241000287828 Gallus gallus Species 0.000 claims 1
- 102100009948 IER3 Human genes 0.000 claims 1
- 108060003855 IER3 Proteins 0.000 claims 1
- 102000004889 Interleukin-6 Human genes 0.000 claims 1
- 108090001005 Interleukin-6 Proteins 0.000 claims 1
- 102100005748 KRT18 Human genes 0.000 claims 1
- 101710026202 KRT18 Proteins 0.000 claims 1
- 102100019015 MEST Human genes 0.000 claims 1
- 101700067359 MEST Proteins 0.000 claims 1
- 108020004999 Messenger RNA Proteins 0.000 claims 1
- 102100017231 NFE2L3 Human genes 0.000 claims 1
- 101710031936 NFE2L3 Proteins 0.000 claims 1
- 102100002456 TGFB2 Human genes 0.000 claims 1
- 101700020851 TGFB2 Proteins 0.000 claims 1
- 102000009618 Transforming Growth Factors Human genes 0.000 claims 1
- 108010009583 Transforming Growth Factors Proteins 0.000 claims 1
- 239000007640 basal medium Substances 0.000 claims 1
- 239000003937 drug carrier Substances 0.000 claims 1
- 239000012091 fetal bovine serum Substances 0.000 claims 1
- 210000002950 fibroblast Anatomy 0.000 claims 1
- 238000001990 intravenous administration Methods 0.000 claims 1
- 108010080821 leucine-rich amelogenin peptide Proteins 0.000 claims 1
- 238000004519 manufacturing process Methods 0.000 claims 1
- 229920002106 messenger RNA Polymers 0.000 claims 1
- 230000001537 neural Effects 0.000 claims 1
- 238000003757 reverse transcription PCR Methods 0.000 claims 1
- 230000004069 differentiation Effects 0.000 description 4
- 210000002449 bone cell Anatomy 0.000 description 2
- 210000001988 somatic stem cell Anatomy 0.000 description 2
- DPFYBZWSVVKNPZ-AQWIXGDGSA-N (3S,4S,6R)-2-[[(2R,4R,5R)-3,5-dihydroxy-4-methoxy-6-(methoxymethyl)oxan-2-yl]methoxymethyl]-6-ethyloxane-3,4,5-triol Chemical compound O[C@H]1[C@@H](O)C(O)[C@@H](CC)OC1COC[C@@H]1C(O)[C@H](OC)[C@H](O)C(COC)O1 DPFYBZWSVVKNPZ-AQWIXGDGSA-N 0.000 description 1
- 101710027066 ALB Proteins 0.000 description 1
- 102100001249 ALB Human genes 0.000 description 1
- 229940072107 Ascorbate Drugs 0.000 description 1
- 102100005377 BMP2 Human genes 0.000 description 1
- 101700000123 BMP2 Proteins 0.000 description 1
- 102100015886 BMP4 Human genes 0.000 description 1
- 101700005069 BMP4 Proteins 0.000 description 1
- 102000007350 Bone Morphogenetic Proteins Human genes 0.000 description 1
- 108010007726 Bone Morphogenetic Proteins Proteins 0.000 description 1
- 229940112869 Bone morphogenetic proteins Drugs 0.000 description 1
- 229940119744 Dextran 40 Drugs 0.000 description 1
- 239000006144 Dulbecco’s modified Eagle's medium Substances 0.000 description 1
- 210000001671 Embryonic Stem Cells Anatomy 0.000 description 1
- 108010010803 Gelatin Proteins 0.000 description 1
- 229940014259 Gelatin Drugs 0.000 description 1
- 229920001612 Hydroxyethyl starch Polymers 0.000 description 1
- 229960003444 IMMUNOSUPPRESSANTS Drugs 0.000 description 1
- 102000016921 Integrin-Binding Sialoprotein Human genes 0.000 description 1
- 108010028750 Integrin-Binding Sialoprotein Proteins 0.000 description 1
- TYQCGQRIZGCHNB-JLAZNSOCSA-N L-ascorbic acid Chemical compound OC[C@H](O)[C@H]1OC(O)=C(O)C1=O TYQCGQRIZGCHNB-JLAZNSOCSA-N 0.000 description 1
- 210000001178 Neural Stem Cells Anatomy 0.000 description 1
- 102000004067 Osteocalcin Human genes 0.000 description 1
- 108090000573 Osteocalcin Proteins 0.000 description 1
- 102000004264 Osteopontin Human genes 0.000 description 1
- 108010081689 Osteopontin Proteins 0.000 description 1
- 102100014320 TGFB1 Human genes 0.000 description 1
- 108010037805 Transforming growth factor beta-1 Proteins 0.000 description 1
- MIJPAVRNWPDMOR-ZAFYKAAXSA-N [(2R)-2-[(1S)-1,2-dihydroxyethyl]-3-hydroxy-5-oxo-2H-furan-4-yl] dihydrogen phosphate Chemical compound OC[C@H](O)[C@H]1OC(=O)C(OP(O)(O)=O)=C1O MIJPAVRNWPDMOR-ZAFYKAAXSA-N 0.000 description 1
- NBIIXXVUZAFLBC-UHFFFAOYSA-K [O-]P([O-])([O-])=O Chemical compound [O-]P([O-])([O-])=O NBIIXXVUZAFLBC-UHFFFAOYSA-K 0.000 description 1
- 229940050528 albumin Drugs 0.000 description 1
- 102000004965 antibodies Human genes 0.000 description 1
- 108090001123 antibodies Proteins 0.000 description 1
- 239000003429 antifungal agent Substances 0.000 description 1
- 235000010323 ascorbic acid Nutrition 0.000 description 1
- 239000011668 ascorbic acid Substances 0.000 description 1
- 230000003115 biocidal Effects 0.000 description 1
- 210000004271 bone marrow stromal cells Anatomy 0.000 description 1
- OYPRJOBELJOOCE-UHFFFAOYSA-N calcium Chemical compound [Ca] OYPRJOBELJOOCE-UHFFFAOYSA-N 0.000 description 1
- 229910052791 calcium Inorganic materials 0.000 description 1
- 239000011575 calcium Substances 0.000 description 1
- 230000000747 cardiac effect Effects 0.000 description 1
- 238000004113 cell culture Methods 0.000 description 1
- 230000001413 cellular Effects 0.000 description 1
- 150000001875 compounds Chemical class 0.000 description 1
- 230000001143 conditioned Effects 0.000 description 1
- 238000001514 detection method Methods 0.000 description 1
- 239000000975 dye Substances 0.000 description 1
- 230000003511 endothelial Effects 0.000 description 1
- 229920000159 gelatin Polymers 0.000 description 1
- 239000008273 gelatin Substances 0.000 description 1
- 235000019322 gelatine Nutrition 0.000 description 1
- 235000011852 gelatine desserts Nutrition 0.000 description 1
- 210000003897 hepatic stem cell Anatomy 0.000 description 1
- 229940050526 hydroxyethylstarch Drugs 0.000 description 1
- 230000001861 immunosuppresant Effects 0.000 description 1
- 239000003018 immunosuppressive agent Substances 0.000 description 1
- 230000001939 inductive effect Effects 0.000 description 1
- 239000007972 injectable composition Substances 0.000 description 1
- 210000001665 muscle stem cell Anatomy 0.000 description 1
- 239000010452 phosphate Substances 0.000 description 1
- 239000003381 stabilizer Substances 0.000 description 1
Description
他の実施態様において、本発明は、前述した幹細胞のうちのいずれ、又は前述した幹細胞集団のうちのいずれかによってならされた培地を含む組成物を提供する。具体的な実施態様において、そのような組成物のいずれも、胎盤から得られない幹細胞を含む。より具体的な実施態様において、前記幹細胞は、胚性幹細胞である。他のより具体的な実施態様において、前記幹細胞は、間葉系幹細胞である。より具体的な実施態様において、前記幹細胞は、骨髄由来の幹細胞である。より具体的な実施態様において、前記幹細胞は、造血前駆細胞である。他のより具体的な実施態様において、前記幹細胞は、体性幹細胞である。さらにより具体的な実施態様において、前記体性幹細胞は、神経幹細胞、肝幹細胞、膵臓幹細胞、内皮幹細胞、心臓幹細胞、又は筋幹細胞である。
（5.5.4 骨細胞への分化誘導）
胎盤幹細胞の骨形成分化は、例えば、胎盤幹細胞を、骨細胞への分化を誘導する細胞培養条件下に置くことにより達成することができる。好ましい骨形成培地は、MSCGM(Cambrex社)又は15％臍帯血清が補充されたDMEMを含み、0.1μMデキサメタゾン、0.05mMアスコルビン酸-2-リン酸塩、10mMベータグリセロリン酸塩を含む骨形成誘導培地(Cambrex社)が続けられる。他の実施態様において、胎盤幹細胞は、約10-7〜約10-9Mデキサメタゾン、約10-50μMアスコルビン酸塩リン酸塩(例えば、アスコルビン酸塩-2-リン酸塩)及び約10nM〜約10mM β-グリセロリン酸塩を含む培地(例えば、DMEM-低グルコース)の中で培養される。骨形成培地は、また、血清、１個以上の抗生剤/抗真菌剤、形質転換成長因子-ベータ(例えば、TGF-β1)及び/又は骨形態形成タンパク質(例えば、BMP-2、BMP-4、又はそれらの組み合わせ)を含むことができる。
分化は、カルシウムに特異的な染料、例えば、von Kossa染色、及び、例えば、アルカリ性ホスファターゼ、オステオカルシン、骨シアロタンパク質及び/又はオステオポンチン遺伝子発現のRT/PCRによる探知を使用して評価することができる。
胎盤幹細胞の骨形成分化は、例えば、胎盤幹細胞を、骨細胞への分化を誘導する細胞培養条件下に置くことにより達成することができる。好ましい骨形成培地は、MSCGM(Cambrex社)又は15％臍帯血清が補充されたDMEMを含み、0.1μMデキサメタゾン、0.05mMアスコルビン酸-2-リン酸塩、10mMベータグリセロリン酸塩を含む骨形成誘導培地(Cambrex社)が続けられる。他の実施態様において、胎盤幹細胞は、約10-7〜約10-9Mデキサメタゾン、約10-50μMアスコルビン酸塩リン酸塩(例えば、アスコルビン酸塩-2-リン酸塩)及び約10nM〜約10mM β-グリセロリン酸塩を含む培地(例えば、DMEM-低グルコース)の中で培養される。骨形成培地は、また、血清、１個以上の抗生剤/抗真菌剤、形質転換成長因子-ベータ(例えば、TGF-β1)及び/又は骨形態形成タンパク質(例えば、BMP-2、BMP-4、又はそれらの組み合わせ)を含むことができる。
分化は、カルシウムに特異的な染料、例えば、von Kossa染色、及び、例えば、アルカリ性ホスファターゼ、オステオカルシン、骨シアロタンパク質及び/又はオステオポンチン遺伝子発現のRT/PCRによる探知を使用して評価することができる。
本発明の医薬組成物は、１個以上の、例えば、生着を促進する化合物(例えば、アンチ-T-細胞レセプタ抗体、免疫抑制剤、又はそのようなものなど)；アルブミン、デキストラン40、ゼラチン、ヒドロキシエチルスターチなどの安定剤、を含むことができる。
注射剤として調製するとき、一実施態様において、本発明の医薬組成物は、約1.25％HSA及び約2.5％デキストランとを含む。細胞製品の投与に適した、他の注射製剤を使用することもできる。
注射剤として調製するとき、一実施態様において、本発明の医薬組成物は、約1.25％HSA及び約2.5％デキストランとを含む。細胞製品の投与に適した、他の注射製剤を使用することもできる。
Claims (61)
- 単離された付着性胎盤幹細胞の集団であって、前記胎盤幹細胞は：
同等数の骨髄由来の間葉系幹細胞（BM-MSC）と比較して検出可能なより高い水準で、遺伝子を発現し、ここで、前記遺伝子は、ELOVL2、ST3GAL6、ST6GALNAC5、又はSLC12A8を含み；前記胎盤幹細胞の少なくとも70％が、由来において非母系であり；かつ
前記胎盤幹細胞が、少なくとも3回継代された、前記集団。 - 単離された付着性胎盤幹細胞の集団であって、前記胎盤幹細胞は：
同等数の骨髄由来の間葉系幹細胞（BM-MSC）と比較して検出可能なより高い水準で、遺伝子を発現し、ここで、前記遺伝子は、CPA4、TCF21、VTN、B4GALT6、FLJ10781、又はNUAK1を含み；前記胎盤幹細胞の少なくとも70％が、由来において非母系であり；かつ
前記胎盤幹細胞が、少なくとも3回継代された、前記集団。 - 前記胎盤幹細胞が、成長条件下で培養された、請求項１又は２記載の集団。
- 前記胎盤幹細胞の少なくとも90％が、由来において非母系である、請求項１又は２記載の集団。
- 前記遺伝子が、さらにCD200を含む、請求項１又は２記載の集団。
- 前記遺伝子が、さらにCD200及びNUAK1を含む、請求項１記載の集団。
- 前記遺伝子が、さらにARTS-1、IER3、IL6、KRT18、LRAP、MEST、NFE2L3、又はTGFB2を含む、請求項５記載の集団。
- 前記遺伝子の前記発現が、3集団倍加に渡って、同等数の骨髄由来の間葉系幹細胞と比較して検出可能なより高い水準である、請求項１又は２記載の集団。
- 前記遺伝子の前記発現が、11〜14集団倍加に渡って、同等数の骨髄由来の間葉系幹細胞と比較して検出可能なより高い水準である、請求項１又は２記載の集団。
- 前記遺伝子の前記発現が、24〜38集団倍加に渡って、同等数の骨髄由来の間葉系幹細胞と比較して検出可能なより高い水準である、請求項１又は２記載の集団。
- 少なくとも5集団倍加を経た、請求項１又は２記載の集団。
- 15〜30集団倍加を経た、請求項１１記載の集団。
- 18〜26集団倍加を経た、請求項１２記載の集団。
- 約20集団倍加を経た、請求項１１記載の集団。
- 前記胎盤幹細胞が、3〜5日の倍加時間を有する、請求項１又は２記載の集団。
- 胎盤組織から採取されない幹細胞をさらに含む、請求項１又は２記載の集団。
- 前記胎盤組織から採取されない幹細胞が、間葉系幹細胞である、請求項１６記載の集団。
- 前記胎盤組織から採取されない幹細胞が、造血前駆細胞である、請求項１６記載の集団。
- 前記胎盤幹細胞が、凍結保存された、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、15％の臍帯血清及び0.01μg/mlの形質転換成長因子（TGFβ）を含む、Dulbeccoの変性必須培地（DMEM）で培養した場合に、軟骨形成細胞の特徴を有する細胞に分化し；かつ前記軟骨形成細胞の特徴が、アルシアンブルー染色での染色に陽性であることである、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、15％の臍帯血清、0.1μMデキサメタゾン、0.05mMアスコルビン酸-2-リン酸塩、及び10mMベータグリセロリン酸塩を含む、DMEMで培養した場合に、骨形成細胞の特徴を有する細胞に分化し；かつ前記骨形成細胞の特徴が、von Kossa染色で染色すること、又はRT-PCRにより決定される、アルカリ性ホスファターゼに対するmRNAの産生である、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、神経細胞の特徴を有する細胞に分化する能力を有する、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、DMEM、低グルコース（DMEM-LG）及びMCDB-201（ニワトリ線維芽細胞基礎培地）；2％ウシ胎仔血清、1xインスリン-トランスフェリン-セレニウム、1xリノレン酸ウシ血清アルブミン、10 -9 Mデキサメタゾン、10 -4 Mアスコルビン酸2-リン酸塩、10ng/ml上皮細胞成長因子、及び10ng/ml血小板由来の成長因子を含む培地中において、同等数のBM-MSCと比較して検出可能なより高い水準で、1個以上の遺伝子を発現する、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、培養中に、10〜40回複製する能力を有する、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、DMEM及びウシ胎仔血清において、培養中に、10〜40回複製する能力を有する、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、トリプシンを用いる消化によりヒトの分娩後の胎盤から単離されるか、又はトリプシンを用いる消化によりヒトの分娩後の胎盤から単離された細胞から培養される、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、該胎盤幹細胞が単離される胎盤の少なくとも90％の細胞のから分離された、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、該胎盤幹細胞が単離される胎盤の少なくとも95％の細胞のから分離された、請求項２７記載の集団。
- 前記胎盤幹細胞が、該胎盤幹細胞が単離される胎盤の少なくとも99％の細胞のから分離された、請求項２８記載の集団。
- 前記胎盤幹細胞が、3〜10回継代された、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、4〜8回継代された、請求項３０記載の集団。
- 前記胎盤幹細胞が、6回継代された、請求項３０記載の集団。
- 前記集団における少なくとも90％の細胞が、前記胎盤幹細胞である、請求項１又は２記載の集団。
- 前記集団における少なくとも95％の細胞が、前記胎盤幹細胞である、請求項１又は２記載の集団。
- 前記集団における少なくとも99％の細胞が、前記胎盤幹細胞である、請求項１又は２記載の集団。
- 前記胎盤幹細胞が、同等数のBM-MSCと比較して少なくとも3倍高い水準で、前記遺伝子を発現する、請求項１又は２記載の集団。
- 前記胎盤幹細胞により発現される前記遺伝子がELOVL2、ST3GAL6、ST6GALNAC5、及びSLC12A8を含む、請求項１記載の集団。
- 前記胎盤幹細胞により発現される前記遺伝子がCPA4、TCF21、VTN、B4GALT6、FLJ10781、及びNUAK1を含む、請求項２記載の集団。
- 前記胎盤幹細胞が、DMEM-LG及びMCDB-201；2％ウシ胎仔血清、1xインスリン-トランスフェリン-セレニウム、1xリノレン酸ウシ血清アルブミン、10 -9 Mデキサメタゾン、10 -4 Mアスコルビン酸2-リン酸塩、10ng/ml上皮細胞成長因子、及び10ng/ml血小板由来の成長因子を含む培地中において、同等数のBM-MSCと比較して検出可能なより高い水準で、前記遺伝子を発現する、請求項３７又は３８記載の集団。
- 10 6 〜10 7 個の胎盤幹細胞を含む、請求項１、２、３７、３８又は３９記載の集団。
- 10 7 〜10 8 個の胎盤幹細胞を含む、請求項１、２、３７、３８又は３９記載の集団。
- 少なくとも10 9 個の胎盤幹細胞を含む、請求項１、２、３７、３８又は３９記載の集団。
- 1 x 10 8 〜5 x 10 8 個の胎盤幹細胞を含む、請求項１、２、３７、３８又は３９記載の集団。
- 5 x 10 8 〜1 x 10 9 個の胎盤幹細胞を含む、請求項１、２、３７、３８又は３９記載の集団。
- 1 x 10 9 〜5 x 10 9 個の胎盤幹細胞を含む、請求項１、２、３７、３８又は３９記載の集団。
- 前記遺伝子が、ELOVL2を含む、請求項１記載の集団。
- 前記遺伝子が、ST3GAL6を含む、請求項１記載の集団。
- 前記遺伝子が、ST6GALNAC5を含む、請求項１記載の集団。
- 前記遺伝子が、SLC12A8を含む、請求項１記載の集団。
- 前記遺伝子が、CPA4を含む、請求項２記載の集団。
- 前記遺伝子が、TCF21を含む、請求項２記載の集団。
- 前記遺伝子が、VTNを含む、請求項２記載の集団。
- 前記遺伝子が、B4GALT6を含む、請求項２記載の集団。
- 前記遺伝子が、FLJ10781を含む、請求項２記載の集団。
- 前記遺伝子が、NUAK1を含む、請求項２記載の集団。
- ジメチルスルホキシド（DMSO）、ヒト血清アルブミン（HSA）、又はデキストランを含む組成物中に存在する、請求項１、２、３７、３８又は３９記載の集団。
- 医薬品として許容可能な運搬体中に、請求項１、２、３７、３８又は３９記載の集団を含む、医薬組成物。
- 前記集団が、10 6 〜10 7 個の胎盤幹細胞を含む、請求項５７記載の医薬組成物。
- 前記集団が、10 7 〜10 8 個の胎盤幹細胞を含む、請求項５７記載の医薬組成物。
- 注射剤である、請求項５７記載の医薬組成物。
- 静脈内投与に適した形態である、請求項５７記載の医薬組成物。
Applications Claiming Priority (5)
| Application Number | Priority Date | Filing Date | Title |
|---|---|---|---|
| US75496805P | 2005-12-29 | 2005-12-29 | |
| US60/754,968 | 2005-12-29 | ||
| US84664106P | 2006-09-22 | 2006-09-22 | |
| US60/846,641 | 2006-09-22 | ||
| PCT/US2006/049491 WO2007079183A2 (en) | 2005-12-29 | 2006-12-28 | Placental stem cell populations |
Related Child Applications (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013002575A Division JP5739918B2 (ja) | 2005-12-29 | 2013-01-10 | 胎盤幹細胞集団 |
Publications (3)
| Publication Number | Publication Date |
|---|---|
| JP2009521929A JP2009521929A (ja) | 2009-06-11 |
| JP2009521929A5 true JP2009521929A5 (ja) | 2013-02-28 |
| JP5550235B2 JP5550235B2 (ja) | 2014-07-16 |
Family
ID=38069162
Family Applications (2)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2008548745A Active JP5550235B2 (ja) | 2005-12-29 | 2006-12-28 | 胎盤幹細胞集団 |
| JP2013002575A Active JP5739918B2 (ja) | 2005-12-29 | 2013-01-10 | 胎盤幹細胞集団 |
Family Applications After (1)
| Application Number | Title | Priority Date | Filing Date |
|---|---|---|---|
| JP2013002575A Active JP5739918B2 (ja) | 2005-12-29 | 2013-01-10 | 胎盤幹細胞集団 |
Country Status (18)
| Country | Link |
|---|---|
| US (7) | US8057788B2 (ja) |
| EP (7) | EP2471905B1 (ja) |
| JP (2) | JP5550235B2 (ja) |
| KR (9) | KR20190104428A (ja) |
| CN (5) | CN103060263B (ja) |
| AU (1) | AU2006332678B2 (ja) |
| CA (2) | CA2635253C (ja) |
| DK (5) | DK2471907T3 (ja) |
| ES (6) | ES2708933T3 (ja) |
| HK (1) | HK1184817A1 (ja) |
| IL (6) | IL192457A0 (ja) |
| MX (4) | MX2018012512A (ja) |
| NZ (4) | NZ569562A (ja) |
| PE (1) | PE20080146A1 (ja) |
| PL (6) | PL1976977T3 (ja) |
| PT (5) | PT2471905T (ja) |
| WO (1) | WO2007079183A2 (ja) |
| ZA (2) | ZA201004182B (ja) |
Families Citing this family (182)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US20080152629A1 (en) * | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| US7311905B2 (en) * | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| EP1349918B1 (en) * | 2000-12-06 | 2014-08-06 | Anthrogenesis Corporation | Method of collecting placental stem cells |
| ES2444548T3 (es) | 2001-02-14 | 2014-02-25 | Anthrogenesis Corporation | Renovación y repoblación de tejidos y órganos cadavéricos descelularizados por células madre |
| US7682803B2 (en) | 2005-10-13 | 2010-03-23 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
| US7498171B2 (en) | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| CA2505534A1 (en) * | 2002-11-26 | 2004-06-10 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
| US8518390B2 (en) | 2003-06-27 | 2013-08-27 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of stroke and other acute neural degenerative disorders via intranasal administration of umbilical cord-derived cells |
| US9572840B2 (en) | 2003-06-27 | 2017-02-21 | DePuy Synthes Products, Inc. | Regeneration and repair of neural tissue using postpartum-derived cells |
| US8491883B2 (en) | 2003-06-27 | 2013-07-23 | Advanced Technologies And Regenerative Medicine, Llc | Treatment of amyotrophic lateral sclerosis using umbilical derived cells |
| US8790637B2 (en) | 2003-06-27 | 2014-07-29 | DePuy Synthes Products, LLC | Repair and regeneration of ocular tissue using postpartum-derived cells |
| US7875272B2 (en) * | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| AU2004252570C1 (en) | 2003-06-27 | 2012-03-01 | Ethicon, Incorporated | Soft tissue repair and regeneration using postpartum-derived cells |
| US9592258B2 (en) | 2003-06-27 | 2017-03-14 | DePuy Synthes Products, Inc. | Treatment of neurological injury by administration of human umbilical cord tissue-derived cells |
| GB0321337D0 (en) * | 2003-09-11 | 2003-10-15 | Massone Mobile Advertising Sys | Method and system for distributing advertisements |
| US20050143420A1 (en) * | 2003-12-02 | 2005-06-30 | Moutouh-De Parseval Laure | Methods and compositions for the treatment and management of hemoglobinopathy and anemia |
| US20050176139A1 (en) * | 2004-01-12 | 2005-08-11 | Yao-Chang Chen | Placental stem cell and methods thereof |
| CN1961283A (zh) * | 2004-03-26 | 2007-05-09 | 细胞基因公司 | 建立干细胞库的系统和方法 |
| EP1833496B1 (en) | 2004-12-23 | 2013-07-31 | Ethicon, Incorporated | Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells |
| PL1831356T3 (pl) | 2004-12-23 | 2017-07-31 | DePuy Synthes Products, Inc. | Komórki poporodowe pochodzące z tkanki pępowinowej i sposoby ich wytwarzania i stosowania |
| US20100028312A1 (en) * | 2005-03-24 | 2010-02-04 | Caritas St. Elizabeth Medical Center of Boston Inc | Stably transformed bone marrow-derived cells and uses thereof |
| WO2007047465A1 (en) * | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Production of oligodendrocytes from placenta-derived stem cells |
| CN101374946B (zh) | 2005-12-16 | 2017-07-18 | 伊西康公司 | 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法 |
| JP5179376B2 (ja) | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
| US9125906B2 (en) | 2005-12-28 | 2015-09-08 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using umbilical cord tissue-derived cells |
| CN103060263B (zh) | 2005-12-29 | 2016-03-16 | 人类起源公司 | 胎盘干细胞群 |
| KR20080081088A (ko) * | 2005-12-29 | 2008-09-05 | 안트로제네시스 코포레이션 | 태반 줄기세포와 제2 세포원으로부터 얻은 줄기세포의 공동배양 |
| US9598669B2 (en) * | 2005-12-29 | 2017-03-21 | Anthrogenesis Corporation | Composition for collecting placental stem cells and methods of using the composition |
| US9944900B2 (en) * | 2006-01-18 | 2018-04-17 | Hemacell Perfusion | Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells |
| CA2909053C (en) * | 2006-05-11 | 2021-02-09 | Cord Blood Science Inc. | Methods for collecting and using placenta cord blood stem cells |
| US20080050814A1 (en) * | 2006-06-05 | 2008-02-28 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of fetal placental cells |
| US7993918B2 (en) * | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| US8372437B2 (en) | 2006-08-17 | 2013-02-12 | Mimedx Group, Inc. | Placental tissue grafts |
| CN103255098A (zh) * | 2006-10-23 | 2013-08-21 | 人类起源公司 | 用胎盘细胞群治疗骨缺损的方法和组合物 |
| WO2008088738A2 (en) | 2007-01-17 | 2008-07-24 | Stemnion, Inc. | Novel methods for modulating inflammatory and/or immune responses |
| KR20090109127A (ko) * | 2007-02-12 | 2009-10-19 | 안트로제네시스 코포레이션 | 부착성 태반 줄기세포에서 유래한 간세포와 연골세포 및 ｃｄ34＋, ｃｄ45－ 태반 줄기세포가 농축된 세포군 |
| SI2120977T1 (sl) * | 2007-02-12 | 2014-01-31 | Anthrogenesis Coroporation | Zdravljenje vnetnih bolezni z uporabo placentarnih matičnih celic |
| US8673547B2 (en) * | 2007-03-08 | 2014-03-18 | Hemacell Perfusion, Inc. | Method for isolation of afterbirth derived cells |
| US20100172830A1 (en) * | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
| WO2008156659A1 (en) | 2007-06-18 | 2008-12-24 | Children's Hospital & Research Center At Oakland | Method of isolating stem and progenitor cells from placenta |
| EP2014294A1 (en) * | 2007-07-13 | 2009-01-14 | Institut National De La Sante Et De La Recherche Medicale (Inserm) | Use of CD200 as a mesenchymal stem cells marker |
| WO2009014668A2 (en) * | 2007-07-24 | 2009-01-29 | Stemnion, Inc. | Methods for promoting hair growth |
| US9200253B1 (en) | 2007-08-06 | 2015-12-01 | Anthrogenesis Corporation | Method of producing erythrocytes |
| CA2736663C (en) | 2007-09-07 | 2018-01-02 | Surgical Biologics, Llc. | Placental tissue grafts and improved methods of preparing and using the same |
| US20090074731A1 (en) * | 2007-09-13 | 2009-03-19 | Librach Clifford L | Method of isolation and use of cells derived from first trimester umbilical cord tissue |
| US10925903B2 (en) | 2007-09-13 | 2021-02-23 | Reprobiogen Inc. | Use of cells derived from first trimester umbilical cord tissue |
| EP3103463B1 (en) | 2007-09-19 | 2020-01-01 | Pluristem Ltd. | Adherent cells from adipose or placenta tissues and use thereof in therapy |
| JP5703493B2 (ja) * | 2007-09-26 | 2015-04-22 | アンスロジェネシス コーポレーション | ヒト胎盤灌流液由来の血管形成細胞 |
| KR20210127819A (ko) | 2007-09-28 | 2021-10-22 | 안트로제네시스 코포레이션 | 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법 |
| AU2008308531B2 (en) | 2007-10-05 | 2014-04-24 | Ethicon, Incorporated | Repair and regeneration of renal tissue using human umbilical cord tissue-derived cells |
| RU2010123002A (ru) * | 2007-11-07 | 2011-12-20 | Антродженезис Корпорейшн (Us) | Лечение осложнений преждевременных родов |
| CN101765657A (zh) | 2007-11-09 | 2010-06-30 | Rnl生物技术株式会社 | 分离和培养来自人羊膜上皮细胞的成人干细胞的方法 |
| US8236538B2 (en) | 2007-12-20 | 2012-08-07 | Advanced Technologies And Regenerative Medicine, Llc | Methods for sterilizing materials containing biologically active agents |
| EP2250497B1 (en) * | 2008-02-18 | 2014-09-10 | Genetic Technologies Limited | Cell processing and/or enrichment methods |
| US9458431B2 (en) | 2008-03-17 | 2016-10-04 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| US8716018B2 (en) | 2008-03-17 | 2014-05-06 | Agency For Science, Technology And Research | Microcarriers for stem cell culture |
| US20120028352A1 (en) * | 2008-03-17 | 2012-02-02 | Agency For Science, Technology And Research | Microcarriers for Stem Cell Culture |
| US8497122B2 (en) | 2008-04-11 | 2013-07-30 | Washington University | Biomarkers for Niemann-pick C disease and related disorders |
| WO2009131568A1 (en) * | 2008-04-21 | 2009-10-29 | Cythera, Inc. | Methods for purifying endoderm and pancreatic endoderm cells derived from human embryonic stem cells |
| AU2009252722A1 (en) * | 2008-05-27 | 2009-12-03 | Pluristem Ltd. | Methods of treating inflammatory colon diseases |
| MX2011001991A (es) * | 2008-08-20 | 2011-03-29 | Anthrogenesis Corp | Tratamiento de la apoplejia utilizando celulas placentarias aisladas. |
| CN105766891A (zh) * | 2008-08-20 | 2016-07-20 | 人类起源公司 | 改进的细胞组合物及制备所述组合物的方法 |
| MX2011001992A (es) | 2008-08-22 | 2011-03-29 | Anthrogenesis Corp | Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias. |
| EP2331957B1 (en) * | 2008-09-02 | 2016-11-02 | Pluristem Ltd. | Methods of selection of cells for transplantation |
| AU2009288781B2 (en) * | 2008-09-02 | 2015-01-29 | Pluri Biotech Ltd | Adherent cells from placenta tissue and use thereof in therapy |
| US9096827B2 (en) * | 2008-09-02 | 2015-08-04 | Pluristem Ltd. | Adherent cells from placenta tissue and use thereof in therapy |
| WO2010040262A1 (zh) * | 2008-10-10 | 2010-04-15 | 深圳市嘉天源生物科技有限公司 | 分离动物胚胎间质性干细胞并提取其分泌物的方法 |
| WO2010043076A1 (zh) * | 2008-10-17 | 2010-04-22 | 宁夏医科大学附属医院 | 适于临床应用的人胎盘间质细胞库的建立方法 |
| JP5869342B2 (ja) | 2008-11-19 | 2016-02-24 | アンスロジェネシス コーポレーション | 羊膜由来接着細胞 |
| CA2743573C (en) * | 2008-11-21 | 2021-04-27 | Anthrogenesis Corporation | Treatment of diseases, disorders or conditions of the lung using placental cells |
| BRPI0923068B1 (pt) | 2008-12-19 | 2021-05-25 | Advanced Technologies And Regenerative Medicine, Llc | Uso de células derivadas de tecido de cordão umbilical para tratar um paciente tendo uma doença, distúrbio ou injúria pulmonar |
| US10179900B2 (en) | 2008-12-19 | 2019-01-15 | DePuy Synthes Products, Inc. | Conditioned media and methods of making a conditioned media |
| US8771677B2 (en) | 2008-12-29 | 2014-07-08 | Vladimir B Serikov | Colony-forming unit cell of human chorion and method to obtain and use thereof |
| RU2642988C2 (ru) | 2009-03-25 | 2018-01-29 | Антродженезис Корпорейшн | Супрессия опухолей с использованием полученных из плаценты человека промежуточных естественных киллерных клеток и иммуномодулирующих соединений |
| CN102498204B (zh) | 2009-03-26 | 2015-02-04 | 德普伊新特斯产品有限责任公司 | 人脐带组织细胞作为用于阿尔茨海默病的疗法 |
| SG175282A1 (en) | 2009-04-21 | 2011-11-28 | Genetic Technologies Ltd | Methods for obtaining fetal genetic material |
| US20100323446A1 (en) | 2009-06-05 | 2010-12-23 | Jill Renee Barnett | Method of collecting placental cells |
| US8796315B2 (en) | 2009-06-25 | 2014-08-05 | Darlene E. McCord | Methods for improved wound closure employing olivamine and human umbilical vein endothelial cells |
| EP2449095A1 (en) | 2009-07-02 | 2012-05-09 | Anthrogenesis Corporation | Method of producing erythrocytes without feeder cells |
| CN101942413B (zh) * | 2009-07-07 | 2015-02-11 | 翁炳焕 | 出生缺陷细胞库及其构建方法 |
| US8647617B2 (en) | 2009-07-13 | 2014-02-11 | Stemnion, Inc. | Methods for modulating inflammatory and/or immune responses |
| SG177467A1 (en) * | 2009-07-23 | 2012-02-28 | Agency Science Tech & Res | Pre-natal mesenchymal stem cells |
| EP3170891B1 (en) * | 2009-10-23 | 2020-11-25 | Caladrius Biosciences, Inc. | Compositions and uses for treating progressive myocardial injury due to a vascular insufficiency |
| WO2011094181A1 (en) | 2010-01-26 | 2011-08-04 | Anthrogenesis Corporation | Treatment of bone-related cancers using placental stem cells |
| CA2790340A1 (en) | 2010-02-18 | 2011-08-25 | Osiris Therapeutics, Inc. | Methods of manufacture of therapeutic products comprising vitalized placental dispersions |
| PL2556145T3 (pl) | 2010-04-07 | 2017-02-28 | Anthrogenesis Corporation | Angiogeneza z zastosowaniem łożyskowych komórek macierzystych |
| AU2013203479B2 (en) * | 2010-04-07 | 2016-05-19 | Celularity Inc. | Angiogenesis using placental stem cells |
| WO2011127113A1 (en) * | 2010-04-08 | 2011-10-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
| US10130736B1 (en) | 2010-05-14 | 2018-11-20 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US9352003B1 (en) | 2010-05-14 | 2016-05-31 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| US8883210B1 (en) | 2010-05-14 | 2014-11-11 | Musculoskeletal Transplant Foundation | Tissue-derived tissuegenic implants, and methods of fabricating and using same |
| WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
| KR101211913B1 (ko) * | 2010-07-16 | 2012-12-13 | 주식회사 알앤엘바이오 | 양막유래 중간엽 줄기세포 배양을 위한 배지조성물 및 이를 이용한 양막유래 중간엽 줄기세포의 배양방법 |
| CA2821818A1 (en) * | 2010-12-17 | 2012-06-21 | Anthrogenesis Corporation | Treatment of spinal cord injury and traumatic brain injury using placental stem cells |
| US8574899B2 (en) | 2010-12-22 | 2013-11-05 | Vladimir B Serikov | Methods for augmentation collection of placental hematopoietic stem cells and uses thereof |
| AR084754A1 (es) | 2010-12-30 | 2013-06-05 | Anthrogenesis Corp | Composiciones que comprenden celulas madre de placenta y plasma rico en plaquetas, y sus metodos de uso |
| AR084753A1 (es) | 2010-12-30 | 2013-06-05 | Anthrogenesis Corp | Composiciones que comprenden celulas adherentes derivadas del saco amniotico (amdac) y plasma rico en plaquetas (prp) |
| AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
| US20140017209A1 (en) * | 2011-03-22 | 2014-01-16 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
| EP3260533B1 (en) | 2011-03-22 | 2019-09-11 | Pluristem Ltd. | Methods for treating radiation or chemical injury |
| US20120276215A1 (en) * | 2011-04-26 | 2012-11-01 | Riordan Neil H | Therapeutic Conditioned Media |
| MX357749B (es) | 2011-06-01 | 2018-07-23 | Anthrogenesis Corp | Tratamiento contra el dolor utilizando células madre placentarias. |
| WO2013012698A1 (en) * | 2011-07-15 | 2013-01-24 | Anthrogenesis Corporation | Treatment of radiation injury using amnion derived adherent cells |
| CN102676451B (zh) * | 2011-09-05 | 2014-04-16 | 博雅干细胞科技有限公司 | 从胎盘中分离间充质干细胞的方法 |
| US9925221B2 (en) | 2011-09-09 | 2018-03-27 | Celularity, Inc. | Treatment of amyotrophic lateral sclerosis using placental stem cells |
| US20140242038A1 (en) * | 2011-10-11 | 2014-08-28 | The Trustees Of Columbia University In The City Of New York | Method for generating beta cells |
| EP2773746A4 (en) * | 2011-11-01 | 2015-08-05 | Neostem Inc | COMPOSITIONS OF ADULT MESENCHYMAL STEM CELLS (MSC) AND PREPARATION METHODS THEREOF |
| US9611513B2 (en) | 2011-12-23 | 2017-04-04 | DePuy Synthes Products, Inc. | Detection of human umbilical cord tissue derived cells |
| US11311367B2 (en) | 2012-01-31 | 2022-04-26 | Wake Forest University Health Sciences | Tissue-engineered gut-sphincter complexes and methods of making the same |
| WO2017117229A1 (en) | 2015-12-30 | 2017-07-06 | Wake Forest University Health Sciences | Tissue-engineered gut-sphincter complexes and methods of making the same |
| EP3338548B1 (en) | 2012-02-23 | 2020-04-08 | Celularity, Inc. | Identification of antitumor compounds using placenta |
| WO2013131192A1 (en) * | 2012-03-06 | 2013-09-12 | Aris Aziz | Placental stem cells, methods for isolating same and use thereof |
| KR101422559B1 (ko) * | 2012-03-09 | 2014-07-24 | 창원대학교 산학협력단 | 지방유래 줄기세포 배양액, 이의 제조방법, 및 이를 포함하는 발모촉진용 조성물 |
| KR101523040B1 (ko) * | 2012-06-26 | 2015-05-26 | 라정찬 | 고농도의 줄기세포 제조방법 |
| US9657290B2 (en) | 2012-07-03 | 2017-05-23 | The Board Of Trustees Of The Leland Stanford Junior University | Scalable bio-element analysis |
| KR20150063374A (ko) | 2012-08-13 | 2015-06-09 | 안트로제네시스 코포레이션 | 자연 살해 세포 및 그의 용도 |
| KR101532556B1 (ko) | 2012-09-03 | 2015-06-30 | 메디포스트(주) | 간엽줄기세포의 배양 방법 |
| US20150224226A1 (en) | 2012-09-04 | 2015-08-13 | Anthrogenesis Corporation | Methods of tissue generation |
| EP2892996B1 (en) * | 2012-09-07 | 2019-08-14 | BioLamina AB | Stem cell bank |
| US20160166618A1 (en) | 2012-10-19 | 2016-06-16 | Anthrogenesis Corproation | Treatment of pain using amnion derived adherent cells |
| EP2925307B1 (en) | 2012-11-30 | 2020-10-28 | McCord, Darlene E. | Hydroxytyrosol and oleuropein compositions for induction of dna damage, cell death and lsd1 inhibition |
| US20150313948A1 (en) | 2012-12-07 | 2015-11-05 | Anthrogenesis Corporation | Treating oral lesions using placental extracellular matrix |
| WO2014093753A1 (en) | 2012-12-14 | 2014-06-19 | Anthrogenesis Corporation | Anoikis resistant placental stem cells and uses thereof |
| AU2013204922B2 (en) | 2012-12-20 | 2015-05-14 | Celgene Corporation | Chimeric antigen receptors |
| EP3622960A1 (en) | 2013-02-05 | 2020-03-18 | Celularity, Inc. | Natural killer cells from placenta |
| US10493104B2 (en) * | 2013-02-20 | 2019-12-03 | Samsung Life Public Welfare Foundation | Composition for treating inflammatory brain diseases which includes stem cell as active ingredient |
| WO2014159826A1 (en) * | 2013-03-14 | 2014-10-02 | Antrhogenesis Corporation | Use of placental stem cells in treatment of acute kidney injury |
| EP2970883B8 (en) | 2013-03-14 | 2021-06-23 | Celularity Inc. | Enhanced placental stem cells and uses thereof |
| CN105518018B (zh) | 2013-03-15 | 2020-04-03 | 细胞基因公司 | 修饰的t淋巴细胞 |
| NO2975611T3 (ja) | 2013-03-15 | 2018-06-09 | ||
| EP2970877B1 (en) | 2013-03-15 | 2018-07-25 | Wake Forest University Health Sciences | Neural progenitor cell differentiation |
| ES2968068T3 (es) * | 2013-03-15 | 2024-05-07 | Prime Merger Sub Llc | Preparaciones derivadas de materiales placentarios y métodos para fabricarlas y utilizarlas |
| US9795639B1 (en) * | 2013-03-16 | 2017-10-24 | BioDlogics, LLC | Methods for the treatment of erectile dysfunction by human birth tissue material compostion |
| CN103173405B (zh) * | 2013-03-21 | 2017-11-07 | 北京京蒙高科干细胞技术有限公司 | 一种人胎盘成肌纤维母细胞的简易分离及鉴定方法 |
| KR101583569B1 (ko) * | 2013-05-15 | 2016-01-08 | 라정찬 | 정맥 투여용 줄기세포 조성물 |
| WO2014209856A1 (en) | 2013-06-24 | 2014-12-31 | Anthrogenesis Corporation | Extracellular matrix composition beads for cell culture |
| JP2016537362A (ja) * | 2013-11-15 | 2016-12-01 | アントフロゲネシス コーポレーション | ヒト胎盤灌流液細胞、その亜集団を含む組成物、およびそれらの使用 |
| JP6545690B2 (ja) * | 2014-01-08 | 2019-07-17 | サムスン ライフ パブリック ウェルフェア ファウンデーション | 栄養膜基底層から由来した幹細胞及びそれを含む細胞治療剤 |
| US20160326487A1 (en) * | 2014-01-08 | 2016-11-10 | Samsung Life Public Welfare Foundation | Stem Cells Derived from Pure Chorionic Trophoblast Layer and Cell Therapy Comprising Same |
| CN103756965B (zh) * | 2014-01-27 | 2016-04-06 | 山东省齐鲁干细胞工程有限公司 | 一种从胎盘中灌洗造血干细胞的方法 |
| US20170042944A1 (en) * | 2014-04-21 | 2017-02-16 | Anthrogenesis Corporation | Treatment of conditions and complications in infants |
| EP3167058B1 (en) | 2014-07-11 | 2020-05-27 | Celgene Corporation | Methods of improving vector transduction efficiency into t lymphocytes |
| US20180080008A1 (en) | 2014-08-12 | 2018-03-22 | Anthrogenesis Corporation | Car-t lymphocytes engineered to home to lymph node b cell zone, skin, or gastrointestinal tract |
| CN107106615A (zh) | 2014-10-09 | 2017-08-29 | 人类起源公司 | 胎盘来源的贴壁细胞外泌体及其用途 |
| WO2016068616A1 (ko) * | 2014-10-29 | 2016-05-06 | 차의과학대학교 산학협력단 | C3 또는 c1r 보체를 분비하는 태반 유래 세포 및 이를 포함하는 조성물 |
| EP3259385A4 (en) | 2015-02-22 | 2018-07-25 | The Board of Trustees of the Leland Stanford Junior University | Micro-screening apparatus, process, and products |
| WO2016149492A1 (en) * | 2015-03-18 | 2016-09-22 | Anthrogenesis Corporation | Methods of banking placental tissue and cells |
| CA2986702C (en) | 2015-05-21 | 2023-04-04 | David Wang | Modified demineralized cortical bone fibers |
| KR20180019613A (ko) * | 2015-05-28 | 2018-02-26 | 셀룰래리티, 인코포레이티드 | 태반-유래 줄기 세포 및 그의 재생 엔진 복구, 프로테옴 결함 수정 및 노화 객체의 수명 연장 용도 |
| WO2017039251A1 (ko) * | 2015-08-28 | 2017-03-09 | 주식회사 차바이오텍 | 향상된 산후 부착형 세포 및 그의 용도 |
| CN108367028A (zh) | 2015-09-15 | 2018-08-03 | 细胞结构公司 | 使用胎盘细胞治疗糖尿病性周围神经病变 |
| CN108368479A (zh) * | 2015-09-29 | 2018-08-03 | 细胞结构公司 | 细胞效能分析 |
| AU2017235446A1 (en) * | 2016-03-16 | 2018-11-08 | Cell Medicine, Inc. | Mesenchymal stem cells with enhanced efficacy |
| WO2018053485A1 (en) * | 2016-09-19 | 2018-03-22 | The Board Of Trustees Of The Leland Stanford Junior University | Micro-screening and sorting apparatus, process, and products |
| CN110198786A (zh) | 2016-11-14 | 2019-09-03 | 浩康生物系统公司 | 用于分选目标颗粒的方法和装置 |
| CN110402147A (zh) | 2016-12-05 | 2019-11-01 | 细胞结构公司 | 使用胎盘贴壁细胞治疗淋巴水肿和相关病症 |
| US10433112B2 (en) * | 2017-02-22 | 2019-10-01 | Middle Chart, LLC | Methods and apparatus for orienteering |
| TW201834669A (zh) | 2017-03-15 | 2018-10-01 | 美商歐卡生物系統公司 | 用於造血幹細胞移植的組合物及方法 |
| CN110494556B (zh) * | 2017-04-03 | 2024-04-30 | 株式会社钟化 | 包含间充质系干细胞的细胞群、其制造方法、以及医药组合物 |
| CN107586757A (zh) * | 2017-11-01 | 2018-01-16 | 天津昂赛细胞基因工程有限公司 | 一种猪间充质干细胞培养液及其制备方法 |
| US10142452B1 (en) * | 2018-05-29 | 2018-11-27 | Guangzhou Zhijing Technology Co., Ltd | Mobile terminal unlock method |
| KR20210111762A (ko) | 2018-11-30 | 2021-09-13 | 셀룰래리티 인코포레이티드 | 신규 방향족 화합물을 사용한 자연 살해 세포 및 ilc3 세포의 증식 |
| AU2020247621A1 (en) * | 2019-03-27 | 2021-07-22 | Pluri Biotech Ltd | Methods and compositions for aesthetic and cosmetic treatment and stimulating hair growth |
| CN109908351B (zh) * | 2019-04-08 | 2021-04-06 | 中南大学 | circ_ADARB1在制备鼻咽癌治疗制剂中的应用和治疗制剂 |
| US20220265712A1 (en) | 2019-06-14 | 2022-08-25 | Celularity Inc. | Populations of natural killer cells for treating cancers |
| WO2021003254A1 (en) * | 2019-07-01 | 2021-01-07 | Auxocell Laboratories, Inc. | Cryopreservation medium comprising a tissue extract |
| CN110468099B (zh) * | 2019-07-19 | 2023-08-15 | 海门生原干细胞科技有限公司 | 一种骨髓间充质干细胞培养基及其应用 |
| US20220273716A1 (en) | 2019-07-25 | 2022-09-01 | Celularity Inc. | Populations of natural killer cells comprising a cd38 chimeric antigen receptor |
| US20230355759A1 (en) | 2019-07-31 | 2023-11-09 | Celularity Inc. | Populations of natural killer cells comprising a cleavage resistant cd16 |
| CN110592005A (zh) * | 2019-08-14 | 2019-12-20 | 广州乾晖生物科技有限公司 | 间充质干细胞的分离方法 |
| WO2021113849A1 (en) | 2019-12-05 | 2021-06-10 | Celularity Inc. | Her2+ cancer treatment with populations of natural killer cells comprising a cleavage resistant cd16 |
| WO2021155312A1 (en) | 2020-01-29 | 2021-08-05 | Celularity Inc. | Placental derived natural killer cells for treatment of coronavirus infections |
| US20230210909A1 (en) | 2020-05-08 | 2023-07-06 | Celularity Inc. | Placenta-derived adherent (pda) stem cell for the treatment of adults with sars-cov-2 related acute respiratory failure and ards (covid-19) |
| WO2021257073A1 (en) * | 2020-06-17 | 2021-12-23 | Joy Kong | Method for producing mesenchymal stem cells from neonatal stem cells |
| CN111956787A (zh) * | 2020-07-06 | 2020-11-20 | 沃森克里克（北京）生物科技有限公司 | 一种毛发增长剂和育毛剂及其应用 |
| US20240002788A1 (en) * | 2020-12-03 | 2024-01-04 | VityleBio, Inc. | Regenerative Tissue Extract from Non-Human Mammalian Placenta |
| CN112592885B (zh) * | 2020-12-23 | 2022-06-17 | 山东华领奥源生物科技有限公司 | 一种胎盘亚全能干细胞的分离培养方法 |
| WO2023278628A1 (en) | 2021-06-29 | 2023-01-05 | Celularity Inc. | Human placental hematopoietic stem cell derived natural killer cells in acute myeloid leukemia (aml) remission with minimal residual disease (mrd) or relapsed/refractory aml |
| WO2023010123A1 (en) | 2021-07-29 | 2023-02-02 | Celularity Inc. | Placenta-dervied nk cells as a senolytic for therapeutic and other uses |
| WO2023137344A1 (en) | 2022-01-11 | 2023-07-20 | Celularity Inc. | Cleavage resistant cd16 constructs and uses thereof |
| CN115478111A (zh) * | 2022-06-07 | 2022-12-16 | 兰州大学 | 一种与绵羊免疫性状相关的分子标记、其检测方法和应用 |
| CN116144583B (zh) * | 2023-04-19 | 2023-08-25 | 北京雪颜博润生物科技有限公司 | 一种获取人胎盘胚源干细胞的方法及应用 |
Family Cites Families (336)
| Publication number | Priority date | Publication date | Assignee | Title |
|---|---|---|---|---|
| US3862002A (en) * | 1962-05-08 | 1975-01-21 | Sanfar Lab Inc | Production of physiologically active placental substances |
| US3372581A (en) | 1965-04-27 | 1968-03-12 | Tell Sven Axel | Dynamometer |
| US4829000A (en) * | 1985-08-30 | 1989-05-09 | The United States Of America As Represented By The Secretary Of The Department Of Health And Human Services | Reconstituted basement membrane complex with biological activity |
| US4798824A (en) | 1985-10-03 | 1989-01-17 | Wisconsin Alumni Research Foundation | Perfusate for the preservation of organs |
| US5902741A (en) | 1986-04-18 | 1999-05-11 | Advanced Tissue Sciences, Inc. | Three-dimensional cartilage cultures |
| US5266480A (en) | 1986-04-18 | 1993-11-30 | Advanced Tissue Sciences, Inc. | Three-dimensional skin culture system |
| US5863531A (en) * | 1986-04-18 | 1999-01-26 | Advanced Tissue Sciences, Inc. | In vitro preparation of tubular tissue structures by stromal cell culture on a three-dimensional framework |
| US5744347A (en) | 1987-01-16 | 1998-04-28 | Ohio University Edison Biotechnology Institute | Yolk sac stem cells and their uses |
| NZ226750A (en) | 1987-10-29 | 1990-09-26 | Amrad Corp Ltd | Immortalisation of neural precursor cells by introducing a retrovirus vector containing a myc-oncogene |
| US5004681B1 (en) | 1987-11-12 | 2000-04-11 | Biocyte Corp | Preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood |
| US5192553A (en) | 1987-11-12 | 1993-03-09 | Biocyte Corporation | Isolation and preservation of fetal and neonatal hematopoietic stem and progenitor cells of the blood and methods of therapeutic use |
| GB8803697D0 (en) | 1988-02-17 | 1988-03-16 | Deltanine Research Ltd | Clinical developments using amniotic membrane cells |
| US5284766A (en) * | 1989-02-10 | 1994-02-08 | Kao Corporation | Bed material for cell culture |
| FR2646438B1 (fr) | 1989-03-20 | 2007-11-02 | Pasteur Institut | Procede de remplacement specifique d'une copie d'un gene present dans le genome receveur par l'integration d'un gene different de celui ou se fait l'integration |
| US5763266A (en) | 1989-06-15 | 1998-06-09 | The Regents Of The University Of Michigan | Methods, compositions and devices for maintaining and growing human stem and/or hematopoietics cells |
| US5437994A (en) | 1989-06-15 | 1995-08-01 | Regents Of The University Of Michigan | Method for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5635386A (en) | 1989-06-15 | 1997-06-03 | The Regents Of The University Of Michigan | Methods for regulating the specific lineages of cells produced in a human hematopoietic cell culture |
| US5399493A (en) | 1989-06-15 | 1995-03-21 | The Regents Of The University Of Michigan | Methods and compositions for the optimization of human hematopoietic progenitor cell cultures |
| US5605822A (en) * | 1989-06-15 | 1997-02-25 | The Regents Of The University Of Michigan | Methods, compositions and devices for growing human hematopoietic cells |
| KR100226158B1 (ko) | 1989-07-25 | 1999-10-15 | 스티븐 에이. 서윈. 엠.디. | 만능공급세포 및 잡종 포유동물 숙주를 위한 동종 재조합 |
| US5464764A (en) | 1989-08-22 | 1995-11-07 | University Of Utah Research Foundation | Positive-negative selection methods and vectors |
| DK0452484T3 (da) | 1989-11-06 | 1996-10-14 | Cell Genesys Inc | Fremstilling af proteiner ved homolog rekombination |
| US5272071A (en) | 1989-12-22 | 1993-12-21 | Applied Research Systems Ars Holding N.V. | Method for the modification of the expression characteristics of an endogenous gene of a given cell line |
| US5061620A (en) * | 1990-03-30 | 1991-10-29 | Systemix, Inc. | Human hematopoietic stem cell |
| US5635387A (en) | 1990-04-23 | 1997-06-03 | Cellpro, Inc. | Methods and device for culturing human hematopoietic cells and their precursors |
| US6326198B1 (en) | 1990-06-14 | 2001-12-04 | Regents Of The University Of Michigan | Methods and compositions for the ex vivo replication of stem cells, for the optimization of hematopoietic progenitor cell cultures, and for increasing the metabolism, GM-CSF secretion and/or IL-6 secretion of human stromal cells |
| US5197985A (en) * | 1990-11-16 | 1993-03-30 | Caplan Arnold I | Method for enhancing the implantation and differentiation of marrow-derived mesenchymal cells |
| US5811094A (en) | 1990-11-16 | 1998-09-22 | Osiris Therapeutics, Inc. | Connective tissue regeneration using human mesenchymal stem cell preparations |
| US5837539A (en) | 1990-11-16 | 1998-11-17 | Osiris Therapeutics, Inc. | Monoclonal antibodies for human mesenchymal stem cells |
| US5486359A (en) | 1990-11-16 | 1996-01-23 | Osiris Therapeutics, Inc. | Human mesenchymal stem cells |
| US5733542A (en) * | 1990-11-16 | 1998-03-31 | Haynesworth; Stephen E. | Enhancing bone marrow engraftment using MSCS |
| US6010696A (en) * | 1990-11-16 | 2000-01-04 | Osiris Therapeutics, Inc. | Enhancing hematopoietic progenitor cell engraftment using mesenchymal stem cells |
| US5226914A (en) | 1990-11-16 | 1993-07-13 | Caplan Arnold I | Method for treating connective tissue disorders |
| US5190556A (en) | 1991-03-19 | 1993-03-02 | O.B. Tech, Inc. | Cord cutter sampler |
| US5744361A (en) * | 1991-04-09 | 1998-04-28 | Indiana University | Expansion of human hematopoietic progenitor cells in a liquid medium |
| US5750376A (en) | 1991-07-08 | 1998-05-12 | Neurospheres Holdings Ltd. | In vitro growth and proliferation of genetically modified multipotent neural stem cells and their progeny |
| WO1993003139A1 (en) | 1991-08-08 | 1993-02-18 | Kao Corporation | Cell culture support, production thereof, and production of cell cluster using same |
| EP0529751A1 (en) | 1991-08-09 | 1993-03-03 | W.R. Grace & Co.-Conn. | Cell culture substrate, test material for cell culture and preparations thereof |
| AU2515992A (en) | 1991-08-20 | 1993-03-16 | Genpharm International, Inc. | Gene targeting in animal cells using isogenic dna constructs |
| US5356373A (en) | 1991-11-15 | 1994-10-18 | Miles Inc. | Method and apparatus for autologous transfusions in premature infants |
| EP0627003A1 (en) | 1991-12-23 | 1994-12-07 | British Bio-Technology Limited | Stem cell inhibiting proteins |
| US5668104A (en) | 1992-03-31 | 1997-09-16 | Toray Industries, Inc. | Hematopoietic stem cell growth-promoting compositions containing a fibroblast-derived fragment of fibronectin and a growth factor, and methods employing them in vitro or in vivo |
| US5460964A (en) | 1992-04-03 | 1995-10-24 | Regents Of The University Of Minnesota | Method for culturing hematopoietic cells |
| US5552267A (en) | 1992-04-03 | 1996-09-03 | The Trustees Of Columbia University In The City Of New York | Solution for prolonged organ preservation |
| WO1994000484A1 (en) | 1992-06-22 | 1994-01-06 | Young Henry E | Scar inhibitory factor and use thereof |
| US5693482A (en) | 1992-07-27 | 1997-12-02 | California Institute Of Technology | Neural chest stem cell assay |
| US5849553A (en) | 1992-07-27 | 1998-12-15 | California Institute Of Technology | Mammalian multipotent neural stem cells |
| US5672346A (en) | 1992-07-27 | 1997-09-30 | Indiana University Foundation | Human stem cell compositions and methods |
| SG86980A1 (en) | 1992-11-16 | 2002-03-19 | Applied Immunesciences | Pluripotential quiescent stem cell population |
| US5772992A (en) | 1992-11-24 | 1998-06-30 | G.D. Searle & Co. | Compositions for co-administration of interleukin-3 mutants and other cytokines and hematopoietic factors |
| US5654186A (en) | 1993-02-26 | 1997-08-05 | The Picower Institute For Medical Research | Blood-borne mesenchymal cells |
| AU694111B2 (en) * | 1993-03-31 | 1998-07-16 | Pro-Neuron, Inc. | Inhibitor of stem cell proliferation and uses thereof |
| GB9308271D0 (en) | 1993-04-21 | 1993-06-02 | Univ Edinburgh | Method of isolating and/or enriching and/or selectively propagating pluripotential animal cells and animals for use in said method |
| US5709854A (en) * | 1993-04-30 | 1998-01-20 | Massachusetts Institute Of Technology | Tissue formation by injecting a cell-polymeric solution that gels in vivo |
| US5372581A (en) | 1993-07-21 | 1994-12-13 | Minneapolis Children's Services Corporation | Method and apparatus for placental blood collection |
| IL107483A0 (en) | 1993-11-03 | 1994-02-27 | Yeda Res & Dev | Bone marrow transplantation |
| US5591625A (en) * | 1993-11-24 | 1997-01-07 | Case Western Reserve University | Transduced mesenchymal stem cells |
| US6288030B1 (en) * | 1993-12-22 | 2001-09-11 | Amgen Inc. | Stem cell factor formulations and methods |
| US6001654A (en) | 1994-01-28 | 1999-12-14 | California Institute Of Technology | Methods for differentiating neural stem cells to neurons or smooth muscle cells using TGT-β super family growth factors |
| US5942496A (en) | 1994-02-18 | 1999-08-24 | The Regent Of The University Of Michigan | Methods and compositions for multiple gene transfer into bone cells |
| US5580724A (en) | 1994-03-25 | 1996-12-03 | Board Of Regents, The University Of Texas System | Differential expansion of fetal stem cells in maternal circulation for use in prenatal genetic analysis |
| CA2192103C (en) * | 1994-06-06 | 2002-02-05 | Arnold I. Caplan | Biomatrix for tissue regeneration |
| US6174333B1 (en) * | 1994-06-06 | 2001-01-16 | Osiris Therapeutics, Inc. | Biomatrix for soft tissue regeneration using mesenchymal stem cells |
| DE4422667A1 (de) | 1994-06-30 | 1996-01-04 | Boehringer Ingelheim Int | Verfahren zur Herstellung und Züchtung hämatopoetischer Vorläuferzellen |
| US6103522A (en) * | 1994-07-20 | 2000-08-15 | Fred Hutchinson Cancer Research Center | Human marrow stromal cell lines which sustain hematopoiesis |
| US5516532A (en) * | 1994-08-05 | 1996-05-14 | Children's Medical Center Corporation | Injectable non-immunogenic cartilage and bone preparation |
| US5840502A (en) | 1994-08-31 | 1998-11-24 | Activated Cell Therapy, Inc. | Methods for enriching specific cell-types by density gradient centrifugation |
| US5827742A (en) | 1994-09-01 | 1998-10-27 | Beth Israel Deaconess Medical Center, Inc. | Method of selecting pluripotent hematopioetic progenitor cells |
| US5665557A (en) | 1994-11-14 | 1997-09-09 | Systemix, Inc. | Method of purifying a population of cells enriched for hematopoietic stem cells populations of cells obtained thereby and methods of use thereof |
| US5914268A (en) | 1994-11-21 | 1999-06-22 | National Jewish Center For Immunology & Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5874301A (en) * | 1994-11-21 | 1999-02-23 | National Jewish Center For Immunology And Respiratory Medicine | Embryonic cell populations and methods to isolate such populations |
| US5789147A (en) | 1994-12-05 | 1998-08-04 | New York Blood Center, Inc. | Method for concentrating white cells from whole blood by adding a red cell sedimentation reagent to whole anticoagulated blood |
| US5736396A (en) * | 1995-01-24 | 1998-04-07 | Case Western Reserve University | Lineage-directed induction of human mesenchymal stem cell differentiation |
| US7410773B2 (en) | 1995-02-02 | 2008-08-12 | Ghazi Jaswinder Dhoot | Method of preparing an undifferentiated cell |
| US5695998A (en) * | 1995-02-10 | 1997-12-09 | Purdue Research Foundation | Submucosa as a growth substrate for islet cells |
| US6011000A (en) * | 1995-03-03 | 2000-01-04 | Perrine; Susan P. | Compositions for the treatment of blood disorders |
| US5906934A (en) | 1995-03-14 | 1999-05-25 | Morphogen Pharmaceuticals, Inc. | Mesenchymal stem cells for cartilage repair |
| US6974571B2 (en) | 1995-03-28 | 2005-12-13 | Thomas Jefferson University | Isolated stromal cells and methods of using the same |
| US5716616A (en) * | 1995-03-28 | 1998-02-10 | Thomas Jefferson University | Isolated stromal cells for treating diseases, disorders or conditions characterized by bone defects |
| US5733541A (en) * | 1995-04-21 | 1998-03-31 | The Regent Of The University Of Michigan | Hematopoietic cells: compositions and methods |
| US5677139A (en) | 1995-04-21 | 1997-10-14 | President And Fellows Of Harvard College | In vitro differentiation of CD34+ progenitor cells into T lymphocytes |
| ATE177450T1 (de) | 1995-04-27 | 1999-03-15 | Procter & Gamble | Trägersubstrat behandelt mit einer inversen emulsion mit hohem gehalt an diskontinuierlicher wasserphase, die mit einem polyoxyalkylenpolysiloxan-emulgator hergestellt wird |
| US5925567A (en) * | 1995-05-19 | 1999-07-20 | T. Breeders, Inc. | Selective expansion of target cell populations |
| US5908782A (en) | 1995-06-05 | 1999-06-01 | Osiris Therapeutics, Inc. | Chemically defined medium for human mesenchymal stem cells |
| US5830708A (en) | 1995-06-06 | 1998-11-03 | Advanced Tissue Sciences, Inc. | Methods for production of a naturally secreted extracellular matrix |
| AU6223296A (en) | 1995-06-07 | 1996-12-30 | Novartis Ag | Methods for obtaining compositions enriched for hematopoieti c stem cells and antibodies for use therein |
| US6306575B1 (en) | 1995-06-16 | 2001-10-23 | Stemcell Technologies, Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5654381A (en) | 1995-06-16 | 1997-08-05 | Massachusetts Institute Of Technology | Functionalized polyester graft copolymers |
| US5877299A (en) * | 1995-06-16 | 1999-03-02 | Stemcell Technologies Inc. | Methods for preparing enriched human hematopoietic cell preparations |
| US5935576A (en) | 1995-09-13 | 1999-08-10 | Fordham University | Compositions and methods for the treatment and prevention of neoplastic diseases using heat shock proteins complexed with exogenous antigens |
| US5800539A (en) | 1995-11-08 | 1998-09-01 | Emory University | Method of allogeneic hematopoietic stem cell transplantation without graft failure or graft vs. host disease |
| US5858782A (en) * | 1995-11-13 | 1999-01-12 | Regents Of The University Of Michigan | Functional human hematopoietic cells |
| WO1997018298A1 (en) | 1995-11-14 | 1997-05-22 | Regents Of The University Of Minnesota | Ex vivo culture of stem cells |
| JP3781433B2 (ja) | 1995-11-16 | 2006-05-31 | ケース ウエスターン リザーブ ユニバーシティ | ヒト間葉幹細胞の試験管内軟骨形成誘導 |
| US6337387B1 (en) * | 1995-11-17 | 2002-01-08 | Asahi Kasei Kabushiki Kaisha | Differentiation-suppressive polypeptide |
| US5716794A (en) * | 1996-03-29 | 1998-02-10 | Xybernaut Corporation | Celiac antigen |
| EP2311471A3 (en) * | 1996-04-19 | 2013-05-15 | Osiris Therapeutics, Inc. | Regeneration and augmentation of bone using mesenchymal stem cells |
| CA2253724A1 (en) | 1996-04-26 | 1997-11-06 | Case Western Reserve University | Skin regeneration using mesenchymal stem cells |
| US6455678B1 (en) | 1996-04-26 | 2002-09-24 | Amcell Corporation | Human hematopoietic stem and progenitor cell antigen |
| US5919176A (en) * | 1996-05-14 | 1999-07-06 | Children's Hospital Medical Center Of Northern California | Apparatus and method for collecting blood from an umbilical cord |
| US5827740A (en) | 1996-07-30 | 1998-10-27 | Osiris Therapeutics, Inc. | Adipogenic differentiation of human mesenchymal stem cells |
| US6358737B1 (en) | 1996-07-31 | 2002-03-19 | Board Of Regents, The University Of Texas System | Osteocyte cell lines |
| US5851984A (en) | 1996-08-16 | 1998-12-22 | Genentech, Inc. | Method of enhancing proliferation or differentiation of hematopoietic stem cells using Wnt polypeptides |
| US5916202A (en) | 1996-08-30 | 1999-06-29 | Haswell; John N. | Umbilical cord blood collection |
| US6227202B1 (en) | 1996-09-03 | 2001-05-08 | Maulana Azad Medical College | Method of organogenesis and tissue regeneration/repair using surgical techniques |
| US5945337A (en) | 1996-10-18 | 1999-08-31 | Quality Biological, Inc. | Method for culturing CD34+ cells in a serum-free medium |
| US5919702A (en) | 1996-10-23 | 1999-07-06 | Advanced Tissue Science, Inc. | Production of cartilage tissue using cells isolated from Wharton's jelly |
| US5969105A (en) | 1996-10-25 | 1999-10-19 | Feng; Yiqing | Stem cell factor receptor agonists |
| US6335195B1 (en) * | 1997-01-28 | 2002-01-01 | Maret Corporation | Method for promoting hematopoietic and mesenchymal cell proliferation and differentiation |
| US6152142A (en) | 1997-02-28 | 2000-11-28 | Tseng; Scheffer C. G. | Grafts made from amniotic membrane; methods of separating, preserving, and using such grafts in surgeries |
| US6231880B1 (en) | 1997-05-30 | 2001-05-15 | Susan P. Perrine | Compositions and administration of compositions for the treatment of blood disorders |
| DK1028737T3 (da) | 1997-07-03 | 2007-08-13 | Osiris Therapeutics Inc | Humane mesenchymale stamceller fra perifert blod |
| WO1999003973A1 (en) | 1997-07-14 | 1999-01-28 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US7514074B2 (en) | 1997-07-14 | 2009-04-07 | Osiris Therapeutics, Inc. | Cardiac muscle regeneration using mesenchymal stem cells |
| US6077708A (en) | 1997-07-18 | 2000-06-20 | Collins; Paul C. | Method of determining progenitor cell content of a hematopoietic cell culture |
| US5879318A (en) * | 1997-08-18 | 1999-03-09 | Npbi International B.V. | Method of and closed system for collecting and processing umbilical cord blood |
| WO1999011287A1 (en) * | 1997-09-04 | 1999-03-11 | Osiris Therapeutics, Inc. | Ligands that modulate differentiation of mesenchymal stem cells |
| US5968829A (en) | 1997-09-05 | 1999-10-19 | Cytotherapeutics, Inc. | Human CNS neural stem cells |
| US6093531A (en) | 1997-09-29 | 2000-07-25 | Neurospheres Holdings Ltd. | Generation of hematopoietic cells from multipotent neural stem cells |
| US6800480B1 (en) | 1997-10-23 | 2004-10-05 | Geron Corporation | Methods and materials for the growth of primate-derived primordial stem cells in feeder-free culture |
| US6248587B1 (en) | 1997-11-26 | 2001-06-19 | University Of Southern Cailfornia | Method for promoting mesenchymal stem and lineage-specific cell proliferation |
| US6059968A (en) | 1998-01-20 | 2000-05-09 | Baxter International Inc. | Systems for processing and storing placenta/umbilical cord blood |
| US6291240B1 (en) | 1998-01-29 | 2001-09-18 | Advanced Tissue Sciences, Inc. | Cells or tissues with increased protein factors and methods of making and using same |
| EP1062321B1 (en) * | 1998-03-13 | 2004-12-29 | Osiris Therapeutics, Inc. | Uses for humane non-autologous mesenchymal stem cells |
| US6368636B1 (en) * | 1998-03-18 | 2002-04-09 | Osiris Therapeutics, Inc. | Mesenchymal stem cells for prevention and treatment of immune responses in transplantation |
| DK1066052T3 (da) | 1998-03-18 | 2006-06-12 | Osiris Therapeutics Inc | Mesenchymstamceller til forebyggelse og behandling af immunreaktioner ved transplantationer |
| PT1066060E (pt) | 1998-04-03 | 2003-12-31 | Osiris Therapeutics Inc | Celulas estaminais mesenquimais como imunossupressores |
| CA2331122A1 (en) | 1998-05-04 | 1999-11-11 | Point Therapeutics, Inc. | Hematopoietic stimulation |
| WO1999056759A1 (en) | 1998-05-07 | 1999-11-11 | University Of South Florida | Bone marrow cells as a source of neurons for brain and spinal cord repair |
| US6835377B2 (en) | 1998-05-13 | 2004-12-28 | Osiris Therapeutics, Inc. | Osteoarthritis cartilage regeneration |
| AU4094099A (en) | 1998-05-22 | 1999-12-13 | Osiris Therapeutics, Inc. | Production of megakaryocytes by co-culturing human mesenchymal stem cells with cd34+ cells |
| WO1999061587A1 (en) | 1998-05-29 | 1999-12-02 | Osiris Therapeutics, Inc. | Human cd45+ and/or fibroblast + mesenchymal stem cells |
| AU4336599A (en) * | 1998-06-08 | 1999-12-30 | Osiris Therapeutics, Inc. | (in vitro) maintenance of hematopoietic stem cells |
| CA2330190C (en) | 1998-06-08 | 2009-12-22 | Osiris Therapeutics, Inc. | Regulation of hematopoietic stem cell differentiation by the use of human mesenchymal stem cells |
| US6713245B2 (en) | 1998-07-06 | 2004-03-30 | Diacrin, Inc. | Methods for storing neural cells such that they are suitable for transplantation |
| ES2198067T3 (es) * | 1998-07-28 | 2004-01-16 | Synthes Ag Chur | Utilizacion de compuestos a base de creatina para tratar las celulas y los tejidos oseos y cartilaginosos. |
| US5958767A (en) | 1998-08-14 | 1999-09-28 | The Children's Medical Center Corp. | Engraftable human neural stem cells |
| JP3517359B2 (ja) | 1998-09-14 | 2004-04-12 | テルモ株式会社 | 細胞分離・回収装置および細胞の分離・回収方法 |
| WO2000017325A1 (en) | 1998-09-23 | 2000-03-30 | Mount Sinai Hospital | Trophoblast cell preparations |
| WO2000027995A1 (en) * | 1998-11-09 | 2000-05-18 | Monash University | Embryonic stem cells |
| US6548299B1 (en) * | 1999-11-12 | 2003-04-15 | Mark J. Pykett | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices |
| EP1135463B1 (en) | 1998-11-12 | 2008-01-09 | Cytomatrix, LLC | Lymphoid tissue-specific cell production from hematopoietic progenitor cells in three-dimensional devices |
| US6184035B1 (en) * | 1998-11-18 | 2001-02-06 | California Institute Of Technology | Methods for isolation and activation of, and control of differentiation from, skeletal muscle stem or progenitor cells |
| US6102871A (en) | 1998-11-23 | 2000-08-15 | Coe; Rosemarie O. | Blood collection funnel |
| US6328765B1 (en) | 1998-12-03 | 2001-12-11 | Gore Enterprise Holdings, Inc. | Methods and articles for regenerating living tissue |
| EP1144026B1 (en) | 1998-12-24 | 2004-07-28 | Biosafe S.A. | Blood separation system particularly for concentrating hematopoietic stem cells |
| DE60043534D1 (de) | 1999-02-04 | 2010-01-28 | Pluristem Ltd | VERFAHREN UND VORRICHTUNG ZUR HALTUNG UND EXPANSION VON HEMATOPOIETISCHEN STAMMZELLEN UND/ODER VORLäUFERZELLEN |
| US20030007954A1 (en) * | 1999-04-12 | 2003-01-09 | Gail K. Naughton | Methods for using a three-dimensional stromal tissue to promote angiogenesis |
| DE60034045T2 (de) | 1999-04-16 | 2007-11-22 | WM. Marsh Rice University, Houston | Mit Polypropylenfumarat-Diacrylat-Makromeren vernetzte biologisch abbaubare Polypropylenfumarat-Netzwerke |
| IN191359B (ja) | 1999-04-20 | 2003-11-29 | Nat Inst Immunology | |
| WO2000073421A2 (en) | 1999-06-02 | 2000-12-07 | Lifebank Services, L.L.C. | Methods of isolation, cryopreservation, and therapeutic use of human amniotic epithelial cells |
| US6355699B1 (en) | 1999-06-30 | 2002-03-12 | Ethicon, Inc. | Process for manufacturing biomedical foams |
| US6333029B1 (en) | 1999-06-30 | 2001-12-25 | Ethicon, Inc. | Porous tissue scaffoldings for the repair of regeneration of tissue |
| CA2852534A1 (en) | 1999-08-05 | 2001-02-15 | Abt Holding Company | Multipotent adult stem cells and methods for isolation |
| US8147824B2 (en) | 1999-08-05 | 2012-04-03 | Athersys, Inc. | Immunomodulatory properties of multipotent adult progenitor cells and uses thereof |
| US8075881B2 (en) * | 1999-08-05 | 2011-12-13 | Regents Of The University Of Minnesota | Use of multipotent adult stem cells in treatment of myocardial infarction and congestive heart failure |
| US7015037B1 (en) | 1999-08-05 | 2006-03-21 | Regents Of The University Of Minnesota | Multiponent adult stem cells and methods for isolation |
| US6239157B1 (en) | 1999-09-10 | 2001-05-29 | Osiris Therapeutics, Inc. | Inhibition of osteoclastogenesis |
| WO2001021767A2 (en) | 1999-09-24 | 2001-03-29 | Morphogen Pharmaceuticals, Inc. | Pluripotent embryonic-like stem cells, compositions, methods and uses thereof |
| US6685936B2 (en) | 1999-10-12 | 2004-02-03 | Osiris Therapeutics, Inc. | Suppressor cells induced by culture with mesenchymal stem cells for treatment of immune responses in transplantation |
| US6280718B1 (en) | 1999-11-08 | 2001-08-28 | Wisconsin Alumni Reasearch Foundation | Hematopoietic differentiation of human pluripotent embryonic stem cells |
| DE19954421A1 (de) | 1999-11-12 | 2001-05-31 | Lohmann Therapie Syst Lts | Filmförmige Zubereitung zur biphasigen Freisetzung pharmakologisch wirksamer oder anderer Substanzen |
| CN1423523A (zh) | 1999-11-17 | 2003-06-11 | 罗切斯特大学 | 来自人体内的免疫系统 |
| US7455983B2 (en) | 2000-01-11 | 2008-11-25 | Geron Corporation | Medium for growing human embryonic stem cells |
| JP2004500824A (ja) | 2000-03-09 | 2004-01-15 | クリオ−セル インターナショナル インコーポレーティッド | 脳および脊髄の修復のための神経組織源としてのヒト臍帯血 |
| EP2298858A1 (en) | 2000-03-16 | 2011-03-23 | Cellseed Inc. | Bed material for cell culture, method for co-culture of cell and co-cultured cell sheet obtainable therefrom |
| US20010038836A1 (en) | 2000-04-04 | 2001-11-08 | Matthew During | Application of myeloid-origin cells to the nervous system |
| WO2001093909A2 (en) | 2000-06-06 | 2001-12-13 | Glaxo Group Limited | Cancer treatment composition containing an anti-neoplastic agent and a pde4 inhibitor |
| US20050009876A1 (en) * | 2000-07-31 | 2005-01-13 | Bhagwat Shripad S. | Indazole compounds, compositions thereof and methods of treatment therewith |
| US7560280B2 (en) | 2000-11-03 | 2009-07-14 | Kourion Therapeutics Gmbh | Human cord blood derived unrestricted somatic stem cells (USSC) |
| AU2002239294B2 (en) | 2000-11-22 | 2006-05-11 | Asterias Biotherapeutics, Inc. | Tolerizing allografts of pluripotent stem cells |
| EP1349918B1 (en) | 2000-12-06 | 2014-08-06 | Anthrogenesis Corporation | Method of collecting placental stem cells |
| US20080152629A1 (en) | 2000-12-06 | 2008-06-26 | James Edinger | Placental stem cell populations |
| US7311905B2 (en) | 2002-02-13 | 2007-12-25 | Anthrogenesis Corporation | Embryonic-like stem cells derived from post-partum mammalian placenta, and uses and methods of treatment using said cells |
| US20030045552A1 (en) * | 2000-12-27 | 2003-03-06 | Robarge Michael J. | Isoindole-imide compounds, compositions, and uses thereof |
| US7091353B2 (en) | 2000-12-27 | 2006-08-15 | Celgene Corporation | Isoindole-imide compounds, compositions, and uses thereof |
| EP1367899A4 (en) | 2001-02-14 | 2004-07-28 | Leo T Furcht | TOTIPOTENT ADULT STEM CELLS, SOURCES OF SUCH CELLS, METHODS FOR OBTAINING AND MAINTAINING SAME, METHODS FOR DIFFERENTIATING THESE CELLS, METHODS OF USING SAME, AND CELLS DERIVED FROM THE ABOVE-MENTIONED CELLS |
| WO2002064755A2 (en) * | 2001-02-14 | 2002-08-22 | Anthrogenesis Corporation | Post-partum mammalian placenta, its use and placental stem cells therefrom |
| ES2444548T3 (es) | 2001-02-14 | 2014-02-25 | Anthrogenesis Corporation | Renovación y repoblación de tejidos y órganos cadavéricos descelularizados por células madre |
| US20020132343A1 (en) | 2001-03-19 | 2002-09-19 | Clark Lum | System and method for delivering umbilical cord-derived tissue-matched stem cells for transplantation |
| CA2396536A1 (en) | 2001-08-10 | 2003-02-10 | Saiko Uchida | Human stem cells originated from human amniotic mesenchymal cell layer |
| DE10139783C1 (de) | 2001-08-14 | 2003-04-17 | Transtissue Technologies Gmbh | Zellzusammensetzungen zur Behandlung von Osteoarthrose, sowie Verfahren zu deren Herstellung |
| US20030044976A1 (en) | 2001-08-27 | 2003-03-06 | Advanced Cell Technology | De-differentiation and re-differentiation of somatic cells and production of cells for cell therapies |
| EP1288293A1 (en) | 2001-08-30 | 2003-03-05 | Norio Sakuragawa | Human neural stem cells originated from human amniotic mesenchymal cell layer |
| CN1195055C (zh) * | 2001-09-06 | 2005-03-30 | 周胜利 | 从胎盘组织中提取造血干细胞用于建立造血干细胞库的新方法 |
| US9969980B2 (en) | 2001-09-21 | 2018-05-15 | Garnet Biotherapeutics | Cell populations which co-express CD49c and CD90 |
| CA2466880A1 (en) | 2001-11-09 | 2003-05-15 | Artecel Sciences, Inc. | Methods and compositions for the use of stromal cells to support embryonic and adult stem cells |
| JP4330995B2 (ja) | 2001-11-15 | 2009-09-16 | チルドレンズ メディカル センター コーポレーション | 絨毛膜絨毛、羊水、および胎盤からの胎児性幹細胞を単離、増殖、および分化させる方法、ならびにその治療的使用方法 |
| JP3728750B2 (ja) | 2001-11-22 | 2005-12-21 | ニプロ株式会社 | 培養皮膚及びその製造方法 |
| US7799324B2 (en) | 2001-12-07 | 2010-09-21 | Geron Corporation | Using undifferentiated embryonic stem cells to control the immune system |
| JP3934539B2 (ja) | 2001-12-12 | 2007-06-20 | 独立行政法人科学技術振興機構 | 胎盤等由来の成体又は生後組織の前駆細胞 |
| EP1458854B1 (en) * | 2001-12-21 | 2010-04-14 | Mount Sinai Hospital | Cellular compositions and methods of making and using them |
| WO2003061591A2 (en) * | 2002-01-22 | 2003-07-31 | Advanced Cell Technology, Inc. | Stem cell-derived endothelial cells modified to disrupt tumor angiogenesis |
| US7682803B2 (en) * | 2005-10-13 | 2010-03-23 | Anthrogenesis Corporation | Immunomodulation using placental stem cells |
| EP1482787A4 (en) * | 2002-02-13 | 2006-02-15 | Anthrogenesis Corp | EMBRYONIC TYPE DERIVED STEM CELLS DERIVED FROM MAMMALIAN POST-PARTUM PLACENTA, USES THEREOF, AND METHODS OF TREATMENT BASED ON CELLS OF THIS TYPE |
| CN1281739C (zh) * | 2002-02-19 | 2006-10-25 | 美迪宝斯特有限公司 | 从脐带血中分离并扩大培养间充质干细胞/祖细胞及将脐带血来源的间充质干细胞/祖细胞分化成各种间充质组织的方法 |
| US20080299090A1 (en) | 2002-02-25 | 2008-12-04 | Kansas State University Research Foundation | Use Of Umbilical Cord Matrix Cells |
| US7736892B2 (en) | 2002-02-25 | 2010-06-15 | Kansas State University Research Foundation | Cultures, products and methods using umbilical cord matrix cells |
| US20030161818A1 (en) | 2002-02-25 | 2003-08-28 | Kansas State University Research Foundation | Cultures, products and methods using stem cells |
| WO2003077865A2 (en) | 2002-03-15 | 2003-09-25 | Baxter International Inc. | Methods and compositions for directing cells to target organs |
| US20030187515A1 (en) | 2002-03-26 | 2003-10-02 | Hariri Robert J. | Collagen biofabric and methods of preparing and using the collagen biofabric |
| AU2003221173A1 (en) * | 2002-03-27 | 2003-10-08 | Asahi Kasei Kabushiki Kaisha | Placenta-origin mesenchymal cells and medicinal use thereof |
| KR20050000400A (ko) | 2002-04-12 | 2005-01-03 | 셀진 코포레이션 | 줄기 및 전구 세포 분화의 조절, 측정 및 이들의 용도 |
| EP1496878A4 (en) | 2002-04-12 | 2007-12-26 | Celgene Corp | TECHNIQUES FOR IDENTIFYING ANGIOGENESIS MODULATORS, COMPOUNDS DISCOVERED BY THESE TECHNIQUES AND TREATMENT TECHNIQUES USING THESE COMPOUNDS |
| US7498171B2 (en) * | 2002-04-12 | 2009-03-03 | Anthrogenesis Corporation | Modulation of stem and progenitor cell differentiation, assays, and uses thereof |
| US20040161419A1 (en) | 2002-04-19 | 2004-08-19 | Strom Stephen C. | Placental stem cells and uses thereof |
| CA2483010A1 (en) | 2002-04-19 | 2003-10-30 | University Of Pittsburgh Of The Commonwealth System Of Higher Education | Placental derived stem cells and uses thereof |
| US20050058641A1 (en) | 2002-05-22 | 2005-03-17 | Siemionow Maria Z. | Tolerance induction and maintenance in hematopoietic stem cell allografts |
| WO2003102151A2 (en) | 2002-05-30 | 2003-12-11 | Celgene Corporation | Modulating cell differentiation and treating myeloprolifertive disorders with jnk/mkk inhibitors |
| AU2003273574A1 (en) | 2002-05-31 | 2003-12-19 | Osiris Therapeutics, Inc. | Intraperitoneal delivery of genetically engineered mesenchymal stem cells |
| US7422736B2 (en) * | 2002-07-26 | 2008-09-09 | Food Industry Research And Development Institute | Somatic pluripotent cells |
| AU2003278212B2 (en) | 2002-07-31 | 2009-07-09 | Centre National De La Recherche Scientifique | Stem cells derived from adipous tissue and differentiated cells derived from said cells |
| US20060147424A1 (en) | 2002-08-23 | 2006-07-06 | Norio Sakuragawa | Human bone stem cells |
| KR100476790B1 (ko) | 2002-09-13 | 2005-03-16 | 주식회사 제넨메드 | 세포 저장 용액과 이를 이용한 동물 세포의 동결 및 저장방법 |
| US20040062753A1 (en) | 2002-09-27 | 2004-04-01 | Alireza Rezania | Composite scaffolds seeded with mammalian cells |
| CA2505534A1 (en) | 2002-11-26 | 2004-06-10 | Anthrogenesis Corporation | Cytotherapeutics, cytotherapeutic units and methods for treatments using them |
| JP2004210713A (ja) * | 2002-12-27 | 2004-07-29 | Asahi Kasei Corp | 医療用胎盤由来細胞製剤 |
| EP1594957B1 (en) | 2003-02-11 | 2010-08-25 | John E. Davies | Progenitor cells from wharton's jelly of human umbilical cord |
| MXPA05008445A (es) | 2003-02-13 | 2005-10-18 | Anthrogenesis Corp | Uso de sangre del cordon umbilical para tratar individuos que tienen una enfermedad, un trastorno o una afeccion. |
| WO2004087896A2 (en) | 2003-03-31 | 2004-10-14 | Pfizer Products Inc. | Hepatocyte differentiation of stem cells |
| CN1548529A (zh) | 2003-05-09 | 2004-11-24 | 中国人民解放军军事医学科学院基础医 | 一种人胎盘间充质干细胞的分离方法 |
| US7875272B2 (en) | 2003-06-27 | 2011-01-25 | Ethicon, Incorporated | Treatment of stroke and other acute neuraldegenerative disorders using postpartum derived cells |
| AU2004252570C1 (en) | 2003-06-27 | 2012-03-01 | Ethicon, Incorporated | Soft tissue repair and regeneration using postpartum-derived cells |
| US7569385B2 (en) * | 2003-08-14 | 2009-08-04 | The Regents Of The University Of California | Multipotent amniotic fetal stem cells |
| AR046123A1 (es) | 2003-10-17 | 2005-11-23 | Crc For Innovative Dairy Produ | Aislamiento de celulas simil-celulas madre, uso de las mismas |
| US20050089513A1 (en) * | 2003-10-28 | 2005-04-28 | Norio Sakuragawa | Side population cells originated from human amnion and their uses |
| EP1682654A2 (en) | 2003-11-10 | 2006-07-26 | Amgen Inc. | Methods of using g-csf mobilized c-kit+cells in the production of embryoid body-like cell clusters for tissue repair and in the treatment of cardiac myopathy |
| KR100560340B1 (ko) * | 2003-11-11 | 2006-03-14 | 한훈 | 제대혈로부터 중간엽 줄기세포의 분리 및 배양 방법 |
| JP2005151907A (ja) | 2003-11-27 | 2005-06-16 | Shigeo Saito | 胎盤又は羊膜由来ヒト幹細胞及びその樹立方法並びに臓器への分化誘導方法 |
| TWI338714B (en) | 2003-12-02 | 2011-03-11 | Cathay General Hospital | Method of isolation and enrichment of mesenchymal stem cells from amniotic fluid |
| US20050143420A1 (en) | 2003-12-02 | 2005-06-30 | Moutouh-De Parseval Laure | Methods and compositions for the treatment and management of hemoglobinopathy and anemia |
| WO2007059007A2 (en) * | 2005-11-14 | 2007-05-24 | Cythera, Inc. | Markers of definitive endoderm |
| US20050176139A1 (en) | 2004-01-12 | 2005-08-11 | Yao-Chang Chen | Placental stem cell and methods thereof |
| US20050266391A1 (en) | 2004-01-15 | 2005-12-01 | Bennett Brydon L | Methods for preserving tissue |
| US20080095749A1 (en) | 2004-03-22 | 2008-04-24 | Sudeepta Aggarwal | Mesenchymal stem cells and uses therefor |
| EP3461884A1 (en) | 2004-03-22 | 2019-04-03 | Mesoblast International Sàrl | Mesenchymal stem cells and uses therefor |
| CN1961283A (zh) | 2004-03-26 | 2007-05-09 | 细胞基因公司 | 建立干细胞库的系统和方法 |
| WO2005105992A1 (en) | 2004-04-21 | 2005-11-10 | New York Eye & Ear Infirmary | Chondrocyte culture formulations |
| JP2006006249A (ja) | 2004-06-28 | 2006-01-12 | Hiroshima Univ | 羊膜由来細胞の培養方法及びその利用 |
| CN100564518C (zh) | 2004-07-20 | 2009-12-02 | 成都军区昆明总医院 | 胎盘羊膜细胞提取物及其在间充质干细胞诱导分化中的应用 |
| US7244759B2 (en) | 2004-07-28 | 2007-07-17 | Celgene Corporation | Isoindoline compounds and methods of making and using the same |
| US20080292597A1 (en) | 2004-07-29 | 2008-11-27 | David A Steenblock | Umbilical Cord Stem Cell Composition & Method of Treating Neurological Diseases |
| CN101040042B (zh) * | 2004-08-16 | 2013-06-19 | 细胞研究私人有限公司 | 自脐带羊膜分离干/祖细胞 |
| WO2006028723A1 (en) | 2004-09-03 | 2006-03-16 | Moraga Biotechnology Inc. | Non-embryonic totipotent blastomer-like stem cells and methods therefor |
| WO2006030442A2 (en) | 2004-09-16 | 2006-03-23 | Gamida-Cell Ltd. | Methods of ex vivo progenitor and stem cell expansion by co-culture with mesenchymal cells |
| US7909806B2 (en) | 2004-09-23 | 2011-03-22 | Anthrogenesis Corporation | Cord blood and placenta collection kit |
| US7147626B2 (en) * | 2004-09-23 | 2006-12-12 | Celgene Corporation | Cord blood and placenta collection kit |
| US20080260694A1 (en) | 2004-09-24 | 2008-10-23 | Angioblast Systems, Inc. | Multipotential Expanded Mesenchymal Precursor Cell Progeny (Memp) and Uses Thereof |
| US20060069009A1 (en) | 2004-09-28 | 2006-03-30 | Messina Darin J | Treatment of neurological deficits in the striatum or substanta nigra pars compacta |
| US8039258B2 (en) | 2004-09-28 | 2011-10-18 | Ethicon, Inc. | Tissue-engineering scaffolds containing self-assembled-peptide hydrogels |
| US20060069008A1 (en) | 2004-09-28 | 2006-03-30 | Sanjay Mistry | Treatment of neurological deficits in the striatum or substanta nigra pars compacta |
| US20060166361A1 (en) | 2004-12-21 | 2006-07-27 | Agnieszka Seyda | Postpartum cells derived from placental tissue, and methods of making, culturing, and using the same |
| US20060171930A1 (en) | 2004-12-21 | 2006-08-03 | Agnieszka Seyda | Postpartum cells derived from umbilical cord tissue, and methods of making, culturing, and using the same |
| EP1833496B1 (en) | 2004-12-23 | 2013-07-31 | Ethicon, Incorporated | Treatment of stroke and other acute neural degenerative disorders using postpartum derived cells |
| PL1831356T3 (pl) | 2004-12-23 | 2017-07-31 | DePuy Synthes Products, Inc. | Komórki poporodowe pochodzące z tkanki pępowinowej i sposoby ich wytwarzania i stosowania |
| US20070041943A1 (en) | 2004-12-29 | 2007-02-22 | Children's Hospital Research | Expression of virus entry inhibitors and recombinant AAV thereof |
| WO2006074308A2 (en) * | 2005-01-07 | 2006-07-13 | Wake Forest University Health Sciences | Regeneration of pancreatic islets by amniotic fluid stem cell therapy |
| WO2006091766A2 (en) * | 2005-02-24 | 2006-08-31 | Jau-Nan Lee | Human trophoblast stem cells and use thereof |
| US20100028306A1 (en) | 2005-03-31 | 2010-02-04 | Stemnion, Inc. | Amnion-Derived Cell Compositions, Methods of Making and Uses Thereof |
| US20060222634A1 (en) | 2005-03-31 | 2006-10-05 | Clarke Diana L | Amnion-derived cell compositions, methods of making and uses thereof |
| ES2654428T3 (es) | 2005-04-12 | 2018-02-13 | Mesoblast, Inc. | Aislamiento de células multipotenciales adultas por fosfatasa alcalina no específica de tejido |
| AU2006238733A1 (en) * | 2005-04-16 | 2006-10-26 | Axordia Limited | Cytotrophoblast stem cell |
| WO2006117889A1 (ja) | 2005-04-28 | 2006-11-09 | Stemcell Institute Inc. | 移植用臓器の調製方法 |
| EP2210937A1 (en) | 2005-05-09 | 2010-07-28 | Olympus Corporation | Culture method for mesenchymal stem cell and process for production of supporting material for biological tissue |
| AU2006202209B2 (en) | 2005-05-27 | 2011-04-14 | Lifescan, Inc. | Amniotic fluid derived cells |
| MX2007015541A (es) * | 2005-06-10 | 2008-03-06 | Celgene Corp | Composiciones de colageno de placenta humana proceso para su preparacion, metodos de uso y equipos que contienen las composiciones. |
| US20070038298A1 (en) * | 2005-06-30 | 2007-02-15 | Sulner Joseph W | Repair of tympanic membrane using placenta derived collagen biofabric |
| EP1919500A2 (en) | 2005-07-13 | 2008-05-14 | Anthrogenesis Corporation | Treatment of leg ulcers using placenta derived collagen biofabric |
| WO2007009061A2 (en) * | 2005-07-13 | 2007-01-18 | Anthrogenesis Corporation | Ocular plug formed from placenta derived collagen biofabric |
| WO2007011693A2 (en) * | 2005-07-14 | 2007-01-25 | Medistem Laboratories, Inc. | Compositions of placentally-derived stem cells for the treatment of cancer |
| US7923007B2 (en) | 2005-08-08 | 2011-04-12 | Academia Sinica | Brain tissue damage therapies |
| EP1915440A4 (en) | 2005-08-19 | 2009-11-04 | Bio Regenerate Inc | COMPOSITIONS OF CELLS ENRICHED WITH COMBINATIONS OF VARIOUS STRAIN AND PRECURSOR CELL POPULATIONS, METHOD OF USE THEREOF, AND METHOD FOR THE PREPARATION OF PRIVATE BANKS THEREOF |
| ZA200803930B (en) * | 2005-10-13 | 2010-03-31 | Anthrogenesis Corp | Immunomodulation using placental stem cells |
| WO2007047465A1 (en) | 2005-10-13 | 2007-04-26 | Anthrogenesis Corporation | Production of oligodendrocytes from placenta-derived stem cells |
| CN100344757C (zh) * | 2005-10-18 | 2007-10-24 | 天津昂赛细胞基因工程有限公司 | 人胎盘、脐带间充质干细胞库及其构建方法 |
| CN101374946B (zh) | 2005-12-16 | 2017-07-18 | 伊西康公司 | 用于在组织相容性不匹配的移植中抑制有害的免疫反应的组合物和方法 |
| JP5179376B2 (ja) | 2005-12-19 | 2013-04-10 | エシコン・インコーポレイテッド | ローラーボトルでの分娩後取り出し細胞の体外増殖 |
| SG10201401805YA (en) | 2005-12-22 | 2014-08-28 | Jane Ennis | Viable cells from frozen umbilical cord tissue |
| EP1979050B1 (en) | 2005-12-28 | 2017-04-19 | DePuy Synthes Products, Inc. | Treatment of peripheral vascular disease using postpartum-derived cells |
| KR20080081088A (ko) | 2005-12-29 | 2008-09-05 | 안트로제네시스 코포레이션 | 태반 줄기세포와 제2 세포원으로부터 얻은 줄기세포의 공동배양 |
| CN103060263B (zh) | 2005-12-29 | 2016-03-16 | 人类起源公司 | 胎盘干细胞群 |
| US9598669B2 (en) | 2005-12-29 | 2017-03-21 | Anthrogenesis Corporation | Composition for collecting placental stem cells and methods of using the composition |
| US20070253931A1 (en) | 2006-01-12 | 2007-11-01 | Osiris Therapeutics, Inc. | Use of mesenchymal stem cells for treating genetic diseases and disorders |
| US20080286249A1 (en) | 2006-01-12 | 2008-11-20 | Varney Timothy R | Use of mesenchymal stem cells for treating genetic diseases and disorders |
| MX2008008774A (es) | 2006-01-13 | 2008-09-26 | Osiris Therapeutics Inc | Celulas madre mesenquimales que expresan los receptores tnf-alfa. |
| CN100545260C (zh) | 2006-01-13 | 2009-09-30 | 深圳市北科生物科技有限公司 | 人羊膜间充质干细胞的分离及培养方法及医用组合物 |
| US9944900B2 (en) | 2006-01-18 | 2018-04-17 | Hemacell Perfusion | Pulsatile perfusion extraction method for non-embryonic pluripotent stem cells |
| PL1981515T3 (pl) | 2006-01-23 | 2014-02-28 | Athersys Inc | Leczenie urazów i chorób mózgu za pomocą MAPC |
| CN101410126A (zh) | 2006-01-23 | 2009-04-15 | 阿特西斯公司 | 无附加的免疫抑制治疗的mapc治疗法 |
| EP1845154A1 (en) | 2006-04-12 | 2007-10-17 | RNL Bio Co., Ltd. | Multipotent stem cells derived from placenta tissue and cellular therapeutic agents comprising the same |
| CA2909053C (en) | 2006-05-11 | 2021-02-09 | Cord Blood Science Inc. | Methods for collecting and using placenta cord blood stem cells |
| WO2007136673A2 (en) | 2006-05-19 | 2007-11-29 | Medistem Laboratories, Inc. | Treatment of disc degenerative disease and compositions for same |
| US20080064098A1 (en) | 2006-06-05 | 2008-03-13 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of maternal placental cells |
| US20080050814A1 (en) | 2006-06-05 | 2008-02-28 | Cryo-Cell International, Inc. | Procurement, isolation and cryopreservation of fetal placental cells |
| ZA200810412B (en) * | 2006-06-09 | 2010-03-31 | Anthrogenesis Corp | Placental niche and use thereof to culture stem cells |
| US20070287176A1 (en) | 2006-06-13 | 2007-12-13 | Alireza Rezania | Chorionic villus derived cells |
| US8475788B2 (en) | 2006-06-14 | 2013-07-02 | Stemnion, Inc. | Methods of treating spinal cord injury and minimizing scarring |
| WO2007149548A2 (en) | 2006-06-22 | 2007-12-27 | Medistem Laboratories, Inc. | Treatment of erectile dysfunction by stem cell therapy |
| PL2046946T3 (pl) | 2006-06-26 | 2017-04-28 | Lifescan, Inc. | Hodowla pluripotencjalnych komórek macierzystych |
| US8980630B2 (en) | 2006-06-28 | 2015-03-17 | Rutgers, The State University Of New Jersey | Obtaining multipotent amnion-derived stem cell (ADSC) from amniotic membrane tissue without enzymatic digestion |
| US7993918B2 (en) | 2006-08-04 | 2011-08-09 | Anthrogenesis Corporation | Tumor suppression using placental stem cells |
| US20090081171A1 (en) | 2006-08-11 | 2009-03-26 | Yu-Show Fu | Cell system for alleviating syndromes of Parkinson's disease in a mammal |
| WO2008021391A1 (en) * | 2006-08-15 | 2008-02-21 | Anthrogenesis Corporation | Umbilical cord biomaterial for medical use |
| US20080050347A1 (en) | 2006-08-23 | 2008-02-28 | Ichim Thomas E | Stem cell therapy for cardiac valvular dysfunction |
| WO2008036374A2 (en) | 2006-09-21 | 2008-03-27 | Medistem Laboratories, Inc. | Allogeneic stem cell transplants in non-conditioned recipients |
| WO2008042441A1 (en) | 2006-10-03 | 2008-04-10 | Anthrogenesis Corporation | Use of umbilical cord biomaterial for ocular surgery |
| US8071135B2 (en) | 2006-10-04 | 2011-12-06 | Anthrogenesis Corporation | Placental tissue compositions |
| KR20230146124A (ko) | 2006-10-06 | 2023-10-18 | 셀룰래리티 인코포레이티드 | 천연(텔로펩티드) 태반 콜라겐 조성물 |
| CN103255098A (zh) | 2006-10-23 | 2013-08-21 | 人类起源公司 | 用胎盘细胞群治疗骨缺损的方法和组合物 |
| US9102915B2 (en) | 2006-11-13 | 2015-08-11 | DePuy Synthes Products, Inc. | In vitro expansion of postpartum-derived cells using microcarriers |
| US8241621B2 (en) | 2006-12-18 | 2012-08-14 | Medistem Laboratories | Stem cell mediated treg activation/expansion for therapeutic immune modulation |
| KR20090109127A (ko) | 2007-02-12 | 2009-10-19 | 안트로제네시스 코포레이션 | 부착성 태반 줄기세포에서 유래한 간세포와 연골세포 및 ｃｄ34＋, ｃｄ45－ 태반 줄기세포가 농축된 세포군 |
| SI2120977T1 (sl) | 2007-02-12 | 2014-01-31 | Anthrogenesis Coroporation | Zdravljenje vnetnih bolezni z uporabo placentarnih matičnih celic |
| US20100172830A1 (en) | 2007-03-29 | 2010-07-08 | Cellx Inc. | Extraembryonic Tissue cells and method of use thereof |
| US20080254005A1 (en) | 2007-04-06 | 2008-10-16 | Medistem Labortories | Stem Cell Therapy for the Treatment of Autism and Other Disorders |
| JP5703493B2 (ja) * | 2007-09-26 | 2015-04-22 | アンスロジェネシス コーポレーション | ヒト胎盤灌流液由来の血管形成細胞 |
| KR20210127819A (ko) | 2007-09-28 | 2021-10-22 | 안트로제네시스 코포레이션 | 인간 태반 관류액 및 인간 태반-유래 중간체 천연 킬러 세포를 사용한 종양 억제 방법 |
| RU2010123002A (ru) | 2007-11-07 | 2011-12-20 | Антродженезис Корпорейшн (Us) | Лечение осложнений преждевременных родов |
| US8216997B2 (en) | 2008-08-14 | 2012-07-10 | Acceleron Pharma, Inc. | Methods for increasing red blood cell levels and treating anemia using a combination of GDF traps and erythropoietin receptor activators |
| CN105766891A (zh) * | 2008-08-20 | 2016-07-20 | 人类起源公司 | 改进的细胞组合物及制备所述组合物的方法 |
| MX2011001991A (es) * | 2008-08-20 | 2011-03-29 | Anthrogenesis Corp | Tratamiento de la apoplejia utilizando celulas placentarias aisladas. |
| MX2011001992A (es) * | 2008-08-22 | 2011-03-29 | Anthrogenesis Corp | Metodos y composiciones para el tratamiento de defectos oseos con poblaciones de celulas placentarias. |
| JP5869342B2 (ja) | 2008-11-19 | 2016-02-24 | アンスロジェネシス コーポレーション | 羊膜由来接着細胞 |
| CA2743573C (en) | 2008-11-21 | 2021-04-27 | Anthrogenesis Corporation | Treatment of diseases, disorders or conditions of the lung using placental cells |
| US20100323446A1 (en) | 2009-06-05 | 2010-12-23 | Jill Renee Barnett | Method of collecting placental cells |
| EP2449095A1 (en) * | 2009-07-02 | 2012-05-09 | Anthrogenesis Corporation | Method of producing erythrocytes without feeder cells |
| WO2011094181A1 (en) | 2010-01-26 | 2011-08-04 | Anthrogenesis Corporation | Treatment of bone-related cancers using placental stem cells |
| US20110280849A1 (en) | 2010-03-26 | 2011-11-17 | Anthrogenesis Corporation | Tumor suppression using human placenta-derived intermediate natural killer cells and immunomodulatory compounds |
| PL2556145T3 (pl) | 2010-04-07 | 2017-02-28 | Anthrogenesis Corporation | Angiogeneza z zastosowaniem łożyskowych komórek macierzystych |
| WO2011127113A1 (en) | 2010-04-08 | 2011-10-13 | Anthrogenesis Corporation | Treatment of sarcoidosis using placental stem cells |
| WO2012009422A1 (en) | 2010-07-13 | 2012-01-19 | Anthrogenesis Corporation | Methods of generating natural killer cells |
| KR20230084328A (ko) | 2010-12-30 | 2023-06-12 | 셀룰래리티 인코포레이티드 | 세포의 동결보존 및 캡슐화 방법 |
| AR084754A1 (es) | 2010-12-30 | 2013-06-05 | Anthrogenesis Corp | Composiciones que comprenden celulas madre de placenta y plasma rico en plaquetas, y sus metodos de uso |
| AR084753A1 (es) | 2010-12-30 | 2013-06-05 | Anthrogenesis Corp | Composiciones que comprenden celulas adherentes derivadas del saco amniotico (amdac) y plasma rico en plaquetas (prp) |
| AR093183A1 (es) | 2010-12-31 | 2015-05-27 | Anthrogenesis Corp | Aumento de la potencia de celulas madre de placenta usando moleculas de arn moduladoras |
| MX357749B (es) | 2011-06-01 | 2018-07-23 | Anthrogenesis Corp | Tratamiento contra el dolor utilizando células madre placentarias. |
-
2006
- 2006-12-28 CN CN201210477851.6A patent/CN103060263B/zh active Active
- 2006-12-28 PL PL06848281T patent/PL1976977T3/pl unknown
- 2006-12-28 DK DK12150934.3T patent/DK2471907T3/en active
- 2006-12-28 KR KR1020197025129A patent/KR20190104428A/ko active Application Filing
- 2006-12-28 NZ NZ569562A patent/NZ569562A/en unknown
- 2006-12-28 EP EP12150924.4A patent/EP2471905B1/en active Active
- 2006-12-28 WO PCT/US2006/049491 patent/WO2007079183A2/en active Application Filing
- 2006-12-28 AU AU2006332678A patent/AU2006332678B2/en active Active
- 2006-12-28 PL PL12150912T patent/PL2471903T3/pl unknown
- 2006-12-28 DK DK12150928.5T patent/DK2471906T3/en active
- 2006-12-28 ES ES12150928T patent/ES2708933T3/es active Active
- 2006-12-28 KR KR1020227015349A patent/KR20220063304A/ko not_active Application Discontinuation
- 2006-12-28 DK DK12150912.9T patent/DK2471903T3/en active
- 2006-12-28 CN CN201310405648.2A patent/CN103525758B/zh active Active
- 2006-12-28 JP JP2008548745A patent/JP5550235B2/ja active Active
- 2006-12-28 ES ES06848281.9T patent/ES2549111T3/es active Active
- 2006-12-28 KR KR1020157020367A patent/KR101722577B1/ko active IP Right Grant
- 2006-12-28 EP EP12150934.3A patent/EP2471907B1/en active Active
- 2006-12-28 CA CA2635253A patent/CA2635253C/en active Active
- 2006-12-28 EP EP12150919.4A patent/EP2471904B1/en active Active
- 2006-12-28 KR KR1020237019606A patent/KR20230091193A/ko not_active Application Discontinuation
- 2006-12-28 DK DK12150919.4T patent/DK2471904T3/en active
- 2006-12-28 EP EP12150928.5A patent/EP2471906B1/en active Active
- 2006-12-28 PT PT12150924T patent/PT2471905T/pt unknown
- 2006-12-28 PL PL12150919T patent/PL2471904T3/pl unknown
- 2006-12-28 US US11/648,813 patent/US8057788B2/en not_active Expired - Lifetime
- 2006-12-28 ES ES12150934T patent/ES2706726T3/es active Active
- 2006-12-28 EP EP06848281.9A patent/EP1976977B1/en active Active
- 2006-12-28 CA CA2957336A patent/CA2957336C/en active Active
- 2006-12-28 KR KR1020177008335A patent/KR101900809B1/ko active IP Right Grant
- 2006-12-28 EP EP18196002.2A patent/EP3486314B1/en active Active
- 2006-12-28 NZ NZ622377A patent/NZ622377A/en unknown
- 2006-12-28 EP EP12150912.9A patent/EP2471903B1/en active Active
- 2006-12-28 ES ES12150924T patent/ES2703502T3/es active Active
- 2006-12-28 ES ES12150912.9T patent/ES2671355T3/es active Active
- 2006-12-28 PT PT12150934T patent/PT2471907T/pt unknown
- 2006-12-28 KR KR1020087018508A patent/KR101585241B1/ko active IP Right Grant
- 2006-12-28 KR KR1020217031368A patent/KR20210122908A/ko not_active Application Discontinuation
- 2006-12-28 PT PT12150928T patent/PT2471906T/pt unknown
- 2006-12-28 KR KR1020207030297A patent/KR20200123283A/ko not_active Application Discontinuation
- 2006-12-28 PL PL12150934T patent/PL2471907T3/pl unknown
- 2006-12-28 PL PL12150924T patent/PL2471905T3/pl unknown
- 2006-12-28 PT PT121509129T patent/PT2471903T/pt unknown
- 2006-12-28 PL PL12150928T patent/PL2471906T3/pl unknown
- 2006-12-28 NZ NZ595786A patent/NZ595786A/xx unknown
- 2006-12-28 PT PT12150919T patent/PT2471904T/pt unknown
- 2006-12-28 KR KR1020187026653A patent/KR20180105266A/ko not_active Application Discontinuation
- 2006-12-28 NZ NZ712789A patent/NZ712789A/en unknown
- 2006-12-28 CN CN200680053575.3A patent/CN101395266B/zh active Active
- 2006-12-28 ES ES12150919T patent/ES2711278T3/es active Active
- 2006-12-28 CN CN201310024293.2A patent/CN103146640B/zh active Active
- 2006-12-28 CN CN201810489408.8A patent/CN108559725A/zh active Pending
- 2006-12-28 DK DK12150924.4T patent/DK2471905T3/da active
- 2006-12-28 US US11/648,804 patent/US20080032401A1/en not_active Abandoned
- 2006-12-29 PE PE2006001722A patent/PE20080146A1/es not_active Application Discontinuation
-
2008
- 2008-06-25 MX MX2018012512A patent/MX2018012512A/es unknown
- 2008-06-25 MX MX2020001944A patent/MX2020001944A/es unknown
- 2008-06-25 MX MX2014002006A patent/MX348414B/es unknown
- 2008-06-25 MX MX2013009297A patent/MX338534B/es unknown
- 2008-06-26 IL IL192457A patent/IL192457A0/en active IP Right Grant
-
2010
- 2010-06-11 ZA ZA2010/04182A patent/ZA201004182B/en unknown
- 2010-07-30 US US12/848,007 patent/US8202703B2/en active Active
-
2012
- 2012-05-16 US US13/473,509 patent/US8591883B2/en active Active
- 2012-05-24 US US13/480,370 patent/US8691217B2/en active Active
- 2012-11-20 IL IL243876A patent/IL243876B/en active IP Right Grant
- 2012-11-20 IL IL223156A patent/IL223156A0/en active IP Right Grant
- 2012-11-22 IL IL223194A patent/IL223194A/en active IP Right Grant
-
2013
- 2013-01-10 JP JP2013002575A patent/JP5739918B2/ja active Active
- 2013-10-29 HK HK13112141.8A patent/HK1184817A1/zh unknown
-
2014
- 2014-02-14 US US14/181,159 patent/US9078898B2/en active Active
-
2015
- 2015-06-10 US US14/735,727 patent/US10383897B2/en active Active
-
2016
- 2016-01-31 IL IL243876A patent/IL243876A0/en unknown
-
2017
- 2017-05-08 ZA ZA2017/03181A patent/ZA201703181B/en unknown
-
2019
- 2019-05-28 IL IL266958A patent/IL266958A/en unknown
Similar Documents
| Publication | Publication Date | Title |
|---|---|---|
| JP2009521929A5 (ja) | ||
| US20220096564A1 (en) | Methods and compositions for treatment of bone defects with placental cell populations | |
| US10383897B2 (en) | Placental stem cell populations | |
| TWI756797B (zh) | 利用胎盤幹細胞之血管新生 | |
| US20120122215A1 (en) | Placental stem cell populations | |
| KR20210118946A (ko) | 인간 태반 관류액으로부터의 혈관형성 세포 | |
| AU2022201955A1 (en) | Placental stem cell populations |